Kaïs Rtibi

ISEP-BG Soukra University of Carthage · Biology

Background The prompt development of obesity/constipation is the most serious problem for both children and adults. Limited studies suggested an association between them but lacked preclinical studies. This study allows to evaluate their crosslink and to compare the aqueous extracts laxative actions of two edible wild fruits of Arbutus unedo (AUAE)...

A growing interest has been drawn to the use of traditional medicinal plants for the treatment of human diseases and, in particular, infertility and reproductive toxicity associated with environmental factors. The Mediterranean basin area is a recognized source of plant species with therapeutic interest. In this frame, Eruca sativa (ES) is an annua...

The current study investigated the possible mechanisms of aqueous extract Salvia officinalis flowers (SF‐AE) and its protective effects against hepatorenal toxicities produced by simultaneous acute administration of ethanol (EtOH)/castor oil (CO). Healthy male rats ( N = 50) were separated into five equal groups: control, Ethanol (EtOH) + Castor oi...

Abstract Background and Objectives: Urtica dioica, a source of bioactive functional compounds, provides nutritional and gastrointestinal therapeutic benefits. This study attempted to investigate the prophylactic coloprotective action of an aqueous extract of Urtica dioica (AEUD) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC). Mater...

Arbutus unedo and Crataegus monogyna are widely distributed throughout the Mediterranean basin and commonly used in folk medicine against a wide range of diseases. Therefore, the present study has been designed to evaluate the anti-obesity potential of two aqueous extracts of the fruits of A. unedo (AUAE) and C. monogyna (CMAE). Male Wistar rats we...

The microbiota-gut-hormone axis represents a promising area of research for understanding and treating metabolic disorders. Targeting this axis through various interventions could offer novel therapeutic strategies to improve metabolic health and combat conditions like obesity and type 2 diabetes. However, more research is needed to fully elucidate...

Inflammatory bowel disease is associated with multiple extraintestinal disorders, including hepato-nephrological disruptions. The aim of this study was to evaluate the hepato-nephroprotective effect of Salvia officinalis leaf decoction extract (SLDE) on acetic acid (AA)-induced colitis accompanied with liver and kidney injuries. Wistar albinos rats...

Ginger ( Zingiber officinale) rhizomes are commonly used in foods and employed for many ailments including gastrointestinal disorders. Our main objective was to evaluate the effect of Zingiber officinale aqueous extract (ZOAE) on gastrointestinal (GI) physiological motility and colonic dysmotility. Thereby, Wistar rats were given loperamide (LP, 3...

Essential oils-(EOs) are organic compounds derived from aromatic plant sources such as roots, bark, flowers, leaves and seeds. Essential oils were obtained via two different methods of extraction: steam distillation (SD) and water distillation (WD). EOs-therapy, refers to a range of traditional, alternative or complementary therapies that use essen...

Medicinal plants are known by pharmacological relevance and were used for long time to prevent/treat numerous gastrointestinal (GI) disorders. The current study focuses on the phytochemical/antioxidant characteristics of sage aqueous extract (SAE), as well as its pharmacological actions on altering motor function in the intestine and related disrup...

The present study was conducted to investigate the protective action of Salvia officinalis flowers aqueous extract (SOFAE) against combined gastro-intestinal (GI) disorders-induced by ethanol and castor oil administration in rats. Adult male Wistar rats were divided into seven groups of ten each and various doses of SOFAE (50, 100, and 200 mg kg À1...

Trigonella foenum graecum (Fenugreek) is used in traditional phytomedicine for its anti-inflammatory, antiseptic, antidiabetic, and several other therapeutic virtues. The current study was intended to investigate the protecting effects of fenugreek seeds' aqueous extract (FSAE) using experimentally ethanol (EtOH)-induced gastric peptic ulcer in rat...

A series of nine new 6-aryl-7-alkyl/aryl-[1,2,4]triazolo[4,3-a][1,3,5]triazine-5(6H)-thiones (2a-i) were synthesized by a reaction of N-triazol-3-yl imidates (1) with three different isothiocyanate derivatives (RNCS) in refluxing toluene. The structures of the final heterocyclic compounds were confirmed by 1H-NMR, 13C-NMR, FT-IR, elemental analysis...

Quercus ilex fruit is widely used in the treatment of various gastrointestinal disorders, including diarrhea, for its bioactive compounds and astringent property. The current study focuses on the phytochemical characterization of the Q. ilex-aqueous extract (QIAE) and its protective effect against gastroduodenal (GD) ulcer (GDU) produced by absolut...

