About
77
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Introduction
Kalman Czeibert currently works at the LimesVet Ltd., making various 3D visualisations, and developing custom-made (and 3D-printed) veterinary equipment (eg., surgical guides, implants, anatomical models).
Beforehand, he worked at the Department of Ethology (ELTE University), where he was participating in the study of cognitive ageing in dogs in the framework of an ERC Starting Grant (680040). He also has clinical experience, and was an anatomy lecturer at the University of Veterinary Medicine.
Skills and Expertise
Additional affiliations
September 2021 - May 2023
Limes Model Ltd.
Position
- Engineer
Description
- Creating custom-designed veterinary anatomical and surgical models (based on CT and MRI images, surface scanning etc.), using subtractive (CNC) and additive (3D-printing) manufacture, and researching new fields in the supportive veterinary care.
Education
September 2013 - July 2020
September 2003 - November 2008
Faculty of Veterinary Sciences
Field of study
Publications
Publications (77)
Computed tomography (CT) is a non-invasive, three-dimensional imaging tool used in medical imaging, forensic science, industry and engineering, anthropology, and archaeology. The current study used high-resolution medical CT scanning of 431 animal skulls, including 399 dog skulls from 152 breeds, 14 cat skulls from 9 breeds, 14 skulls from 8 wild c...
This case series describes the surgical removal of lateral ventricular tumors using a transcallosal approach, long-term follow-up, and magnetic resonance imaging (MRI) results of 3 dogs. Two tumors were benign choroid plexus tumors (CPT). One was a grade 2 astrocytoma. Complete tumor removal was achieved using the transcallosal approach. All dogs h...
When addressing preverbal infants and family dogs, people tend to use specific speech styles. While recent studies suggest acoustic parallels between infant- and dog-directed speech, it is unclear whether dogs, like infants, show enhanced neural sensitivity to prosodic aspects of speech directed to them. Using functional magnetic resonance imaging...
Full English version of Cranioplasty with a digitally designed and costume made implant in a dog article.
Domestication is a well-known example of the relaxation of environmentally-based cognitive selection that leads to reductions in brain size. However, little is known about how brain size evolves after domestication and whether subsequent directional/artificial selection can compensate for domestication effects. The first animal to be domesticated w...
Compared to the field of human fMRI, knowledge about functional networks in dogs is scarce. In this paper, we present the first anatomically-defined ROI (region of interest) based functional network map of the companion dog brain. We scanned 33 awake dogs in a “task-free condition”. Our trained subjects, similarly to humans, remain willingly motion...
An 8-year-old Maltese dog was referred for surgery due to an intracranial foreign body. The dog had been hit by a car and had experienced three generalised tonic-clonic seizures. Examination by computed tomography revealed an intracranial metallic object oriented in a vertical direction. The ventral end protruded by 2 mm, in close proximity to the...
Objective: To describe in detail the arterial vasculature of metacarpophalangeal joints 2-5 on cadaver specimens and to compare it to ultrasound imaging of healthy subjects.
Methods: Eighteen hands of donated human cadavers were arterially injected and investigated with either corrosion casting or cryosectioning. Each layer of cryosectioned specim...
SUMMARY During cranioplasty the primary goals are the correction of skull defects, the protection of the exposed soft tissues (especially the brain), and restoration of the original shape of the head. In human medicine the most widely used materials for cranioplasty are polymethyl-methacrylate (PMMA), calcium phosphate-based implants (CaP), titaniu...
Dogs may possess a unique translational potential to investigate neural aging and dementia because they are prone to age-related cognitive decline, including an Alzheimer’s disease–like pathological condition. Yet very little is known about the molecular mechanisms underlying canine cognitive decline. The goal of the current study was to explore th...
Alzheimer’s disease (AD) is a significant burden for human health that is increasing in prevalence as the global population ages. There is growing recognition that current preclinical models of AD are insufficient to recapitulate key aspects of the disease. Laboratory models for AD include mice, which do not naturally develop AD-like pathology duri...
In humans, social relationship with the speaker affects neural processing of speech, as exemplified by children's auditory and reward responses to their mother's utterances. Family dogs show human analogue attachment behavior towards the owner, and neuroimaging revealed auditory cortex and reward center sensitivity to verbal praises in dog brains....
