Karina Moslova

University of Helsinki | HY · Department of Chemistry

Caralluma europaea is a medicinal plant used in Morocco to treat various illnesses. This study aimed to determine the lipidic composition, the antioxidant, the antiproliferative, the anti-inflammatory, and the wound healing activities of C. europaea lipid extract. The chemical composition of C. europaea was analyzed using Time-of-Flight Mass Spectr...

Porous silicon (PSi) nanoparticles have been applied in various fields, such as catalysis, imaging, and biomedical applications, because of their large specific surface area, easily modifiable surface chemistry, biocompatibility, and biodegradability. For biomedical applications, it is important to precisely control the surface modification of PSi-...

Oral insulin delivery could change the life of millions of diabetic patients as an effective, safe, easy-to-use, and affordable alternative to insulin injections, known by an inherently thwarted patient compliance. Here, we designed a multistage nanoparticle (NP) system capable of circumventing the biological barriers that lead to poor drug absorpt...

Gold is a valuable metal that can be dissolved with common household chemicals as reported by Timo Repo et al. in their Research Article (e202117587). By applying catalytic iodine, aqueous hydrogen peroxide and 2‐mercaptobenzimidazol, gold promptly dissolves in ethanol. Catalytic reactions and environmentally benign solvents and reagents are the ba...

Gold ist ein wertvolles Metall, das mit gewöhnlichen Haushaltschemikalien aufgelöst werden kann, wie Timo Repo et al. in ihrem Forschungsartikel (e202117587) berichten. Durch den Einsatz von katalytischem Iod, wässrigem Wasserstoffperoxid und 2‐Mercaptobenzimidazol löst sich Gold sofort in Ethanol auf. Katalytische Reaktionen und umweltverträgliche...

Gold is a scarce element in the Earth’s crust but indispensable in modern electronic devices. New, sustainable methods of gold recycling are essential to meet the growing eco‐social demand of gold. Here, we describe a simple, inexpensive, and environmentally benign dissolution of gold under mild conditions. Gold dissolves quantitatively in ethanol...

Gold is a scarce element in the Earth’s crust but indispensable in modern electronic devices. New, sustainable methods of gold recycling are essential to meet the growing eco‐social demand of gold. Here, we describe a simple, inexpensive, and environmentally benign dissolution of gold under mild conditions. Gold dissolves quantitatively in ethanol...

Magmas readily react with their wall-rocks forming metamorphic contact aureoles. Sulphurand possibly metal mobilization within these contact aureoles is essential in the formation o feconomic magmatic sulphide deposits. We performed heating and partial melting experiments on a black shale sample from the Paleoproterozoic Virginia Formation, which i...

Well-established label in biomolecules analysis, fluorescein isothiocyanate is commercially available in its two different isomers with equal fluorescence sensitivity, differing in meta- vs. para-isothiocyanate position. It was found in this study that the stability of the isomers depends on the polarity of different solvents and the pyridine (stab...

The synthesis of new types of furan-based compounds other than 5-hydroxymethylfurfural from glucose is a very attractive yet underexploited strategy. We report here a catalytic conversion of glucose with acetylacetone (acac) to furan-centered chemicals, 2-methyl-3-acetylfuran (MAF) and 1-(5-(1,2-dihydroxyethyl)-2-methylfuran-3-yl)ethan-1-one (DMAF)...

Invited for the cover of this issue is the group of Timo Repo at the University of Helsinki. The image depicts a ligand‐exchange reaction as a battle between hummingbirds and golden birds, which represent two different thiol ligands. Read the full text of the article at 10.1002/chem.202101028. “Gold is a valuable component in electronic waste, but...

Dissolution of elemental gold occurs promptly with two different thiol ligands that act in a cooperative manner. The reaction benefits from the dynamic coordination sphere of AuI species that enables the dissolution to proceed via ligand‐exchange reactions. The dissolution proceeds from left to right and the birds represent the different Au species...

A new selective synthesis of novel quinoline carboxamides was developed by the N-alkylation reaction of methyl (2-oxo-1,2- dihydroquinolin-4-yl)-L-alaninate via phase transfer catalysis in a basic medium at room temperature. The compounds were obtained in excellent yields (70-90%) and characterized by ¹H, ¹³CNMR spectroscopy and mass spectra. In ad...

