Kamaldeen Okuneye

• Applied Mathematics
• Sr. Research Investigator at Incyte Corporation

Bladder cancer is a common malignancy with over 80,000 estimated new cases and nearly 18,000 deaths per year in the United States alone. Therapeutic options for metastatic bladder cancer had not evolved much for nearly four decades, until recently, when five immune checkpoint inhibitors were approved by the FDA. Despite the activity of these drugs...

Background For their 2021–2025 National Malaria Strategic Plan (NMSP), Nigeria’s National Malaria Elimination Programme (NMEP), in partnership with the World Health Organization (WHO), developed a targeted approach to intervention deployment at the local government area (LGA) level as part of the High Burden to High Impact response. Mathematical mo...

Background For their 2021 – 2025 National Malaria Strategic Plan (NMSP), Nigeria’s National Malaria Elimination Program (NMEP), in partnership with the World Health Organization (WHO), developed a targeted approach to intervention deployment at the local government area (LGA) level as part of the High Burden to High Impact response. Mathematical mo...

Bladder cancer is a common malignancy with over 80,000 estimated new cases and nearly 18,000 deaths per year in the United States alone. Therapeutic options for metastatic bladder cancer had not evolved much for nearly four decades, until recently, when five immune checkpoint inhibitors were approved by the U.S. Food and Drug Administration (FDA)....

Malaria is mainly a tropical disease and its transmission cycle is heavily influenced by environment: The life-cycles of the Anopheles mosquito vector and Plasmodium parasite are both strongly affected by ambient temperature, while suitable aquatic habitat is necessary for immature mosquito development. Therefore, how global warming may affect mala...

Aedes aegypti is the vector for numerous diseases in humans and other (reservoir) hosts, such as chikungunya, dengue fever and Zika virus. A new deterministic model is designed and used to assess the dynamics of the three diseases in a population where Aedes mosquitoes are abundant. The model to be designed incorporates the recently-released imperf...

Deterministic (ordinary differential equation) models for the transmission dynamics of vector-borne diseases that incorporate disease-induced death in the host(s) population(s) are generally known to exhibit the phenomenon of backward bifurcation (where a stable disease-free equilibrium of the model coexists with a stable endemic equilibrium when t...

A new deterministic model for the population biology of immature and mature mosquitoes is designed and used to assess the impact of temperature and rainfall on the abundance of mosquitoes in a community. The trivial equilibrium of the model is globally-asymptotically stable when the associated vectorial reproduction number (R0) is less than unity....

A new non-autonomous model is designed and used to assess the impact of variability in temperature and rainfall on the transmission dynamics of malaria in a population. In addition to adding age-structure in the host population and the dynamics of of immature malaria mosquitoes, a notable feature of the new model is that recovered individuals do no...

In the weeks following the first imported case of Ebola in the U. S. on September 29, 2014, coverage of the very limited outbreak dominated the news media, in a manner quite disproportionate to the actual threat to national public health; by the end of October, 2014, there were only four laboratory confirmed cases of Ebola in the entire nation. Pub...