Karen S Quigley

Karen S Quigley
Northeastern University | NEU · Department of Psychology

Ph.D.

About

202
Publications
48,285
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
8,716
Citations
Additional affiliations
January 2013 - present
University Center Rochester
January 2012 - present

Publications

Publications (202)
Article
The theory of constructed emotion is a systems neuroscience approach to understanding the nature of emotion. It is also a general theoretical framework to guide hypothesis generation for how actions and experiences are constructed as the brain continually anticipates metabolic needs and attempts to meet those needs before they arise (termed allosta...
Article
Humans imbue the objects of their perception with affective meaning, a phenomenon called affective realism. The affective realism hypothesis proposes that a brain continually predicts the meaning of sensations (e.g., identifying a sound as a siren, or a visual array as a face) in part by representing the current state of the body and the immediate...
Preprint
Humans imbue the objects of their perception with affective meaning, a phenomenon called affective realism. The affective realism hypothesis proposes that a brain continually predicts the meaning of sensations (e.g., identifying a sound as a siren, or a visual array as a face) in part by representing the current state of the body and the immediate...
Article
This paper integrates emerging evidence from two broad scientific literatures into one common framework: (1) Hierarchical gradients of functional connectivity that reflect the brain’s large-scale structural architecture (e.g., a lamination gradient in the cerebral cortex) and (2) approaches to predictive processing and one of its specific instantia...
Preprint
Classical accounts of emotion often assume that fear triggers a single specific autonomic response pattern. This assumption underlies attempts to generalize research findings on fear across experimental paradigms, individuals, and even species. Alternatively, constructionist theoretical accounts suggest that the relationship between fear and autono...
Preprint
The brain regulates the body by anticipating its needs and attempting to meet them before they arise – a process called allostasis. Allostasis requires a model of the changing sensory conditions within the body, a process called interoception. In this paper, we examine how interoception may provide performance feedback for allostasis. We suggest st...
Article
Background Insomnia is a prevalent and debilitating disorder among veterans. Cognitive behavioral therapy for insomnia (CBTI) can be effective for treating insomnia, although many cannot access this care. Technology-based solutions and lifestyle changes, such as physical activity (PA), offer affordable and accessible self-management alternatives to...
Article
Full-text available
Objective Conditions defined by persistent “medically unexplained” physical symptoms and syndromes (MUS) are common and disabling. Veterans from the Gulf War (deployed 1990–1991) have notably high prevalence and disability from MUS conditions. Individuals with MUS report that providers do not recognize their MUS conditions. Our goal was to determin...
Article
The brain regulates the body by anticipating its needs and attempting to meet them before they arise – a process called allostasis. Allostasis requires a model of the changing sensory conditions within the body, a process called interoception. In this paper, we examine how interoception may provide performance feedback for allostasis. We suggest st...
Article
Expertise refers to outstanding skill or ability in a particular domain. In the domain of emotion, expertise refers to the observation that some people are better at a range of competencies related to understanding and experiencing emotions, and these competencies may help them lead healthier lives. These individual differences are represented by m...
Article
Physical activity (PA) is suggested as an easily accessible adjunctive lifestyle intervention for insomnia. It is not clear if PA is equally beneficial across different levels of insomnia severity. The current study examined the relationship between daily PA (steps) and sleep (duration, efficiency, and quality) across the spectrum of insomnia sever...
Preprint
Aerobic glycolysis is a form of glucose-inefficient metabolism that occurs when cells metabolize glucose without oxygen, despite oxygen being abundant; the result is less energy per glucose molecule and increased glucose consumption. Aerobic glycolysis in the brain is a metabolic paradox: this inefficient metabolic process is a hallmark of neural a...
Preprint
Psychophysiologists often record electrodermal activity (EDA) exosomatically to derive measures of slow, tonic activity—skin conductance level (SCL)—and faster, more punctate changes—skin conductance responses (SCRs). An SCR is considered relevant when its amplitude exceeds a researcher-determined threshold (e.g., 0.05 μS), typically fixed across s...
Preprint
Full-text available
This paper integrates emerging evidence from two broad scientific literatures into one common framework: (1) Hierarchical gradients of functional connectivity that reflect the brain’s large- scale structural architecture (e.g., a lamination gradient in the cerebral cortex) and (2) approaches to predictive processing and one of its specific instanti...
