Karl-Heinz Ladwig

Karl-Heinz Ladwig
Technische Universität München | TUM · Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie

Prof. Dr.

About

368
Publications
39,949
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
10,286
Citations
Citations since 2016
130 Research Items
6498 Citations
201620172018201920202021202202004006008001,000
201620172018201920202021202202004006008001,000
201620172018201920202021202202004006008001,000
201620172018201920202021202202004006008001,000
Additional affiliations
January 2013 - present
January 2013 - present
January 2011 - December 2012

Publications

Publications (368)
Article
Zusammenfassung Erste Ergebnisse einer bundesweiten Studie deuten auf geschlechtsspezifische Muster mit weniger berichteten Fällen von Kindesvernachlässigung und Gewalt in den Neuen im Vergleich zu den Alten Bundesländern. Ziel der vorliegenden Studie war es diese Ergebnisse in zwei größeren regionalen Stichproben zu überprüfen. Methode: Prävalenze...
Article
Full-text available
Management of radiological incidental findings (IF) is of rising importance; however, psychosocial implications of IF reporting remain unclear. We compared long-term psychosocial effects between individuals who underwent whole-body magnetic resonance imaging (MRI) with and without reported IF, and individuals who did not undergo imaging. We used a...
Article
Objective: Low levels of social connectivity are related to the onset of type II diabetes (T2D) and this study investigates the role of body weight in this association. Methods: In a sample of 9,448 participants followed for a mean of 15.3 years (186,158.5 person-years) from the MONICA/KORA population-based cohort conducted in Germany we investi...
Article
Full-text available
Gender specific all-cause mortality risk associated with a high somatic symptom burden (SSB) in a population-based cohort was investigated. The study population included 5679 women and 5861 men aged 25–74 years from the population-based MONICA/KORA Cohort. SSB was assessed following the Somatic Symptom Scale-8 and categorized as very high (≥ 95th p...
Article
Objective To assess the stability of somatic symptoms in community-dwelling participants. Methods The study included 2472 participants (1190 men, 1282 women; mean age 44.3 ± 10.9) from the prospective population-based MONICA-S3 cohort (1994/95) and the 10-year follow-up KORA-F3 cohort. Somatic symptoms were assessed by an adapted version of the So...
Preprint
Full-text available
Background: The traumatic burden of the Covid-19 pandemic during its early phases posed significant psychological threats particularly for medical frontline personal. It is unclear whether the medical workforce with the passage of time has adapted to these threats or whether emotional perturbations have generalized to wider medical settings. Partic...
Preprint
Metabolome reflects the interplay of genome and exposome at molecular level and thus can provide deep insights into the pathogenesis of a complex disease like major depression. To identify metabolites associated with depression we performed a metabolome-wide association analysis in 13,596 participants from five European population-based cohorts cha...
Article
Full-text available
Background The dysregulation of glucose homeostasis via mental health stress is increasingly acknowledged, whereby depression independently increases the risk of the onset of type 2 diabetes by up to 60%. Contributing mental health factors starting in early life have further been considered, indicating that exposure to childhood emotional abuse is...
Article
Full-text available
Zusammenfassung Herz-Kreislauf-Erkrankungen, zu denen in erster Linie die koronare Herzerkrankung (KHK), Herzrhythmusstörungen und die Herzinsuffizienz (HI) gehören, sind für die meisten Todesfälle und schwerwiegenden Krankheitsverläufe in der Europäischen Union verantwortlich. Das akute Geschehen steht meist im Vordergrund der klinischen Aufmerksa...
Article
Full-text available
Mind and body interventions aim to harness the "relaxation response", reduce stress, and improve quality of life, which is important in the search for more holistic treatment approaches in cardiovascular medicine. This article describes the pertinent pathophysiological correlates building the mechanistic backbone for these interventions. They can b...
Preprint
Full-text available
Objective Atypical symptoms of patients with acute myocardial infarction (AMI) are associated with more delays in care-seeking. Still, patients with typical chest pain have not received enough attention. This study aimed to investigate the effect of pain characters on pre-hospital delays in AMI patients with chest pain. Methods Participants from th...
Article
Background Suicidal ideation and behavior constitute important public mental health issues. In this study, we examined whether social integration prevents suicidal ideation over time and whether gender modifies this association. Methods Data from the Gutenberg Health Study (population-based representative community sample in midwest Germany) and t...
