Kaat Hebbrecht

Kaat Hebbrecht
KU Leuven | ku leuven

MD, psychiatry trainee, PhD student

About

18
Publications
1,685
Reads
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70
Citations
Citations since 2016
18 Research Items
69 Citations
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2016201720182019202020212022051015202530
2016201720182019202020212022051015202530

Publications

Publications (18)
Article
Cognitive function during an ECT care pathway is mainly investigated at the group level by analyzing mean cognitive test scores over time. However, there are important inter-individual differences, with some patients experiencing residual invalidating cognitive deficits. This study provides a nuanced examination of cognitive functioning during and...
Article
The risk of relapse following successful acute-phase treatment of late-life depression (LLD), including electroconvulsive therapy (ECT), is substantial. In order to improve reliable prediction of individuals' risk of relapse, we assessed the association between individual residual symptoms following a successful acute course of ECT for LLD and rela...
Article
Full-text available
Introduction: Chronic low-grade inflammation is suggested to play a pathophysiological role in bipolar disorder (BD) and its related cognitive dysfunctions. Although kynurenine (KYN) pathway metabolites are key inflammatory mediators, studies investigating the association between KYN metabolism and cognition in BD are scarce. We aimed to explore t...
Article
Full-text available
Objective Tryptophan catabolites (TRYCATs) are implicated in the pathophysiology of mood disorders by mediating immune-inflammation and neurodegenerative processes. We performed a meta-analysis of TRYCAT levels in bipolar disorder (BD) patients compared to healthy controls. Methods A systematic literature search in seven electronic databases (PubM...
Article
Full-text available
Background Major depressive disorder (MDD) shows large heterogeneity of symptoms between patients, but within patients, particular symptom clusters may show similar trajectories. While symptom clusters and networks have mostly been studied using cross-sectional designs, temporal dynamics of symptoms within patients may yield information that facili...
Article
Full-text available
Objective: The Montreal Cognitive Assessment (MoCA) is a sensitive and clinically practical test but its usefulness in measuring long-term cognitive effects of ECT is unclear. Using the MoCA, we investigated short- and long-term global cognitive change in ECT-treated patients with a Major Depressive Episode (MDE). Methods: We included 65 consecu...
Article
Full-text available
Background: Although differences in symptom profiles and outcome between depressive patients with an underlying major depressive disorder (MDD) and bipolar depression (BD) have been reported, studies with sequential short-interval assessments in a real-life inpatient setting are scarce. Objectives: To examine potential differences in symptom pro...
Poster
Full-text available
Corresponding author. Background and aims.-Many studies investigated differences in symptom profile and outcome between major depressive disorder(MDD) and bipolar depression (BD). However, studies with short-interval assessments in real-life inpatients settings are scarce. Our aim was to study the differences in baseline symptom profile and time to...
Preprint
Full-text available
Vergeleken met de algemene bevolking zouden patiënten na een opname in een psychiatrisch ziekenhuis een hoger risico hebben op verschillende ongunstige gebeurtenissen. Voorgaande studies vertonen methodologische beperkingen omtrent inclusie van stoornissen en uitkomstmaten. Onderzoeksvraag: In welke mate hebben mensen na een eerste opname in een p...
Article
Full-text available
ACHTERGROND De opleiding tot psychiater in Vlaanderen bestaat uit 5 jaar klinische stage in combinatie met een theoretische opleiding. De opleiding wordt universitair georganiseerd zonder gecentraliseerde financiering van de arts-specialist in opleiding (aso). Recent heeft de overheid de opleiders verplicht om psychotherapie te integreren in de opl...
Article
Full-text available
Background: In Belgium, psychiatry training is still organised by each university separately without a structured centralised funding plan for the financing of psychiatry trainees. Recently, the government has obliged trainers to integrate psychotherapy into psychiatry training. AIM: An overview is provided of the current training in psychiatry in...
Conference Paper
Transcranial magnetic stimulation (TMS) is an accepted, evidence-based treatment option for the treatment of depressive episodes in patients with major depressive disorder. However, due to the lack of TMS studies in bipolar depressed patients, the antidepressant efficacy in bipolar depression remains unclear. This study therefore aims to investigat...
Article
Objective To investigate the potential role of the Maudsley Staging Method (MSM) in the prediction of electroconvulsive therapy (ECT) outcome in severely depressed adults. Method Between August 2015 and August 2017, 73 consecutive patients with a major depressive episode (DSM‐IV‐TR) scheduled for ECT were recruited. Prior to their first ECT sessio...
Article
Introduction Bipolar disorder is a severe, chronic psychiatric disorder with a need for long-term treatment. Patient non-adherence is frequent and poses a major problem in maintenance therapy. Aripiprazole once-monthly long-acting injectable (AOM LAI) is a recently FDA approved treatment option for maintenance therapy that could be of great value....
Article
Full-text available
Introduction: A seasonal affective disorder (SAD) is a subtype of unipolar and bipolar major depressive disorders. It is characterized by its annual recurrence of depressive episodes at a particular season, mostly seen in winter and is responsible for 10–20% of the prevalence of major depressive disorders. Some pathophysiological hypotheses, such a...

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Projects

Projects (4)
Project
To investigate the effect of continuous theta burst stimulation (cTBS) TMS to the right DLPFC, as an add-on treatment, on depressive symptoms, cognitive symptoms and psychomotor symptoms in a sample of bipolar depressed patients (type I/II).
Project
In this project, we evaluate the role of immune dysregulation in mood and psychotic disorders, by use of peripheral markers (cytokines, kynurenine pathway metabolites) as well as central markers (TSPO tracers). We evaluate the transdiagnostical role of these abnormalities and want to evaluate the natural evolution throughout the illness. Currently, we also focus on scrutinizing the immunological role of COVID-19 in the onset of psychiatric illness.