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Introduction
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Publications
Publications (62)
Background
The robust relationship between vitamin B6 and inflammation has become apparent over the last decade. However, the mechanistic nature of this relationship remains unclear. Evidence suggests an inverse relationship between blood levels of B6 and inflammation, but also a potential two-way relationship between the two. Thus, whereas inflamm...
Background
Currently, faecal calprotectin (fCal) is considered the best available biomarker for both diagnosing and monitoring IBD. However, little is known about the stability of this protein in stool: The few studies available are contradictory. Our aim was to investigate the pre-analytical and biological variability of fCal in order to provide t...
Background:
In the absence of a feasible noninvasive gold standard, iron deficiency (ID) anemia (IDA) is best measured using multiple indicators. However, the choice of an appropriate single iron biomarker for ID screening continues to be debated. Low hemoglobin density (LHD%) from Coulter counters has been suggested as a useful tool to detect ID....
Chronic intestinal failure (CIF) is a rare but feared complication of Crohn’s
disease. Depending on the remaining length of the small intestine, the affected
intestinal segment, and the residual bowel function, CIF can result in a wide
spectrum of symptoms, from single micronutrient malabsorption to complete
intestinal failure. Management of CIF ha...
Background
It is well established that inflammation can mimic some aspects of iron deficiency (ID) by impairing the utilisation of existing iron stores for red cell production and inducing an iron-sequestration syndrome and hypoferraemia. Diagnosis of ID is therefore complex and there is currently no standard clinical test capable of clearly distin...
Background
Vitamin D deficiency is highly prevalent in patients with inflammatory bowel disease (IBD). The question of whether vitamin D status is a contributory factor or a consequence of IBD, or maybe both, remains unanswered, and is confounded by the complexity of inflammation, IBD and vitamin D. Fat malabsorption has been proposed as a possible...
Iron deficiency, with or without anemia, is the most frequent hematological manifestation in individuals with cancer, and is especially common in patients with colorectal cancer. Iron is a vital micronutrient that plays an essential role in many biological functions, in the context of which it has been found to be intimately linked to cancer biolog...
Iron deficiency (ID) is a common manifestation of inflammatory bowel disease (IBD), arising primarily due to chronic inflammation and/or blood loss. There is no gold standard for ID diagnosis , which is often complicated by concomitant inflammation. Zinc protoporphyrin (ZnPP) correlates with parameters of iron homeostasis and has been identified as...
Beim Kurzdarmsyndrom (KDS) handelt es sich um ein Malabsorptionssyndrom infolge eines chirurgisch oder kongenital bedingten Verlustes quantitativ und/oder funktionell bedeutender Dünndarmabschnitte. Analog zu Leber- und Nierenversagen sollte dabei zwischen Darminsuffizienz und Darmversagen i. S. einer Darminsuffizienz unterschieden werden. Chronisc...
Medical therapies have developed to the point where an overwhelming majority of patients with mild to moderate symptoms of GERD can be quite successfully treated by this therapeutic option. Along with diet, important lifestyle components can be used to treat GERD symptoms. The effectivity of PPIs compared to other medical agents has been shown in m...
Background
The IL-12/23 inhibitor ustekinumab (UST) opened up new treatment options for patients with Crohn’s disease (CD). Due to the recent approval, Real-World German data on long-term efficacy and safety are lacking. This study aimed to assess the clinical course of CD patients under UST therapy and to identify potential predictive markers.
Me...
Die Messung der intragastralen Azidität kann entweder mittels Aspirationsmethode (→ direkte Magensaftanalyse) oder durch kontinuierliche Registrierung des intragastralen pH analog zur ösophagealen Langzeit-pH-Metrie erfolgen. Während für die Magensaftanalyse zumindest in der Abklärung des Gastrinoms ein praktischer Stellenwert zukommt (s. unten), e...
Eine exokrine Pankreasinsuffizienz (ePI) ist definiert als eine funktionelle Einschränkung der Pankreasenzym- und Bikarbonatsekretion – unabhängig von ihrer Genese. Sie führt in fortgeschrittenen Stadien mit einem Ausfall von mehr als 90 % der exokrinen Kapazität zu einer Steatorrhö und durch die sekretagoge Wirkung von Hydroxyfettsäuren – sekundär...
