Kamal Kant Sahu

Kamal Kant Sahu
University of Utah | UOU · Hematology and Medical Oncology

Hematology/Oncology Fellow at Huntsman Cancer Institute (University of Utah at Salt Lake City)/DM Clinical Hematology (PGIMER Chandigarh INDIA)

About

293
Publications
33,869
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2,723
Citations
Citations since 2017
245 Research Items
2676 Citations
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20172018201920202021202220230200400600800
Introduction
I am a Hematology/Oncology fellow in my second year of training at Huntsman Cancer Institute, University of Utah (NCI-designated Comprehensive Cancer Center). I am pursuing a research track fellowship. My research is in genitourinary oncology with an interest in clinical trials, health services, and outcomes research. Back in India, I was trained in PGI Chandigarh and had a great exposure to clinical care during my medicine residency (2013), and fellowship in Clinical Hematology/BMT (2016).
Additional affiliations
June 2018 - February 2020
Saint Vincent Hospital
Position
  • Internal Medicine
July 2013 - May 2016
Postgraduate Institute of Medical Education and Research
Position
  • Fellow
July 2010 - June 2013
Postgraduate Institute of Medical Education and Research
Position
  • Internal Medicine

Publications

Publications (293)
Article
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Background: The bone health of patients with locally advanced and metastatic prostate cancer is at risk from treatment-related bone density loss and skeletal-related events from metastatic disease in bones. Evidence-based guidelines recommend using denosumab or zoledronic acid at bone metastasis-indicated dosages in the setting of castration-resis...
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Background COVID-19 vaccination is one of the pivotal key tools against the ongoing pandemic, but its acceptance relies on efficacy and safety data among various populations, including patients with cancers. However, there is limited data on seroconversion rates, efficacy, and safety of the COVID-19 vaccine in patients with cancer. Breakthrough inf...
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Introduction: Relugolix is the first oral gonadotrophin-releasing hormone (GnRH) receptor antagonist. Based on the phase III HERO trial results, relugolix received Food and Drug Administration approval for adult patients with advanced prostate cancer (PCa). Areas covered: : We provide an overview of the preclinical and clinical development of re...
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Introduction: Patients leaving against medical advice (AMA) are commonly encountered in hospital medicine. The problem is prevalent worldwide and across all fields of medicine. A retrospective study of 47,583 patients reported a 3.3% AMA rate in 2015. Objectives: In this retrospective study, we aimed (1) to study the demographic, clinical, and l...
Article
Androgen receptor axis–targeted therapies (ARATs; androgen receptor or androgen synthesis inhibitors) have been approved for the treatment of patients with metastatic castration-sensitive and castration-resistant prostate cancer (mCSPC and mCRPC) on the basis of improved overall survival (OS) in randomized clinical trials. However, it is not clear...
Article
Methemoglobin is a form of hemoglobin that has been oxidized, changing its heme iron configuration from the ferrous to the ferric state. Unlike normal hemoglobin, methemoglobin does not bind oxygen and as a result, cannot deliver oxygen to the tissues. At the presentation in the emergency department, an electrocardiogram (EKG) is usually performed...
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Introduction: Use of upfront chemotherapy or novel hormonal therapy (NHT) in patients (pts) with mCSPC has been approved based on improved outcomes. Baseline clinical and genomic correlates associated with inferior outcomes on intensified therapy would help identify pts at high risk for early progression or death, may improve patient counselling an...
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In developing countries, anti-D has been used in immune thrombocytopenia (ITP) as a cheaper alternative to human immunoglobulin. We aim to analyze the response and safety profile of anti-D in patients with severe ITP. A retrospective study was conducted at a tertiary care hospital in Northern India. Patients received a single intravenous infusion o...
Article
5080 Background: Pts with DN-mCSPC have been reported to experience worse prognosis and outcomes compared to those with PLT-mCSPC. We hypothesized that gene expression profiling of pre-treatment primary prostate tumors from PLT-mCSPC pts would be distinct from those with DN-mCSPC. Methods: Eligibility criteria: histologically confirmed mCSPC and av...
