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Publications (29)
Dispersion has attracted considerable interest as an efficient means of improving the solubility, dissolution rate & bioavailability of hydrophobic drugs. This strategy has proven to improve the bioavailability by dispersing the class II & IV drug as very fine particles within the hydrophilic matrix resulting in increased solubility with the increa...
Objective: The objective of this study was to enhance the solubility and dissolution rate of a poorly water-soluble drug by solid dispersion (SD) technique, in order to conduct an investigation of the effect of these natural hydrophilic polymers on release mechanism from SD.Methods: The SD of diazepam (DZM) were prepared by using modified sodium al...
The objective of this study was to formulate, optimize and evaluate ketoconazole transfersomes gel. Sixteen formulations of ketoconazole loaded transfersomes were prepared by conventional thin layer evaporation technique using design expert software. The effect of independent process variables like concentration of soya lecithin and surfactant on d...
Colon targeting is a comparatively new approach for the localized delivery of drugs to obtain maximum possible output for the treatment of ailments. In order to target a drug inside the body it is required to be in the form of a dosage form. Various conventional dosage forms are there to target drugs to the colon but they don't prove to be efficien...
The objective of present study was to preclude of poor dissolution of relatively water insoluble and poorly permeable drug by formulating gastroretentive floating tablet using solid dispersion (SD) of the drug. It aimed to increase the drug solubility and gastric retention of the drug for better absorption profile. Cefpodoxime proxetil is an orally...
For many decades for the treatment of disease many of the dosage form are using which are including tablets, capsules, pills, creams, ointments, liquids, injectables. To maintain the concentration of drug it is necessary to take these types of dosage form several times of day. A novel drug delivery system thus aim at releasing one or more drug cont...
Ketorolac tromethamine (KT) is a non-steroidal anti-inflammatory drug that belongs to class of heteroacetyl derivatives. An attempt has been made to make use of ointments, creams and gels as suitable vehicles for KT, which will released the drug effectively on surface when applied topically. Formulations belongs to ointment, cream and gel bases con...
The aim of present work is to develop sonophoretic transdermal drug delivery system of Ketorolac tromethamine (KT) and evaluation of it. In vitro dissolution study was carried out for simple gel, proniosomal gel and marketed gel in phosphate buffer pH 7.4. The high release rate formulation is optimized using response surface methodology by face cen...
Objective: The present research has been undertaken with the aim to develop a transdermal gel formulation of Ketorolac tromethamine (KT), which would attenuate the gastrointestinal related toxicities associated with oral administration. Methods: In vitro dissolution study was carried out for carbopol gel, proniosomal gel and marketed gel in phospha...
Delivery of drugs through the skin has been an attractive as well as a challenging area for research. Compared to other conventional routes of drug delivery such as oral, injection and inhaler, transdermal delivery has a variety of advantages. Transdermal systems are non-invasive, convenient, and inexpensive and can be self-administered. They can p...
In present study, the fast dissolving tablets of Amoxicillin Trihydrate were prepared by direct compression technique using microcrystalline cellulose (MCC) as direct compressible diluents. Sodium starch glycolate (SSG) and croscarmillose sodium (CCS) used as synthetic superdisintegrants. The swelling indices of the superdisintegrants were also com...
The aim of this work was to study the permeation of ziprasidone hydrochloride monohydrate across the skin. The effect of physical technique sonophoresis was investigated. Permeation experiments were performed by using rat abdominal skin as barrier. The formulated gel containing tulsi oil at different concentrations (5%, 10%, 15%, 20% & 25%) was inv...
An orodispersible tablet or orally disintegrating tablets (ODT) is a drug dosage form developed to facilitate ease of medication and the field has become a rapidly growing area in the pharmaceutical industry. They are designed to be dissolved on the tongue rather than swallowed whole. In addition, orodispersible or orally disintegrating tablet (ODT...
Nanotechnology is an advancing technology which brings revolutionary changes in the field of science including drug delivery, diagnosis, neutraceuticals and biomedical for implants and prosthesis. Provesicular system is one of the advancing nanotechnologies. Provesicular system resolve the stability issues pertaining to the conventional vesicular s...
Oral drug delivery remains the most preferred route for administration of various therapeutic agents. Among all newly discovered chemical entities about 40%drugs are lipophilic and fail to reach market due to their poor water solubility. The solubility behavior of drugs remains one of the most challenging aspects in formulation development. The des...
Dissolution testing is a critical methodology which is widely utilized in the development of a new pharmaceutical product. The test, in its simplest form, consists of placing the formulation in a dissolution apparatus containing suitable dissolution medium, allowing it to dissolve over a specified period of time and then assaying the resultant solu...
Sublingual route is usually preferred when rapid onset of action is required than orally ingested tablets. Sublingual tablets offer fast release of drug from the formulation and it reaches systemic circulation directly, which bypasses the metabolism of drug in liver. The demand of fast disintegrating sublingual tablets has been growing, during the...
Transdermal drug delivery is an alternative approach in comparison with conventional oral drug delivery systems. However, the stratum corneum, the outermost layer of the skin, acts as a barrier that limits the penetration of substances through the skin. Application of ultrasound to the skin increases its permeability (sonophoresis) and enables the...
Proniosomal gel is nonionic surfactant based vesicle system which exists in different liquid crystalline phases. Mixing of the surfactant in an alcohol and limited hydration with aqueous phase leads to the formation of proniosomal gel. Due to the limited amount of water present, these systems behave as viscous phases. The various phases of liquid c...
The desire of improved palatability in orally administered products has prompted the development of numerous formulations with improved performance and acceptability. Orally Disintegrating tablets (ODTs) have received ever-increasing demand during the last few decades, and the field has become a rapidly growing area in the pharmaceutical industry....
A number of novel drug delivery systems have emerged encompassing various routes of administration to achieve controlled and targeted drug delivery. Encapsulation of the drug in vesicular structures is one such system, which can be predicted to prolong the existence of the drug in systemic circulation and reduce the toxicity, if selective uptake ca...
Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) is a medicinal plant traditionally used as an abortifacient and to treat constipation, oedema, bacterial infections, cancer and diabetes. Preliminary phytochemical screening of the plant showed the presence of large amounts of phenolics and flavonoids. Subsequent quantification showed the presence...
Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) is a medicinal plant traditionally used as an abortifacient and to treat constipation, oedema, bacterial infections, cancer and diabetes. Preliminary phytochemical screening of the plant showed the presence of large amounts of phenolics and flavonoids. Subsequent quantification showed the presence...
Over the last few years a comprehensive research has been done over proniosomal gel as a provesicular approach for transdermal drug delivery. However skin has a very tough diffusion barrier that is lipid bilayer in the stratum corneum inhibiting penetration of drug moiety which is rate limiting barrier for penetration of drugs. Vesicular systems (n...