Kamuran Karaman

• Doctor of Medicine
• Medical Doctor at Van Yuzuncu Yil University

Aim Oral mucositis (OM) is a common side effect of systemic chemotherapy (CT) in cancer patients. The aim of this study was to investigate the effect of hyaluronic acid (HA) gel on OM in children receiving CT. Material and method A total of 40 pediatric patients aged between 3 and 18 years who were diagnosed with leukemia and treated with CT in the...

Background Physiotherapy is recommended for people with hemophilic arthropathy (PwHA) to improve musculoskeletal health and is typically administered in 2 or 3 sessions per week. We aimed to investigate the effects of once a week comprehensive physiotherapy and home exercise on musculoskeletal system of PwHA. Methods In this study 19 young PwHA wi...

Aim Dermoid tumors are uncommon intracranial tumors that grow slowly and typically manifest in individuals aged between their third and fifth decade. Dermoid cyst is an uncommon ectoderm originated benign cyst. Giant dermoid cysts are more rare, especially in the posterior fossa. Although intracranial dermoid cyst may commonly occur in the cerebell...

In this study, the effect of early X-ray exposure on infertility was investigated by creating a newborn model with rats. Fifteen Pregnant rats were divided into five groups. After birth, the study was continued with 12 babies (6 males, 6 females) rat in each group. Different amounts of X-rays were applied to the experimental groups. At the end of t...

Hemophilic arthropathy (HA) of the elbow joint should be examined separately from the knee and ankle because of the anatomical and biomechanical differences of the elbow. The aim is to investigate possible correlations between age, range of motion (ROM), muscle strength, upper extremity functions, joint health and radiological findings. Twenty-seve...

Background and Aim: Oral mucositis (OM) is a common side effect of systemic chemotherapy (CT) in cancer patients. The aim was to evaluate the effect of low-level laser therapy (LLLT) for the treatment of CT-induced OM children. Patients and Methods: The study was carried out in 40 pediatric patients aged 3 to 18, who were hospitalized for the di...

Objective:Brucellosis is the most common bacterial zoonotic disease transmitted via unpasteurised milk and dairy products from infected animals. This study aimed to evaluate paediatric patients treated for brucellosis and followed for 2 years.Materials and Methods:The records of 73 patients with childhood brucellosis who had undergone treatment and...

Tuberous sclerosis complex is a rare multisystem genetic disorder characterised by the growth of numerous tumour-like malformations in many parts of the body including skin, kidneys, brain, lung, eyes, liver, and heart. Mutations in the TSC1 or TSC2 genes have been reported to cause disruption in the TSC1–TSC2 intracellular protein complex, causing...

Background: Although the exact pathophysiology of functional gastrointestinal diseases remains unclear, numerous etiologies have been blamed, including visceral hypersensitivity, gastrointestinal motility disorders, psychological factors, intestinal mucosal inflammation, intestinal microbiota, and post-infectious syndromes. In the present study, w...

Introduction Recurrent hemarthroses disturbing force/movement control are likely to impair postural balance. Aim To investigate the possible changes in static postural balance parameters in children with haemophilia (CwH) and to reveal its relationship with Haemophilia Joint Health Score (HJHS). Methods Twenty‐one CwH aged 6–18 who had haemophili...

Introduction and Purpose: The Urinary Neutrophil-gelatinase associated lipocalin (NGAL) levels which are a biomarker for early diagnosis of kidney damage that may develop in patients with Polycystic Ovary Syndrome (PCOS) were investigated in the study. Material and Methods: The 30 patients diagnosed with Polycystic Ovarian Syndrome between the ages...

Psoriasis is a chronic inflammatory disorder affecting the skin, nails, and joints. Its lifetime prevelance has been estimated to be at 1% to 3%. This study was designed to examine the association between serum pentraxin 3 (PTX3) and cardiovascular function in psoriatic children. Thirty-three children who were diagnosed with psoriasis, and 29 healt...

Glanzmann’s thrombasthenia (GT) is an autosomal recessive disorder in which the underlying problem is the lack or dysfunction of the GpIIb/IIIa receptor on the platelet surface. The present study determines the genetic mutation typology and analyzes the association between mutation types and clinical findings in patients diagnosed with GT who were...