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The use of immune checkpoint inhibitors (ICIs) is rapidly increasing as more combinations and clinical indications are approved in the field of genitourinary malignancies. Most immunotherapeutic agents being approved are for the treatment of renal cell carcinoma and bladder cancer, which mainly involve PD-1/PD-L1 and CTLA-4 pathways. There is an on...
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Patients with infective endocarditis can have multiple neurological manifestations. Cerebrovascular events (CVE) in patients with IE can be hemorrhagic or embolic. Multiple factors are known to predispose to CVE and increased mortality in patients with IE. In this study, we aimed to describe various outcomes among patients with IE and CVE. We retro...
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121 Background: Novel hormonal therapy (NHT) i.e. novel androgen receptor or androgen synthesis inhibitors have been approved for treatment of pts with mCSPC and mCRPC based on improved OS. However, OS of patients after progression on first-line NHT for mCSPC is not well characterized. It is currently unknown whether the OS in pts “after” progressi...
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123 Background: In pts with mCSPC undergoing intensified ADT, achieving a PSA nadir ≤0.2 ng/mL “anytime” after the start of treatment was associated with a significantly improved overall survival (OS) versus those with a PSA >0.2 ng/mL: HR 0.17 (95% CI, 0.13-0.23) (Chi AUA 2021, abstract 1281). Our objective was to validate these findings in a real...
Article
186 Background: Dn-hv-mCSPC have the poorest survival outcomes among various subsets pts with mCSPC (Fizazi, Lancet Oncol 2019). However, the molecular underpinnings behind the poor prognosis is not entirely understood. In this study, we aimed to assess the tumoral genomic characteristics in pts with dn-hv-mCSPC. Methods: In this IRB-approved study...
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Background Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are novel antidiabetic agents with overwhelming cardiorenal protection. Recent trials focusing on the nephroprotective role of SGLT2i have underscored its success as a phenomenal agent in halting the progression of kidney disease in patients with and without Type 2 diabetes mellitus. Mul...
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Sai Vikram Alampoondi Venkataramanan,1 Lovin George,1 Kamal Kant Sahu2 1Department of Medicine, Saint Vincent Hospital, Worcester, MA, USA; 2Department of Hematology and Medical Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USACorrespondence: Kamal Kant SahuDivision of Hematology and Oncology, Department of Internal M...
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Background: Cardiovascular complications of the Coronarvirus disease (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have been documented both in the acute phase and in convalescence. One such complication is the formation of left ventricular (LV) thrombus. There is a lack of clarity regarding the in...
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Background: Cardiovascular complications of the coronavirus disease 2019 (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2), have been documented both in the acute phase and in convalescence. One such complication is the formation of the left ventricular (LV) thrombus. There is a lack of clarity regard...
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Platelet-derived growth factor-beta (PDGFRB) gene maps for the receptor tyrosine kinase PDGRFβ. PDGFRB gene fusions have been implicated in multiple myeloid and lymphoid neoplasms and have shown exquisite sensitivity to tyrosine kinase inhibitors. We report a case of a 29-year-old male who presented with acute myeloid leukemia who was eventually fo...
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Background Clostridioides difficile infection (CDI) is a considerable healthcare burden, and now identified as the leading cause of acquired diarrheal illness in patients receiving antibiotics. Patients with malignancies are more prone to acquire CDI, owing to their frequent exposure to risk factors. Objective This study aims to investigate the fa...
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Aim: To compare the demographical profile, indications, efficacy, and contributors to adverse outcome following administration of 4F-PCC in patients on warfarin with supratherapeutic INR. Methodology: Retrospective cross-sectional study was performed in a community based teaching hospital. All patients 18 years and older on warfarin with suprath...
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Virus infections can cause tissue damage in many ways. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a cause of the current COVID-19 pandemic, has been extensively studied so far to investigate its pathophysiology and evaluate its impact on the metabolic system of human cells. This has given a lead to study the role of 2-deoxy-D-glu...
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Background: Immune Thrombocytopenia (ITP) is characterized by low platelet counts. Splenectomy has been in practice for the treatment of ITP since the early 20th century. We aimed to analyze the data of ITP patients from our hospital who underwent splenectomy and further present the long-term outcome and safety profile in these patients. Method:...
