Kalle Lagerblom

Measur

2‐Oxazolidinones are saturated heterocyclic compounds, which are highly desired structures in modern drug design. In their Communication on page 10284 ff., T. Repo et al. describe the use of CO2 as a carbonyl source for a new, single‐step approach to 3,4‐disubstituted 2‐oxazolidinones. The modular reaction, which occurs between a γ‐brominated Micha...

2‐Oxazolidinones are saturated heterocyclic compounds, which are highly attractive targets in modern drug design. Herein, we describe a new, single‐step approach to 3,4‐disubstituted 2‐oxazolidinones by aza‐Michael addition using CO2 as a carbonyl source and 1,1,3,3‐tetramethylguanidine (TMG) as a catalyst. The modular reaction, which occurs betwee...

We report here new copper(I)-Schiff base complexes for the selective oxidation of primary alcohols to aldehydes under ambient conditions (with 2,2,6,6-tetramethylpiperdine-N-oxyl (TEMPO), N-methylimidazole (NMI), ambient air, acetonitril and RT). Particularly, the copper(I) complex bearing N-(4-fluorophenyl)-1-(furan-2-yl)methanimine (L2) showed hi...

Dissolution of elemental Au in organic solutions is a contemporary approach to lower environmental burden related to gold recycling. Here we describe fundamental studies on a highly efficient method for dissolution of elemental Au which is based on DMF solutions containing pyridine‐4‐thiol (4‐PSH) as a reactive ligand and hydrogen peroxide as an ox...

Dissolution of elemental Au in organic solutions is a contemporary approach to lower environmental burden related to gold recycling. Here we describe fundamental studies on a highly efficient method for dissolution of elemental Au which is based on DMF solutions containing pyridine‐4‐thiol (4‐PSH) as a reactive ligand and hydrogen peroxide as an ox...

Herein, we report an efficient transition metal triflate catalyzed approach to convert biomass-based compounds, such as monoterpene alcohols, sugar alcohols, octyl acetate and tea tree oil, to their corresponding olefins in high yields. The reaction proceeds through C–O bond cleavage under solvent-free conditions, where the catalytic activity is de...

Homogeneous Mn(NO3)2/2,2,6,6‐tetramethylpiperidin‐1‐yl)oxyl/2‐picolinic acid catalyst system has been found highly active and versatile for the selective aerobic oxidation of alcohols (2,2,6,6‐tetramethylpiperidin‐1‐yl)oxyl = TEMPO, 2‐picolinic acid = PyCOOH ). The catalytic method enables near quantitative conversion of various primary alcohols to...

Herein, we describe an efficient two-step pathway for isosorbide synthesis from cellulose with the use of new recyclable Ru-catalysts. We show that the oxidative and sulfonation treatments of the new Ru-catalysts increase the acidity and the hydrophilicity of the activated carbon support material, thus reducing the catalyst fouling caused by build-...

A highly efficient, ligand enhanced TEMPO/Mn(NO3)2 catalyst system for the aerobic oxidation of alcohols is described. From the series of coordinating ligands studied herein, 2-picolinic acid (PyCOOH) remarkably improves the catalytic activity of TEMPO/Mn(NO3)2. Under ambient air, at room temperature and in acetic acid, the ligand-enhanced catalyst...

Solvent-free NaOH catalyzed aldol condensation of biomass-derived 5-hydroxymethyl furfural (HMF) and furfural with methyl isobutyl ketone (MIBK) was studied, producing branched C11 and C12 furan compounds in high yields of up to 96%. Through use of a Pd/C and Eu(OTf)3 catalytic system, the condensation products of the bio-based starting materials w...

C6-substituted thymidines are biochemically important compounds, whereas thymidine (6-4) photoproduct (5-hydroxy-6-(thymidine-4-yl) dihydrothymidine) is one of the major DNA damage caused by the UV component of sunlight. This report describes a metal-free cis-diastereoselective ring opening of thymidine 5,6-epoxides using mildly nucleophilic organo...

A method for aerobic alcohol oxidation catalysed by Fe(NO3)3/2,2’-bipyridine/TEMPO has allowed highly selective conversion of primary alcohols into either aldehydes or carboxylic acids in one-step. The oxidation of primary alcohols proceeded selectively to aldehydes, as TEMPO was present in the reaction. Nevertheless, the aldehydes were further oxi...