Karl-Josef Gundermann

• Dr.rer.nat.Dr.med.hab.
• Pomeranian Medical University

Aim: To review the published and unpublished experimental and clinical studies about the efficacy and tolerability of STW1 and to compare the results to the efficacy and tolerability of investigated NSAIDs in parallel. Content. STW1 (Phytodolor®) contains a fixed combination of extracts from aspen leaves and bark (Populus tremula), common ash bark...

Введение. Несмотря на то, что эссенциальные фосфолипиды (ЭФЛ) из сои часто используются при мембранно-ассоциированных расстройствах и заболеваниях, их влияние на распространенные заболевания печени, особенно на жировые болезни печени разного происхождения, до сих пор широко не известны, в связи ч чем, и в настоящее время ведутся активные исследован...

Increasing numbers of patients request lipolytic injection therapy for aesthetic indications instead of surgical procedures. Deoxycholic acid (DC) with or without phosphatidylcholine (PC) is widely used to reduce localized fat accumulation and lipomas. DC induces inflammation and reduces the adipocytes by necrosis, and the usefulness is controversi...

Aim Although essential phospholipids (EPL) from soybean are often used in membrane-associated disorders and diseases, their high quality of purification and effects on prevalent liver diseases, especially on fatty liver diseases (FLDs) of different origin, are still widely unknown and a matter of continuous active research. The aim of this article...

Polyenylphosphatidylcholine (PPC) derived from soy beans is an unspecific membrane therapeutic. Nearly 2,000 publications and experimental as well as clinical studies have shown that PPC has an unspecific effect on almost all cell membranes, making them more flexible, thus improving membrane dependent, metabolic disorders. Even anti aging medicine...

Essential phospholipids (EPL) contain a highly purified extract of polyenylphosphatidylcholine (PPC) molecules from soybean. The main active ingredient is 1,2-dilinoleoylphosphatidylcholine (DLPC), which differentiates it from other phospholipids, lecithins, or extracts from other sources. Although EPLis widely used in liver diseases of various ori...

In order to develop a liver support system using a device with a simple technique, hemoperfusion was performed with pig livers obtained freshly or preserved by freezing in the form of 5-mm cubic pieces. In the fresh liver pieces, the amount of ATP increased significantly from 0.080 to 0.266 μmol/gm wet weight (P<0.025) 120 min after the start of pe...

The objective of this study was to assess the efficacy and safety of the phytopharmacon STW 5 versus metoclopramide in functional dyspepsia. A retrolective, epidemiological cohort study with parallel groups in 23 randomised centres where both drugs were used routinely was performed. The main outcome variable was improvement of 10 dyspepsia-specific...

Functional dyspepsia (FD) constitutes a complex picture with a variety of epigastric symptoms. No standard therapy is currently available for FD. This multicenter, placebo-controlled, double-blind study evaluated the efficacy and tolerability of the herbal drug STW 5, mainly comprising a fresh plant extract from Iberis amara. Patients with FD were...

Unlabelled: Herbal antirheumatics are successfully used in painful inflammatory or degenerative rheumatic diseases. One of these herbal medicines is Phytodolor (STW 1), a fixed combination of extracts from aspen leaves and bark (Populus tremula), common ash bark (Fraxinus excelsior), and golden rod herb (Solidago virgaurea). Its effects as well as...

Functional gastrointestinal disorders such as functional (or non-ulcer) dyspepsia are characterized by a broad spectrum of symptoms referred to the upper abdomen without a detectable cause utilizing routine diagnostic measures. It is now believed that disordered gut function (including abnormalities like disturbances of motility such as postprandia...

Functional dyspepsia is a heterogeneous clinical entity of incompletely known etiology. Overall, four randomized double-blind studies from the nineteen-nineties investigating acute treatment of this condition with the combination herbal medicine Iberogast, are available. A meta-analysis of the studieswas carried out to evaluate the overall therapeu...