Preprint
Full-text available
Predictive processing is emerging as a common computational hypothesis to account for diverse psychological functions subserved by a brain, providing a systems-level framework for characterizing structure-function relationships of its distinct substructures. Here, we contribute to this framework by examining gradients of functional connectivity as...
Article
Full-text available
Background Amplified muscle activity in reaction to daily life stressors might explain chronic pain in temporomandibular disorder (TMD). Objectives To assess whether patients with myofascial TMD pain (MFP) react to standardized stressors with greater masticatory muscle activity than demographically-matched controls. Methods 124 female MFP patient...
Article
Full-text available
Individuals differ in their ability to create instances of emotion that are precise and context-specific. This skill – referred to as emotional granularity or emotion differentiation – is associated with positive mental health outcomes. To date, however, little work has examined whether and how emotional granularity might be increased. Emotional gr...
Article
Prior research has demonstrated that angry participants exhibit biased threat detection whereby they are more likely to misidentify neutral objects as guns. Yet, it is unclear whether independent components of anger, such as conceptual knowledge about anger or the affective features of an anger instance, could lead to altered bias alone. Consistent...
Preprint
BACKGROUND Insomnia is a prevalent and debilitating disorder among veterans. Cognitive behavioral therapy for insomnia (CBTI) can be effective for treating insomnia, although many cannot access this care. Technology-based solutions and lifestyle changes, such as physical activity (PA), offer affordable and accessible self-management alternatives to...
Article
Emotional granularity describes the ability to create emotional experiences that are precise and context-specific. Despite growing evidence of a link between emotional granularity and mental health, the physiological correlates of granularity have been under-investigated. This study explored the relationship between granularity and cardiorespirator...
Article
Full-text available
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Article
We review recent work on the functions of interoceptive processing, by which the nervous system anticipates, senses, and integrates signals originating from the body. We focus on several exemplar functions of interoception, including energy regulation (ingestion and excretion), memory, affective and emotional experience, and the psychological sense...
Article
Full-text available
Machine learning methods provide powerful tools to map physical measurements to scientific categories. But are such methods suitable for discovering the ground truth about psychological categories? We use the science of emotion as a test case to explore this question. In studies of emotion, researchers use supervised classifiers, guided by emotion...
Article
Full-text available
The ability to learn new emotion concepts is adaptive and socially valuable as it communicates culturally held understandings about values, goals, and experiences. Yet, little work has examined the underlying mechanisms that allow for new emotion concepts and words to be integrated into the conceptual system. One such mechanism may be conceptual co...
Preprint
Emotional granularity describes the ability to create emotional experiences that are precise and context-specific. Despite growing evidence of a link between emotional granularity and mental health, the physiological correlates of granularity have been under-investigated. This study explored the relationship between granularity and cardiorespirator...
Article
Post-traumatic stress disorder (PTSD) can lead to multiple deleterious outcomes and has negative, sometimes debilitating, impacts on general functioning of those affected. This systematic review of 26 articles evaluates the existing literature on social functioning outcomes used in PTSD research, the association between PTSD and social functioning,...
Preprint
Expertise refers to outstanding skill or ability in a particular domain. In the domain of emotion, expertise refers to the observation that some people are better at a range of competencies related to understanding, experiencing and managing emotions, and these competencies may help them lead healthier lives. Individual differences in emotional exp...
Article
Full-text available
Commercially available consumer electronics in (smartwatches and wearable biosensors) are increasingly enabling acquisition of peripheral physiological and physical activity data inside and outside of laboratory settings. However, there is scant literature available for selecting and assessing the suitability of these novel devices for scientific u...
Article
Full-text available
Emotion research typically searches for consistency and specificity in physiological activity across instances of an emotion category, such as anger or fear, yet studies to date have observed more variation than expected. In the present study, we adopt an alternative approach, searching inductively for structure within variation, both within and ac...
Preprint
Emotional granularity describes an individual’s ability to create instances of emotion that are diverse and context-specific. Considerable evidence suggests that higher emotional granularity is a protective factor for mental and physical well-being. In the present study, we examined emotional granularity using a network analytic approach that produ...
Article
Full-text available
Background: Between 10 and 50% of primary care patients present with persistent physical symptoms (PPS). Patients with PPS tend to utilize excessive or inappropriate health care services, while being stuck in a deleterious cycle of inactivity, deconditioning, and further worsening of symptoms and disability. Since military deployment (relative to...