Bereits leichte reversible Schädigungen der Hepatozyten, die in erster Linie die Zellmembran betreffen, führen infolge einer pathologisch gesteigerten Membranpermeabilität zu einer Freisetzung zytologisch gelöster Zellbestandteile ins Blut. Demgegenüber gelangen bei Zellnekrose auch die an Strukturelemente von Zellorganellen (z. B. Mitochondrien, L...
Eine normale Funktion des Verdauungstraktes ist an die Integrität (Barrierefunktion) und den koordinierten Ablauf einer Vielzahl von digestiv-resorptiven und sekretorischen Partialfunktionen gebunden.
Synthese und Exkretion von Gallenflüssigkeit (Cholerese) ins Lumen der Gallenkapillaren (Canaliculi) stellen fundamentale Funktionen des Hepatozyten dar und dienen letztlich der Elimination endogener (Bilirubin, Gallensäuren, Cholesterin) und exogener (Medikamente) Substanzen. Der Gallefluss (ca. 500 ml/Tag) beruht auf energieabhängigen, aktiven Tr...
Die Diagnose, Differenzialdiagnose und Verlaufsbeobachtung von Leberkrankheiten stützen sich bei anamnestischen und klinischem Verdacht auf klinisch-chemische, immunologische, genetische und virologische Methoden, die ggf. durch bildgebende Verfahren (Sonografie, MRT, CT) und nicht zuletzt eine histomorphologische Beurteilung (Leberbiopsie) ergänzt...
Introduction: Iron deficiency and iron deficiency anemia are the most common extra-intestinal manifestations of chronic inflammatory bowel disease (IBD), significantly impairing patient’s quality of life. Since the diagnostic value of ferritin as an acute phase protein (aPP) in IBD is therefore
limited1
, the simultaneous determination of the C-rea...
Introduction: Iron deficiency and iron deficiency anemia are the most common extra-intestinal manifestations of chronic inflammatory bowel disease (IBD), significantly impairing patient’s quality of life. Since the diagnostic value of ferritin as an acute phase protein (aPP) in IBD is therefore
limited1
, the simultaneous determination of the C-rea...
Background
Vedolizumab (VLZ), an α4β7 integrin antagonist, is a therapeutic monoclonal antibody approved by Health Canada in 2017 for use in moderate to severe Crohn’s disease (CD) and ulcerative colitis (UC). Since loss of response to VLZ in patients with inflammatory bowel disease is likely due to low drug serum levels, modifying dosage on the ba...
Background
Iron deficiency anemia (IDA) is a frequent complication of inflammatory bowel disease (IBD). Oral iron compounds are ineffectively absorbed and poorly tolerated by IBD patients, resulting in limited efficacy and poor compliance. Since oral iron is evidentially less effective than intravenous (IV) iron for IDA in IBD, international guidel...
Background
Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder presenting with phases of active inflammation, remission and relapse. Fecal calprotectin (fcal) measurement has become established for the monitoring of inflammation activity. Periodical assessment of fcal levels has been demonstrated to be an important non-in...
Background
Golimumab is a therapeutic anti-TNF monoclonal antibody approved for use in moderate to severe ulcerative colitis (UC). The PURSUIT trials showed a significant exposure-response relationship of golimumab in UC. Interindividual differences in response to golimumab treatment may be explained in part by interindividual variability in pharma...
The endoscopically implanted duodenal–jejunal bypass liner (DJBL) is an impermeable fluoropolymer device which prevents food making contact with the proximal intestine, thus inducing weight loss and improvement of type 2 diabetes mellitus (T2DM). However, weight and HbA1c levels generally increase post explantation. This study investigated the safe...
Background:
Hepcidin has been shown to be inversely associated with iron absorption and the expression of iron transport proteins in healthy females and patients with iron deficiency. Data describing the relationship between hepcidin expression and iron absorption in patients with inflammatory bowel disease (IBD) are lacking. The objective of this...
