Karl Gassmann

Karl Gassmann
Geriatrics Center Erlangen, Malteser Waldkrankenhaus St.Marien

Professor

About

69
Publications
7,964
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2,013
Citations
Citations since 2016
26 Research Items
1252 Citations
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200

Publications

Publications (69)
Article
Full-text available
Aims: Automated checks for medication-related problems have become a cornerstone of medication safety. In many clinical settings medication checks remain confined to drug-drug interactions because only medication data are available in an adequately coded form, leaving possible contraindicated drug-disease combinations unaccounted for. Therefore, w...
Poster
Full-text available
Der bisherige Erfolg des MoSi®-Programms in Bayern macht Mut und der sicherlich bestehende Bedarf an einem solchen Angebot für die ältere Bevölkerung fordert dessen weitere Ausbreitung geradezu heraus. Nun gilt es, dieses Trainingsangebot neben einer weiteren Ausbreitung in Bayern auch über dessen Grenzen hinweg noch umfangreicher zu etablieren. Da...
Article
Background: Atrial fibrillation (AF) is the most frequent cardiac arrhythmia with an impact on morbidity and mortality found in the geriatric population. Objective: This retrospective study is the first to investigate the prevalence, treatment and comorbidities of AF in a large cohort of older adults. Material and methods: Older adults with AF...
Article
Background: Geriatric assessment is an integral part of geriatrics and leads to various improvements in the treatment of geriatric patients. Material and methods: Analysis of assessment data and patient characteristics in a large inpatient geriatric patient population. Evaluation of data from the Geriatrics in Bavaria Database (GiB-DAT) over 20...
Article
Introduction: Older patients undergoing major urological tumor surgery are at severe risk of functional deterioration, complications, and mortality. We prospectively evaluated geriatric assessment tools and developed a novel easy-to-use assessment tool for clinical use. Methods: In 159 patients, geriatric assessment tools were used prior to cyst...
Article
Full-text available
Objective: An analysis of the relationships between static equilibrium parameters and frailty status and/or severity across four different frailty measures. Design: Cross-sectional analysis. Setting: Geriatric wards of a general hospital. Participants: One hundred twenty-three geriatric inpatients comprising 70 women (56.5%) and 53 men (42.7...
Article
Full-text available
Recently we introduced a modified Mini Nutritional Assessment (MNA) Short Form (MNA-SF) and Long Form (MNA-SF) with operationalization of the ‘mobility’ and ‘neuropsychological problems’ items of the MNA using scores on Barthel Index mobility item and Mini Mental State Examination and Geriatric Depression Scale scores. We have now evaluated the abi...
Article
Full-text available
Background: We aimed to evaluate the abilities of a 21-item frailty index based on laboratory blood and urine tests (FI-Lab21) assessed at different points in time, ie, at admission to hospital (FI-Lab21admission) and before discharge from hospital (FI-Lab21discharge), and the change of the FI-Lab21 during the hospital stay to predict 6-month and...
Poster
Full-text available
Wearable exoskeletons require extensive technical expertise innovation. Still the most innovative systems cannot be successful should they fail to be accepted by their intended users. This research provides an important step into the exploration of wearable soft biomimetic lower-limb exoskeletons as assistive devices from a user´s perspective.
Article
Full-text available
Background Uncomplicated frailty instruments are desirable for use in a busy clinical setting. The aim of this study was to operationalize a frailty index (FI) from routine blood and urine tests, and to evaluate the properties of this FI compared to other frailty instruments. Materials and methods We conducted a secondary analysis of a prospective...
Poster
Full-text available
Standardisierte Verfahren wie das Performance-Oriented Mobility Assessment, welche internationale Anerkennung genießen, dienen neben dem Einsatz in der Outcome- und Evaluationsforschung auch als Instrument für die Vorhersage und Feststellung von Interventionsbedarf, Dokumentation und Evaluation von Behandlungsverläufen und der Rechtfertigung gegenü...
Article
Objective: Accurate estimation of spatial gait characteristics is critical to assess motor impairments resulting from neurological or musculoskeletal disease. Currently, however, methodological constraints limit clinical applicability of state-of-the-art double integration approaches to gait patterns with a clear zero-velocity phase. Methods: We...
Article
Full-text available
Background In an increasing aging society, reduced mobility is one of the most important factors limiting activities of daily living and overall quality of life. The ability to walk independently contributes to the mobility, but is increasingly restricted by numerous diseases that impair gait and balance. The aim of this cross-sectional observation...
Article
Full-text available
Purpose Previous studies suggest an association between use of anticholinergic drugs in elderly patients and cognitive impairment. However, there are still limited data on the association of anticholinergic drug use and cognitive impairment as well as contribution of individual drugs to anticholinergic load using large, well-documented patient coho...
Data
Flow-chart for multivariable analyses. (TIF)
Data
Correlation between ACB score and various variables. (PDF)
Data
Univariable analysis of the association of MMSE with various parameters. (PDF)
Data
Assessment of the item dementia of the 4D+S scale. (PDF)
Article
Background Studies evaluating and comparing the power of frailty, comorbidity, and disability instruments, together and in parallel, for predicting mortality are limited. Objective This study aimed to evaluate and compare the measures of frailty, comorbidity, and disability in predicting 1-year mortality in geriatric inpatients. Design Prospectiv...
Article
Frailty is a major health burden in an aging society. It constitutes a clinical state of reduced physiological reserves that is associated with a diminished ability to withstand internal and external stressors. Frail patients have an increased risk for adverse clinical outcomes, such as mortality, readmission to hospital, institutionalization and f...
