Kamsiah Jaarin

• MD Hons UKM 1979, MSc Pharmacology 1988
• Professor at National Defence University of Malaysia

Addition of citrus leaf extract (CLE) into frying oil was found to be renoprotective in rats that consumed heated palm oil diet. This study examined the effects of dietary CLE supplementation on renal vasoactive substances in rats given heated palm oil diet. Forty-two male Sprague-Dawley rats were randomly split and fed with (i) control, (ii) fresh...

The use of repeatedly heated vegetable oil for cooking is commonly practiced to reduce the cost of food preparation. This practice is not only restricted in domestic use but by also by food vendors. Repeatedly heated oil may have detrimental effects on health as heating produces harmful products of lipid peroxidation, which have been believed to be...

Background: Cosmos caudatus (Ulam Raja) is an appetizer (ulam) eaten with rice in Malaysia. Previous studies showed that Cosmos caudatus possess high antioxidant content. Nrf2 is a transcription factor which regulates the expression of phase II enzymes and antioxidant proteins. The aim of this study is to investigate the effects of Cosmos caudatus...

Parkia speciosa Hassk is a plant found abundantly in Southeast Asia region. Its seeds with or without pods and roots have been used in traditional medicine in this region to treat hypertension. Therefore, we aimed to investigate the potential effect of the plant empty pod extract on hypertension development and changes in heart induced by N(G)-nitr...

Soybean oil is used as cooking oil worldwide. It is rich in polyunsaturated fatty acids and vitamin E. It also contains phytoestrogen, and genistein. It possesses antioxidant and anti-inflammatory activities. Most cooking oils are used repeatedly by consumers to save cost of food preparation. Many studies have been conducted to investigate the effe...

Cardiovascular disease is one of the leading causes of death in many countries. It has multiple risk factors which include obesity, diabetes mellitus, dyslipidemia, hypertension, sedentary life style, stress and dietary habits. Herbal treatments are the most popular form of traditional medicine and are highly lucrative in the international market....

Cardiovascular disease (CVD) is one of the leading major causes of morbidity and mortality worldwide. It may result from the interactions between multiple genetic and environmental factors including sedentary lifestyle and dietary habits. The quality of dietary oils and fats has been widely recognised to be inextricably linking to the pathogenesis...

Cardiovascular disease is one of the leading causes of death in many countries. It has multiple risk factors which include obesity, diabetes mellitus, dyslipidemia, hypertension, sedentary life style, stress and dietary habits. Herbal treatments are the most popular form of traditional medicine and are highly lucrative in the international market....

ABSTRACT Background and aims. Consumption of repeatedly heated soy oil has been linked with incidence of atherosclerosis particularly in oestrogen deficient states. In the present study, effect of curcumin extract on the prevention of atherosclerosis was evaluated. Materials and Methods. Forty eight female Spraque-Dawley rats (weighing 200-250 gm)...

Background and aims. Consumption of repeatedly heated soy oil has been linked with incidence of atherosclerosis particularly in oestrogen deficient states. In the present study, effect of curcumin extract on the prevention of atherosclerosis was evaluated. Materials and Methods. Forty eight female Spraque-Dawley rats (weighing 200-250 gm) were divi...

Background. Palm oil is commonly consumed in Asia. Repeatedly heating the oil is very common during food processing. Aim. This study is aimed to report on the risk of atherosclerosis due to the reheated oil consumption. Material and Methods. Twenty four male Sprague Dawley rats were divided into control, fresh-oil, 5 times heated-oil and 10 times h...

eated palm oil increases the risk of atherosclerosis in the oestrogen deficient state. Curcumin, an active compound from the herb Curcuma longa (turmeric) possesses potent anti-oxidant effects. The main aim of the study was to observe the aortic changes in ovariectomised rats fed with high cholesterol and heated palm oil diet with or without curcum...

This study was performed to compare the oxidative quality of repeatedly heated palm and soybean oils, which were used to fry keropok lekors and potato chips. A kilogramme of keropok lekors or potato chips was fried in 2.5 L of palm or soybean oil at 180 °C for 10 minutes. The frying process was repeated once and four times to obtain twice-heated an...

Oxidative stress is associated with the pathogenesis of cardiovascular diseases. The process of deep-fat frying in dietary cooking oil plays a role in the generation of free radicals. In this study, palm olein heated to 180 °C was tested for its effect on the activity of blood pressure-regulating enzymes and lipid peroxidation. Forty-two adult male...

Vitamin E has been shown to have anabolic action on bone of normal male rats. The presence of vitamin E in palm and soy oil, the commonly used plant-derived frying oils have rendered them more resistant to oxidation when repeatedly heated. Previous studies have shown that repeatedly heated frying oils had caused bone loss in ovariectomised rats. Th...