A meta-analysis was performed of double-blind, randomized clinical studies that evaluated the efficacy of the herbal preparation Iberogast in patients with functional dyspepsia. All studies had the same duration and used the same dosage of active treatment and the same primary outcome measure, a dyspepsia-specific gastrointestinal symptom score. Of...

The aim of this study was to determine whether serum lipid composition and lipolytic activities in alcoholinduced liver dystrophy were modified by the co-administration of polyunsaturated phosphatidylcholine (PPC). Chronic alcohol intoxication was induced in rats by intragastric ethanol administration of 3.5 g/kg body weight per day over 56 days. A...

A formal meta-analysis was performed including nine randomised placebo- controlled double-blind trials on the clinical efficacy of essential phospholipids from soybean (EPL) in patients suffering from chronic liver disease, published between 1978 and 1995. This analysis summarises and compares subjective, clinical, biochemical and histological data...

The combination of hypolipidemic drugs is considered an effective approach in the treatment of hyperlipidemias. We selected the combination of polyunsaturated phospholipids (EPL) and Lovastatin (HMG CoA reductase inhibitor) for investigation in a prospective, randomized, double-blind, placebo-controlled parallel group trial. It has been conclusivel...

Polyenoylphosphatidylcholine (PPC: 100 or 300 mg kg-1 b.w., by gastric intubation for 30 days) produced a clearcut protection of the liver of rats treated with alloxan (150 mg kg-1 b.w., i.p.). The liver of rats treated with alloxan was characterized by hydropic dystrophy and lymphocytic infiltrations. Treatment with alloxan increased serum gamma-G...

The effect of "essential" Phospholipids from the Soybean (EPL) during and after thalassotherapy in patients with psoriasis vulgaris was studied in the frame of a randomized double-blind study. 60 patients (28 men and 32 women) were enrolled into the study. During the treatment period; 30 patients received over 3 months 6 capsules of EPL daily, wher...

Essentiale and Lipostabil contain "essential" phospholipids from the soybean, mainly 1,2-dilinoleoyl-phosphatidylcholine (CAS 998-06-1, DLPC) which is considered as the main active ingredient. A single oral dose of d15-DLPC loaded with deuterium 9 times in the choline and 6 times in the linoleic acid of the 1-position was given to volunteers. Sera...

In patients with moderate, dietary noncorrigible hyperlipoproteinemia type IIb and ischemic heart disease, treatment with nicotinic acid is limited by the side effects of the drug. In 100 patients, 6-month treatment with nicotinic acid (n=50) or essential phospholipids (EPL); Lipostabil, manufacturer: Rhne-Poulenc Rorer) (n=50) indicated comparable...

The purpose of the review is to evaluate the results obtained with the use of EPL (essential phospholipids) for the treatment of diabetes mellitus in the light of modern scientific knowledge, as well as to highlight the role of lipostabil in the treatment of diabetes mellitus. Since some studies did not set as their primary task the study of the ef...

The paper deals with studies into the mechanism of hepatoprotective action of essential phospholipids (EP) in chronic alcohol intoxication. EPs reduce the count of hepatocytes with hypotopic and fatty dystrophic signs, normalize hepatic triglycerides. The EP antioxidative effect found is associated with vitamin E admixture in the preparation. EPs r...

Fatty infiltration of steatosis occurs in obesity, diabetes, malnutrition, during hyperalimentation and in other conditions including pregnancy, drug therapy and intoxication with alcohol, carbon tetrachloride, etc. Autopsy studies showed the incidence of fatty liver to be at 20-30%, compared with 15-22% in the non diabetic population. Therefore st...

A charcoal sorbent fiber (Enka, F.R.G.), was assessed for impurities, surface area, and adsorptive properties of its native charcoal, and compared with other uncoated activated charcoals. In vivo and in vitro hemocompatibility of the fiber were assessed as well as the adsorptive properties for endogenous toxins. The charcoal of the fiber had few im...