Preprint
Full-text available
Machine learning methods provide powerful tools to map physical measurements to scientific categories. But are such methods suitable for discovering the ground truth about psychological categories? We use the science of emotion as a test case to explore this question. In studies of emotion, researchers use supervised classifiers, guided by emotion...
Article
Lieder and Griffiths rightly urge that computational cognitive models be constrained by resource usage, but they should go further. The brain's primary function is to regulate resource usage. As a consequence, resource usage should not simply select among algorithmic models of “aspects of cognition.” Rather, “aspects of cognition” should be underst...
Preprint
Lieder and Griffiths rightly urge that computational cognitive models be constrained by resource usage, but they should go further. The brain’s primary function is to regulate resource usage. As a consequence, resource usage should not simply select among algorithmic models of “aspects of cognition.” Rather, “aspects of cognition” should be underst...
Preprint
Emotion research typically searches for consistency and specificity in physiological activity across instances of an emotion category, such as anger or fear, yet studies to date have observed more variation than expected. In the present study, we adopt an alternative approach, searching inductively for structure within variation, both within and ac...
Article
Full-text available
John Cacioppo and colleagues’ Somatovisceral Afference Model of Emotion (SAME) highlighted the importance of interoception in emotional experience. Here we compare how the SAME and the more recent Theory of Constructed Emotion (TCE) view the role of interoceptive signals in creating emotional experiences. We describe the characteristics of touch se...
Article
Full-text available
Promoting physical activity (PA) is of top priority in chronic obstructive pulmonary disease (COPD). This study examines the influence of an internet-delivered intervention on the relationship between exercise self-efficacy and changes in PA, physical health, and exercise capacity in COPD. 112 U.S. Veterans with COPD were randomized to either a com...
Article
Full-text available
Background Medically unexplained syndromes (MUS) are both prevalent and disabling. While illness beliefs and behaviors are thought to maintain MUS-related disability, little is known about which specific behavioral responses to MUS are related to disability or the way in which beliefs and behaviors interact to impact functioning. The purpose of the...
Article
Full-text available
Law enforcement personnel commonly make decisions in stressful circumstances, where the costs associated with errors are high and sometimes fatal. In this paper, we apply a powerful theoretical approach, the theory of constructed emotion (TCE), to understand decision making under evocative circumstances. This theory posits that the primary purpose...
Article
We utilized a data-driven, unsupervised machine learning approach to examine patterns of peripheral physiological responses during a motivated performance context across two large, independent data sets, each with multiple peripheral physiological measures. Results revealed that patterns of cardiovascular response commonly associated with challenge...
Article
Challenge and threat characterize distinct patterns of physiological response to a motivated performance task where the response patterns vary as a function of an individual's evaluation of task demands relative to his/her available resources to cope with the demands. Challenge and threat responses during motivated performance have been used to und...
Article
Full-text available
Background: Sleep disturbance is a major health concern among US veterans who have served since 2001 in a combat theater in Iraq or Afghanistan. We report subjective and objective sleep results from a pilot trial assessing self-management-guided use of a mobile app (CBT-i Coach, which is based on cognitive behavioral therapy for insomnia) as an in...
Article
Recent theoretical advances have motivated the hypothesis that the periaqueductal gray (PAG) participates in behaviors that involve changes in the autonomic control of visceromotor activity, including during cognitively demanding tasks. We used ultra-high-field (7 tesla) fMRI to measure human brain activity at 1.1 mm resolution while participants c...
Article
Full-text available
Background: The mutual maintenance model proposes that post-traumatic stress disorder (PTSD) symptoms and chronic physical symptoms have a bi-directional temporal relationship. Despite widespread support for this model, there are relatively few empirical tests of the model and these have primarily examined patients with a traumatic physical injury....
Preprint
Full-text available
Commercially available consumer electronics in the form of smartwatches and wearable biosensors are increasingly enabling acquisition of peripheral physiological and physical activity data inside and outside of laboratory settings. However, there are no current guidelines for selecting and assessing the suitability of these novel devices for scient...
Article
Full-text available
Exposure to media coverage of mass violence has been shown to predict poorer mental health symptomology. However, it is unknown whether such media coverage can have ubiquitous effects on average community members, extending to biological and perceptual processes that underlie everyday decision making and behavior. Here, we used a repeated-measures...
Data
Changes in affective tone of recent marathon-related coverage predicts distress, startle reactivity, perceptual sensitivity, and shooting behavior: Variance components. r0 and r1 refer, respectively, to the participant-level variability in the intercept and slope values (i.e., across-participant variability). r2 refers to the participant-level vari...
