Kalyani Sakhare

BITS Pilani, Hyderabad · Department of Biological Sciences

Folate receptor (FR) has long been the subject of active interest as regards its potential to serve as a target for cancer therapy. FR is overexpressed in several cancers, including clinical samples of different stages from Oral Squamous Cell Carcinoma (OSCC) patients. However, no clear correlation or conclusive finding has been obtained so far whi...

Conveyance of pathogens between organisms causes communicable diseases. On the other hand, a non-communicable disease (NCD) was always thought to have no causative transmissible infective agents. Today, this clear distinction is increasingly getting blurred and NCDs are found to be associated with some transmissible components. The human microbiota...

Cimetidine, a histamine-2 (H2) receptor antagonist, has been found to have anticancer properties against a number of cancer-type cells. In this report, we have demonstrated that cimetidine can acts as a hydrophilic domain in cationic lipids and targetable to the gastric system by carrying reporter genes and therapeutic genes through in vitro transf...

Conventionally, nanoparticles are synthesized by chemical and physical routes. However, the synthesis of nanoparticles through conventional approaches has many drawbacks, such as being expensive, use of hazardous substrates, generation of toxic by-products, and consumption of enormous energy. To overcome the demerits mentioned above, biological age...

The production of efficient vectors is an essential segment for gene therapy, which is a revolutionary method for delivering therapeutic nucleic acids. Targetable gene therapy is a current challenging task...

The steroid hormone receptors (SHRs) among nuclear hormone receptors (NHRs) are steroid ligand‐dependent transcription factors that play important roles in the regulation of transcription of genes promoted via hormone responsive elements in our genome. Aberrant expression patterns and context‐specific regulation of these receptors in cancer, have b...

OSCC (Oral Squamous Cell Carcinoma) is currently one of the most formidable cancers plagued by challenges like low overall survivability, lymph node associated metastasis, drug resistance, and poor diagnostics. The tumor microenvironment (TME) and its constituent stromal elements are crucial modulators of tumor growth and treatment response. Intere...

[This corrects the article DOI: 10.1371/journal.pone.0228156.].

Mutations conferring susceptibility to complex disorders also occur in healthy individuals but at significantly lower frequencies than in patients, indicating that these mutations are not completely penetrant. Therefore, it is important to estimate the penetrance or the likelihood of developing a disease in presence of a mutation. Recently, a metho...