Karin Zitterl-Eglseer

Karin Zitterl-Eglseer
University of Veterinary Medicine, Vienna | vetmed · Department for Farm Animals and Veterinary Public Health

Doctor of Pharmacy

About

74
Publications
14,989
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1,894
Citations
Additional affiliations
December 1986 - present
University of Veterinary Medicine, Vienna
Position
  • Ao. Univ.-Prof. Mag. Dr.
December 1986 - present
University of Veterinary Medicine, Vienna
Position
  • Ao. Univ.-Prof. Mag. Dr.
Description
  • Pharmacognosy Botany Phytotherapy Nutrition

Publications

Publications (74)
Article
This study aimed to evaluate the efficacy of Norway spruce ointments on wound healing of castration wounds in piglets. This study included 95 male pigs randomly divided into five treatment groups: Norway spruce balm (Vulpuran), Norway spruce resin (Abilar), pork lard (ointment base of Vulpuran), no treatment (negative control) and antibiotic blue s...
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The objective of this study was the detection of thymol in rabbit plasma, tissues, large intestinal content, and faeces. Forty-eight rabbits were divided into control and experimental groups (thymol 250 mg/kg feed). Thymol was administered for 21 days and then withdrawn for 7 days. Concentration of thymol in the intestinal wall (IW) was significant...
Article
To our knowledge, no study has been carried out to evaluate the effects of thymol sustained administration on gut health and immune response in terms of its bioavailability in the rabbit organism. A total of 48 rabbits were randomly divided at 35 days of age into two dietary treatment groups (C/control or T/thymol at 0.025% addition). Thymol was ad...
Article
Viruses have a high mutation rate, and, thus, there is a continual emergence of new antiviral-resistant strains. Therefore, it becomes imperative to explore and develop new antiviral compounds continually. The search for pharmacological substances of plant origin that are effective against animal viruses, which have a high mortality rate or cause l...
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Thymol concentrations in rabbit plasma, intestinal wall (IW) and faeces were detected, and the effects of thymol application and withdrawal on biochemical, antioxidant parameters and fatty acids (FA) in blood (B) and muscle (M) were studied. Forty-eight rabbits were divided into two experimental groups (control, C and with thymol 250-mg/kg feed, T)...
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Antioxidants and flavonoids are beneficial compounds used in the pharmaceutical and food industries that are derived from natural sources. A two-year field experiment was undertaken to investigate the effect of agricultural management practices on the trigonelline content, antioxidant activity measured with DPPH (2,2-Diphenyl-1-Picrylhydrazyl) and...
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Supplementing the diet of weaning pigs with peat had no effect on the incidence of diarrhoea. Feeding a ration containing 2.5 % and 5 % dried blueberry resulted in lower, but statistically not significant different scores for faeces compared to the control group and less, but statistically not significant different antibiotic treatments. This sligh...
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Devil's claw is used for the treatment of inflammatory symptoms and degenerative disorders in horses since many years, but without the substantive pharmacokinetic data. The pharmacokinetic parameters of harpagoside, the main active constituent of Harpagophytum procumbens DC ex Meisn., were evaluated in equine plasma after administration of Harpagop...
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Koi herpesvirus (KHV) causes an important emerging disease that causes considerable economic losses in common carp (Cyprinus carpio) and koi aquaculture, so the development of effective treatment and prophylactic measures is important. Melissa officinalis L. is one of the best known medicinal plants with documented antiviral effects in vitro and in...
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Orally administered extracts of butterbur are a popular treatment option for equine asthma syndrome in veterinary practice, despite the fact that none of these preparations are registered as phytopharmaceutical products for horses. The aim of the present study was to establish a sensitive LC/MS/MS method for measurement of petasin, isopetasin and n...
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Disposal of organic plant wastes and by-products from the food or pharmaceutical industries usually involves high costs. In the present study, 42 samples derived from such by-products were screened in vitro against Cryptosporidium parvum, a protozoan parasite that may contaminate drinking water and cause diarrhoea. The novel bioassay was previously...
Article
The major effects of arbuscular mycorrhizal fungi (AMF) colonization on plant growth, monoterpenoids and coumarins were determined in two genotypes of angelica (Angelica archangelica L., Apiaceae). Genetically uniform experimental plants were used, which was achieved by in vitro propagation of two genotypes (individual plants). The effects of Glomu...
Article
