Karl D'Souza- MS, MBA
- Director at Dassault Systèmes
Karl D'Souza
- MS, MBA
- Director at Dassault Systèmes
About
13
Publications
3,012
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
165
Citations
Introduction
With over 20 years of experience in computational modeling and simulation, Karl D'Souza is highly skilled in technology consulting, product management, and business development as they pertain to simulation-based solutions for science and technology companies. In his current role as Life Sciences Industry Solution Experience Director, he is responsible for managing the Design and Engineering portfolio of Dassault Systemes' solutions for medical devices, bio-pharmaceuticals, and patient care.
Current institution
Publications
Publications (13)
Health Digital Twins (HDT) can bring a decisive contribution to personalized, precise, successful medical treatments. They will rely on combining the latest fundamental knowledge from research with a patient’s exact history and unique physiology. First use cases of HDT have been developed in the last decade in specific domains, with the examples of...
Translational medical research seeks to foster the multidirectional and multidisciplinary integration of basic research, patient-oriented research, and population-based research, with the long-term aim of improving the health of the public (Rubio D, et al., Acad Med. 85:470–475, 2010). A prerequisite of the translation process is a foundation suita...
Transcatheter aortic valve replacement (TAVR) is a minimally invasive procedure that provides an effective alternative to open-heart surgical valve replacement for treating advanced calcific aortic valve disease patients. However, complications, such as valve durability, device migration, paravalvular leakage (PVL), and thrombogenicity may lead to...
A common but serious side effect of many drugs is their propensity to cause cardiac electrical rhythm disturbances . Despite significant advances, the mechanisms that trigger electrical anomalies remain incompletely understood. Mathematical models and computational simulation have the potential to address this challenge. The current study addresses...
Transcranial Electrical Stimulation (tES) is a noninvasive neuromodulation technique wherein low intensity electrical current is applied to the head via scalp-mounted electrodes. Transcranial Direct Current Stimulation (tDCS, a form of tES) is increasingly being used in the treatment of several neurological and psychiatric disorders such as stroke...
Introduction: The durability of the pacemaker electrodes is of great importance since damage to them can mean they no longer provide life-saving electrical stimulus. A pacemaker electrode is meant to be a permanent implant, where it is expected to perform for many years without failure. The SIMULIA Living Heart Human Model provides a unique testing...
The engine valve cover is known to be major contributor to powertrain noise due to its large surface area and relatively small thickness. Thus, the acoustic analysis of the valve cover has become one of the key steps in the design process. The present paper describes an acoustic infinite element approach to model the sound radiation of the valve co...
This article describes the simulation of the mechanical behavior of two types of endosseous-threaded dental implants and the development of design guidelines for such implants. Two- and three-dimensional representations, static and dynamic cyclic loads, different material models, axial loads, and loads directed at the occlusal angle are all used. A...