Biobanking refers to the systematic collection , storage, and distribution of pre-or post-mortem biological samples derived from volunteer donors. The demand for high-quality human specimens is clearly demonstrated by the number of newly emerging biobanking facilities and large international collabora-tive networks. Several animal species are relev...
Describing evolutionary conserved physiological or molecular patterns, which can reliably mark the age of both model organisms and humans or predict the onset of age-related pathologies has become a priority in aging research. The age-related gene-expression changes of the Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) gene have been well-documented...
Purpose:
The purpose of this study was to create a detailed cross-sectional anatomical reference atlas of the Pannon minipig by correlating good resolution CT and MR images with high quality cross-sectional anatomical images. According to the authors knowledge, no detailed anatomical atlas is available for the minipig.
Material and method:
An ad...
The privately owned companion dog is an increasingly important model in aging research because it shares the human environment, is exposed to similar environmental risk factors, receives comparable medical care, and develops many of the same age-related pathologies. One such pathology is Canine Cognitive Dysfunction (CCD), which shares many of the...
Computed tomography (CT) is one of the most useful techniques for digitizing bone structures and making endocranial models from the neurocranium. The resulting digital endocasts reflect the morphology of the brain and the associated structures. Our first aim was to document the methodology behind creating detailed digital endocasts of canine skulls...
A 6-years-old female Staffordshire terrier was referred for periodic generalized seizures and asymmetric visual deficits. Magnetic resonance imaging revealed a 23.2 × 19.3 × 23.0 mm soft tissue mass within the right lateral ventricle and consequential dilatation of the lateral ventricles. Surgically, an interhemispheric approach was performed next...
Background:
Recent studies suggest that clinically sound ventriculomegaly in dogs could be a preliminary form of the clinically significant hydrocephalus. We evaluated changes of ventricular volumes in awake functional magnetic resonance imaging (fMRI) trained dogs with indirectly assessed cognitive abilities over time (thus avoiding the use of an...
Our aim was to create high-quality macro-anatomical cross-sectional images and 3-dimensional (3D) models of a canine brain that could be paired with the results of magnetic resonance imaging (MRI) and computed tomography (CT) techniques from the same specimen. In this way, multimodal and multiplanar imaging was possible, and by segmenting certain s...
The birth of conjoined or Siamese twins occurs once in every 50,000 births. Attachment at the skull (craniopagus malformation) is very rare and seen in only 2% to 6% of all cases of conjoined twins, which makes the incidence of craniopagus twins 1 in 2.5 million births. In this report, we present a case of craniopagus twins with special anatomic ch...
In this study we described two different indications of ventriculo- and cystoperitoneal shunting (VPS, CPS) procedures in six dogs, including their clinical data and magnetic resonance imaging (MRI) examinations. One dog had moderate and two dogs had severe congenital hydrocephalus, one was presented with intracranial pressure elevation due to meni...
The dog rhinarium (naked and often moist skin on the nose-tip) is prominent and richly innervated, suggesting a sensory function. Compared to nose-tips of herbivorous artio- and perissodactyla, carnivoran rhinaria are considerably colder. We hypothesized that this coldness makes the dog rhinarium particularly sensitive to radiating heat. We trained...
Resting-state networks are spatially distributed, functionally connected brain regions. Studying these networks gives us information about the large-scale functional organization of the brain and alternations in these networks are considered to play a role in a wide range of neurological conditions and aging. To describe resting-state networks in d...
Background: Dogs ( Canis familiaris ) are natural models of several human diseases, including age-related dementia. However, the molecular techniques, which are routinely applied in invertebrate and rodent models to study disease pathologies and mechanisms, has limited applicability in dogs, mainly because of ethical reasons. In the case of humans,...
In order to visualize a canine brain with multimodal imaging and enhanced detailedness we made a comparative neuroanatomical study. A two-year-old female Beagle dog was scanned ante- and post mortem with CT and MRI. Arteries were filled with red polyurethane resin through the common carotid arteries post mortem (all procedures were approved in PEI/...
SUMMARY Background: Meningeoma is a common intracranial tumour type in dogs and cats. Epilepsy and obtunded mental state are the most common clinical signs of frontal meningiomas. Frontal lobe and olfactory bulb are the most typical place of meningioma in dogs. Many surgical procedures have been described about the removal of meningioma which depen...