Background
Ustekinumab is a monoclonal therapeutic anti-interleukin-12 and anti-interleukin-23 antibody approved for use in moderate to severe Crohn’s disease (CD). Analysis of data from the Phase 3 induction trials, UNITI-1 and UNITI-2, demonstrated a significant exposure–response relationship of ustekinumab in CD. Interindividual differences in r...
Background
Anaemia occurs with an estimated prevalence of ca. 74% in patients with IBD, causing increased morbidity and hospitalisation rates and impacting quality of life. Oral iron compounds cause gastrointestinal side effects and therapy adherence is poor. Modern intravenous (IV) iron compounds have been shown to be safe and effective in IBD. EC...
Background
Iron deficiency (ID) is a common manifestation of IBD but frequently overlooked, even if anaemia is present. Causes of anaemia in IBD include intestinal bleeding, reduced iron intake, and impaired iron absorption due to acute inflammation. Thus, anaemia in patients with IBD is most commonly iron deficiency anaemia (IDA), anaemia of chron...
Background
Patients with IBD have high rates of iron deficiency (ID) with adverse clinical consequences. Serum ferritin is normally a sensitive marker for iron status, but as an acute-phase reactant, ferritin becomes elevated in response to inflammation, complicating the diagnosis.¹ ECCO guidelines recommend adjusting serum ferritin concentrations...
Iron deficiency anaemia (IDA) is widely accepted to be the most frequent systemic complication and extra-intestinal manifestation of inflammatory bowel disease (IBD). IDA is caused by a variety of factors directly or indirectly related to IBD. Since iron deficiency (ID); even without manifest anaemia, can substantially impact the quality of life of...
Aims: Iron deficiency anaemia (IDA) is common in patients with inflammatory bowel disease (IBD), who are often treated with intravenous iron. This observational study aimed to investigate the effectiveness and safety of iron isomaltoside in routine practical care of IDA in IBD patients.
Methods: The study included 197 IBD patients designated for tr...
Patients with inflammatory conditions such as inflammatory bowel disease (IBD), chronic heart failure (CHF), and chronic kidney disease (CKD) have high rates of iron deficiency with adverse clinical consequences. Under normal circumstances, serum ferritin levels are a sensitive marker for iron status but ferritin is an acute-phase reactant that bec...
Background
In the absence of a feasible, non-invasive gold standard, iron deficiency anaemia (IDA) is best measured using multiple indicators. However, the choice of an appropriate single iron biomarker to replace the multiple-criteria model for IDA screening at the population level continues to be debated. Recently, low haemoglobin density (LHD%)...
Background
Vedolizumab (VLZ), an α4β7 integrin antagonist, is a therapeutic monoclonal antibody recently approved for use in moderate-to-severe Crohn's disease (CD) and ulcerative colitis (UC). Since loss of response to VLZ in patients with inflammatory bowel disease is likely due to low drug serum levels, modifying dosage on the basis of VLZ drug...
Background
Iron deficiency anaemia is a common extraintestinal manifestation of inflammatory bowel disease and is usually diagnosed by multiple parameters. Choice of a single iron biomarker for IDA screening remains controversial.¹ The most commonly used parameter, ferritin, is an acute-phase protein and may therefore be strongly influenced by infl...
Background
Golimumab is a therapeutic anti-TNF monoclonal antibody approved for use in moderate-to-severe ulcerative colitis (UC). The PURSUIT trials showed a significant exposure-response relationship of golimumab in UC. Interindividual differences in response to golimumab treatment may be explained in part by interindividual variability in pharma...
Introduction: Anaemia is a common extraintestinal manifestation in patients with inflammatory bowel disease, impacting disease prognosis, morbidity, hospitalisation rates and time lost from work. While iron deficiency anaemia and anaemia of chronic inflammation predominate, combinations of haematimetric and biochemical markers facilitate the diagno...
Aims:
Spinocerebellar ataxia type 2 (SCA2) belongs to the CAG repeat or polyglutamine diseases. Along with a large variety of motor, behavioural and neuropsychological symptoms the clinical picture of patients suffering from this autosomal dominantly inherited ataxia may also include deficits of attention, impairments of memory, as well as frontal...
