
Karel Kostev- Prof. Dr.
- Scientific Principal at IQVIA, Frankfurt am Main, Germany
Karel Kostev
- Prof. Dr.
- Scientific Principal at IQVIA, Frankfurt am Main, Germany
About
955
Publications
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Introduction
Current institution
IQVIA, Frankfurt am Main, Germany
Current position
- Scientific Principal
Additional affiliations
January 2017 - March 2017
IMS HEALTH, Frankfurt am Main, Germany
Position
- Senior Manager Epidemiology Research
Publications
Publications (955)
Background
There is currently no established standard of care for recurrent glioblastoma (GBM). Re-irradiation (re-RT) and Bevacizumab (BEV) are both used in salvage treatment, but their combined efficacy remains uncertain.
Objectives
To evaluate whether combining re-irradiation with BEV improves survival outcomes compared to BEV alone in patients...
Background
Depression is one of the most common psychiatric condition in patients with chronic kidney disease (CKD). It is associated with decreased adherence and quality of life as well as increased risk for dialysis, hospitalization and mortality. Large population based analysis evaluating the effect of CKD on the incidence of depression are miss...
Background
Events of cardiovascular disease (CVD) remain a critical concern in patients with Type 2 diabetes mellitus (T2D). Over 17 years, this study analyzed time changes in the 5‐year incidence of myocardial infarction (MI), chronic coronary heart disease (CHD), transient ischemic attack (TIA), and ischemic stroke (IS).
Methods
This retrospecti...
Background and Objectives: Acute myocardial infarction (AMI) is one of the leading causes of mortality worldwide and caused ~1.8 million deaths in the European Union from 2012 to 2020. This study aimed to analyze and quantify sex-based disparities, identifying both clinical and systemic contributors to in-hospital mortality differences between male...
Background and Aims
A low intake of fruit and vegetable consumption has been found to be associated with a plethora of negative health outcomes in adolescents. However, there is a scarcity of literature on long‐term trends in fruit and vegetable intake in the adolescent population. Therefore, we examined this trend in a nationally representative sa...
Background
The aim of the present study was to evaluate the factors associated with a higher or lower likelihood of being early diagnosed with melanoma at stage I in Germany.
Methods
This retrospective cross-sectional study utilizes data from the German skin cancer registry (Arbeitsgemeinschaft Dermatologische Onkologie Registry) and included 12 6...
Aims
A systematic review and meta-analysis was conducted to investigate the prevalence and antecedents/outcomes of loneliness and social isolation among individuals with severe mental disorders (SMD), such as schizophrenia, schizoaffective disorder, bipolar disorder or major depressive disorder.
Methods
Five well-known electronic databases (PubMed...
Background
Cryolipolysis is a nonsurgical adiposity reduction treatment that is increasing in popularity globally. The aim of this paper was to carry out a systematic review with meta-analysis on cryolipolysis and associated health outcomes, adverse events (AE) and patient satisfaction.
Methods
Major databases were searched from inception until Ap...
Studies from high-income countries have shown that multimorbidity is associated with increased fall risk among older adults. However, studies specifically on this topic from low- and middle-income counties (LMICs) are lacking. Thus, we aimed to assess this association among adults aged ≥ 50 years from six LMICs.
Cross-sectional, community-based dat...
Aim
Our aim was to identify multimorbidity clusters and, in particular, to examine their contribution to well-being outcomes among the oldest old in Germany.
Methods
Data were taken from the large nationally representative D80+ study including community-dwelling and institutionalized individuals aged 80 years and over residing in Germany(n=8,773)....
Aim
The aim was to investigate the association of procrastination with loneliness, social isolation, and social withdrawal (also stratified by sex).
Subjects and methods
Data were used from a large sample of the general adult population in Germany, consisting of individuals aged 18 to 74 years (analytic sample, n = 5000 individuals, mean age: 46.9...
For Silexan, a proprietary preparation of Lavandula angustifolia flowers, efficacy and tolerability in adults with anxiety disorders was demonstrated in clinical trials lasting up to 10 weeks. The present study investigated the extent and tolerability of long-term and adolescent use in real world. For the retrospective analysis of patients with a f...
Background: The objective of this study was to investigate the prevalence of discharge against medical advice (DAMA) among schizophrenia patients in Germany and to identify factors associated with the risk of DAMA. Methods: This multicenter cross-sectional study was based on data from the IQVIA hospital database, which contains records from 36 hosp...