We aimed in the present research to evaluate the ameliorative effect of Salvia officinalis leaves decoction extract (SOLDE) against ulcerative colitis (UC) induced by acetic acid intoxication in rat as well as the mechanisms implicated in such protection. The RP-HPLC-DAD analysis revealed the presence of 8 phenolic compounds with rosmarinic acid be...

Medicinal plants were used to prevent and treat numerous gastrointestinal disorders owing, in part, to their antioxidant capacity. The protective effects of Diospyros kaki fruit aqueous extract (DKFAE) against castor oil (CO)-induced diarrhea was studied. The in vitro antioxidant and antibacterial properties were investigated using colorimetric and...

ABSTRACT This study aimed to evaluate the influence of the carob powder (CP) and sweet whey powder (WhP) inclusion into weaning feed on the gut morphology, hemato-biochemical parameters, and antioxidant biomarkers. The addition of 10 g/kg (basal diet +10 g/kg of CP, of WhP) or the mixture (5 g/kg of CP and 5 g/kg of WhP) in the rabbit's standard di...

Gastrointestinal (GI) disturbance is the main side effects of cancer chemotherapy agents on the tumor patients undergoing cancer treatment characterized by ulceration of the whole GI tract. Intolerable damage such as nausea, vomiting, diarrhea, and constipation appears. 5-Fluorouracil (5-FU), a chemotherapy drug, was widely employed to treat the ga...

Background Diarrhea is a multifactorial gastrointestinal disorder responsible for about 5 million deaths annually. The chemical composition, the antioxidant activity of Crataegus azarolus berries aqueous extract (CABAE) as well as its protective effects against castor oil–induced diarrhea, oxidative stress, and inflammation in rat were studied. Me...

An abundant literature suggests that obesity-associated with taking a high fat diet is related to an elevated risk of type 2 diabetes and metabolic syndrome. However, metabolic disorders may be involved in the induction of the anxiogenic-like symptoms. The current study was designed to elucidate the mechanisms by which a high fat diet (HFD) can cau...

The present study was carried out to determine the phytochemical composition of Salvia officinalis flowers decoction extract (SOFDE) as well as its individual and/or synergistic actions with sulfasalazine against ethanol (EtOH)-induced peptic ulcer in Wistar rats. In this respect, rats were divided into six groups of eight animals each: control, Et...

This study was undertaken to investigate the involvement of the reactive oxygen species (ROS) and proinflammatory cytokine production in the pathogenicity of gastrointestinal nematode Heligmosomoides polygyrus in mice and also the protective effect of myrtle (Myrtus communis L.) berry seeds aqueous extract (MBSAE). With this aim, Swiss Albino mice...

Bisphenols, and in particular bisphenol A (BPA), have been widely used for the production of plastic manufacts in the last 50 years. Currently, BPA is present in a variety of daily use polycarbonate plastics and epoxy resins, and dietary ingestion is considered the main route of human exposure. Accordingly, BPA is the chemical pollutant with the wi...

Rosa canina is a well-known medicinal plant used in folk remedy that alleviates various disorders, including inflammation, gastritis, and diarrhea. The objective of this investigation was to identify and quantify the phenolic components of R. canina methanolic extract (RCME) and to determine its protective action with dextran sulfate sodium (DSS)-g...

Background Chronic constipation is a gastrointestinal functional disorder which affects patient quality of life. Therefore, many studies were oriented to search herbal laxative agents. In this study, we investigated the effect of Globularia alypum L. leaves aqueous extract (GAAE) against loperamide (LOP)‐produced constipation. Methods Animals were...

Carob (Ceratonia siliqua L.) contains a wide variety of polyphenols with high antioxidant properties. In this study, we investigated the effects of aqueous extract of carob pods (AECP) on emotional behavior impairments and metabolic disorders in ovariectomized (OVX) rats. Female Wistar rats were assigned to three groups: group 1, control non-OVX ra...

The aim of this study was to develop a novel kefir beverage using date syrup, whey permeate, and whey. The levels of the kefir grain inoculum (2–5% w/v), fruit syrup (10–50% w/v), and whey permeate (0–5% w/v) on pH, total phenolic content, antioxidant activity, lactic acid bacteria and yeast counts, and overall acceptability were investigated using...