Introduction:
For research applications or veterinary diagnostic work one should know the exact 2‐ and 3‐dimensional anatomy of the desired animal. 3D surgical planning and virtual anatomy teaching both require detailed knowledge of different body regions.
Materials and Methods:
Whole body ante‐ and post mortem CT and MRI scannings were performe...
Introduction:
The equine carpal and tarsal joints are complex structures with separate cavities, intra‐ and extraarticular ligaments and tendon sheaths around them. There are only a few studies about the detailed CT‐ and MRI‐anatomy of these joints and none of them contains 3‐dimensional reconstructions of these structures. In our study, we create...
Introduction. Creating a novel anatomical atlas requires a technique showing an organ in a different perspective, or that the applied method results in an enhanced image quality compared to previous work. We visualized a canine brain with multimodal imaging techniques for comparative studies.
Materials and Methods. A two-year-old female Beagle do...
Analyzing gross morphology and inter-species differences of the brain can be done in different ways. Direct methods allow to examine the organ either ex situ by removing it or in situ, through imaging methods (e.g., CT, MRI). Indirect methods rely on the estimation of the volume of an endocranial cast, obtained by filling the endocranium with a cer...
Background and aims:
Dogs have recently become an important model species for comparative social and cognitive neuroscience. Brain template-related label maps are essential for functional magnetic resonance imaging (fMRI) data analysis, to localize neural responses. In this study, we present a detailed, individual-based, T1-weighted MRI-based brai...
SUMMARY Background: Hypercortisolism is one of the most common endocrine disease in dogs. It could have peripheral or central aetiology. The central hypercortisolism is caused by adrenocorticotropic hormone dependent pituitary gland adenoma in most cases. According to another grading system, P/B ratio is a good method to distinguish microtumours fr...
Introduction. Neurological clinical signs are often ambiguous, and even in the case of severe brain disorder, the patient shows sometimes only mild clinical symptoms or behavioural changes. In our study, we present examples of how severe intracranial disorders could hide behind the moderate symptoms. Materials and Methods. We present three canine c...
Introduction. Neurological clinical signs are often ambiguous, and even in the case of severe brain disorder, the patient shows sometimes only mild clinical symptoms or behavioural changes. In our study, we present examples of how severe intracranial disorders could hide behind the moderate symptoms.
Materials and Methods. We present three canine...
A 9-years-old spayed female mixed-breed dog was referred for the evaluation of intermittent head tremors, obtundation, long-standing blindness, and a tendency to seek confined spaces. The dog lost its vision 6 months before the current presentation. A menace response was absent on ophthalmological examination. Neurological examination did not show...
SUMMARY. Background: Arachnoid cyst is a developmental disorder which can cause compression of the brain and due to this neurological symptoms could occur. A special
intracranial-intra arachnoid cyst (IAC) is called quadrigeminal cyst (QC) which can
develop due to arachnoid duplication. A study described 4100 retrospective MRI
evaluations and found...
Most common methods that directly show macro- or microscopic anatomy of the brain usually require the removal of the organ from the neurocranium. However, the brain can be revealed in situ by using proper sectioning techniques. Our aim was to both improve the cryosectioning method, test its limits and create a high-resolution macro-anatomical image...
The embedding box (A) and the frozen head block inside the holder (B).
(TIF)
The cryomacrotomisation process.
(TIF)
SUMMARY Background: The petrosal bone is one of the smallest and most complex among the bones of the equine skull. Its irregular surface, several projections and channels, and hidden inner structures make its visualization challenging. Textbooks usually show this bone on different drawings and photographs, where the structures' relationship and the...
The purpose of the study was to investigate how the brain ventricles’ volume changes with age in a unique sample, i.e. dogs trained to lay awake in an MRI during scanning. Structural MRI data were obtained at least twice (1-6 years between scans) from 21 family dogs (Mage = 3.81 years, range 1.1-11.4; F = 7, M = 14) trained to lay motionless (movem...
Resting-state networks are spatially distributed, functionally connected brain regions. Studying these networks gives us information about the large-scale functional organization of the brain and alternations in these networks are considered to play a role in a wide range of neurological conditions and aging. To describe resting-state networks in d...