Objective: The usage of repeatedly heated cooking oil is a common practice amongst Malaysians. When oil is heated repeatedly, oxidation and hydrolysis occur due to thermal decomposition. Several studies have suggested that consumption of repeatedly heated oil can be detrimental to health. Therefore, this study was conducted in order to assess the l...

The present study aims to examine the effects of a palm-oil-derived vitamin E mixture containing tocotrienol (~70%) and tocopherol (~30%) on plasma lipids and on the formation of atherosclerotic plaques in rabbits given a 2% cholesterol diet. Eighteen New Zealand White rabbits (2.2-2.8 kg) were divided into three groups; group 1 (control) was fed a...

Hypercholesterolaemia, increase in lipid peroxidation and hyperhomocysteinaemia may contribute to the pathogenesis of atherosclerosis. This study was performed to examine the effects of repeatedly heated palm oil mixed with 2% cholesterol diet on atherosclerosis in oestrogen-deficient postmenopausal rats. Ovariectomy causes disruption of tunica int...

Oxidized unsaturated fatty acids may contribute to the pathogenesis of atherosclerosis. In the present study, we examined the effects of heated palm oil mixed with 2% cholesterol diet on serum lipid profile, homocysteine and thiobarbituric acid reactive substances (TBARS) levels in estrogen-deficient rats. Twenty-four female Sprague Dawley rats wer...

Repeated heating of soy oil may promote lipid peroxidation. Oxidized unsaturated fatty acids may contribute to the pathogenesis of atherosclerosis, especially in estrogen-deficient states. This study was performed to explore the deleterious effects of repeatedly heated soy oil on the development of atherosclerosis using ovariectomized rats, which r...

The short-term and long- term effects of heated soy oil on bone metabolism in ovariectomised Sprague-Dawley rats were studied. Three-month-old female rats, were divided into five groups: normal control (NC); ovariectomised control (OVXC); ovariectomised and fed rat chow with added fresh soybean oil (SOF) or once-heated soy oil (SO1) or five-times-h...

The use of repeatedly heated frying oils and intake of high cholesterol diet have been linked to bone damage. The aim of this study is to determine the combined effects of taking repeatedly heated frying oils (palm or soy oil) and high cholesterol diet on the dynamic histomorphometric parameters of bone. Ovariectomised rats were used as animal mode...

Palm oil is shown to have antioxidant, anticancer and cholesterol lowering effects. It is resistant to oxidation when heated compared to other frying oils such as soy oil. When a frying oil is heated repeatedly, it forms toxic degradation products, such as aldehydes which when consumed, may be absorbed into the systemic circulation. We have studied...

Heating palm oil for l0 minutes (P()lH) caused signil-icant reduction in cr-tocopherol (a-tl). o-tocotrienol (cr-tt). y-tocotrienol (T-tt) and 6-tocotrjenol (6-tt) cornparccl to fresh palm oil (P()F-). Hcatcd l'ive tinres palnr oil (PO5lJ) also caused a lurther reduction in s-tf. o-tt, y-tt and 6-tt. Up to 98%, of thc thrcc nrost abundant vitarnin...

This study examined the effects of various doses of palm vitamin E and tocopherol with and without aspirin on gastric acid, malondialdehye (MDA) and mucus in rats. The study was divided into two phases: phase 1 determined the effects of various doses of palm vitamin E and tocopherol on the factors affecting mucosal integrity. Sixty-four male rats o...

This study examined the effects of vitamin E on the prevention of aspirin induced gastric lesions. Sixty-four rats of Sprague-Dawley species (200-250 g) were randomized into four groups. Group I was fed a normal diet, Groups II to Group IV were fed with palm vitamin E and tocopherol enriched diet in a dose of 100, 150 and 30 mg kg^-1 food...

The effect of chronic consumption of fresh and heated soya bean oil (SO) on lipid profile, lipid peroxidation, were investigated. Forty male Sprague-Dawley rats were divided equally into four groups, each treated with the following prescribed course of food: (i) basal diet as the control (without oil), or (ii) basal diet fortifred with 15 Vo weighV...

This study examined the effects of vitamin E on the prevention of aspirin-induced gastric lesions. The study was divided into two phases. Phase 1 determined the effects of various doses of palm vitamin E on the factors affecting mucosal integrity. Thirty-two male rats of the Sprague-Dawley strain (200-250 g) were randomly divided into four groups....

The present study aims to examine the effects of a palm-oil-derived vitamin E mixture containing tocotrienol (similar to 70%) and tocopherol (similar to 30%) on plasma lipids and on the formation of atherosclerotic plaques in rabbits given a 2% cholesterol diet. Eighteen New Zealand White rabbits (2.2-2.8 kg) were divided into three groups; group 1...

The effect of palm vitamin E on the healing of ethanol-induced gastric lesions and various biochemical parameters were investigated. The study was divided into two phases. In the first phase of the study, 42 rats of Sprague Dawley species (200-250 gm weight) were randomly divided into two groups fed with a normal diet (control) or palm vitamin E en...