Article
Infection related thrombosis is a well-known entity. Antigen burden, immune response, complement activation, pro-coagulant condition, and smoking are only a few amongst the multiple risk factors which interplay in the development of thrombosis in any given case. Viral infections are amongst the many inciting factors known to predispose a prothrombo...
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Introduction: Acute myeloid leukemia (AML) is the commonest leukemia in adults. Mortality in thew first 30-days ranges from 6% to 43%, while infections account for 30-66% of early deaths. We aim to present our experience of infections in newly-diagnosed AML. Method: This prospective, observational study, was undertaken at a tertiary care hospital i...
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Introduction Acute myeloid leukemia (AML) is the commonest leukemia in adults. Mortality in thew first 30-days ranges from 6% to 43%, while infections account for 30–66% of early deaths. We aim to present our experience of infections in newly-diagnosed AML. Method This prospective, observational study, was undertaken at a tertiary care hospital in...
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Background: Immune thrombocytopenia (ITP) is a benign hematological disorder characterized by low platelet counts in peripheral blood and spectrum of various bleeding manifestations. Azathioprine is one of the effective, readily available, and affordable immunosupressants available for ITP management in developing countries. We aimed to study the...
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Immune thrombocytopenia (ITP) is a relapsing– remitting disease often requiring more than one line of therapy. Rituximab is a recommended second-line therapy, but the real-world data on its efficacy and safety from resource constraint settings is limited. We aimed to analyze the safety and efficacy of rituximab in ITP. This is a single- center, ret...
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Lower extremity soft-tissue lesions are frequently encountered in clinical practice. Cellulitis, osteomyelitis, and diabetic foot ulcerations remain the top differentials. The acuity of illness, imaging studies, and deep wound cultures are helpful in most cases. Malignancies are rare but need immediate attention. Hereby, we report a case of a chron...
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Introduction: Raoultella planticola is an aerobic gram-negative rod predominantly found in soil and aquatic environments. The typical reservoirs of Raoultella spp. include the gastrointestinal tract and the upper respiratory tract. It usually causes pneumonia, biliary tract infections, and bacteremia. Urinary tract infection (UTI) secondary to R. p...
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3593 Background: Doublet chemotherapy FOLFOX and FOLFIRI are standard for first‐line treatment of metastatic colorectal cancer (mCRC). Recently, use of triplet chemotherapy FOLFOXIRI has shown an increased anti-cancer activity but still there is uncertainty regarding first line backbone chemotherapy. Therefore, we conducted this metanalysis to dete...
Chapter
Currently, coronavirus disease 2019 (COVID-19) has spread worldwide and continues to rise. There remains a significant unmet need for patients with hematological malignancies requiring specialized procedures and treatments, like cellular therapy to treat or cure their disease. For instance, chimeric antigen receptor T (CAR-T) cell therapy is approv...
Chapter
With more than 5 million cases and 333,212 deaths, COVID-19 (or SARS-CoV-2) continues to spread. General symptoms of this disease are similar to that of many other viral respiratory diseases, including fever, cough, dyspnea, and fatigue, with a chance of progression to more severe complications. However, the virus does not affect all people equally...
Chapter
A newly discovered coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing pandemic of coronavirus disease 2019 (COVID-19), which is not only physically challenging but also has many subtle and overt mental impacts. The concern of being infected, lack of antiviral agents, preventive strategies of socia...
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For the last few months, various geographical regions and health sectors have been facing challenges posed by the current COVID-19 pandemic. COVID-19 has led to significant disruption in the normal functioning of potentially life-saving therapies of hematopoietic cell transplant and chimeric antigen receptor therapy. As transplant physicians are ga...
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We read with great interest the article by D'Ettorre et al. on workplace safety and violence against healthcare workers in emergency medicine recently published in your esteemed journal. Authors address one of the critical issues faced in healthcare industry today. We wish to complement the article with some additional thoughts. As authors try to f...
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Coronavirus disease-2019 (COVID-19) is a rapidly evolving health crisis caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is a novel disease entity and we are in a learning phase with regards to the pathogenesis, disease manifestations, and therapeutics. In addition to the primary lung injury, many patients especi...