Objective: Malnutrition is commonly seen in children with exocrine pancreatic insufficiency (EPI). Pancreatic enzyme replacement therapy (PERT) is the mainstay treatment of acute malnutrition in children detected with a disease closely associated with EPI (eg, cystic fibrosis). The effectiveness of PERT in children with malnutrition without any ch...

Objective: To investigate the effect of inflammation on the conducting system of the heart in patients diagnosed with brucellosis. Methods: A total of 42 patients diagnosed with brucellosis and 39 age and sex-matched healthy children were enrolled into the study. Pre- and post-treatment electrocardiographic parameters in brucellosis and control...

Background and aim: Neutrophil gelatinase-associated lipocalin (NGAL) is found in the granules of human neutrophils, with many diverse functions. Expression of NGAL is induced under various pathophysiological conditions, for example, infection, inflammation, kidney injury, cardiovascular disease, burn injury, and intoxication, and it has an import...

The aim of our study was to evaluate whether cardiovascular disease risks seen in adults with polycystic ovary syndrome (PCOS) develop in adolescents with PCOS using conventional Doppler echocardiography (CDE) and tissue Doppler echocardiography (TDE) or not. The other aim was to investigate the association of paraoxonase-1 (PON-1) level with cardi...

Typhoid fever is an acute and systemic infectious disease that is specific to humans and is caused by Salmonella typhi. Patients may present with different findings ranging from simple fever to multiple organ failure. Hemophagocytosis and rhabdomyolysis are rare complications of typhoid fever. In this study, we presented a case of hemophagocytic ly...

DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome is a rare type of delayed drug hypersensitivity reaction characterised by fever, skin rash, lymphadenopathy, and visceral involvement, which can be life threatening and is a childhood event. An eight-year-old boy was admitted with complaints of extensive rash and fever three wee...

Hemophagocytic lymphohistiocytosis (HLH) is a fatal condition of severe hyperin-flammation that results from an uncontrolled proliferation of activated lymphocytes and histiocytes secreting high amounts of inflammatory cytokines. The perforin gene mutation was the first genetic deffect to be described in association with HLH. HLH is a distinct clin...

Objective: Thrombocytopenia is the most common hematological disorder that is encountered in the neonatal intensive care unit (NICU). The incidence of thrombocytopenia in neonates may varies greatly depending upon admitted patients population of unit. This study was performed on neonates admitted to Yuzuncu Yil University of Dursun Odabaş Medical C...

Juvenile myelomonocytic leukemia (JMML) is a malignant disease characterized by excessive proliferation of monocytic and granulocytic cells resulting in clonal defect of the hematopoietic stem cell, which accounts for about 2% of pediatric leukemia in early childhood. İn nowadays; molecular pathology in 85-90% of cases can be detected. Below we pre...

Vincristine; many malignancies such as lymphoma and leukemia are highly specific vinka alkaloids for the cell cycle frequently used in the chemotherapy protocol. The differential diagnosis of drug-induced neuropathy should be made absolutely. Vincristine neurotoxicity can be seen in four different ways: peripheral neuropathy, autonomic neuropathy,...

INTRODUCTION: In this study, we have compared the reliability and accuracy of catheter and sack urine culture in 229 children admitted with suspects and complaints of urinary tract infection. METHODS: The study was held in Yuzuncu Yil University Pediatrics Outpatient Department. Whole urine examination and microscopic examination of urine sediments...

Background: The aim of this study was to investigate characteristics, outcomes and clinical features of acute intoxications among children in Van region of Turkey. Methods: All cases with a diagnosis of acute intoxication admitted to the Pediatric Emergency Department of the Yüzüncü Yıl University of Van from June 1, 2010 to November 30, 2011 we...

Background: The Wiskott–Aldrich syndrome (WAS) is X-linked recessive disorder associated with microplatelet thrombocytopenia, eczema, infections, and an increased risk of autoimmunity and lymphoid neoplasia. The originally described features of WAS include susceptibility to infections, microthrombocytopenia, and eczema. Aim: In this case report, we...

Objective: To determine levels of trace elements [copper (Cu), zinc (Zn), selenium (Se), and cobalt (Co)] and heavy metals [arsenic (As), mercury (Hg), lead (Pb), and cadmium (Cd)] in the plasma of mothers and infants and investigate the relationship between those levels and neural tube defects (NTD). Methods: A total of 100 neonates diagnosed with...