Article
Psychosocial stress has been associated with an increased risk for cardiovascular disease and death. Dysregulated diurnal cortisol slopes, which have also been associated with stress, might mediate this association. However, existing evidence on the cardiovascular health consequences of dysregulated cortisol slopes remains limited and inconclusive....
Article
Full-text available
Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with impaired health-related quality of life (HRQoL), high symptom severity, and poor cardiovascular outcomes. Both clinical and psychological factors may contribute to symptom severity and HRQoL in AF. Methods: Using data from the observationa...
Article
Full-text available
Background While risk factors for age-related diseases may increase multimorbidity (MM), early life deprivation may also accelerate the development of chronic diseases and MM. Methods This study explores the prevalence and pattern of MM in 65–71 year-old individuals born before, during, and after World War II in Southern Germany based on two large...
Article
The prevalence and public health burden of chronic heart failure (CHF) in Europe is steadily increasing mainly caused by the ageing population and prolonged survival of CHF patients. Frequent hospitalizations, high morbidity and mortality rates, and enormous healthcare costs contribute to the health related burden. However, multidisciplinary framew...
Article
Full-text available
Disturbances of HPA axis functioning as represented by cortisol awakening reaction (CAR) belong to the mediating pathways linking psychosocial distress and cardiovascular risk. Both depression and anxiety have been confirmed as independent risk factors for coronary artery disease (CAD). However, data on anxiety and cortisol output in CAD patients a...
Article
Full-text available
Depression constitutes a leading cause of disability worldwide. Despite extensive research on its interaction with psychobiological factors, associated pathways are far from being elucidated. Metabolomics, assessing the final products of complex biochemical reactions, has emerged as a valuable tool for exploring molecular pathways. We conducted a m...
Article
Full-text available
Background Information on long-term alcohol consumption is relevant for medical and public health research, disease therapy, and other areas. Recently, DNA methylation-based inference of alcohol consumption from blood was reported with high accuracy, but these results were based on employing the same dataset for model training and testing, which ca...
Article
Introduction A hyper-coagulant state is a biological mechanism that triggers cardiac events in patients with coronary artery disease (CAD). Depressive symptoms and anxiety predict an unfavourable course of CAD. The SPIRR-CAD-RCT examined the effects of a psychological intervention and provided the opportunity to explore cross-sectional associations...
Article
Full-text available
Childhood maltreatment has been shown to relate to adult obesity. In this epidemiological study, we investigate the association between childhood maltreatment and waist-to-height-ratio (WHtR) in a sample of the German adult population, comprising of N = 2936 participants. WHtR, an indicator for risk of obesity, was the primary outcome. Childhood ma...
Article
Full-text available
(1) Background: The study aimed to investigate the role of subclinical inflammation on the association between diurnal cortisol patterns and glycaemia in an aged population. (2) Methods: Salivary cortisol, interleukin-6 (IL-6) and glycated haemoglobin (HbA1c) were analysed in a sample of 394 men and 364 women (mean age = 5 ± 6.3, 65–90 years). The...
Article
Herzerkrankungen stehen bei der Prävention im Fokus: Sie sind die häufigste Todesursache und ihr Verlauf lässt sich präventiv beeinflussen. Vor Eintritt der Herzerkrankung können durch präventives Handeln viele Erkrankungen verhindert werden – ein Ziel, das von vielen geteilt, aber nur selten praktisch umgesetzt wird. Die Evidenz zu psychosozialen...
Article
Full-text available
Introduction As white matter hyperintensities (WMHs) of the brain are associated with an increased risk of stroke, cognitive decline, and depression, elucidating the associated risk factors is important. In addition to age and hypertension, pre-diabetes and diabetes may play important roles in the development of WMHs. Previous studies have, however...
Article
Full-text available
Background: Although cardiovascular rehabilitation (CR) is well accepted in general, CR-attendance and delivery still considerably vary between the European countries. Moreover, clinical and prognostic effects of CR are not well established for a variety of cardiovascular diseases. Methods: The guidelines address all aspects of CR including indi...
Article
Full-text available
Background The Patient Health Questionnaire-9 (PHQ-9) has been proposed as a reliable and valid screening instrument for depressive symptoms with one latent factor. However, studies explicitly testing alternative model structures found support for a two-dimensional structure reflecting a somatic and a cognitive-affective dimension. We investigated...
Preprint
Full-text available
While risk factors for age-related diseases may increase multimorbidity (MM), early life deprivation may also accelerate the development of chronic diseases and MM. This study explores the prevalence and pattern of MM in 65-71 year-olds individuals born before, during, and after World War II in Southern Germany based on two KORA (Cooperative Health...