We investigated the association between unclean cooking fuel use and sleep problems in a nationally representative sample of adults aged ≥65 years from six low- and middle-income countries (China, Ghana, India, Mexico, Russia, South Africa). Cross-sectional, community-based data from the WHO Study on global AGEing and adult health (SAGE) were analy...
Background: Sleep disorders are prevalent conditions that may influence the progression of various heart diseases.However, the relationship between sleep disorders and the onset of heart failure (HF) remains unclear.
Objective: The purpose of this study was to investigate whether sleep disorders are associated with an increasedrisk of developing H...
Purpose
Little is known about the relationship between conflict at work and incident chronic low back pain (CLBP). Thus, this retrospective cohort study analyzed the association between conflict at work and the five-year incidence of CLBP in adults living in Germany.
Methods
This study included individuals aged 18–65 years reporting conflict at wo...
Background: Thyroid dysfunctions, such as hypothyroidism, hyperthyroidism, are known to influence metabolism, but their long-term impact on the development of type 2 diabetes mellitus (T2D) in humans remains elusive. Thus, this study aimed to assess the cumulative incidence and association between thyroid disorders and T2D development.
Methods: We...
Background
This study aims to evaluate the current rates and outcomes of minimally invasive versus open surgery for colonic diverticular disease in Germany, using a nationwide dataset.
Methods
We analyzed data from 36 hospitals, encompassing approximately 1.25 million hospitalizations from 1 January 2019 to 31 December 2023. Patients aged 18 years...
Background:
Discharge against medical advice (DAMA) disrupts continuity of care and is associated with increased readmission rates, morbidity, and mortality. While extensively studied in general hospital populations, its prevalence and associated factors in cancer patients, where treatment adherence is critical for outcomes, remain underexplored....
Background/Objectives: Previous research indicates that Ginkgo biloba extract (Gbe) may contribute to slowing down the progression of dementia. This retrospective cohort study analyzed the association between Gbe prescriptions and the progression of dementia severity in a real-world setting. Methods: This study was conducted using data from patient...
Purpose: The purpose of this study was to investigate a possible association between Herpes Zoster (HZ) and the subsequent diagnosis of breast cancer (BC). Methods: Utilizing the Disease Analyzer database, anonymized medical records from German office-based practices were accessed. Longitudinal data of female patients aged 18 years and above diagno...
Consumption of fast-food in adolescence is detrimental to mental and physical health. However, data on the temporal trends of fast-food consumption in this population are scarce, particularly from non-Western or non-high-income settings. Therefore, we aimed to examine this trend in representative samples of school-going adolescents aged 12–15 years...
Purpose
Anal fissures and anorectal fistulas are diseases often associated with significant pain and prolonged discomfort, resulting in a significantly reduced quality of life (QoL). They are not only a surgical problem but also have a profound psychosocial impact and influence on QoL. The aim of this study was to investigate the incidence of depre...
Background: Since previous studies have reported contradictory findings regarding the relationship between schizophrenia and cancer, we evaluated the association between schizophrenia and cancer diagnoses. Methods: In this retrospective cohort study, the IQVIA Disease Analyzer database was utilized to examine the incidence of cancer among patients...
Background
Documented risk factors and prodromal features of dementia in primary care practices may support dementia prevention and early detection in routine care.
Objective
To identify documented prodromal features and risk factors of dementia before the incident dementia diagnosis in German primary care practices.
Methods
This case-control stu...
Objective: There is a scarcity of data on the long-term relationship between cancer and chronic low back pain (CLBP). Therefore, this retrospective cohort study investigated the association between cancer and the 10-year incidence of CLBP in Germany. Methods: Data collected in 1293 German general practices between 2005 and 2022 were used for the st...
Background: The goal of this study was to evaluate whether the medical recommendation of Angocin® Anti-Infekt N, compared to standard antibiotic treatment shortly after the diagnosis of a urinary tract infection (UTI) or cystitis, is negatively associated with an early, sporadic, or recurrent UTI, subsequent antibiotic prescriptions, pyelonephritis...
The aim of this study is to analyze the incidence of sexually transmitted infections (STI) in dermatological, urological, and gynecological practices in Germany. Data from the nationwide IQVIA Disease Analyzer database was used for this study. This cross-sectional study included 6,535 patients in 2014 and 6,491 patients in 2023 with an insured diag...
Purpose: The aim of the present study was to explore whether diabetes mellitus (DM) is associated with in-hospital mortality in patients admitted for femur fractures. Methods: Our multicenter case–control study included patients aged ≥65 with a primary diagnosis of femur fracture with and without DM treated in 36 German hospitals between January 20...