Eruca sativa action on the male reproductive system and fertility has not been precisely defined. In this study, the aim was to investigate the ameliorative activity of E. sativa aqueous extracts (ESAE) on reproductive toxicity associated with oxidative stress induced by bisphenol A (BPA). Wistar rats were used and divided into six groups of animal...

We aimed in the present study to investigate the chemical composition, the antioxidant capacities as well as the in vitro fermentation properties of Salvia officinalis leaves aqueous extract (SOLAE) grown in four regions of northwestern Tunisia. Our data firstly indicated a spatial variation (P <0.05) in condensed tannins, total lipids, polyphenols...

Natural bioactive compounds with small-bowel glucose/antiabsorption and sugar digestion enzymes' inhibition actions: new strategy to relieve hyperglycemia and diabetes. Abstract Intestinal glucose absorption/inhibition activity by natural bioactive compounds is considered a new strategy for prevention/treatment of uncontrolled hyperglycemia and dia...

Thyme is a rich source of bioactive phytochemicals and it is frequently used in folk-medicine to treat gastroenteritis irritations. The current study was performed to examine the potential of Thymus vulgaris aqueous extract (TV-AE) to protect against delayed gastric emptying (DGE) and colonic constipation in rats. Stomach ulcer was caused by a sing...

Phytotherapy is one of the oldest medicines in the world. Indeed, humans have tested and selected the best medicinal plants for treatment. In this context, we are interested in the realization of an ethnobotanical survey concerning the traditional use of officinal sage (Salvia officinalis L.) in the regions of Tabarka and Ain Draham (northwestern o...

Phytotherapy is an excellent therapeutic benefit in functional gastrointestinal diseases (FGIDs). In this case, there are several bioactive compounds in nature that have therapeutic activities that allow prevention or treatment of the gastrointestinal disorders such as constipation and diarrhea. Thus, in the current mini-review we will discuss the...

Abstract Background The current study was conducted to evaluate the protective effect of Lavandula stoechas essential oils (LSEO) against malathion (M) exposure-caused reprotoxicity in male mice as well as the possible mechanisms implicated in such protection. Methods Six–eight-week-old male mice weighting 25–30 g were used and divided into four gr...

Ethnopharmacological relevance: Ficus carica fruit, a source of bioactive functional ingredients, have been traditionally long time used for its medicinal benefits as they improve the digestive system, treating constipation and used as a natural laxative. Aim of the study: The recent study was investigated the ameliorative effect of Ficus carica...

The phytochemical composition and the effect of the green and ripe Opuntia ficus-indica juice on some gastrointestinal (GI) physiological parameters such as stomach emptying and small-intestinal motility and permeability were determined in rats administered multiple concentrations of the prickly pear juice (5, 10, and 20 mL kg-1, b.w., p.o.). Other...

Methotrexate (MTX), a chemotherapeutic agent, is used to treat various types of cancers. MTX was known for its toxic effects, particularly in the gastrointestinal (GI) tract. Consequently, the objective of this present research was to investigate the GI disorders during oxidative stress in rats subjected to oral dose of MTX (100 mg kg ⁻¹ ). Thirty...

The present study was undertaken to determine the effects of malathion exposure on oxidative stress, functional and metabolic parameters in kidney and liver of prepubertal male mice. For this reason, two separated groups of prepubertal male mice were used in this experiment. Animals were divided into two groups, group 1 served as a control and rece...

This study was designed to examine the contribution of oxidative stress in gastrointestinal disorders after an intraperitoneal administration of 5 fluorouracil (5-FU; 100 mg/kg of body weight (b.w.)) and capecitabine oral administration (500 mg/kg b.w.). The animals were divided into three groups: Group A (NaCl,10 ml/kg of b.w.) considered as contr...

This study was conducted to compare the effects of juice and seeds on gastric emptying, small-bowel motility and intestinal ion transport. Separate groups of rats were randomized to receive NaCl, increasing doses of juice (5, 10, and 20 mL/kg, b.w.) or seeds aqueous extract (100, 200, and 400 mg/kg, b.w.). Simultaneously, two other groups were rece...

Introduction: Several research studies have reported on the pharmacological relevance of the medicinal plants used for treating various gastrointestinal disorders and controlling the dietary glucose uptake in the intestinal tract. Methods: Male rats were used to investigate the pharmacological effects of green oak acorn aqueous extract (GOAE) on...

Carob tree, Ceratonia siliqua L., is a medicinal plant used in Tunisian traditional medicine for the treatment of the gastro-intestinal (GI) disorders. In this respect, a relatively large number of scientific publications on the carob tree have been published in recent years. Therefore, the present review was aimed to analyze the traditional uses,...