Article
Objective We analyzed associations between a battery of gait characteristics and frailty status across four different frailty instruments in old patients. Design Cross-sectional study. Setting Geriatric wards of a general hospital. Participants 123 hospitalized patients aged ≥65 years. Measurements Spatio-temporal and three-dimensional gait charact...
Article
Background In clinical research as well as good clinical practice increasing importance is placed on standardized and evaluated procedures. They provide information which is important for the prognosis, determination of the need for interventions, determination of treatment goals and evaluation of treatment approaches and outcomes. Furthermore, the...
Article
Background: The present study aimed to evaluate a short-form (MNA-SF) version of the Mini Nutritional Assessment (MNA), in which some of the items were operationalised, based on scores from tools used for a comprehensive geriatric assessment, as a method for analysing the nutritional status of hospitalised geriatric patients. We compared this MNA-...
Article
Full-text available
Background: Drug-induced QT-interval prolongation is associated with occurrence of potentially fatal Torsades de Pointes arrhythmias (TdP). So far, data regarding the overall burden of QT-interval prolonging drugs (QT-drugs) in geriatric patients are limited. Objective: This study was performed to assess the individual burden of QT-interval prol...
Article
Background: Data comparing the ability of different major frailty instruments for predicting mortality in hospitalized geriatric patients are scare. Material and methods: 307 patients ≥65years who were hospitalized on geriatric wards were included in this prospective analysis. A fifty-item frailty index (FI), a ten-domain+co-morbidity frailty in...
Article
Objective To compare the ability of different frailty indexes based on a standardized comprehensive geriatric assessment (FI-CGAs) for predicting adverse outcomes. Design and Setting Prospective cohort study. Geriatric wards of a general hospital. Participants 307 hospitalized patients ≥ 65 years. Measurements The FI-CGA-10D (potential health defic...
Article
Objectives There are few data regarding the accuracy of short frailty tools as predictors of mortality and other clinical outcomes of older patients admitted to a geriatric ward. We therefore analyzed the accuracy of Rockwood et al’s Clinical Frailty Scale and an easy and quick to perform operationalization of Fried et al’s frailty phenotype, as pr...
Article
The role of instrumented balance and gait assessment when screening for prospective fallers is currently a topic of controversial discussion. This study analyzed the association between variables derived from static posturography, instrumented gait analysis and clinical assessments with the occurrence of prospective falls in a sample of community d...
Article
Full-text available
A detailed and quantitative gait analysis can provide evidence of various gait impairments in elderly people. To provide an objective decision-making basis for gait analysis, simple applicable tests analyzing a high number of strides are required. A mobile gait analysis system, which is mounted on shoes, can fulfill these requirements. This paper p...
Article
Dear Doctor Letters (also known as Direct Healthcare Professional Communications) inform physicians about significant newly discovered drug risks and about measures to take to reduce these risks. How far these warnings actually influence prescribing behavior is unclear. The Geriatrics in Bavaria-Database (GiB-DAT, Geriatrie in Bayern Datenbank) col...
Article
Objective: With the aim of reducing the risk of adverse drug effects, expert groups have defined lists of potentially inappropriate medications (PIM) for drug therapy in the elderly. However, it is unclear whether use of PIM at discharge from specialized geriatric units is associated with altered clinical characteristics. Methods: A post-hoc ana...
Article
The aim of this project was to obtain information about drug therapy in geriatric units. Members of the geriatrics in Bavaria database (GiB-DAT) collected data on discharge medication and transferred them to the database. A total of 88,840 data sets of geriatric rehabilitation clinics and acute geriatric units were evaluated according to the anatom...
Article
Fragestellung: In der Arbeit soll untersucht werden, welche medizinischen und psychologischen Prädiktoren die Nachhaltigkeit von geriatrischer Rehabilitation bei Patienten, die nach Hause entlassen werden, vorhersagen. Material und Methode: Es wurde eine prospektive längsschnittliche Kohortenstudie mit 3 Messzeitpunkten im Feld durchgeführt. Es han...
Article
Full-text available
Background: A falls clinic was established at the Waldkrankenhaus St. Marien, Erlangen, Germany. Risk factors for falls in community dwelling elderly adults were assessed and targeted interventions were recommended. Methods: The assessment consisted of patient history, physical examination, evaluation of medication intake, clinical gait assessment,...
Article
Frequency-based analysis of body sway has been used to distinguish between healthy young, healthy elderly adults and elderly adults with Huntingtons disease. Our aim was to assess the reliability of spectral-based outcomes of the centre of pressure (CoP) kinematics in order to determine if these outcomes could be tested for their capability to dist...
Article
Full-text available
Background “Mobility and safety for the elderly (MoSi)©” is a new intervention, especially designed for elderly people with gait disorders and for fallers. Method 165 persons, 65 years or older, participated in this study.The participants were assessed prior to and after the 5-week intervention. The intervention included various elements of strengt...
Article
Full-text available
Static posturography is used to quantify body sway. It is used to assess the balance of elderly persons who are prone to falls. There is still no general opinion concerning the reliability of force platform measurements. The aim of this study was to test the reliability of force platform parameters when measuring elderly persons. The reliability of...
Article