In the frame of "veterinary phytotherapy" five clinical and one in vitro study were conducted at the University of Veterinary Medicine Vienna in the last years, which are summarized in this article. They strike AcidProtect® and Cirotex® liquid, two feed supplements, and the herbal medicinal products Bronchipret® and Sinupret®. AcidProtect® is used...
Article
Arbuscular mycorrhizal (AM) fungi penetrate the cortical cells of the roots of vascular plants, and are widely distributed in soil. The formation of these symbiotic bodies accelerates the absorption and utilization of mineral elements, enhances plant resistance to stress, boosts the growth of plants, and increases the survival rate of transplanted...
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Methane is a major greenhouse gas, and ruminants cause about a quarter of all anthropogenic methane emissions. The objective of this study was to testplant secondary products in terms of their effects on methane production, and to follow active compounds analytically during incubation. In a simplifi ed model of ruminal methane production, a glycero...
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Peru balsams (PB) are ingredients of human and veterinarian pharmaceuticals, but they are also considered to bear a risk to provoke allergenic reactions. Although observations after the application of 25 % PB in petrolatum exist in dogs, chemically defined undiluted balsams have not been investigated so far. Therefore, in the present study the derm...
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The objective of this study was to investigate the effects of a mixture of dried pulps of Daucus carota L, aerial parts of Echinacea purpurea L Moench, sawdust and extracts of Larix decidua Mill., all industrial waste, as feed additive in different concentrations (3 % and 5 % of the diet) for the prophylaxis of E. coli-diarrhoea in weaner piglets....
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In some medicinal plants a specific plant-fungus association, known as arbuscular mycorrhizal (AM) symbiosis, increases the levels of secondary plant metabolites and/or plant growth. In this study, the effects of three different AM treatments on biomass and sesquiterpenic acid concentrations in two IN VITRO propagated genotypes of valerian ( VALERI...
Article
To our knowledge, no studies have investigated the predictive value of central serotonin transporter (SERT) availability for treatment response to serotonin reuptake inhibitors (SSRIs) in patients with obsessive-compulsive disorder (OCD). This study used brain imaging to examine the relationship between pretreatment SERT availability and transporte...
Article
BACKGROUND: Garden sage (Salvia officinalis L., Lamiaceae) has gained importance during the last decade as a natural antioxidant, mainly owing to the antioxidant secondary plant metabolites rosmarinic acid (RA) and diterpenes such as carnosic acid. The aim of this work was to study the biomass production, the concentrations of total phenolics and R...
Article
Organic wastes as well as their ethanolic, water and heptane extracts and fermented products derived from herbs, fruit and vegetables obtained worldwide from food and pharmaceutical industries were investigated regarding their antioxidant activities using different methods [1.1-diphenyl-2-picrylhydrazyl, FeIII-reduction method and photochemilumines...
Article
Industrial pulp and fiber of Eucalyptus and Fagus were investigated for possible identification of secondary metabolites, using chloroform, ethanol and methanol/HCl extracts. The total phenolics test was positive with all the samples and some phenolic compounds like vanillin, vanillic acid and syringic acid were identified by HPLC analysis in the e...
Article
In the present study the antimicrobial potential of various extracts from 12 medicinal plants has been investigated in vitro on multiple antibiotic resistant pathogens and some selected protozoa isolated from poultry. The initial examination was performed on E. coli (n = 10) using disc and agar well diffusion assays. Only two plants, Peganum harmal...
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To the authors' knowledge there is as of yet no study demonstrating in vivo alterations in human serotonin transporters (SERT) during clomipramine treatment in patients with obsessive-compulsive disorder. The only study in which SERT binding has been investigated in obsessive-compulsive disorder (OCD) patients before and after treatment is a small...
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In a feeding trial involving 120 weaned piglets the phytobiotic feed additive Biomin® P.E.P 1000 (essential oils blended derived from oregano, anise and citrus peels) was compared with the antibiotic growth promoter avilamycin and a negative control group. The main compounds of the phytobiotic zootechnical additive, carvacrol and thymol, could be r...
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Numerous findings indicate alterations in brain serotonin systems in obsessive-compulsive disorder (OCD). We investigated the in vivo availability of thalamus-hypothalamus serotonin transporters (SERT) in patients with DSM-IV OCD who displayed prominent behavioral checking compulsions (OC-checkers). Four hours after injection of [(123)I]-2beta-carb...