SUMMARY Background: Pituitary tumors are rare in dogs. In most of the cases these tumours are benign types, and according to the literature malignant hypophy-sis tumours are rare. One common form of the benign tumours is the hormone dependent adenoma. Mei et al. found a technique to remove hypophysis tumor via os sphenoidale. Radiotherapy is recomm...
Evaluation of the paranasal sinus system at different animals and their relation to the neurocranium
Cardiac CT examinations and evaluation on different species and breeds.
Over the last decades there have been several publications of anatomical and neurological textbooks, which include descriptions about the dogs' brain. However, the terminology used is inconsistent, partly due to individual differences in neocortical gyration and partly due to the common practice of adapting terms from human and murine anatomy. In o...
Introduction: Dogs’ middle cranial fossa includes several important structures, but due to its relative small size and the pachymeningeal coverage, usually it can be challenging to study for veterinary students, although it has a great importance for certain neurosurgical interventions. Thus we used different techniques to comprehensively visualize...
Introduction: Surface description terminology of the dogs’ brain is sometimes divergent among different literature sources, partly due to individual differences in the gyration and partly because those medical terms derived from the human and rodent anatomy. As more dog studies and atlases are published, there is a need for a more consistent termin...
Recent advances in genomics have made domestic dogs our best friends in fighting genetic disease, thanks to their unique population structure and high genetic variability. Genome wide association studies, based on blood samples taken harmlessly from living animals, have already shed light on many genes related to canine diseases and their human cou...
Resting-state networks (RSNs) are spatially distributed, functionally connected brain regions, characterized by the correlation of the time series of spontaneous, low frequency fluctuations of the blood-oxygen level dependent (BOLD) signal. Studying these networks gives us information about the large-scale functional organization of the brain and a...
Introduction. Enlargement of the lateral ventricles of the brain is considered to be a phenomenon caused by cortical or medullary tissue loss, most commonly atrophy, which can lead to impairment in sensory-motor, or cognitive function. Up to this date there is no clear classification that divides the ventricular size to normal, enlarged, or hydroce...
Ageing, the process of becoming old, affects every organ. However, adapting to changes in the body is possible as long as the brain remains healthy. Therefore, ageing research needs to focus on healthy brain ageing, or in other words, on successful cognitive ageing. In the Senior Family Dog Project (SFDP) our aim is to explore the cognitive ageing...
Dogs (Canis familiaris) are good models for the study of age related cortico-medullary
atrophy causing brain ventricles’ enlargement. Dogs trained to lay in an fMRI
machine allow for non-invasive research comparable to that performed in humans.
We investigated ventricular changes in 18 dogs trained to stay motionless in an MR
scanner without sedati...
SSZeFoGLALÁS A szerzők jelen tanulmányukban a ló térdízületének, keresztmetszeti képalkotással (CT, MR) nyert adatokból, képfúzió segítségével létrehozott, digitális 3D modelljeit mutatják be. Röviden ismertetik a mágneses rezonanciás vizsgálat technikai alapjait, irodalmi adatok alapján áttekintik a ló térdízületének CT és MR anatómiáját. A cikkso...
SUMMARY Background: Computed tomography (CT) and magnetic resonance imaging (MR) became important diagnostic tools in the veterinary practice in the past decades. Data gained with those scanning methods can be used for 3D displaying of different organs, organ systems and body regions as well. There are numerous reconstructional softwares to create...
SSzeFoGLALÁS A szerzők jelen tanulmányukban bemutatják a légzőszervrendszer egyes elemei-nek CT-vizsgálatra alapozott 3D modelljeit. Ismertetik a madarak légzsákjainak, a lovak orrmelléküregeinek anatómiai alapjait, ezen szervrendszerek vizsgálatának nehézségeit. Röviden bemutatják a vizsgálóeljárás technikai részleteit, irodalmi adatok alapján átt...
SUMMARY Background: Computed tomography (CT) became an important diagnostic imaging method in the veterinary practice in the past decades. Data gained with the scanning can be used for 3D displaying of organs or body regions as well. The viewer softwares provide more and more options for reconstruction of the target area. Objectives: The authors pr...
