Kameliya Vinketova

Institute of Biology and Immunology of Reproduction "Acad. Kiril Bratanov" · Molecular Immunology

Maternal immunity regulates tolerance to the semi-allogeneic fetus during pregnancy via modulation of immune regulatory factors. The serum factor CD83 is known to undergo changes during gestation in mice. Here we characterize serum levels of CD83 in women for the first time, revealing a consistent decline as pregnancy progresses and recovery to non...

Background: Endometriosis is a chronic and debilitating gynecologic disorder, driven by endocrine and immune dysfunctions, which lead to poor endometrial differentiation and attenuated fertility. Escape from immune surveillance and involvement of inflammatory mechanisms appear to be factors in disease progression. Current diagnostic guidelines for...

Objective CD90 is a glycoprotein involved in leukocyte relocation and cell differentiation. CD90 is expressed in endothelial and stromal cells in human endometrium; however, its role in the remodeling of the decidual tissue during pregnancy is poorly understood. Here, we investigate how CD90 expression in decidual stromal cells (DSCs) is regulated....

CD90 is a glycoprotein involved in leukocyte homing and cell differentiation. In human endometrium CD90 is described on endothelial and stromal cells. If pregnancy occurs, the tissue is infiltrated by immune and trophoblast cells, which cooperate to remodel the tissue. The process requires a fine regulation of cell adhesion and migration. The expre...

The human decidua is a specialized tissue characterized by embryo-receptive properties. It is formed during the secretory phase of menstrual cycle from uterine mucosa termed endometrium. The decidua is composed of glands, immune cells, blood and lymph vessels, and decidual stromal cells (DSCs). In the process of decidualization, which is controlled...