Karen J Wedekind

Karen J Wedekind
Novus International, Inc. · Biology and Discovery

About

32
Publications
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Publications

Publications (32)
Article
The purpose of this study was to determine the iodine (I) requirement in adult cats. Forty-two healthy euthyroid cats (1.6-13.6 years old) were utilized in a randomized complete block design. Cats were fed a dry basal diet (0.23 mg/kg I) for a minimum of 1 month (pre-test) then switched to a different basal diet supplemented with seven levels of KI...
Article
Nutritional antioxidants have experienced a surge in research and interest in the past 20 years. this surge may be attributed to the improved methodology for investigation as well as the focus on diseases and aging processes related to oxidative stress that lend themselves to opportunistic outcomes. As such, the field of veterinary nutritional anti...
Article
Selenium (Se) plays an important role in hair growth. The objective of this study was to investigate the effect of dietary selenium concentration on hair growth in dogs. Thirty-six beagles were stratified into six groups based on age, gender and body condition score. The dogs were fed a torula yeast-based canned food for 3 weeks. Then the dogs were...
Article
Thyroid to salivary (TS) ratio is the most commonly used scintigraphic parameter for differentiating euthyroid and hyperthyroid cats. Studies to determine the normal TS ratio have been performed in small cat populations. In this study, the TS ratio was determined in 32 cats between 8 and 13 years of age. The study population was documented to be eu...
Article
The main purpose of this study was to investigate whether consumption of diets enriched in antioxidants attenuates the level of oxidative stress in the senescence-accelerated mouse (SAM). In separate and independent studies, two different dietary mixtures, one enriched with vitamin E, vitamin C, L-carnitine, and lipoic acid (Diet I) and another die...
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The objective of this study was to evaluate the effect of supplementary antioxidants (AOX) and whey protein on the immune function health of puppies. Four groups of 10 puppies were fed a control and 3 different test foods (control + antioxidants (AOX), control + AOX + 1% whey protein, and a grocery brand (low AOX)) for 6 weeks. A standard vaccinati...
Article
Current selenium (Se) recommendations for the puppy are based on extrapolation from other species (0.11 mg Se/kg diet). The purpose of this study was to experimentally determine the Se requirement in puppies. Thirty beagle puppies (average = 8.8 weeks old) were utilized in a randomized complete block design with age, litter and gender used as block...
Article
The purpose of this study was to determine the selenium (Se) requirement in kittens. Thirty-six specific-pathogen-free kittens (9.8 weeks old) were utilized in a randomized complete block design to determine the Se requirement in cats with gender and weight used as blocking criteria. Kittens were fed a low Se (0.02 mg/kg Se) torula yeast-based diet...
Article
The effect of a low-selenium diet on thyroid hormone metabolism was investigated in growing kittens. Twelve specific-pathogen-free kittens with ages ranging from 16 to 18 weeks were divided into two groups of equal number with equal sex distribution in each group. One group was fed a yeast-based low-selenium diet (0.02 mg Se/kg diet) while the othe...
Article
Oxidative damage to DNA, proteins, and lipids has been implicated as a contributor to aging and various chronic diseases. The presence of total alkenals (malondialdehyde and 4-hydroxyalkenals) in blood or tissues is an indicator of lipid peroxidation, which may be a result of in vivo oxidative reactions. Vitamin E functions as a chain-breaking anti...
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Two experiments were conducted with pigs 1) to determine the effect of supplemental Zn on growth performance, bone Zn, and plasma Zn in pigs fed Zn-unsupplemented, corn-soybean meal diets and 2) to assess bioavailability of Zn from inorganic and organic Zn sources. In both experiments, weanling pigs were fed a diet with no supplemental Zn for 5 wk...
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Bile Cu accumulation in Cu-depleted chicks fed Cu concentrations between .56 and 1.56 mg/kg was used to estimate Cu bioavailability in several feed ingredients from both plant and animal sources, including liver from different species. Liver from slaughtered animals is rich in minerals and vitamins and is a significant source of Cu in canned pet fo...
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The bioavailability of zinc-methionine (ZnMET) was compared to that of feed-grade ZnSO4.H2O using three different diets: purified (crystalline amino acid [AA]), semipurified (soy isolate), and complex (corn-soybean [C-SBM]) diet. With the Zn-deficient purified or semipurified diet, weight gain and tibia Zn responded linearly to both ZnSO4.H2O and Z...