The aim of this study was to determine the prevalence and related predictors of dizziness in a sample of community-dwelling people 65 years of age and older living in a metropolitan area in Germany. Prospective cohort study. Interdisciplinary Centre of Gerontology at the University of Erlangen- Nuremberg, Germany. 6000 people aged 65 years and olde...
Article
To investigate the intrasession reliability of center of pressure (COP) parameters calculated from force platform measurements. A cross-sectional study. Gait and balance laboratory. Community-dwelling healthy older adults (N=63) above the age of 62 years (mean age, 78.74 y). Not applicable. COP was estimated from a force platform, and the following...
Article
Full-text available
Several publications indicate that the female gender experiences a higher incidence of adverse drug reactions (ADRs) than does the male gender. The reasons, however, remain unclear. Gender-specific differences in the pharmacokinetic and pharmacodynamic behaviour of drugs could not be identified as an explanation. The aim of this study was to analys...
Article
Full-text available
Little is known about the prevalence of falls and the related risk factors in the general population of community-living older people in Germany. To assess the prevalence and related predictors of different types of falls in a sample of community-dwelling 65 years and older people in Germany living in a metropolitan area. Study design and setting p...
Article
We determined in vitro the potency of macrolides as P-glycoprotein inhibitors and tested in hospitalised patients whether coadministration of P-glycoprotein inhibitors leads to increased serum concentrations of the P-glycoprotein substrates digoxin and digitoxin. In vitro, the effect of macrolides on polarised P-glycoprotein-mediated digoxin transp...
Article
Falls in the elderly are a common health condition. Approximately 30% of subjects over 65 years experience a fall at least once a year, increasing to well over 50% of those 80 years or older. Although serious consequences occur in just 10%, the overall incidence of falls is nontheless resulting in a significant number of fractures, esp. hip fractur...
Article
Unter dem Begriff „Anti-Aging” wird ein großes Spektrum an Therapien angeboten. Ein Teil davon zielt darauf ab einen gesunden Lebensstil zu vermitteln. Die Wirksamkeit dieser Maßnahmen ist bekannt, sie dienen der Krankheitsprävention und fördern somit ein gesundes Altern. Funktionelle Einschränkungen, die durch die physiologischen Altersveränderung...
Article
Unter dem Begriff „Anti-Aging” wird ein großes Spektrum an Therapien angeboten. Ein Teil davon zielt darauf ab einen gesunden Lebensstil zu vermitteln. Die Wirksamkeit dieser Maßnahmen ist bekannt, sie dienen der Krankheitsprävention und fördern somit ein gesundes Altern. Funktionelle Einschränkungen, die durch die physiologischen Altersveränderung...
Article
Background and objective Up to 23% of the population, depending on their ethnic background, has genetically determined differences in the metabolism of drugs by the cytochrome P450 (CYP) enzymes CYP2C9, CYP2C19 and CYP2D6. The aim of this survey was to determine the relationship between genetical polymorphisms in these CYP enzymes and adverse drug...
Article
Full-text available
Up to 23% of the population, depending on their ethnic background, has genetically determined differences in the metabolism of drugs by the cytochrome P450 (CYP) enzymes CYP2C9, CYP2C19 and CYP2D6. The aim of this survey was to determine the relationship between genetical polymorphisms in these CYP enzymes and adverse drug reactions (ADRs) in geria...
Article
Full-text available
Geriatric patients with multiple comorbidities are at high risk of experiencing an adverse drug reaction (ADR) during hospitalisation. The aim of the study was to compare the rate of ADRs as predicted by a computerised pharmacological database to the actual rate determined by direct observation in a sample of geriatric patients. During a 4-month pe...
Article
In the last years it has been reported about a new type of diffuse cortical dementia: Lewy body disease (LBD). An important neuropathologic feature is the presence of Lewy bodies in the brainstem and cerebral cortex with different subtypes. LBD shows the following major clinical symptoms: progressive dementia with cognitive impairment, psychiatric...
Article
BACKGROUND and In Germany, basic data on stroke morbidity are lacking. If a population-based register in former East Germany is excluded, only routine mortality statistics have thus far provided information on epidemiology of stroke. Therefore, a population-based register of stroke was set up in Southern Germany to determine incidence and case fata...
Article
Geriatric rehabilitation is very effective in providing a better functional status for recovering geriatric patients and preparing these patients for the activities of home-management and daily life outside the hospital. Data from 214 patients from a geriatric rehabilitation centre were evaluated. All the patients underwent formal geriatric assessm...
Article
Because of age-related modifications of the heart, lung, and circulation, several cardiopulmonary parameters present altered normal and reference values with increasing age. Other parameters, for example, arterial blood pressure, change only insignificantly with age. In older age groups it is more difficult to establish reference ranges and values...
Article
During the interdisciplinary study 'Conditions of Preservation and Support of Independence in Old Age (SIMA)' 375 independently living persons aged 75-93 have been examined. The research project also included detailed medical screening. The present paper shows part of the results concerning the subjects' state of health. The basic results are: 1. V...
Chapter
Die steigende Zahl psychisch kranker älterer Menschen stellt zunehmende Anforderungen an betreuende Personen und versorgende Institutionen. Im bestehenden Versorgungssystem nehmen psychiatrische Landeskrankenhäuser bei der Behandlung älterer chronisch psychisch Kranker und multimorbider Patienten eine wichtige Stellung ein.
Chapter
In der Gerontopsychiatrie eines Landeskrankenhauses spielen bei vielen Patienten neben überwiegend schweren und chronischen psychischen Erkrankungen körperliche Krankheiten und Beeinträchtigungen eine wichtige Rolle. Im Mittelpunkt dieser Studie, die retrospektiv alle im 1. Halbjahr 1989 in unserem Zentrum aufgenommenen Patienten über 65 Jahre umfa...

