Kannan Natarajan

Manipal Academy of Higher Education | MAHE · Department of Biotechnology

There have been significant developments in the use of siRNA in the silencing of cancer-allied target proteins with substantial apoptotic effects. Nevertheless, the challenges regarding siRNA delivery for cancer therapy remain a major concern for taking these therapies successfully from laboratory to in vivo studies. Biomaterials are defined tradit...

The study aims to characterize and understand the toxicological effects of colloidal mercuric formulation. The physiochemical characterization was carried out using Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), Energy dispersive X-ray microanalysis system (EDS), Inductively coupled plasma optical emission s...

The present study focuses on a novel method to integrate the electro-oxidation process with membrane bioreactor to reduce biofouling and increase the biodegradability index. Here, we used electro-oxidation as pretreatment with membrane bioreactor operating at a current density of 1.5 mA/cm2 with hydraulic retention time at six h. The mixed liquor s...

The main source of every day’s energy is dependent on fossil fuels and plays a vital role in all energy applications. The present study focuses on the effective development of nitrogen-doped graphene (NG)/Poly(3,4-ethylenedioxythiophene) (PEDOT) composite as competent electrode materials for various energy and power applications. Graphene oxide and...

[This corrects the article DOI: 10.1371/journal.pone.0209948.].

Background The application of polymeric materials in medical industry has grown drastically in the last two decades due to their various advantages compared to existing materials. The present research work emphases on the sol-gel technique to formulate the polymethyl methyl acrylate/polystyrene/silica composite membrane. Methods The characteristic...

The data set of FTIR. (OPJ)

The data set of tensile strength. (OPJ)

The data set of water absorption. (OPJ)

Background The application of polymeric materials in medical industry has grown drastically in the last two decades due to their various advantages compared to existing materials. The present research work emphases on the sol-gel technique to formulate the polymethyl methyl acrylate/polystyrene/silica composite membrane. Methods The characteristic...

[This corrects the article DOI: 10.1371/journal.pone.0195800.].

Background The present study is aimed to evaluate the physiochemical properties and cytotoxicity of mercury-based formulation for the development of anticancer therapeuticals. Methods The elemental and morphological features of the formulation were characterized by FE-SEM, XPS and EDS. The described formulation was evaluated for its cytotoxicity o...

Background: The traditional Indian medicine 'Siddha' uses metals, metalloids and minerals including toxic ones with no proven toxicity. Thalagak karuppu (TK) is remarkably stable over a century and used for treating Suram (Fever), Kaasam (Cough), Elai (Tuberculosis) and Eraippu Erumal (Bronchial Asthma). Objective: The present study addresses el...

Bioinspiration through biological nanomachines and their assemblies at molecular level provide guiding principles to build nanoscale functional devices. The rapid advances in the biosynthesis of nanomaterials, including hybrid nanomaterials and their applications are reviewed. Biological synthesis of nanostructures using whole organism as well as b...

Tannin acyl hydrolase (tannase) production by Lactobacillus plantarum MTCC1407 was studied in submerged and solid-state fermentation process. Sequential optimization strategy using Plackett–Burman screening and response surface methodology was adopted to optimize the submerged fermentation process. Eight medium components were evaluated initially b...

Large number of papers has been published recently on the eleventh group metallic elements such as Ag, Au and Cu. Our study was focused on biosynthesis of silver nanoparticles, their morphology, reactivity and stability. We were interested to check these properties in two different samples, S1 and S2, respectively. The biosynthesis of silver nanopa...

Production of tannase and microbial biomass by Lactobacillus plantarum MTCC 1407 was studied in submerged batch fermentation. The tannase production was performed in different media compositions maintaining the fermentation conditions constant at 30°C, initial pH 5.5 and agitation speed at 120 rpm. Maximum tannase activity of 5.22 U mL-l was obtain...

In the last decade, synthesis of nanoparticles has been the subject of a lot of studies due to its commercial importance and applications. Their interesting characteristics and wide applications have led to numerous methods being developed for synthesis of nanoparticles of various shapes and sizes. Typically, the methods employed for their synthesi...

In the last decade, synthesis of nanoparticles has been the subject of a lot of studies due to its commercial importance and applications. Their interesting characteristics and wide applications have led to numerous methods being developed for synthesis of nanoparticles of various shapes and sizes. Typically, the methods employed for their synthesi...

The biological process with the ability to study the shape of particles produced would therefore be a limelight of modern nanotechnology. The bacterial strain Escherichia coli, used for the biosynthesis of silver nanoparticles were investigated. These silver nanoparticles were characterized by means of UV–vis spectroscopy, particle size analyzer. T...

Lactobacillus plantarum MTCC 1407 represents a valuable source of an economically attractive stable long-life tannase with potential for application in various industries. The effect of fermentation parameters such as pH, temperature and agitation speed on the growth of biomass and production of tannase using liquid medium were determined at the en...

Tannase (tannin acyl hydrolase, E.C.3.1.1.20) is an extracellular hydrolase enzyme that catalyzes the hydrolysis of aster and depside bonds in hydrolysable tannins or gallic acid esters, liberating glucose and gallic acid (GA). Tannase cleaves the ester linkages between galloyl groups present in various compounds such as epigallocatechin and epigal...

Tannase also referred to as tannin acyl hydrolase (EC 3.1.1.20), is mainly used for the bioconversion of tannic acid (hydrolysable) to nine parts of gallic acid and one molecule of sugar moiety (Lekha and Lonsane, 1997) (Fig 1). Tannase is widely present in many tannin-rich plant materials, such as myrobalan (Terminalia chebula) fruits, divi divi (...