Hydatid disease is the most common mediterranean parasitic infection; it commonly affects the liver and lungs and rarely involves multiple organs. A 14-year-old girl presented with a 1-year history of dyspnoea and fatigue. She was found to have pulmonary hypertension owing to hydatid cysts in the right ventricle and both pulmonary arteries. After a...

Invasive pneumococcal infections among children are a serious public health problem in many countries, including Turkey. Pneumococcal conjugate vaccine has been included in Turkey's National Immunization Programme since 2009. We report the first two pediatric cases of invasive pneumococcal infection due to non-vaccine serotype 15A after pneumococca...

Brucellosis is transmitted via animal or animal products. The transmission of infection from animal to human occurs by the ways of; generally the direct contact of secretions of infected animals through the human skin which of broken integrity, consumption of unpasteurized milk and milk products, inhalation and contact with conjunctiva with infecte...

Background Superoxidized water (SOW) is known to be a potent disinfectant. The aim of this study was to evaluate the toxicity and complications on the peritoneal surface and liver after infusion of pH-neutral SOW into the peritoneal cavity of rats. Material/Methods Thirty Wistar-Albino rats weighing 250–300 g were randomly divided into 3 groups (1...

Malnutrition in childhood is a dramatic indicator of poor socio-economical status worldwide. To recognize and reveal the socio-demographic features is crucial, especially for developing countries. Our aim was to investigate the prevalence and association with sociodemographic variables of malnutrition in 0-5 years old children in Van, Turkey. A tot...

As a multisystem infectious disease, there is an inflammation, which causes increase in acute phase reactants in brucellosis. The mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have been identified as markers of inflammatio...

The aim of the present study was to present the hematologic findings of 622 cases diagnosed with acute brucellosis. Medical records of children with brucellosis, admitted to Yuzuncu Yil University Hospital over a 6-year period, were analyzed retrospectively. Three hundred ninety-seven (63.8%) patients were male and 225 (36.2%) were female. The mean...

This retrospective study included seven paediatric cases aged from 4 to 14 (10.2±3.4) years with pathologically proved haemophagocytic lymphohistiocytosis from a single institution during 2009 and 2013. Over this time period, 496 patients with brucellosis were diagnosed. None of the patients (3 boys and 4 girls) had a history of any haematologic di...

Sjögren-Larsson syndrome (SLS) is a rare neurocutane­ous disease showing an autosomal recessive transmis­sion due to a lack of fatty acid aldehyde dehydrogenase. Spastic diplegia or triplegia, mental retardation and con­genital lamellar ichthyosis are the major findings of the disease. The syndrome may be accompanied by various eye and teeth featur...

Acute ITP is a benign, self-limiting disease. Chronic ITP is diagnosed when thrombocytopenia persists beyond 12 months. The main objective of the present study was to examine whether absolute lymphocyte counts at diagnosis has predictive value with chronic ITP. A total of 601 patients diagnosed as ITP between 1995 and 2014 were retrospectively eval...

The aim of the study was to compare the gastrin levels in obese and healthy children and to investigate the relationship of gastrin with obesity anthropometrics, lipid, and baseline insulin levels, and oral glucose tolerance test scores. Gastrin was significantly lower in the obese group compared with the control group (p > 0.001). Gastrin level di...

Objectives: We aimed to assess whether the widened carina angle displayed on X-ray supports the presumptive presence of patent ductus arteriosus. Methods: The study group was arranged by 60 infants under 37 weeks diagnosed with haemodynamically significant patent ductus arteriosus. The control group was constituted by 60 infants with no clinical...

Objective: Typhoid fever can involve various organs, leading to a wide range of presentations: from uncomplicated to complicated typhoid fever. The haematological changes are common in typhoid fever and include anaemia, leucopaenia, thrombocytopaenia and bleeding diathesis. Methods: In this study, records of children and adolescents with typhoid...

We aimed to determine the prevalence of celiac disease (CD) in children with iron deficiency anemia (IDA) and compare the hematological variables of these children with those with IDA, but not with CD. A total of 250 patients aged 1 to 16 years with IDA were included. Upper gastrointestinal system endoscopy was recommended to the patients who were...