Introduction: The present study aims to investigate the protective effects of Rosemary (Rosmarinus officinalis L.) essential oils (ROEO) against alloxan-induced diabetes and oxidative stress in rats. Methods: The animals were divided into four groups: Healthy Control (HC); Diabetic Control (DC); Healthy+ROEO (H+ROEO) and Diabetic+ROEO (D+ROEO)....

Diarrhea pathophysiology and constipation are multifactorial gastrointestinal (GI) disorders characterized by intestinal peristalsis disruption of and an irregularity in secretion/absorption process. Oxidative stress, as an imbalance in prooxidants/antioxidants, has recently been recognized as a significant player in these GI disturbances. In this...

Background Massive alcohol drinking can lead to gastric ulcer. In the present study we investigated the gastroprotective effect of Citrus sinensis peel aqueous extract (CSPE) and Hesperidin (H) in ethanol (EtOH) induced oxidative stress and peptic ulcer in rats. Methods Seventy adult male Wistar rats were divided into seven groups of 10 each: cont...

Irinotecan, a chemotherapy drug, can cause acute diarrhea immediately after administration. Hence, the present study was designed to investigate the gastrointestinal (GI) disturbances after an intraperitoneal (IP) administration of irinotecan in rats.Twenty Wistar rats were separated into two groups of ten. Group A was considered as a control group...

The purpose of this study is to examine the gastrointestinal disorders after injection of vinblastine (2mgkg⁻¹b.w. i.v.) in rats. Animals were divided into two equal groups: Group 1 was considered as a control group (NaCl, 0.9%). Group 2 was treated with intravenous injection of vinblastine for 7 days. Loperamide (2mgkg⁻¹) was injected in a saline...

The present work investigated the effects of prenatal exposure to radiofrequency waves of conventional WiFi devices on postnatal development and behavior of rat offspring. Ten Wistar albino pregnant rats were randomly assigned to two groups (n=5). The experimental group was exposed to a 2.45GHz WiFi signal for 2h a day throughout gestation period....

This study aimed to investigate the antiulcer and antioxidant activities of myrtle berry seed aqueous extract (MBSAE) in a peptic ulcer model induced by ethanol in male Wistar rats. MBSAE is rich in total polyphenols, total flavonoids, and unsaturated fatty acids, particularly linoleic (18:2) and oleic (18:1) acids. MBSAE also exhibited in vitro an...

Introduction: The myrtle (Myrtus communis) belongs to the Myrtaceae family; it is one of the central plants as part of the list of medicinal plants in the Tunisian Pharmacopoeia. Myrtle berry was used for its astringent, tonic, and antiseptic properties, to treat diarrhea, hemorrhoids, and gastrointestinal injury. Methods: Adult male wistar rats...

Background: This study was designed to investigate the effects of immature carob pods aqueous extract (ICPAE) on intestinal glucose absorption in vitro and in vivo using an oral glucose tolerance test as well as the potential anti-diabetic effect in alloxan-induced diabetic rats. Oral glucose tolerance test (OGTT) was carried by administering of g...

The aim of the present study is to investigate the potential protective role of Ceratonia siliqua L. against dextran sodium sulfate (DSS)-induced oxidative damage and inflammation in liver and kidney of rats. The hepatotoxicity and nephrotoxicity were induced in rats by oral administration of synthetic DSS (5%) in the drinking water for over 7 days...

Oxidative stress occurs in diabetic patients and experimental models of diabetes. The antioxidant property of Pelargonium graveolens essential oil (PGEO) might have a beneficial effect in ameliorating the disease. In this context, the aim of the present study was to investigate the effects of PGEO on oxidative stress in alloxan-induced diabetes in...

The aim of the study was to evaluate the bioavailability and clinical benefits of oral new formulation (HB12 ) of Hydroxocobalamin (Hdrx) with Hibiscus sabdariffa (HS). First, in an observational study, a cohort of 30 vitamin B12 deficient patients (vit B12 < 200 pg/ml), with neurologic symptoms received oral fixed-dose of Hdrx containing 15 mg Hdr...

The current study was performed to assess the effects of carob pod aqueous extracts (CPAE, pulp, seeds or mixture) on gastrointestinal transit (GIT) and intestinal epithelium permeability. In this aspect, male rats fasted for 16 hours were used and given by oral administration NaCl (0.9%, control group) or various doses of CPAE (50, 100 and 200 mg...