Preprint
Full-text available
Background While risk factors for age-related diseases may increase multimorbidity (MM), early life deprivation may also accelerate the development of chronic diseases and MM. Methods This study explores the prevalence and pattern of MM in 65-71 year-old individuals born before, during, and after World War II in Southern Germany based on two KORA (...
Article
Objectives We explored the male-female health-survival paradox in the context of health expectancy (HE) at age 65 and thereafter, using three different morbidity measures and different severity cut-offs with and without adjustments for the share of nursing home residents. Methods HE at ages 65, 70, 75, 80, and 85 was estimated with the Sullivan me...
Article
Objective To investigate the association of generalized anxiety disorder (GAD) symptomology on the incidence of type 2 diabetes. Research design & methods Participants from the prospective KORA F4/FF4 German cohort were followed for a mean of 6.5 years. Generalized Anxiety Disorder scale (GAD-7) was used to assess GAD symptoms and incident type 2...
Article
Full-text available
In Germany, large, population-based cohort studies have been implemented in order to identify risk and protective factors for maintaining health across the life span. The purpose of this systematic review is to analyse findings from three large ongoing cohorts and to identify sex-specific prevalence rates, risk and protective factors for mental hea...
Article
Full-text available
To identify the most important parameters associated with cerebral white matter hyperintensities (WMH), in consideration of potential collinearity, we used a data-driven machine-learning approach. We analysed two independent cohorts (KORA and SHIP). WMH volumes were derived from cMRI-images (FLAIR). 90 (KORA) and 34 (SHIP) potential determinants of...
Chapter
Railway suicides account for less than 10% of all suicides and are considered a major public health issue because of their consequences for the operation of the transportation system and their deteriorating impact on staff and bystanders. Behaviour patterns include jumping, lying, wandering, and deviant behaviour prodromal to the attempt. Case fata...
Article
Full-text available
Background: Current evidence suggests that the information needs of people with diabetes mellitus differ across patient groups. With a view to being able to provide individualized information, this study aims to identify (i) the diabetes-related information needs of people with diabetes mellitus; (ii) different subgroups of people with specific in...
Article
Mental health research opportunities in the MONICA-KORA studyGoal: Initially, part of the worldwide MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Project of the World Health Organization (WHO), the project was pursued 1996 as KORA (Cooperative Health Research in the Region Augsburg) Study, which now substantially expands the...
Article
Full-text available
The role of self-perceived general health in predicting morbidity and mortality among older people is established. The predictive value of self-perceived mental health and of its possible biological underpinnings for future depressive symptoms is unexplored. This study aimed to assess the role of mental health-related quality of life (HRQOL) and of...
Article
Full-text available
Purpose of the review: Atrial fibrillation (AF) is the most frequent arrhythmia in the general population. This review aims to provide a comprehensive overview of the psychological aspects of AF, compiling evidence from epidemiological, clinical, and basic research sources. Recent findings: Findings from large-scale population-based and clinical...
Article
Background: The Type D Personality (TDP) has been specifically linked to acute myocardial infarction (AMI). However, the impact on prehospital delay of AMI patients is unclear. The aim of this study was to assess the relationship between TDP and pre-hospital delay time (PHT) in a Chinese population. Methods: A total of 256 AMI patients (47 women a...
Article
Full-text available
The study aimed to examine the sex specific association of obesity with cortisol metabolism in a sample of older community dwelling people. The cross-sectional analysis included 394 men and 375 women (aged 65–90 years) of the population-based KORA-Age study. Multivariable regression analyses were employed to examine the association between cortisol...
Article
Full-text available
Genetic variations affecting the course of depressive symptoms in patients with coronary artery disease (CAD) have not yet been well studied. Therefore, we set out to investigate whether distinct haplotypes of the two insertion/deletion polymorphisms in the serotonin-transporter-linked polymorphic region (5-HTTLPR) and the angiotensin I-converting...
Article
Full-text available
Background: Maternal weight variables are important predictors of postpartum depression (PPD). While preliminary evidence points to an association between pre-pregnancy obesity and PPD, the role of excessive gestational weight gain (GWG) on PPD is less studied. In this secondary cohort analysis of the German 'healthy living in pregnancy' (GeliS) t...