Introduction: The equine stifle joint consist of three well recognizable cavities on MR images: the femoropatellar (FPJ), medial femorotibial (MFTJ) and lateral femorotibial joints (LFTJ). In our study we produced 3D reconstruction model of the horse’s stifle joint based on high resolution CT and MR data and image fusion. Materials and Methods: A s...
Introduction: The blood supply of the male genital tract in dogs is a complex system. The testicular artery arises from the abdominal aorta, the prepuce is supplied by the external pudendal artery and the blood supply to the penis is from three branches of the internal pudendal artery. The prostate is supplied by the prostatic artery. The venous dr...
Introduction: In our study we aimed to show the blood supply of the canine orbit using different preparation and reconstruction techniques since proper knowledge about this region is essential for veterinary students and also useful for ophthalmologists. Materials and Methods: Conventional anatomical preparation was performed on two dogs, corrosion...
Introduction: The temporal bone is one of the most complex osseous structures of the body. Due to its irregular shape and complex architecture it is difficult to comprehend the relative position of its inner components based only on two-dimensional images. We used different 3- dimensional imaging techniques to facilitate the approach to this comple...
This booklet you are holding in your hands, shows the anatomy of the cat’s head from an uncommon view. The cross-sectional diagnostic methods (CT, MR) used in human medicine for decades, are becoming more popular in the diagnostic of various health problems of our pets. For analyzing images gained with the above mentioned methods, it requires preci...
For body composition analysis, veterinary diagnostic work and for many research applications one should know the exact anatomy of the desired animal. 3D surgical planning and virtual anatomy teaching both require detailed 3D models of different body regions. There are detailed cross sectional atlases, books with colour images of the desired area wi...
The authors present in their study a labrador retriever with chronic nervous system disorder to demonstrate how could a progressively increasing primary brain tumour (as histopathological findings later confirmed, an ependymoma) affect an animal's attitude, pathological and compulsive behaviour, causing epileptic seizures, while disrupting physiolo...
As in every technical discipline, the objective, reproducible instrumental measurements are indispensable. It is no different at investigating the effect of weather on living organism. The parallel measurement of the atmospheric environment and the physiological parameters is novel and individual, as well as the investigation of epileptic seizures...
The authors, based on literature data and own investigations, present the relationship between epileptic fits and certain meteorological factors in the case of a Jack Russell terrier suffering from epilepsy for years. The seizure-classification was based upon long-term observation of the animal, registration of fits by owners, and evaluation by a s...
Introduction: Correct anatomical visualization and interpretation of the vascular system is a big challenge in the research, clinical work and education. The new 3D reconstruction methods of diagnostic imaging (vascular reconstructions) give us a non-destructive method (Lafayette et al., 2009 : Tissue engineering. 15, 729–738, Mondy WL. Et al. 2013...
Introduction: Correct anatomical visualization and interpretation are essential for clinical, research and educational activity. Neuroanatomy is one of the most researched field during past decades. Diagnostic imaging (CT, MRI, SPECT) and neurosurgery get more importance in small animal veterinary practice, that’s why knowledge of location and path...
The authors, based on literature data and own investigations, present that meteorological changes could determine the occurrence of the provoked epileptic fits of an epileptic dog, since aetiology and classification show many analogies between human and canine epilepsy. The symptom-associated meteorological changes included many factors (front acti...
Genetic contribution has been consistently implicated in several neurological disorders, however only a fraction of candidate genes can be directly linked to these disorders. Many known risk factors for psychiatric diseases are related to the enzymatic regulatory machinery of the actin based cytoskeleton of neuronal cells. Synaptic plasticity - whi...
Introduction: The topographical anatomy of the canine heart is essential for the everyday veterinary clinical work. Experts from different fields (eg. ultrasonography, radiology, internal medicine and surgery) need this basic knowledge for successful diagnosis and treatment. In this study we give a general overview about the anatomy of the dog’s he...
Introduction: In the clinical practice, uni- or bilateral facial nerve dysfunction may occur by itself or in association with other circumstances (eg. the commonly experienced middle ear infection, surgical approach to the bulla for various kind of the treatment, brainstem disorders affecting the nucleus and central part of the facial nerve). To ai...