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The effect of root colonization by Glomus mosseae on the qualitative and quantitative pattern of essential oils (EO) was determined in three oregano genotypes (Origanum sp.). To exclude a simple P-mediated effect through mycorrhization the effect of P application to plants on the EO accumulation was also tested. In two genotypes the leaf biomass wa...
Article
The objective of the study at hand was to investigate within the framework of a pilot project the preference of weaner pigs for either an ad libitum standard feed with thyme or oregano herb as flavouring additive or an ad libitum standard feed without any herbal additive. Thyme or oregano herbs or a combination of both were offered in two different...
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Separation and isolation of the two main compounds suaveolol and methyl suaveolate from leaves of chichinguaste (Hyptis suaveolens Poit., Lamiaceae) could be achieved by means of repeated column chromatography and repeated preparative thin layer chromatography. Their chemical structures were approved by MS, 1H NMR, 13C NMR and 2D-NMR experiments. T...
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Thymi Herba (Thymus vulgaris, rubbed) was given as feed additive to weanling piglets. 3 concentrations (0.1%, 0.5%, 1%) were tested against a control group. Rectal swabs were collected weekly and were sent in for bacterial testing. The shedding of haemolysing E. coli was evaluated. There was no significant difference in the shedding of haemolysing...
Article
The aim of the study was to test Thymi herba (1.66% v/w essential oil with 39% p-cymene and 32% thymol) in the rearing period of piglets as feed additive. Therefore, two feeding trials were performed with piglet groups ranging from 17 to 22 animals each. Either 10 g of Thymi herba/kg feed (Thymi herba group), 10 mg flavophospholipol/kg feed (flavop...
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In the last decades phytopharmaceuticals have stabilized their significance in human medicine. The aim of this study was to obtain information about the present situation of phytomedicine in three German-speaking countries. For that purpose questionnaires were sent via internet to 2675 veterinarians in Austria, Germany and Switzerland and the colle...
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Zusammenfassung Mittels eines Fragebogens wurden die Einsatzhäu-figkeiten und die fachliche Beurteilung von Phytopharma-ka bei österreichischen Tierärztinnen und Tierärzten erhoben. Die Befragung untersuchte den Einsatz pflanz-licher Arzneien hinsichtlich der Indikation, des Krankheitsverlaufes und der Tierart, der Beurteilung der Tierbesitzer und...
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The effect of 2 different blends of essential oils on Clostridium perfringens (Cp) in the intestine and feces of broiler chickens was tested in 6 field trials for each blend. One hundred parts per million of the blends were mixed in a commercial corn-based diet throughout the entire growing period for experimental flocks. Samples from the jejunum,...
Article
Objective: Investigations on effects of galacturonides as feed additive compared with the growth promoter flavophospholipol and a control group of weaned piglets. Material and methods: In a feeding study galacturonides were tested as feed additive compared with the antibiotic feed additive flavophospholipol in the rearing of piglets (galakturonides...
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Introduction: Numerous veterinarians use phytopharmaceuticals in the treatment of various diseases. The aim of this study was to conduct a survey into that use in Austria. Material and methods: Frequency and assessment of phytopharmaceutical treatment as implemented by Austrian veterinarians were evaluated by a questionnaire. The investigation conc...
Article
Zusammenfassung Gegenstand und Fragestellung: Untersuchungen zur Wirkung von Galakturoniden als Futtermittelzusatz im Vergleich zum Leistungsförderer Flavophospholipol und einer Kontrollgruppe bei Absetzferkeln. Material und Methoden: In einer Fütterungsstudie wurden Galakturonide als Futterzusatz im Vergleich zu Flavophospholipol in der Ferkelaufz...
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The effects of an oral preparation containing an extract of thyme and primula (Bronchipret; Bionorica) on the lung function of five horses suffering heaves were determined in a longitudinal study. The horses accepted the product well. The plasma concentrations of the marker substance, thymol, indicated that at least one of the substances in the ext...
Article
Within the continual control of the quality of herbal teas and spices from the market in recent years, unusual foreign matters have sometimes been observed upon macroscopic investigation of some samples of tea-bags containing Matricaria flower or Peppermint leaf. Therefore a spot check of these herbal teas in Austria has recently been performed on...
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The aim of the two studies was to test the efficacy of carrot powder (boiled, dehydrated and grinded carrots) in the prophylaxis of diarrhea of weaners in a piggery. Rations containing carrot powder (group 1), neither carrot powder nor antibiotic feed additive (group 2), and the antibiotic feed additive tylosinphosphate (group 3) were fed to weaner...
