Kalam Sirisha

Vaagdevi College of Pharmacy · Department of Pharmaceutical Chemistry

A series of new C3 heterocyclic-substituted ciprofloxacin derivatives were prepared from ciprofloxacin acid hydrazide as possible chimeric molecules. They were evaluated for their possible in vitro antibacterial (agar cup/bore diffusion method) and antitubercular (Lowenstein–Jensen (LJ) slant method) activities. The results indicated that all the t...

Polycystic ovarian syndrome (PCOS) is one of the most common reproductive endocrinological disorders with a broad spectrum of clinical manifestations affecting about 6-8% women of reproductive age. Many adolescent girls and women lack knowledge of Polycystic ovarian syndrome. The present study was designed so as to evaluate the knowledge of sixty u...

Pharmacological agents that kills parasites are essential drugs in some tropical countries. In this study, a series of 2-amino substituted 4-phenyl thiazole derivatives (4a-e) have been synthesized by the conventional method. The thiazole derivatives were synthesized by three steps. The obtained five derivatives were purified by recrystallization u...

A systematic groundwater analysis was carried out in six villages of Narsampet in Warangal district and two villages of Narketpally in Nalgonda district of Telangana in India. These water samples were collected from respective areas and evaluated under four different categories viz. physico-chemical parameters (such as pH, Electric Conductivity (EC...

A systematic groundwater analysis was carried out in six villages of Narsampet in Warangal district and two villages of Narketpally in Nalgonda district of Telangana in India. These water samples were collected from respective areas and evaluated under four different categories viz. physico-chemical parameters (such as pH, Electric Conductivity (EC...

The present study aimed at the development of foxtail millet based biscuits incorporated with spinach (Spinacia oleracea L.) at different proportions viz. 10%, 15% and 20% using traditional creamery method. These developed biscuits were analysed for physical properties and sensorial qualities using 9 point hedonic scale. Physical characteristics of...

Comparative Phytochemical and Pharmacological Evaluation of flowers of Plumeria rubra L. f. rubra and Plumeria rubra f. lutea

Objective: To develop three novel, sensitive, simple validated visible spectrophotometric methods for the quantitative estimation of sulfamethoxazole (SMZ) and trimethoprim (TMP) in bulk form.Methods: Methods were based on coupling the diazotized aromatic primary amino group of the studied drugs with o-phenylenediamine (OPD) in an acidic medium. Th...

Objective: Diabetes is a group of disorders characterized by high blood glucose levels. Disturbances in serum electrolytes like sodium (Na+) and potassium (K+) are found in diabetes. The purpose of the study was to investigate the disturbances in concentrations of serum electrolytes in hyperglycemic crisis and the effect of syzygium cumini and momo...

P-glycoprotein (P-gp) mediated efflux affects the pharmacokinetics of several drugs. By analogy to verapamil, 1,4-dihydropyridines (DHPs) have been widely studied as P-gp inhibitors. Previously, we have reported on two new DHPs: IA1(A) and IIA5(B) as inhibitors of human MRP1, an efflux protein closely related to P-gp. The aim of the present study w...

Objectives. To measure and compare free fraction of serum levels of VPA (valproic acid) between non-malnourished and malnourished epileptic children and to evaluate the adverse effects (myopathy, hepatotoxicity). Material and methods. It is a prospective comparative observational case control study in which forty epileptic children (malnourished: 1...

Objective: The present study was aimed to investigate the possible effect of newer poly herbal ointment formulations against skin cancers. Materials and Methods: The newer polyherbal ointment formulations (PHF-I, PHF-II and PHF-III) containing varying proportions of Zingiber officinale (rhizome), Curcuma longa (rhizome), Aloe barbadensis (leaf), Ci...

A series of new 10-(alkylamino)-8-methyl-2, 6-dihydroimidazo[1, 2-c]pyrimido[5, 4-e]pyrimidine-5(3H)-thiones (4a-g) were subjected to molecular property prediction (drug-likeness, lipophilicity and solubility parameters) using Osiris Property Explorer, ALOGPS 2.1, Molinspiration and ACD/Chemsketch 12.0 software programmes. The calculated drug-relat...

Two series of new symmetrical 4-aryl-2,6-dimethyl-3,5-bis-N-(aryl/heteroaryl)-carbamoyl-1,4-dihydropyridines (4a-f) and asymmetrical 4-aryl-2,6-dimethyl-3-N-(aryl/hetero-aryl)-carbamoyl-5-ethyl carboxylate-1,4-dihydro-pyridines (5a-f) have been synthesized by simple, economical and eco-friendly, modified Hantzsch reaction using N-aryl/heteroarylace...

Pterostilbene is a naturally occurring dimethyl ether analog of resveratrol identified in several plant species. Telomerase is important in tumor initiation and cellular immortalization. Given the striking correlations between telomerase activity and proliferation capacity in tumor cells, telomerase had been considered as a potentially important mo...

N-aryl/heteryl acetoacetamides are the intermediates used in the synthesis of various heterocyclic compounds like 1,4-dihydropyridines, pyrimidines etc. Three different substituted N-aryl/heteryl acetoacetamide derivatives (I-III) have been prepared from the reaction of ethylacetoacetate and three different aryl/heteryl primary amines under solvent...

Plumeria rubra L (Apocynaceae), commonly known as "Frangipani" is an important medicinal plant, widely distributed throughout Southern India. In traditional medicinal system different parts of this plant have been mentioned to be useful in a wide variety of diseases. The present study is aimed to comparatively evaluate the antioxidant, free radical...

The activation of telomerase represents an early step in carcinogenesis. Increased telomerase expression in malignant tumors suggests that telomerase inactivation may represent a potential chemotherapeutic target. In this work, existing anticancer drugs were docked against telomerase reverse transcriptase (TERT) using a Lamarckian genetic algorithm...

The overexpression of multidrug resistance protein 1 (MRP1) by tumor cells results in multidrug resistance (MDR) to structurally unrelated anticancer drugs. Circumvention of MDR by combination of chemosensitizers with antitumor compounds is a new field of investigation in cancer chemotherapy. Much effort has been put-in recently to identify the mod...

A novel class of 4-aryl/heteroaryl-2,6-dimethyl-3,5-bis-N-(phenyl/substituted phenyl)-carbamoyl-1,4-dihydropyridines has been synthesized by simple, economical and eco-friendly, modified Hantzsch condensation reaction making use of N-arylacetoacetamides, aryl or heteroaryl aldehydes and ammonium acetate. The newly synthesized compounds were charact...

A series of twenty new 4-substituted-2,6-dimethyl-3,5-bis-N-(heteroaryl)-carbamoyl-1,4-dihydropyridines have been prepared from a three-component one-pot condensation reaction of N-heteroaryl acetoacetamide, an aromatic/heteroaromatic aldehyde, and ammonium acetate under four different experimental conditions. Except for the conventional method, al...

Scientific and technical reports are constantly pouring in with respect to improvised synthetic techniques to prepare different 1,4-dihydropyridines and with regard to their varied biological, pharmacological and chemical applications. Unlike earlier years when 1,4-DHPs were only known as the calcium channel blocker, in the present times they are k...