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Publications (15)
The present invention uses a microprocessor, a memory storage device, and a segmentation program comprising a plurality of program modules containing computer-readable instructions that cause the microprocessor to measure the spatial offsets between all pairs of scans in an m-mode image of a blood vessel with a cross-correlation function, convert t...
The advantages of using (2)H(2)O to quantify cholesterol synthesis include i) homogeneous precursor labeling, ii) incorporation of (2)H via multiple pathways, and iii) the ability to perform long-term studies in free-living subjects. However, there are two concerns. First, the t(1/2) of tracer in body water presents a challenge when there is a need...
Quantification of hemodynamics may be invaluable in a drug development setting. However, one of the challenges in the application of imaging technologies for compound screening purposes is the large volume of data in a short amount of time. This article focuses on methods developed for large-scale hemodynamic quantification, as measured from high-f...
High-resolution Magnetic Resonance Imaging (MRI) of humans and animals in vivo is routine and non-invasive. Identifying and quantifying chemical composition of tissue from acquired images is a challenge. MR spectroscopy (MRS) may be used to identify chemical components accurately over a finite volume in the tissue. However, the temporal and spatial...
The artery wall is compliant and stretches in response to the traveling pressure pulse generated by the contracting heart. The dynamics of this motion are known to convey important information about the health of the artery and cardio-vascular system. For example, compliance, a measure of artery flexibility, decreases due to aging, as well as disea...
Improved methods for non-invasive in vivo assessment are needed to guide development of animal models of atherosclerosis and to evaluate target engagement and in vivo efficacy of new drugs. Using novel 3D-micro-ultrasound technology, we developed and validated a novel protocol for 3D acquisition and analysis of imaging to follow lesion progression...
3D‐micro‐ultrasound imaging has emerged as a valuable research tool to co‐register vascular physiology. This co‐registration allows serial interrogation of arterial wall integrity, blood flow and stiffness. We quantified hemodynamic changes associated with the acute administration of Diltiazem, to benchmark high throughput imaging preclinically.
Si...
We describe a method for segmenting arterial vessel wall motion to sub-pixel resolution, using the returns from M-mode ultrasound. The technique involves measuring the spatial offset between all pairs of scans from their cross-correlation, converting the spatial offsets to relative wall motion through a global optimization, and finally translating...
In this paper, we present a one-dimensional model for blood flow in arteries, without assuming an a priori shape for the velocity profile across an artery (Azer, Ph.D. thesis, Courant Institute, New York University, 2006). We combine the one-dimensional equations for conservation of mass and momentum with the Womersley model for the velocity profil...
Phase-contrast Magnetic Resonance Imaging (MRI) was used to measure blood flow distribution and identify plaque growth in the abdominal aorta of two different mouse strains. We present a method to compute wall shear stress (WSS) distribution along a cross section of the abdominal aorta as a function of an azimuthal variable. We track WSS in both a...
The Trans Cell Layer Electrical Field Stimulation (TCL-EFS) system has been developed for high-throughput screening (HTS) of voltage-gated ion channels in microplate format on a Voltage-Ion Probe Reader (VIPR) platform. In this design, a wire electrode is placed above the cell layer of each filter well, and a whole plate perimeter electrode resides...
In this paper, we consider the problem of calculating the axial concentration profile of a solute transported by a time-dependent flow in a rigid straight pipe. This generalizes the result that Taylor derived in 1953 for calculating the axial concentration profile of a solute in a steady flow. Using asymptotic analysis, we derive a time-dependent d...
Typescript. Thesis (Ph.D.)--New York University, Graduate School of Arts and Science, 2006. Includes bibliographical references (leaves 150-158).