Since 1963 when Eiseman et al. used extracorporeal pig liver hemoperfusion for the treatment of acute hepatic failure (Eiseman et al. 1965), many investigators have tried to find criteria for the vitality of the extracorporeally perfused liver. In 1978, Green et al. measured the surface and outflow redox potential of rabbit kidneys to determine suc...

Extracorporeal baboon and human liver hemoperfusions were performed on 14 patients with acute hepatic failure and no history of chronic hepatic diseases. The patients had grade IV or V hepatic coma according to Abouna et al. (1973). Six patients are alive and one patient showed steroid-induced ulcer bleeding 6 days after recovery of consciousness a...

In the last twenty years, clinical data have been presented on short-term use of hemoperfusion in the treatment of drug overdose and renal and hepatic failure (Winchester et al. 1978). Now, commercial hemoperfusion columns, using both coated and uncoated charcoals, are available. However, for repeated or chronic application of charcoal in extracorp...

9 patients with acute hepatic necrosis following virus hepatitis or hepatic intoxication and 2 patients with acute necrosis of cirrhotic liver, all with stage IV or V hepatic coma, were treated by hemoperfusions with baboon livers. Serum levels of alpha 1-fetoprotein (AFP) were examined prae-, intra- and post perfusion by radioimmunoassay. In 4 pat...

We grafted orthotopically 11 DA and 20 WiS-livers into LEW. The recipients of DA-livers survived 10.5 +/- 4.3 days; of the 20 recipients of WiS-liver, however, nine survived 18-37 days, and the other 11 survived indefinitely. The cells of recipients who survived more than 4 months showed GvHR of grade III, and their transfer showed no significant i...

Twelve patients with acute liver failure, two patients with cirrhotic failure of the liver, and one patient in the terminal stage of cirrhotic liver were treated. The patients had grade IV or V hepatic coma. Twenty-seven perfusions were carried out, each lasting 8 to 27 hours, with one to four perfusions per patient. Eight patients with acute liver...

Both toxic and physiological substances are adsorbed during an extracorporeal hemoperfusion for the treatment of exogenous and endogenous intoxications. Using a closed circuit in vitro, we perfused one liter saline or fresh human plasma with 4425 mumol creatinine, 4854 mumol and 97,086 mumol barbital-Na, 597 mumol bromthalein, 1942 mumol and 29,126...

In order to study the immunological status of rats transplanted with H-1-compatible kidney allografts, LEW rats were grafted with F and (Fischer x Lewis)F1 (FLEWF1) kidneys. Most of the F kidneys were rejected within 55 days, only 4 of 24 surviving for more than 4 months. However, two-thirds of the FLEWF1 recipients survived for more than 4 months,...

For the clinical use of charcoal in intoxications the loss of normal substances out of the organism must be avoided. In order to study the possibility of pretreating the charcoal with certain substances without influencing the adsorptive capacity of toxic metabolic products we perfused over 70 g uncoated charcoal for 6 h: 500 mg creatinine, 1 g and...

For the clinical use of charcoal in intoxications the loss of normal substances out of the organism must be avoided. In order to study the possibility of pretreating the charcoal with certain substances without influencing the adsorptive capacity of toxic metabolic products we perfused over 70 g uncoated charcoal for 6 h: 500 mg creatinine, 1 g and...

In 11 patients with hepatic coma (stage IV and V according to Abouna) extracorporeal haemoperfusion using the Scribner shunt (radial or profunda femoris artery) was performed over 12 to 27 hours with 22 baboon and one human livers. Eight patients emerged from coma, six of them showed sufficient regeneration of the diseased liver. Four patients were...

Funkční gastrointestinální onemocnění typu funkční (nebo neulcerózní) dyspepsie jsou charakterizovány širokým spektrem symptomů lokalizovaných v horní oblasti břicha bez příčiny zjistitelné rutinními diagnos- tickými prostředky. V současnosti se věří, že porušená funkce střev hraje v manifestaci těchto onemocnění klíčovou úlohu (včetně abnormalit j...