Karina Alejandra Salvatierra

• PhD of Biotechnology (University of Valencia)
• Professor (Assistant) at National University of Misiones

We describe the burden of influenza B infections in Scotland during a 13-year study period. Influenza A and B viruses cocirculated throughout the period, with numbers of influenza B cases approaching or exceeding those of influenza A during six influenza seasons. Influenza B viruses of both Victoria and Yamagata lineage were detected in two of six...

Until very recently, treatment for chronic hepatitis C virus (HCV) infection has been based on the combination of two non-viral specific drugs: pegylated interferon-α and ribavirin, which is effective in, overall, about 40%-50% of cases. To improve the response to treatment, novel drugs have been designed to specifically block viral proteins. Multi...

La calidad y el cuidado del procesamiento de yerba mate, es decisivo para que el producto mantenga inalterables sus cualidades organolépticas y microbiológicas. El objetivo de este trabajo fue estudiar la contaminación micológica de yerba mate elaborada, evaluando la presencia de géneros micotoxigénicos. Se procesaron 36 muestras de yerba mate elab...

INTRODUCTION: The COVID-19 pandemic has created unprecedented challenges for laboratories around the world. National and subnational governments faced the urgent need to adapt institutions for the detection of SARS-CoV-2 in response to the health emergency declared in 2020. With the aim of increasing diagnostic capacity in the province of Misiones,...

Aflatoxigenic aspergillus isolates from tea (Camellia sinensis ABSTRACT The aim of this study was to isolate and identify, at genera and species level, strains of Aspergillus spp obtained from different stages of black tea traditional processing. Strains taxonomically characterized as Aspergillus flavus and Aspergillus parasiticus were evaluated in...

CRISPR-Cas12a (also called Cpf1) has been commonly used for genomic editing, based on its ability to generate precise double-stranded DNA (dsDNA) breaks. Recently, it was demonstrated that Cas12a exhibits unspecific ssDNAse activity upon target recognition. This feature allows CRISPR-Cas to be coupled with a ssDNA reporter and generate a fast, accu...

Zika virus is a member of the Flaviviridae virus family, similar to other viruses that affect humans, such as hepatitis C and dengue virus. After its first appearance in 1947, Zika virus reappeared in 2016 causing an international public health emergency. Zika virus was considered a non dangerous human pathogen; however, it is currently considered...

Introducción. La leishmaniosis cutánea por Leishmania braziliensis ha sido tradicionalmente endémica en Argentina y se han sido descritos casos de compromiso visceral después de una leishmaniosis cutánea inicial. La leishmaniosis visceral emergió en Argentina en el año 2006 en la ciudad de Posadas, provincia de Misiones, afectando tanto a humanos c...

Influenza viruses are highly contagious respiratory illness and responsible for the severe annual morbidity and mortality worldwide. They are classified into types, influenza A, B and C. Influenza viruses accumulate point mutations during replication, especially in three proteins: matrix-membrane, hemagglutinin, and neuraminidase. Nucleotide and am...

Publicación en línea: 12-09-18 PUBLICACIÓN ANTICIPADA EN LINEA El Comité Editorial de Biomédica ya aprobó para publicación este manuscrito, teniendo en cuenta los conceptos de los pares académicos que lo evaluaron. Se publica anticipadamente en versión pdf en forma provisional con base en la última versión electrónica del manuscrito pero sin que aú...

El virus de la hepatitis C (VHC) continúa siendo un problema de salud pública en todo el mundo. El desarrollo de medicamentos que se dirigen a las proteínas del virus como NS5B, tiene como objetivo proporcionar un tratamiento más eficaz en el futuro. Estos antivirales de acción directa (DAA) han demostrado un potente efecto in vitro e in vivo; sin...

Hepatitis C virus (HCV) continues to be a major disease on the world. The development of inhibitors that target viral proteins such as NS5A, has the purpose of providing effective treatment to eliminate viruses. New direct-acting antivirals (DAAs) have demonstrated a potent antiviral effect; nevertheless, resistance-associated variants (RAVs) have...

In biology, a mutation is a change in the nucleotide sequence of the genome of a microorganisms (e.g., virus, bacteria). Mutations play an important role in biological processes of microorganisms such as drug resistance. Analyzing these mutations becomes a challenge because microorganisms are described by a big amount of data that must be processed...

La infección crónica provocada por el virus de la hepatitis C (VHC) sigue siendo un gran problema de salud pública a nivel mundial, afecta a unos 200 millones de personas en el mundo. Se trata de la primera primera causa de trasplante y de muerte de origen hepático. La evolución natural de la enfermedad es el desarrollo de cirrosis y el riesgo de d...

Introduction The chikungunya virus (CHIKV) is an arbovirus vectored by Aedes mosquitoes that infects humans in tropical and sub-tropical areas of Asia and Africa. Recently, outbreaks have been reported in tropical and sub-tropical areas of countries that were previously unaffected (e.g., Brazil, Colombia). Currently, the following geographical geno...

Background: Continuous surveillance for genetic changes in circulating influenza viruses is needed to guide influenza prevention and control. Objectives: To compare intra-seasonal influenza genetic diversity of hemagglutinin in influenza A strains isolated from influenza hospital admissions collected at two distinct sites during the same season....

Introduction: Infections with hepatitis B and C viruses (HBV and HCV) are a major global health problem. Patients with chronic renal failure (CRF) on hemodialysis constitute a population at risk of HBV and HCV infections. Objective: Determining prevalence of the surface antigen of hepatitis B virus (HBsAg) and antibodies to hepatitis C virus (anti-...

Introduction: Hepatitis C virus (HCV) is considered a major public health problem, with 200 million people infected worldwide. The treatment for HCV chronic infection with pegylated interferon alpha plus ribavirin inhibitors is unspecific; consequently, the treatment is effective in only 50% of patients infected. This has prompted the development o...

Introduction: Hepatitis C virus (HCV) is considered a major public health problem, with 200 million people infected worldwide. The treatment for HCV chronic infection with pegylated interferon alpha plus ribavirin inhibitors is unspecific; consequently, the treatment is effective in only 50% of patients infected. This has prompted the development o...

There is no comprehensive study available on the natural hepatitis C virus (HCV) polymorphism in sites associated with resistance including all viral genotypes, which may present variable susceptibilities to particular direct-acting antivirals (DAA). This study aimed to analyze the frequency, genetic barrier, and evolutionary history of naturally-o...

Introducción: Los pacientes con insuficiencia renal crónica en tratamiento con hemodiálisis constituyen un grupo de riesgo para la infección con el virus de la hepatitis C. La infección por este virus representa la causa más frecuente de enfermedad hepática crónica en los hemodializados. Objetivo: Evaluar la prevalencia y realizar la caracterizació...