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The important question to the research bodies working oncalciphylaxis will be would hybrid image (SPECT/CT) replaceskin biopsy. As suggested by Herrera-Martínez et al., skinbiopsy has its own limitations and complications and anytest like SPECT/CT hold that potential. However, we want tobring into the discussion regarding the close differentials of...
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Background : Immune thrombocytopenia (ITP) is a heterogeneous acquired disorder characterized by isolated thrombocytopenia whose exact pathogenesis is not yet clear. Depending upon the presence or absence of an underlying treatable cause, ITP can be categorized as primary or secondary. Primary ITP is a diagnosis of exclusion and there is no gold st...
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Coronavirus disease (COVID 19) has involved millions of people all over the world. Tuberculosis (TB) continues to affect millions of people every year with high mortality. There is limited literature on the occurrence of COVID 19 in patients with TB. We reviewed the available data on various clinical details, management, and outcome among patients...
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It was with great interest that we read the article “Rare causes of stroke—a frequent stroke etiology (Seltene Schlaganfallursachen – im Alltag gar nicht so selten)” by Schmidt et al. published in Der Nervenarzt in 2019 [1]. Te authors have done an excellent job at identifying and describing the various uncommon causes of stroke and their presentat...
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Esophageal perforation is a fatal entity if not diagnosed in a timely fashion. Once diagnosed, it requires collaborative effort of team of doctors including radiologists, thoracic surgeons and general surgeons. We share hereby our experience with esophageal perforation and successful outcome.
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BK virus (BKV)-related haemorrhagic cystitis (HC) is an important cause of morbidity following allogeneic haematopoietic stem cell transplantation (HSCT). The various risk factors include high-level BKV viruria and/or viremia, myeloablative conditioning, acute graft versus host disease (GVHD), cytomegalovirus viremia, and unrelated or HLA-mismatche...
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Alice Kennedy,1 Kamal Kant Sahu,2 Jan Cerny3 1Department of Internal Medicine, University of Massachusetts Medical School, Worcester, MA, 01655, USA; 2Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA, 01608, USA; 3Division of Hematology and Oncology, Department of Internal Medicine, UMass Memorial Health Care, University of Ma...
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Ajay Kumar Mishra,1 Harshad Arvind Vanjare,2 Anu Anna George,1 Kamal Kant Sahu1 1Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA, USA; 2Department of Radiology, Christian Medical College, Vellore, IndiaCorrespondence: Kamal Kant SahuDepartment of Internal Medicine, Saint Vincent Hospital, Worcester, MA 01608, USAEmail drkksah...
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Coronavirus disease 2019 (COVID‐19) pandemic is expanding at an enormous pace and has already affected over 15 million population This article is protected by copyright. All rights reserved.
Article
The objective of this study is to compare game-based digital therapeutic device and other DHI like (smartphone apps, wearable technologies) for ADHD with the current pharmacological and behavior therapy. The FDA has approved a game-based digital therapeutic device - EndeavorRx, for the treatment of ADHD in pediatric patients belonging to the age gr...
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Coronavirus 19 disease (COVID-19) continues to be a pandemic with global implications. Respiratory system involvement is the most common manifestation in symptomatic patients. In this literature review, we describe the diagnosis, management, and implications of pulmonary hypertension (PH) among patients with COVID-19. We defined pulmonary hypertens...
Article
Various factors interplay when it comes to successful containment of pandemic. In last one year, we have witnessed various countries formulating and practicing their own unique ways to tackle coronavirus. We have seen the most developed countries failing terribly and unable to slow the COVID-19 spread, but at the same time also endorsed the compara...
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Immune thrombocytopenia (ITP) is characterized by decreased platelet count in the peripheral circulation. The first-line therapy is corticosteroids with 53-80% overall response rate. Eltrombopag has been used as second-line therapy in ITP for over a decade now. The long-term efficacy and safety profile have been widely reported in the western world...
