Karel Kalecký

• Baylor University

Previously, our metabolomic, transcriptomic, and genomic studies characterized the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease, and we demonstrated that FTY720, a sphingosine-1-phospahate receptor modulator approved for treatment of multiple sclerosis, recovers synaptic plasticity and memory in APP/PS1 mice. To fur...

We performed liquid chromatography tandem mass spectrometry analysis with the targeted metabolomic kit Biocrates MxP Quant 500, in human brain cortex (Brodmann area 9) and putamen, to reveal metabolic changes characteristic of Parkinson’s disease (PD) and PD-related cognitive decline. This case-control study involved 101 subjects (33 PD without dem...

Ketogenic diets (KD) are very low-carbohydrate diets that promote nutritional ketosis and are widely used for weight loss, although concerns about potential adverse cardiovascular effects remain. In this study, we used apolipoprotein E deficient ( ApoE -/- ) mice to investigate the vascular impact and plasma metabolic signature of a very high-fat K...

Background Metabolites are biological compounds reflecting the functional activity of organs and tissues. Understanding metabolic changes in Alzheimer’s disease (AD) can provide insight into potential risk factors in this multifactorial disease and suggest new intervention strategies or improve non-invasive diagnosis. Objective In this study, we s...

Disruptions in one-carbon metabolism and elevated homocysteine have been previously implicated in the development of dementia associated with Alzheimer’s disease (AD) and Parkinson’s disease (PD). Moreover, a PD diagnosis itself carries substantial risk for the development of dementia. This is the first study that explores alterations in one-carbon...

Background: A healthy diet is a cornerstone of CVD prevention and management. The vascular impact of very-low-carbohydrate (CHO), high-fat diets, or ketogenic diets (KD), remains unclear. Hypothesis: A KD will be protective against atherogenesis compared to a moderate-CHO, high-fat diet (HFD). Methods: Seven-week-old male apoE -/- mice, a model for...

Background: The term triple-negative breast cancer (TNBC) is used to describe breast cancers without expression of estrogen receptor, progesterone receptor or HER2 amplification. To advance targeted treatment options for TNBC, it is critical that the subtypes within this classification be described in regard to their characteristic biology and gen...

Motivation: Cross-species analysis of large-scale protein-protein interaction (PPI) networks has played a significant role in understanding the principles deriving evolution of cellular organizations and functions. Recently, network alignment algorithms have been proposed to predict conserved interactions and functions of proteins. These approache...

Purpose The main objective is to accelerate the mathematical modeling of complex systems and offer the researchers an accessible and standardized platform for model sharing and reusing. Methods We describe a methodology for creating mathematical lumped models, decomposing a system into basic components represented by elementary physical laws and r...