The main focus of the study was to examine the effect of palm vitamin E (a tocotrienol-enriched fraction of palm oil) on the healing of ethanol-induced gastric mucosal lesions. The study was divided into three sections.Study 1 determined the gastric content of vitamin E after dietary supplementation with palm vitamin E for 3 weeks. Seven rats were...

The effect of palm vitamin E on the healing of ethanol-induced gastric lesion was compared with ranitidine. Fifty-six male rats of Sprague-Dawley species (200-250 g of weight) were randomly divided into three groups (N = 14). Gastric mucosal injury was induced by orogastric tube administration of 0.5 ml 100% ethanol. Immediately after induction, Gr...

The effect of nicardipine on fasting plasma lipid profiles was studied in rabbits given a 2% cholesterol diet. Twenty four New Zealand White rabbits (2.2 - 2.8 kg) were divided into 3 groups. Group 1 (control) was fed a normal diet, group II (HC) was fed a 2% cholesterol diet and group III (HC+NICA) was fed a 2% cholesterol diet with nicardipine tr...

The effect of palm vitamin E on the healing of ethanol-induced gastric lesion was compared with ranitidine. Fifty-six male rats of Sprague-Dawley species (200-250 gm of weight) were randomly divided into three groups (n=14). Gastric mucosal injury was induced by orogastric tube administration of 0.5 ml 100% ethanol. Immediately after induction, Gro...

The effects of two antihypertensive agents, nicardipine, a calcium blocker and hydralazine, a direct vasodilator on lipid peroxidation during high cholesterol intake was studied. Twenty-three rabbits were fed a2%o cholesterol diet together with nicardipine (n = 8) or hydralazine (n = 9) injections. The remaining six served as controls. Serum measur...

Twelve rabbits were fed a 2% cholesterol diet (atherogenic diet) for twelve weeks. The rabbits were then put on a standard (regression) diet for the next twelve weeks. Six of these rabbits also received intramuscular injections of nicardipine (0.5 mg/kg) twice daily. After 12 weeks on atherogenic diet, serum cholesterol, malondialdehyde and conjuga...

Nicardipine has been shown to have an anti-atherogenic effect in rabbits given a 2% cholesterol diet. Current evidence suggests that lipid peroxidation plays an important role in atherogenesis. This study examines the effect of nicardipine on lipid peroxidation in rabbits given a 2% cholesterol diet, 8 of these rabbits given nicardipine 0.5 mg/kg t...

We studied the possible effects of hydralazine on lipid peroxidation and atherogenesis in sixteen male rabbits given a 2% cholesterol diet. Of these, eight were given intramuscular injections of hydralazine 1.25 mg kg-1 body weight twice daily for 10 weeks while the remaining eight served as controls. The serum malondialdehyde (MDA) and diene were...

The effects of nicardipine on the suppression of atherosclerosis were studied. Twelve rabbits were fed with a 2% cholesterol (atherogenic) diet and 6 of these rabbits were given nicardipine 0.5 mg kg-1 twice daily intramuscularly for 10 weeks, while the remaining 6 did not receive any treatment. Another 6 rabbits, given a standard diet, were used a...

In a single-blind study conducted at our centres, 78 hypertensive patients were enrolled with 58 completing the study according to the protocol. Mean supine and standing blood pressures were significantly reduced after treatment with felodipine, reductions being 27/21 mmHg (p < 0.0001) and 25/19 mmHg (p < 0.0001) respectively. Of 46 patients given...

Twenty eight patients who satisfied the entry criteria and had completed an initial 2 weeks treatment with placebo were titrated fortnightly with doses of Nicardipine ranging from 30 mg to 90 mg daily in two or three divided doses. Nicardipine treatment significantly reduced blood pressures both in the supine and standing positions (p < 0.0004) whe...

The effects of beta blockers, alpha1 blockers and calcium antagonist on lipid profile were examined in placebo controlled studies in mild to moderate hypertensive patients. Alpha1 blockers like prazosin and doxazosin; and calcium antagonists like nicardipine did not interfere with lipid profiles in hypertensive patients. Acebutolol (a cardioselecti...

We studied the effects of saturated (palm olein) and polyunsaturated (soybean oil) cooking oils on the lipid profiles of Malaysian male adolescents eating normal Malaysian diets for 5 wk. Diets cooked with palm olein did not significantly alter plasma total-cholesterol, LDL cholesterol, and HDL cholesterol concentrations or the ratio of total chole...

The effects clf beta blockers,. aipha, blockers and catcium antagonist on lipid profiia w€re sxamined in placebo coniro,led siudies in mild to moderate hyperterisive patients. Alpha, blockers like praaasin and doxazosin: and calcium antagonists like nicardipine did not inter{ere with lip}d profiles in hypertensive patients. Acebutolol {a cardissele...