Development of new, environmentally benign dissolution methods for metallic gold is driven by needs in the circular economy. Gold is widely used in consumer electronics, but sustainable and selective dissolution methods for Au are scarce. Herein we describe a quantitative dissolution of gold in organic solution under mild conditions using hydrogen...

Breast cancer, with around 2 million new cases in 2019, is the second most common cancer worldwide and the second leading cause of cancer death among females. The aim of this work is to realize a targeting nanomedicine through the conjugation of LinTT1 peptide, a specific molecule targeting p32 protein overexpressed by breast cancer and cancer asso...

N-aryl-oxazolidinones is a prominent family of antimicrobials used for treating infections caused by clinically prevalent Gram-positive bacteria. Recently, boron-containing compounds have displayed intriguing potential in the antibiotic discovery setting. Herein, we report the unprecedented introduction of a boron-containing moiety such as an aryl...

Organoboron compounds are essential reagents in modern C‐C coupling reactions. Their synthesis via catalytic C‐H borylation by main group elements is emerging as a powerful tool alternative to transition metal based catalysis. Herein we report a straightforward metal‐free synthesis of aryldifluoroboranes from BF3 and heteroarenes. The reaction is a...

Herein we report a unique method for preparing diaryl hydroxyl dicarboxylic acids in a diastereospecific manner. The three-component reaction occurs between amino acid, aromatic aldehyde and primary alcohol in alkaline solutions under micro-wave-assisted conditions. The dicarboxylic acids are isolated as sodium salts in high yields (up to 77%) by a...

Stanozolol (STZ) is a drug used to treat serious disorders like aplastic anemia and hereditary angioedema. It is also indicated as an adjunct therapy for the treatment of vascular disorders and growth failures. Encouraging results obtained using animal models demonstrated that STZ increases bone formation and mineralization, thus improving both den...

The advent of nanomedicine has recently started to innovate the treatment of cardiovascular diseases, in particular myocardial infarction. Although current approaches are very promising, there is still urgent need for advanced targeting strategies. In this work, the exploitation of macrophages recruitment is proposed as novel and synergistic approa...

We report here new copper(I)-Schiff base complexes for the selective oxidation of primary alcohols to aldehydes under ambient conditions (with 2,2,6,6-tetramethylpiperdine-N-oxyl (TEMPO), N-methylimidazole (NMI), ambient air, acetonitril and RT). Particularly, the copper(I) complex bearing N-(4-fluorophenyl)-1-(furan-2-yl)methanimine (L2) showed hi...

Microfluidics technology is emerging as a promising strategy to improve the oral delivery of proteins and peptides. Herein, a multistage drug delivery system is proposed as a step forward in the development of non-invasive therapies. Undecylenic acid modified thermally hydrocarbonized porous silicon (UnPSi) nanoparticles (NPs) were functionalized w...

Dissolution of elemental Au in organic solutions is a contemporary approach to lower environmental burden related to gold recycling. Here we describe fundamental studies on a highly efficient method for dissolution of elemental Au which is based on DMF solutions containing pyridine‐4‐thiol (4‐PSH) as a reactive ligand and hydrogen peroxide as an ox...

Dissolution of elemental Au in organic solutions is a contemporary approach to lower environmental burden related to gold recycling. Here we describe fundamental studies on a highly efficient method for dissolution of elemental Au which is based on DMF solutions containing pyridine‐4‐thiol (4‐PSH) as a reactive ligand and hydrogen peroxide as an ox...

The last decade has seen remarkable advances in the development of drug delivery systems as alternative to parenteral injection‐based delivery of insulin. Neonatal Fc receptor (FcRn)‐mediated transcytosis has been recently proposed as a strategy to increase the transport of drugs across the intestinal epithelium. FcRn‐targeted nanoparticles (NPs) c...

The inability of the heart to recover from an ischemic insult leads to the formation of fibrotic scar tissue and heart failure. From the therapeutic strategies under investigation, cardiac regeneration holds the promise of restoring the full functionality of a damaged heart. Taking into consideration the presence of vast numbers of fibroblasts and...