Background: Primary aldosteronism (PA) is a common cause of endocrine hypertension, characterized by excessive aldosterone secretion leading to hypertension, hypokalemia, and metabolic alkalosis. While historically diagnosed based on this classic triad of symptoms, current understanding reveals a more nuanced presentation. This study aimed to inves...
Background
Dynapenic abdominal obesity (DAO) may be associated with an increased risk of disability. However, to date, this has not been investigated in low- and middle-income countries (LMICs), while the mediators are largely unknown.
Aims
Therefore, we aimed to investigate the association between DAO and activities of daily living (ADL) disabili...
Background: Biologics are a cornerstone in the treatment of severe cases of inflammatory bowel disease (IBD) and aim to control the disease and improve quality of life. This study investigated changes in nonbiologic medication prescriptions for IBD patients initiating biologic therapy in Germany. Methods: This study used data from anonymized pharma...
Background: The goal of this study was to evaluate whether the medical recommendation of Angocin® Anti-Infekt N (heretofore referenced as Angocin®) on the day of diagnosis of acute bronchitis is negatively associated with the recurrence of acute bronchitis diagnosis, antibiotic prescriptions, incidence of chronic bronchitis, and duration of sick le...
Background: Depression is the most common mental illness in the world, found in nearly three in ten adolescents globally. This study aims to evaluate the prevalence of antidepressant prescriptions and the types of antidepressant therapy administered among adolescents diagnosed with depression in Germany. Methods: This retrospective cohort study, ba...
Background: Osteoporosis and bone fractures affect health and quality of life. Since bone disease is multifactorial, identifying risk factors is key in prevention. There are multiple reports on how viral hepatitis, especially chronic hepatitis B (CHB) and chronic hepatitis C (CHC), are affecting bone disease, but results vary. Here, we analyzed the...
Objective
Peritonsillar abscess (PTA) is a common soft tissue infection of the head and neck. It remains unclear to what extent inflammatory diseases of the palatine tonsils or other infections contribute to the development of PTA. This study examines the demographic characteristics and seasonal variations of acute tonsillitis (aT) and PTA in ENT p...
Appendicitis is 1 of the most frequent diseases worldwide. In general, it is treated with appendectomy, which, in almost all cases, leads to the healing of the disease and averts acute complications. However, only limited data regarding long-term sequalae, including inflammatory bowel diseases following appendicitis are available. We therefore inve...
Zusammenfassung
Hintergrund Die prognostizierte Anzahl der Menschen mit Demenz (MmD) ist in Deutschland auf 1,8 Mio. MmD angestiegen. In naher Zukunft wird die Zulassung einer Antikörper-Therapie erwartet. Ziel der Studie ist es, die bisherige Antidementiva-Versorgung im Verhältnis zur Diagnoseprävalenz darzustellen.
Methode Auf Basis von Abrechnun...
Background
There is a lack of studies investigating death anxiety among the oldest old based on a large, nationally representative sample during the pandemic. Thus, our aim was to investigate the prevalence and determinants of death anxiety among the oldest old in Germany during the Covid‐19 pandemic.
Methods
Cross‐sectional data were taken from t...
Hawthorn special extract WS 1442 has beneficial effects on the cardiovascular system. Experimental studies have shown an antiarrhythmic effect of the substance. In the present study, we investigated antiarrhythmic effects of WS 1442 compared with magnesium/potassium in a large collective of outpatients. Using the IQVIA Disease Analyzer (DA) databas...
Background: The early diagnosis of pancreatic cancer (ICD-10 C25) can improve the patient’s prognosis. The association between pancreatic cancer and type 2 diabetes (T2D) is known, but not yet fully understood. It is, therefore, necessary to investigate the impact of hemoglobin A1c (HbA1c) serum levels on pancreatic cancer development and the poten...
Background/Objectives: Aortic valve stenosis (AS) represents one of the most common valve diseases in the western world. It often leads to severe symptoms that can lead to a restriction of everyday life and thus to psychological stress. Therefore, we aimed to investigate the association between AS and depression in outpatients in Germany. Methods:...
Background: Osteoporosis and bone fractures affect health and quality of life. Since bone disease is multifactorial, identifying risk factors is key in prevention. There are multiple reports on how viral hepatitis especially chronic hepatitis B (CHB) and chronic hepatitis C (CHC) are affecting bone disease, but results vary. Here, we analyzed the p...