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Projects

Projects (2)
Project
The education of "MoSi®-Trainer" (course instructors). A Bavaria-wide expansion of the MoSi® -Training by acquiring MoSi®-Training Centres in all administrative districts. The implementation of MoSi®-Training to maintain and improve gait safety (mobility) and safety in everyday life as well as the prevention of falls from the age of 65 at all participating MoSi®-Training Centres.
Project
XoSoft: the intelligent trousers Advancement in healthcare and medicine and other comforts of modernity make us live longer than our ancestors: the life expectancy of the average European nearly doubled during the last century. As life expectancy increases, however, so does the number of older people with mild to moderate disability. A number of congenital or chronic conditions as well as the result of an injury can also lead, already at a younger age, to varying degrees of mobility impairment. There are 3.2 million wheelchair users in Europe and another 40 million who cannot walk without an aid. People with limitation in independent movement of their legs can rely on a variety of assistive devices. Yet the currently available assistive aids are usually bulky, fairly inflexible and can therefore only partially support the process of movement. Neither do they encourage or support the activation of legs, which is essential to prevent further atrophy. An international, multidisciplinary consortium of researchers has therefore set out to develop, within the framework of the European Union’s Horizon 2020 Research and Innovation Programme, a novel solution: a wearable, intelligent clothing system, named XoSoft. This soft, modular, lower limb exoskeleton for the elderly and disabled will help increase mobility and thus greatly improve health and quality of life. Advanced textiles and smart materials will be employed to create sensing, variable stiffness joints. Built-in sensors will communicate the user’s motion and intention to the controlling unit for analysis to determine and provide, by way of actuators, the appropriate level of assistance: Depending on the user’s need at a given moment, the device will provide support, release or freedom of movement. The nine organisations from seven European countries involved in this public-private partnership kicked off the revolutionary R&D project in February 2016 with the aim to develop the first fully functional prototype by 2019. Besides five research groups from the disciplines of robotics, bioengineering, ambient intelligence and design, the team also includes four companies and clinical partners with expertise in rehabilitation technologies, geriatrics and prosthetic applications. The EU and Switzerland have committed 5.4 m euros in funding to the project’s budget. Project Partners: • Fondazione Instituto Italiano di Tecnologia, IT (coordinator) • accelopment AG, CH • Consejo Superior de Investigaciones Científicas, ES • Geriatrie-Zentrum Erlangen, DE • Össur hf, IS • Roessingh Research and Development, NL • Saxion University of Applied Science, NL • University of Limerick, IE • Zurich University of Applied Sciences, CH