Article
Full-text available
To identify the most important factors that impact brain volume, while accounting for potential collinearity, we used a data-driven machine-learning approach. Gray Matter Volume (GMV) was derived from magnetic resonance imaging (3T, FLAIR) and adjusted for intracranial volume (ICV). 93 potential determinants of GMV from the categories sociodemograp...
Conference Paper
Introduction: Postpartum depression (PPD) is a common maternal health complication with a complex aetiology influenced by multiple risk factors. Among other factors, maternal pre-pregnancy overweight/obesity and excessive gestational weight gain (GWG) have been suggested to increase the risk of PPD, but evidence remains limited and inconclusive. Th...
Article
Background: Despite well-established evidence on marriage as a psychosocial support for adults, there are studies that indicate loneliness may affect even married adults. Loneliness provokes a dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) axis. Thus, the study aims to examine the sex-specific association of loneliness and cortiso...
Article
Full-text available
Interventions aiming at reducing prehospital delay (PHD) in patients with acute coronary syndrome (ACS) have yielded inconsistent findings. Therefore, we aimed to systematically review studies which investigated the impact of educational interventions on reducing PHD in patients with ACS. We searched four electronic databases (Cumulative Index to N...
Article
Health projections often extrapolate from observations in current ageing cohorts, but health in older age may depend not only on individual characteristics but also on a person's historical context. Our objective was to investigate how health deficit accumulation trajectories after age 65 differed in five adjacent birth cohorts and according to ind...
Article
Context and Aims: Psychosocial risk factors are known to result in either takotsubo syndrome (TTS) or myocardial infarction (MI). In this article, the results of a cross-sectional study are presented within the framework of “progressive somatization” by comparing the psychosocial traits of TTS and MI patients. Design/Subjects and Methods: 136 patie...
Article
Psychocardiological aspects of atrial fibrillation: Atrial fibrillation is a complex biopsy- chosocial systemic disease, often with negative impact on quality of life. The relationship between prevailing heart rhythm, symptoms, cognitions, emotions, biography, socioeco- nomic and functional status of the patients is only partly understood. Patients...
Article
Das Wissen um die »kardiotoxische« Bedeutung psychosozialer Risiken – insbesondere einer depressiven Stimmungslage – auf die Entstehung und Prognose der koronaren Herzerkrankung (KHK) hat weltweit eine intensive Therapie-Forschung zu dieser Thematik angeregt. Nach anfänglichen Rückschlägen zeigt die neueste Generation von Therapiestudien, dass mit...
Article
Full-text available
DNA methylation may be one of the mechanisms by which alcohol consumption is associated with the risk of disease. We conducted a large-scale, cross-sectional, genome-wide DNA methylation association study of alcohol consumption and a longitudinal analysis of repeated measurements taken several years apart. Using the Illumina HumanMethylation450 Bea...
Article
Background: There is evidence for a seasonal pattern of suicides with peaks in spring and early summer; however, only a limited number of studies has investigated whether daily changes in meteorological variables may trigger suicides. Methods: Daily fatal suicide (N = 10,595) and meteorological data were available for four Bavarian cities and te...
Article
Full-text available
Inferring a person’s smoking habit and history from blood is relevant for complementing or replacing self-reports in epidemiological and public health research, and for forensic applications. However, a finite DNA methylation marker set and a validated statistical model based on a large dataset are not yet available. Employing 14 epigenome-wide ass...
Article
Full-text available
Objective The origin of malnutrition in older age is multifactorial and risk factors may vary according to health and living situation. The present study aimed to identify setting-specific risk profiles of malnutrition in older adults and to investigate the association of the number of individual risk factors with malnutrition. Design Data of four...
Article
Full-text available
The etiology of takotsubo cardiomyopathy (TTC)—a rare, reversible, and acquired form of cardiac diseases—is not yet fully explained. An exaggerated activation of the sympathetic-nervous-system (SNS) following stressful psychosocial life events is discussed to be of key importance. In this experimental study, we tested whether TTC patients, compared...
Article
Full-text available
Background: It is highly recommended that all patients with coronary artery disease should be screened for depression. The Major Depression Inventory (MDI) is a widely used self-rating scale for the assessment of depression but is not valid in Chinese language. The present study was designed to assess the reliability and validity of a version of th...
Article
Full-text available
Morbidity trends may result from cohort experiences in critical developmental age. Our objective was to compare the health status of 65–71 year-olds who were in critical developmental age before (1937–June 1945), during (June 1945–June 1948) and after (June 1948–1950) the early reconstruction and food crisis (ERFC) period in Germany following World...