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Introduction: Aerococcus spp. is a Gram‑positive, catalase‑ and oxidase‑negative, microaerophilic, nonmotile bacteria species rarely associated with human infections such as arthritis, bacteremia, endocarditis, and meningitis. The bacteria are also often confused with streptococci species or treated as a contaminant. Patients and Methodology: We...
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to be a public health emergency and a pandemic of international concern. As of April 31st, the reported cases of COVID-19 are three million in 186 countries. Reported case fatality has crossed 200 thousand among which more than fifty thousand has been in the USA. Most...
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The outbreak of the coronavirus disease 2019 (COVID‐19) has posed an unprecedented challenge to the health care communities across the globe. As of June 2, 2020, a total of 6,418,968 confirmed COVID-19 cases with 378,954 deaths have been reported. Different regions of the world have reported varying intensity of COVID-19 severity. The disease burde...
Article
The ongoing COVID-19 pandemic is the most trending and talked topic across the World. From its point of origin in Wuhan, China to clinical laboratory at NIH, a mere six-month-old SARS-CoV-2 virus is keeping the clinicians, and scientists busy at various fronts. However, COVID-19 is an emerging and evolving disease and each day brings in more data,...
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The severe respiratory disease COVID-19 (coronavirus disease 2019) was first reported in late December 2019 in Wuhan City, China. Soon thereafter, the World Health Organization (WHO) officially declared it a pandemic. The adult population is highly affected by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2); however, infants and childr...
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The Coronavirus disease 2019 (COVID‐19) pandemic has threatened patients, healthcare systems, and all countries across the globe with unprecedented challenges and uncertainties. According to the latest literature, most patients with COVID‐19 have mild symptoms that do not require hospital admissions, and only a small percentage of those hospitalize...
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The current pandemic due to coronavirus disease (COVID‐19) has posed an unprecedented challenge for the medical communities, various countries worldwide and their citizens. SARS‐CoV‐2 has been studied for its various pathophysiological pathways and mechanisms through which it causes COVID‐19. In this study, we discussed the immunological impact of...
Article
“Depression is a disease, whereas Burnout is a syndrome that is job-related and situation specific.” This stoic statement by the author sums up the problem fairly accurately.1 Just like any other domain of life, the circumstances in the ecosystem of work change with time. Pacing oneself effectively through a long-desired career is an art that is el...
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Kamal K Sahu,1 Vishal Jindal,2 Joseph Anderson,2 Ahmad D Siddiqui,1 Ishmael A Jaiyesimi2 1Hemato-oncology Division, Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA 01608, USA; 2Department of Hematology and Oncology, Oakland University William Beaumont School of Medicine, Royal Oak, MI 48073, USACorrespondence: Kamal K SahuHem...
Article
Coronavirus disease 2019 (COVID-19) has posed an unparalleled challenge to the medical communities and patients worldwide (1). This is the third coronavirus pandemic of the decade and worst so far in terms of the number of days which was affected and related deaths. Although COVID-19 is a systemic illness, the respiratory system is obvious to be in...
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Sir, Mesenteric hematoma (MH) is a rare but a fatal complication of antithrombotic therapy, if not managed properly. Through this letter, we discuss the important bedside clinical signs of intra-abdominal bleeding and management strategies. Figure 1A: Ecchymosis extending from flank to the front of the lower abdomen, with approximate dimensions of...
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The COVID-19 pandemic has led to a major setback in both the health and economic sectors across the globe. The scale of the problem is enormous because we still do not have any specific anti-SARS-CoV-2 antiviral agent or vaccine. The human immune system has never been exposed to this novel virus, so the viral interactions with the human immune syst...
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It is almost six months since novel Coronavirus disease 2019 (COVID‐19) started as a local outbreak in Wuhan, China(1) For hematologists and patients suffering from hematological disorders, the COVID‐19 pandemic has brought challenges with regards to the diagnosis, treatment, follow‐up, office visits, and so on. (2,3) We hereby discuss the current...
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We read with great interest the article by Jakeman et al, “Addressing Latent Tuberculosis Infection Treatment Through a Collaborative Care Model With Community Pharmacies and a Health Department,” which addressed latent tuberculosis infection (LTBI) treatment through a collaborative approach in New Mexico (1). The authors described a new approach t...