Article
The essential oils of five different cultivars of Cannabis sativa contained as main compounds α-pinene, myrcene, trans-β-ocimene, α-terpinolene, trans-caryophyllene and α-humulene. The content of α-terpinolene divided the cultivars in two distinct groups, an Eastern European group of cultivars of approximately 8% and a French group of cultivars of...
Article
The main compounds of lipophilic extracts of flower heads of marigold (Calendula officinalis L.) are triterpendiol esters, mainly faradiol laurate, faradiol myristate and faradiol palmitate. These faradiol-3-O-monoesters have been quantified for the first time by means of reversed phase HPLC with internal standardisation in different parts of C. of...
Article
Neuropsychological testing provides increasing evidence that certain memory deficits might play an essential role in the emergence of doubts and, as a result, in perpetuating checkers' rituals. Another account of doubting implicates meta-cognitive factors, such as confidence in memory. The present study examined mnestic functioning and self-percept...
Article
Herbs and their extracts with antioxidant capacity could be used directly as stabilisers of fat and indirectly as feed additives, in order to improve quality and shelf-life of meat and fat-containing food. In this work a sensitive analytical method is proposed for determination of the antioxidant activity measured by photochemiluminescence (PCL) in...
Article
Seventy-four patients who met DSM-III-R criteria for obsessive compulsive disorder (OCD) were studied in a prospective follow-up study in order to investigate course and prognosis of OCD with or without comorbid depressive symptomatology. Subjects were examined three times: at admission (baseline), 6 months later (follow-up 1) and 12 months after f...
Article
The presented paper provides a comprehensive survey and evaluation of medicinal plants described in the veterinary literature of the 18th and 19th century as used for the treatment of sheep and goats. A range of 40 books on sheep- and goat-diseases was covered and 381 bibliographical data were evaluated. One aim of this study is to possibly enlarge...
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The faradiol monoesters are responsible for the antiphlogistic activity of marigold and its preparations (CO2 extract, marigold ointment). Using high performance liquid chromatography (HPLC), these active constituents can be separated after an appropriate sample preparation. By adding an internal standard, an accurate quantification of the individu...
Article
Investigations of morphogenetic variability in marigold, Calendula officinalis L., showed the highest amount of faradiol monoesters in dried ray florets, which should be preferred to all other parts of the plant, if a high amount of faradiol monoesters is demanded. The faradiol monoesters seem to have a great stability. No significant losses could...
Article
In an 8-week double-blind placebo-controlled trial we studied the efficacy of fluoxetine (FLX) in 53 Austrian patients with obsessive compulsive disorder (OCD) diagnosed according to DSM-III-R. The dosage of FLX was fixed at either 20, 40, or 60 mg per day. Response was prospectively defined as an at least 25% reduction on the Yale-Brown Obsessive...
Article
Nowadays only a small amount of literature exists concerning phytotherapy, especially therapy of cattle, in veterinary medicine. Nevertheless farmers often apply medicinal plants to their cattle, a fact shown in a questionnaire. Looking back in history, medicinal herbs played a considerably more important part in the therapy of cattle in the past t...
Article
Separation and isolation of the genuine faradiol esters (1, 2) from flower heads of Marigold (Calendula (officinalis L., Asteraceae) could be achieved by means of repeated column chromatography (CC) and HPLC for the first time. Structure elucidation of faradiol-3-myristic acid ester 1, faradiol-3-palmitic acid ester 2 and psi-taraxasterol 3 has bee...
Article
1.1. Seventy-four patients who met DSM-III-R criteria for Obsessive Compulsive Disorder received a serotonin reuptake inhibitor and cognitive behavior therapy for 6 months (baseline to follow-up I).2.2. In order to maximize therapeutic effects, different kinds of treatment were applied between followup I and follow-up II (12 months).3.3. Patients w...
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From the aerial parts of Achillea setacea W. & K. (Asteraceae) the main sesquiterpenes were isolated. Their structures were determined by means of 2D-NMR and MS as 11,13-dehydrodeacetylmatricarin (1) (= 14-deoxylactucin), rupicolin A (2), and rupicolin B (3). These are the first compounds with an alpha-methylene-gamma-lactone structure isolated fro...
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Due to their natural provenance it was assumed that Lenzing's man-made cellulose fibers might still contain secondary constituents from their plant origin with some biological potential. TENCEL® and Lenzing Modal® fibers as well as the basic eucalyptus and beech wood pulps were extracted in ethanol, methanol-HCl, dichloro-methane and supercritical...

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