Objective: To investigate serum concentration of nesfatin-1 in underweight children who have poor appetite, and its association with anthropometric markers of malnutrition. Patients and methods: We recruited 50 underweight children and adolescents (aged 2-18 years) who presented with loss of appetite. Thirty age- and sex-matched controls were al...

Hearing loss can occur in newborns exposed to high-level noise; noise exposure can cause more physiological stress and can lead to DNA damage. This study was designed to determine DNA damage in newborn rats exposed to sound at different concentrations. For this purpose, 28 newborn (3-6 days old) rats were divided into four groups of 7 rats in each...

Background: Hepatitis A is a common infectious disease during childhood worldwide. Recently, great deal of changes in the epidemiology has been reported. The seroepidemiologic studies of this infection are not sufficient in Eastern region of Turkey. Objective: To investigate the seroprevalence and association with socio-demographic variables of...

The aim of the present study was to determine the serum levels of vitamin B12, folate, and homocysteine (Hcy) in mothers and their babies, and to assess the association between these levels and neural tube defect (NTD). The study group included 92 baby-mother pairs, where the babies had NTD, and the control group included 102 pairs, where the babie...

The Löeffler syndrome is characterized by pulmonary infiltrates on a chest x-ray accompanied with peripheral eosinophilia. In this article, we have highlighted the Löeffler syndrome complicated with a eosinophilic leukemoid reaction in a previously healthy boy. The patient was treated with albendazole for five days, with a successful result. In cou...

Bleeding disorders are a common cause of menorrhagia in the adolescent age group. We aimed to evaluate the incidence of hemostatic disorders, using clinical and laboratory findings of bleeding disorders in adolescent girls with menorrhagia. A retrospective chart review used to evaluate adolescent girls with menorrhagia who were referred to Yuzuncu...

Hemophilia A is a rare inherited bleeding disorder resulting from factor VIII deficiency and is a group of diseases characterized by intra-articular and intramuscular bleeding. In this study, we aimed to retrospectively evaluate the treatment outcomes, demographic and clinical characteristics of our patients who were treated and followed up for las...

Voriconazole is a second-generation azole widely used for the prevention and treatment of fungal infection in leukemia patients. Voriconazole is considered the primary antifungal agent for invasive aspergillosis. We report a case of 16-year-old girl who developed visual disturbance and visual and auditory hallucinations after intravenous voriconazo...

Objective: To report a case of pregnant woman with low thrombocyte count which in fact has spurious thrombocytopenia. Methods: A 40-week pregnant woman was admitted to our obstetric clinic with complaint and signs of active labour. She was hospitalized and followed for the vaginal birth. Results: On laboratory examination, the low platelet (Plt) co...

The etiology of vocal cord paralysis is highly variable. Neurological, birth trauma, surgical procedure and idiopathic are notable causes. Clinical findings are different according to type of paralysis. Vocal cord paralysis can be seen unilateral or bilateral. Bilateral vocal cord paralysis are more severe clinical findings than according to unilat...

A 9-day-old male baby was hospitalized after his birth due to some swells under the skin. The hard consistency nodules observed under the skin all over the body of the patient were of different size, and presented lesions, among which the biggest was 1 × 1 cm. No lesions were observed on the fingers. By superficial ultrasonography, multiple isoecho...

In this article, we report a 2-year-old girl with severe phototoxic dermatitis caused by ingestion of Chenopodium album. To the best of our knowledge, this is the first case of phototoxic dermatitis due to Chenopodium album in childhood.

“Ankaferd Blood Stopper©” is a new therapeutic agent which is derived from five different herbal extracts and can stop bleeding within minutes in all type of open hemorrhages. “Ankaferd Blood Stopper©” is the first drug Turkish patent. A 12 years old boy was taken to operation with the diagnosis of liver laceration and disseminated intravascular co...

Psoas abscess is a rare disease in childhood. Usually its diagnosis is diffucult and so delayed. A five-year-old girl was admitted with high fever, sweating, swelling and pain on right thigh and abdominal pain for one week. On family history there was no contact with any known tuberculosis case. She had two siblings who had died due to diarrhea and...