Data
Media signaling indices for each outlet across the three waves. BG = Boston Globe, BH = Boston Herald, MT = Boston Metro, NY = New York Times. Volume refers to the total number of articles published per day, SR refers to the sentiment ratio (SR˜O(t)) for all articles, RR-mara refers to the relevance rate (RR˜O(t)) for marathon-related articles, and...
Data
Changes in extent of recent marathon-related coverage predicts distress, startle reactivity, perceptual sensitivity, and shooting behavior: Variance components. r0 and r1 refer, respectively, to the participant-level variability in the intercept and slope values (i.e., across-participant variability). r2 refers to the participant-level variability...
Data
Scatter plots for the affective tone of marathon-related content related to self-reported distress, startle amplitude, threat response bias, and perceptual sensitivity. In each plot, data points are not independent, as multiple data points are present for each of the 91 subjects included in analyses. (DOCX)
Data
Summary of media data collection across waves. Articles refers to the number of articles collected from each outlet for each wave. Marathon-related articles refers to the number of articles containing the word “marathon” from each outlet for each wave. BG = Boston Globe, BH = Boston Herald, MT = Boston Metro, NY = New York Times. (DOCX)
Data
Scatter plots for the extent of marathon-related content related to self-reported distress, startle amplitude, threat response bias, and perceptual sensitivity. In each plot, data points are not independent, as multiple data points are present for each of the 91 subjects included in analyses. (DOCX)
Article
Full-text available
This report examines responses to a brief online survey, comparing how faith-based (n = 27) and non-faith-based (n = 61) organizations engage with Veteran populations as well as the supportive services they provide. Data were analyzed using two-sample z-tests and Chi-squared tests. No significant differences were noted between respondents for self-...
Article
Full-text available
Background Communication between patients and providers about persistent “medically unexplained” physical symptoms (MUS) is characterized by discordance. While the difficulties are well documented, few studies have examined effective communication. We sought to determine what veterans with Gulf War Illness (GWI) perceive as the most helpful communi...
Article
Full-text available
Patients with chronic physical symptoms (e.g., chronic pain) often have significant functional impairment (i.e., disability). The fear avoidance model is the dominant theoretical model of how the relationship between chronic physical symptoms and functional impairment develops and proposes a cyclical/bidirectional relationship. There has never been...
Article
This work studies the feasibility of using low-cost motion sensors to provide opportunistic heart rate assessments from ballistocardiographic signals during restful periods of daily life. Three wearable devices were used to capture peripheral motions at specific body locations (head, wrist and trouser pocket) of 15 participants during five regular...
Article
Electrocardiogram (ECG), electrodermal activity (EDA), electromyogram (EMG), continuous blood pressure (BP), and impedance cardiography (ICG) are among the most commonly used peripheral physiological signals (biosignals) in psychological studies and healthcare applications including health tracking, sleep quality assessment, disease early-detection...
Preprint
Full-text available
BACKGROUND Sleep disturbance is a major health concern among post-9/11 Veteran. We report subjective and objective sleep results from a pilot trial assessing self-management-guided use of a mobile app (CBT-i Coach, based on cognitive behavioral therapy for insomnia) as an intervention for insomnia in military Veterans. OBJECTIVE A primary aim of t...
Article
Full-text available
We present evidence for the affective realism hypothesis, that incidental affect is a key ingredient in an individual’s experience of the world. In three studies, we used an interocular suppression technique (continuous flash suppression [CFS]) to present smiling, scowling, or neutral faces suppressed from conscious visual awareness while conscious...
Article
Full-text available
Media exposure influences mental health symptomology in response to salient aversive events, like terrorist attacks, but little has been done to explore the impact of news coverage that varies more subtly in affective content. Here, we utilized an existing data set in which participants self-reported physical symptoms, depressive symptoms, and anxi...
Article
Objective: Chronic Fatigue Syndrome (CFS) is a disorder of unknown etiology associated with debilitating fatigue. One symptom commonly reported is disequilibrium. The goal of this study was to determine if CFS patients demonstrated verified balance deficits and if this was effected by comorbid fibromyalgia (FM). Methods: Twenty-seven patients wi...
Article
Full-text available
Affective realism, the phenomenon whereby affect is integrated into an individual’s experience of the world, is a normal consequence of how the brain processes sensory information from the external world in the context of sensations from the body. In the present investigation, we provided compelling empirical evidence that affective realism involve...