Background
Both the risk of developing heart disease and the course of the disease are determined in particular by comorbidities. In this context, gout has recently been identified as an important factor in influencing the development of cardiovascular events such as heart failure or coronary artery disease.
Methods
This retrospective cohort study...
Objective
Peritonsillar abscess (PTA) is the most common deep soft tissue infection necessitating surgical intervention in the head and neck region. Potential causes include infections of the palatine tonsils, palatine glands, or branchiogenic rudiments (“acute tonsillitis hypothesis” vs. “Weber’s gland hypothesis”). Understanding the currently sti...
Background
The objective of this study was to assess the trend from open to modern minimally invasive (laparoscopic and robot-assisted) surgical techniques for colorectal cancer (CRC) in Germany, with a particular focus on hospital mortality, postoperative complications, and length of hospital stay.
Methods
A multicenter cross-sectional study was...
Purpose
The aim of the study was to explore the association between mastitis and subsequent breast cancer.
Methods
This retrospective cohort study included women aged ≥ 18 years with an initial mastitis diagnosis from 315 office-based gynecologists in Germany between January 2005 and December 2021. Women without mastitis were matched to women with...
Introduction: The treatment of acute ischemic stroke due to large artery vessel occlusion experienced a dramatic development within the last decade. This meta-analysis investigates the effectiveness of Bridging Therapy (BT) versus mechanical thrombectomy (MT) alone in treating acute ischemic stroke. Methods: Two independent reviewers assessed two-a...
Background
The increasing life expectancy of individuals with Down syndrome has led to a growing awareness of mid‐ and late‐life conditions.
Methods
Based on the Disease Analyser database (IQVIA), this retrospective cohort study compared adults ≥18 years of age with Down syndrome (ICD‐10: Q90) in general practices in Germany with a propensity scor...
Aims
The significance of micro-embolic signals (MESs) during atrial fibrillation (AF) ablation is unclear. Previous studies had limitations, and cryoballoon (CB) ablation patients were under-represented. Minimizing MESs is recommended due to their uncertain neurocognitive impact.
Methods and results
This prospective observational study included AF...
Background
Helicobacter pylori ( H. pylori ) is a gram-negative gastrointestinal pathogen that colonises the human stomach and is considered a major risk factor for gastric cancer and mucosa-associated lymphoid tissue lymphoma. Furthermore, H. pylori is a potential trigger of a wide spectrum of extragastric cancer entities, extraintestinal chronic...
Pulmonary embolism (PE) is a life-threatening condition, the prognosis of which is determined in particular by acute decompensation and hospitalization. The goal of this study was to investigate the prevalence of and the factors associated with the in-hospital mortality of patients hospitalized with acute PE. This multicenter cross-sectional study...
Objectives
We aimed to evaluate the drug utilization of Ginkgo biloba extract (Gbe), systemic corticosteroids (CSs), and pentoxifylline (PTXF) for the treatment of acute tinnitus by analyzing electronic patient health record data. In addition, we assessed whether the different drug treatments were associated with different frequencies of repeat vis...
Objectives
Mild cognitive Impairment (MCI) is a unique indicator of underlying distress that may be strongly associated with suicide risk. Despite this, to date, no study has examined the association between MCI and suicidal ideation. Therefore, the present study aimed to examine the association between MCI and suicidal ideation among adults aged ≥...
Background: Alterations in the serum lipid profile have been suspected in many psychiatric disorders, such as schizophrenia and depression. However, studies on lipid status in attention-deficit/hyperactivity disorder (ADHD) are sparse and inconsistent. Methods: Using the nationwide, population-based IQVIA Disease Analyzer database, this retrospecti...
Objective: The aim of the present study was to evaluate the hospital length of stay (LoS) and its associated factors among adult patients hospitalized with depression in Germany. Methods: This cross-sectional study included all adults (≥18 years) hospitalized with depression from January 2019 to December 2023 treated in 36 hospitals across Germany....
Denosumab initiation is related to a lower risk of type 2 diabetes than alendronate in anti-osteoporotic treatment-naïve users in primary care practices.
Links have been suggested between bone metabolism and glucose tolerance. Downregulation of the receptor activator of nuclear factor κ B ligand (RANKL) signaling improves glucose metabolism. Denosu...
Background and hypothesis
Patients with chronic kidney disease (CKD) are at high risk for bone fractures, which are associated with high morbidity and mortality. Proton pump inhibitors (PPI) have been linked to an increased risk for fractures in the general population as well as in patients with need for hemodialysis, but studies in patients with C...
