Kamil Elkhoury

Kamil Elkhoury
Laboratoire d’Analyse et d’Architecture des Systèmes (LAAS) | LAAS · Department of Nano Bio Technologies (MNBT)

Doctor of Philosophy

About

19
Publications
3,727
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283
Citations
Introduction
Interested in the nanofunctionalization and biofabrication of natural hydrogels for various tissue engineering applications.
Additional affiliations
December 2017 - November 2020
University of Lorraine
Position
  • PhD Student
Education
December 2017 - December 2020
University of Lorraine
Field of study
  • Biotechnology and Food Engineering
September 2016 - September 2017
University of Birmingham
Field of study
  • Advanced Chemical Engineering
October 2012 - December 2015
University of Balamand
Field of study
  • Chemical Engineering

Publications

Publications (19)
Article
Full-text available
Curcumin, a natural polyphenol, has many biological properties, such as anti-inflammatory, antioxidant, and anti-carcinogenic properties, yet, its sensitivity to light, oxygen, and heat, and its low solubility in water renders its preservation and bioavailability challenging. To increase its bioaccessibility, we fabricated nanoliposomes and chitosa...
Article
Full-text available
Tissue engineering has emerged as an important research area that provides numerous research tools for the fabrication of biologically functional constructs that can be used in drug discovery, disease modeling, and the treatment of diseased or injured organs. From a materials point of view, scaffolds have become an important part of tissue engineer...
Article
Full-text available
Current anticancer drugs exhibit limited efficacy and initiate severe side effects. As such, identifying bioactive anticancer agents that can surpass these limitations is a necessity. One such agent, curcumin, is a polyphenolic compound derived from turmeric, and has been widely investigated for its potential anti-inflammatory and anticancer effect...
Article
Full-text available
Smart engineered and naturally derived nanovesicles, capable of targeting specific tissues and cells and delivering bioactive molecules and drugs into them, are becoming important drug delivery systems. Liposomes stand out among different types of self-assembled nanovesicles, because of their amphiphilicity and non-toxic nature. By modifying their...
Article
Full-text available
Natural hydrogels are one of the most promising biomaterials for tissue engineering applications, due to their biocompatibility, biodegradability, and extracellular matrix mimicking ability. To surpass the limitations of conventional fabrication techniques and to recapitulate the complex architecture of native tissue structure, natural hydrogels ar...
Article
In additive manufacturing, bioink formulations govern strategies to engineer 3D living tissues that mimic the complex architectures and functions of native tissues for successful tissue regeneration. Conventional 3D-printed tissues are limited in their ability to alter the fate of laden cells. Specifically, the efficient delivery of gene expression...
Article
Full-text available
The low efficiency in transfecting rat- and human-derived chondrocytes have been hampering developments in the field of cartilage biology. Transforming growth factor (TGF)-β1 has shown positive effects on chondrocytes, but its applications remain limited due to its short half-life, low stability and poor penetration into cartilage. Naturally derive...
Article
Full-text available
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) play an important role in the development, maintenance, and function of the brain. Dietary supplementation of n-3 PUFAs in neurological diseases has been a subject of particular interest in preventing cognitive deficits, and particularly in age-related neurodegeneration. Developing strategies for the...
Article
Full-text available
Polymeric hydrogels are currently at the center of research due to their particular characteristics. They have tunable physical, chemical, and biological properties making them a material of choice for a large range of applications. Polymer-composite and nanocomposite hydrogels were developed to enhance the native hydrogel’s properties and to inclu...
Article
Gelatin methacryloyl (GelMA) is widely used for tissue engineering applications as an extracellular matrix (ECM) mimicking scaffold due to its cost-effectiveness, ease of synthesis, and high biocompatibility. GelMA is widely synthesized from porcine skin gelatin, which labors under clinical, religious, and economical restrictions. In order to overc...
Thesis
The main objective of this thesis is to develop a new natural material based on methacrylated gelatin (GelMA) nanofunctionalized by the incorporation of nanoliposomes or soft hybrid exosome-liposome nanoparticles. The physicochemical and biological properties of these hydrogel matrices were characterized in order to evaluate their potential use for...
Chapter
The biopolymers alginate and pectin are widely used in food, cosmetics, and medicine. These polysaccharides have received significant attention in recent years due to their natural availability and interesting properties such as nontoxicity, biodegradability, and biocompatibility. This chapter gives an overview about composite hydrogels of alginate...
Article
Full-text available
The development of nanocomposite hydrogels that take advantage of hierarchic building blocks is gaining increased attention due to their added functionality and numerous biomedical applications. Gathering on the unique properties of these platforms, herein we report the synthesis of bioactive nanocomposite hydrogels comprising naringin-loaded salmo...
Article
Full-text available
Curcumin is a hydrophobic drug gaining growing attention because of its high availability, its innocuity, and its anticancer, antitumoral, and antioxidative activity. However, its poor bioavailability in the human body, caused by its low aqueous solubility and fast degradation, presents a big hurdle for its oral administration. Here, we used nano-v...
Article
Full-text available
Investigations in cartilage biology have been hampered by the limited capacity of chondrocytes, especially in rats and humans, to be efficiently transfected. Liposomes are a promising delivery system due to their lipid bilayer structure similar to a biological membrane. Here we used natural rapeseed lecithin, which contains a high level of mono- an...
Article
Full-text available
Breast cancer is the leading cause of death from cancer among women. Higher consumption of dietary marine n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) is associated with a lower risk of breast cancer. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are two n-3 LC-PUFAs found in fish and exert anticancer effects. In this study, n...
Article
Full-text available
Nanoliposomes are widely used as delivery vehicles for active compounds. Nanoliposomes from rapeseed phospholipids were incorporated into interpenetrating polymer network (IPN) hydrogels of gelatin methacryloyl (GelMA) and alginate. The multiscale physicochemical properties of the hydrogels are studied both on the surface and through the thickness...
Article
The major limitation of 3D bioprinting is the availability of inks. In order to develop new ink formulations, both their rheological behavior to obtain the best printability and the target bio-printed objects conformities must be studied. In this paper, for the first time in our knowledge, the preparation and the characterization of novel ink formu...

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