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Commercial, dehulled, solvent-extracted soybean meal (DSBM) was overprocessed by autoclaving at 121 C and 105 kPa for 0, 20, 40, or 60 min. Analyzed concentrations (acid hydrolysis followed by ion-exchange chromatography) of lysine and cystine, and to a lesser extent arginine, in DSBM were reduced by increased autoclaving time. Autoclaving time had...
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Two balance studies with growing chicks were conducted to evaluate the effects of excess Ca or excess P on endogenous fecal Mn excretion and true Mn absorption. An isotope-dilution technique was used to estimate endogenous manganese in excreta. Supplements were added to a corn-soybean diet containing 1% Ca, 0.7% P (0.5% available P) and 37 mg Mn/kg...
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A repletion-depletion assay was conducted to evaluate the effect of Mn status and excess dietary P provided as dicalcium phosphate on Mn excretion and turnover. Chicks were fed either Mn-adequate (30 mg Mn/kg) or high Mn (1000 mg Mn/kg) casein-dextrose diets for 7 d. Following this loading period, the chicks were fed a Mn-deficient casein-dextrose...
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Experiments were conducted to assess protein solubility in .2% KOH as an indicator of soybean protein quality for chicks and pigs and to assess effects of particle size on protein solubility. As the particle size (micron) of soybean meal (SBM) increased, protein solubility (%) decreased (b = -.0206). In two 9-d chick trials, dehulled SBM (48% CP) w...
Article
Two balance studies with growing chicks were conducted to evaluate the effects of excess calcium (Ca) or excess phosphorus (P) on endogenous fecal manganese (Mn) excretion and true Mn absorption determined using an isotope-dilution technique. Supplements were added to a corn-soybean meal diet containing 1% Ca, 0.7% P and 37 mg/kg Mn. In Exp. 1, sup...
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Two experiments were conducted to evaluate the effect of varying levels of excess Ca and P on manganese (Mn) utilization. The criterion used to study the Mn-antagonizing effects of excess Ca and P was the regression of total tibia Mn on supplemental Mn intake. In Experiment 1, high supplemental levels of Mn were fed (0, 500, and 1,000 mg Mn per kg)...
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Three experiments were conducted to assess Mn utilizationin the presence or absence of excess Ca and P from various sources. Supplements were added to a corn-soybean meal diet containing 1% Ca, .7% (.5% available) P and 37 mg of Mn per kg. Three percentages of supplemental Mn from MnSO4 H2 O (0,500, and 1,000 mg of Mn per kg) were used to construct...
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Chick bioassays were used to assess bioavailability of zinc (Zn) from inorganic Zn sources. A soy isolate-dextrose diet containing 13 mg Zn/kg diet was supplemented with feed-grade sources of ZnSO4.H2O (ZnSO4) or ZnO and fed for 2 wk after a 7-d Zn-depletion protest period. Bioavailability of Zn in ZnO relative to ZnSO4 (set at 100%) was determined...
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A histidine (HIS)-deficient, feather meal-corn-dried whey basal diet (19% protein and 3,200 Kcal ME/kg), supplemented with lysine, methionine and tryptophan, was employed to determine the HIS requirement of the growing pig between 10 and 20 kg live weight. Using a chick bioavailability growth assay, the HIS-deficient basal diet was found to contain...
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The fibrolytic microbiota of the human large intestine was examined to determine the numbers and types of cellulolytic and hemicellulolytic bacteria present. Fecal samples from each of five individuals contained bacteria capable of degrading the hydrated cellulose in spinach and in wheat straw pretreated with alkaline hydrogen peroxide (AHP-WS), wh...
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Four adult wethers (45 kg) with permanent ruminal and abomasal cannulae were used in a repeated measures Latin-square arrangement of treatments to quantitate the effects of diet concentrate level and sodium bicarbonate (NaHCO3) on site and extent of forage fiber digestion in the gastrointestinal tract. Experimental diets consisted of Kentucky-31 ta...
Article
A repletion-depletion assay was con ducted to evaluate the effect of Mn status and excess dietary P provided as dicalchim phosphate on Mn ex cretion and turnover. Chicks were fed either Mn-ade- quate (30 mg Mn/kg) or high Mn (1000 mg Mn/kg) casein-dextrose diets for 7 d. Following this loading period, the chicks were fed a Mn-defìcient casein-dex...