Background: Atrial fibrillation (AF) ablation is increasingly effective for managing heart rhythm but poses risks like esophageal fistulas. Minimizing esophageal thermal lesions while simplifying procedures is crucial. Methods: This prospective study involved 100 consecutive AF patients undergoing cryoballoon ablation with simplified sedation, with...
Background: Colorectal cancer (CRC) stands as one of the most prevalent and burdensome malignancies worldwide. Similar to other cancers, CRC has been associated with the development of psychiatric diseases, including anxiety and depression. However, temporal trends in psychiatric disorders rates within CRC patients have not been investigated so far...
Background: Poor quality of sleep is a widespread issue in modern society, and even children are being diagnosed with sleep disorders nowadays. Sleep disruption in children can lead to poor mental health in the long term. The present study aimed to evaluate the association between sleep disorders and subsequent depression in children and adolescent...
Thyroid cancer is the ninth most common cancer worldwide. While differentiated thyroid cancer (DTC) has a high survival rate, concerns arise regarding optimal treatment strategies and potential long-term risks, including second primary malignancies (SPMs), associated with therapies such as radioiodine (RAI). The aim of the present study was to inve...
Background
There is a scarcity of data on the epidemiology of hypertension and its treatment in Germany in recent years.
Objectives
The present study aimed to investigate trends in the number of adults diagnosed with hypertension and those being prescribed antihypertensive drugs each year in general practices from this country between 2013 and 202...
Background: Hawthorn special extract WS® 1442 has beneficial effects on the cardiovascular system. Experimental studies showed an antiarrhythmic effect of the substance. We therefore investigated antiarrhythmic effects of WS® 1442 compared with magnesium/potassium in a large collective of outpatients.
Methods: Using the IQVIA® Disease Analyzer (DA)...
Background
Sedentary behavior, or time spent sitting, may increase risk for dynapenic abdominal obesity (DAO), but there are currently no studies on this topic.
Aims
Therefore, we investigated the association between sedentary behaviour and DAO in a nationally representative sample of older adults from six low- and middle-income countries.
Method...
Background
The aim of the present study was to analyze the cumulative incidence of depression diagnosis in patients with hemorrhoids and to evaluate the association between hemorrhoids and subsequent depression diagnosis.
Methods
This retrospective cohort study was based on electronic medical records from the Disease Analyzer database (IQVIA) and...
Background and Aim
Helicobacter pylori ( H. pylori ) infection is a bacterial disease of the stomach that has been associated with an increased incidence of cholelithiasis. While the updated German guideline emphasizes the relevance of H. pylori as a pathogen and recommends eradication therapy, systematic data on the association between H. pylori i...
Objective: There is a scarcity of data on hospital length of stay (LOS) in the osteoarthritis population. Therefore, this study aimed to investigate hospital LOS and associated factors in patients with osteoarthritis from Germany. Methods: The present cross-sectional study included patients hospitalized for osteoarthritis in one of fourteen hospita...
Background:
Studies have reported higher in-hospital mortality rates in patients living with dementia (PlwD) with limited evidence across age groups, clinical departments, and admission diagnoses. The aim of this study was to compare the in-hospital mortality rate of PlwD with patients without dementia across groups, clinical departments, and admi...
Background
The present study aimed to investigate the association between COVID-19 and the cumulative incidence of depression and the potential role of sick leave in a large representative sample of German adults.
Methods
This retrospective cohort study was based on the Disease Analyzer database (IQVIA) data. This study included individuals aged ≥...
Background/Objective: The association between appendicitis and colon cancer is not yet fully understood. Previous studies have shown contradictory results. Currently, no population-based data from Germany are available with regard to the incidence of colon cancer following appendicitis. This study investigated the association between appendicitis a...
Simple Summary
Proton pump inhibitors (PPIs) are very commonly prescribed drugs in gastroenterology. The present study evaluated a potential association between PPI intake and a subsequent diagnosis of liver cancer in Germany. We observed that long-term PPI intake in women as well as in patients < 60 years might be associated with an increased risk...
Purpose
Appendicitis, characterized by inflammation of the vermiform appendix, is a common abdominal emergency necessitating appendectomy. Recent evidence suggests a potential link between appendicitis and subsequent diverticular disease, yet population-based studies investigating this association are limited.
Methods
Utilizing the Disease Analyze...
Real-world evidence supports SARS-CoV-2 vaccination strategies during the COVID-19 pandemic. This real-world retrospective study utilized the German Disease Analyzer database to characterize recipients of NVX-CoV2373 and explore vaccination outcomes. Recipients (≥12 years) of NVX-CoV2373 as a primary series or booster in Germany were vaccinated bet...
Background
Recent data suggest a potential pathophysiological link between inflammatory bowel disease (IBD) and multiple sclerosis (MS), two immune-mediated diseases both of which can have a significant impact on patients' quality of life. In the present manuscript, we investigate the association between IBD and MS in a German cohort of general pra...
Purpose
To examine the association of several antihypertensive medication classes with incidence of Parkinson’s disease (PD), taking into account possible underlying conditions.
Methods
In a case-control study based on a large primary care database and including 21,981 PD cases and 21,981 non-PD controls matched for age, sex, and possible treatmen...
Background:
In the present study, we used the data from 14 hospitals to systematically evaluate the in-hospital mortality of patients with colorectal cancer as well as its influencing factors in Germany.
Methods:
This multicenter cross-sectional study included hospitalized patients with a main diagnosis of colorectal cancers in the period betwee...
Background: We evaluated whether EPs® 7630 prescription in patients with acute sinusitis (AS) is associated with less frequent recurrence of AS, occurrence of chronic sinusitis or nasal polyps, or fewer antibiotic prescriptions.
Methods: This retrospective cohort study used electronic medical records from the IQVIA Disease Analyzer database. Associ...
Background: There is a lack of studies investigating the prevalence of syncope-related injuries in a large representative cohort. The aim of this cross-sectional study is to investigate the prevalence of, and variables associated with syncope-related injuries and fractures in a large outpatient population in Germany. Methods: The present study used...
Background:
Individuals with Down syndrome are thought to have a unique tumor profile.
Methods:
Using the IQVIA Disease Analyzer database, patients aged ≥18 years diagnosed with Down syndrome in German general practices between 2005 and 2021 were compared with patients without Down syndrome for cancer incidence, adjusting for age, sex, average a...
Background: The gut microbiome modulates the liver immune microenvironment and is deeply integrated into the pathophysiology of metabolic dysfunction-associated steatotic liver disease (MASLD). Appendectomies, which are performed in almost all patients diagnosed with appendicitis, cause long-term alterations to the gut microbiome, providing a poten...
Purpose
Urologists’ practices reported decreasing medical care provision and increasing stress experience in the first wave of the COVID-19 pandemic. However, long-term effects of the pandemic are unknown.
Methods
Medical record data of n = 127 urologists were used to assess changes in healthcare provision, comparing the pandemic with the pre-pand...
Abstract
Purpose
There is a scarcity of literature on temporal trends in physical fighting and physical attacks among the global adolescent population. Therefore, we aimed to examine these trends in a nationally representative sample of school-going adolescents aged 12–15 years from 30 countries in Africa, Asia, and the Americas, for which temporal...
Purpose
Iron deficiency anemia (IDA) is the most common form of anemia worldwide, resulting in a high burden of disease. Accumulating evidence suggests that IDA is associated with the development of gastrointestinal (GI) cancers.
Methods
Data from the IDA database (IQVIA) of primary care practices in Germany of adult patients first diagnosed with...
Background: There is little information on prescription patterns of antiseizure medications (ASMs) during the early management of patients with epilepsy in Germany. Therefore, this study investigated the prevalence of and the factors associated with ASM prescription in patients newly diagnosed with epilepsy in this country. Methods: Adults diagnose...
Carbonated soft-drink consumption is detrimental to multiple facets of adolescent health. However, little is known about temporal trends in carbonated soft-drink consumption among adolescents, particularly in non-Western countries. Therefore, we aimed to examine this trend in representative samples of school-going adolescents from 18 countries in A...
In the original publication [...]
Background:
There is a scarcity of studies on the association between physical multimorbidity and lower levels of physical activity among older adults from low- and middle-income countries, while the potential mediating variables in this association are largely unknown.
Methods:
Cross-sectional, community-based, nationally representative data fr...
The aims of this study were to analyze proton pump inhibitor (PPI) users in Germany, defining and classifying them in terms of treatment appropriateness, and to analyze the PPI prescription practices of healthcare providers. The updated DGVS (Deutsche Gesellschaft für Gastroenterologie, Verdauungs-und Stoffwechselkrankheiten) gastroesophageal reflu...