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Publications
Publications (28)
Purpose:
To present an evidence-based guideline for non-vital pulp therapies due to deep caries or trauma in primary teeth.
Methods:
The authors, working with the American Academy of Pediatric Dentistry, conducted a systematic review/meta-analysis for studies on non-vital primary teeth resulting from trauma or caries and used the GRADE approach to...
Purpose:
The purpose of this systematic review and meta-analysis was to assess success rates for nonvital treatment in primary teeth for caries/trauma.
Methods:
Databases were searched between 1960 and 2020 for randomized controlled trials, cohorts, case series, and in vitro studies. The primary outcome was overall success (clinical and radiograph...
Purpose:
This systematic review and meta-analysis assessed outcomes in primary teeth for the vital pulp therapy (VPT) options of indirect pulp therapy (IPT), direct pulp capping (DPC), and pulpotomy after a minimum of 12 months to determine whether one VPT was superior.
Methods:
The following databases were searched from 1960 to September 2016:...
The conservation of primary teeth in form and function until their normal exfoliation is one of the fundamental objectives of pediatric dentistry. Not only is it important for normal speech, development, and self-esteem, it is the best way to preserve arch length and avoid secondary issues such as space loss and permanent tooth impaction.
Purpose:
The purpose of this protocol for a systematic review of randomized controlled trials of primary tooth vital pulp therapy is to describe the reasoning and need for the review, the objectives of the review, and the methodology that will be used to analyse data from the included studies. Publication of a systematic review protocol also helps...
To report the findings of a survey to determine the educational experiences, opinions and clinical practices relative to the use of coolant during cavity preparation of pediatric dentist members of the American Academy of Pediatric Dentistry (AAPD) and to determine whether teaching policies influenced the type of coolant used in private practice.
F...
The purpose of this study was to provide reliability and criteria data on a newly defined parental cooperation scale (PCS) and in addition correlate between parent scores and their child's behavior in the dental setting.
244 parents accompanying their child to a dental visit were evaluated by two independent pediatric dentist evaluators. 150 parent...
To determine current teaching policies regarding the use of coolant type during tooth preparation with high-speed hand-pieces in pediatric dental residency programs in the US.
A 17-question survey was electronically mailed to 63 program directors with one follow-up. Multiple-choice questions asked about school and program teaching of cavity prepara...
The purpose of this study was to identify factors that may influence current American Academy of Pediatric Dentistry (AAPD) members' definitions of a successful oral sedation.
Surveys were electronically mailed to all AAPD members with registered e-mail addresses, and printed surveys were sent via postal mail to all other members. The survey includ...
The purpose of this study was to evaluate the recall rate and caries experience of children seen under general anesthesia (GA) at The University of Iowa Hospitals and Clinics.
After a retrospective chart review, information from 217ASA (American Society of Anesthesiologists) 1 patients undergoing GA between 1998 and 2002 was gleaned regarding: (1)...
The purpose of this study was to compare the effectiveness of 5% sodium hypochlorite (NaOCl) to that of ferric sulfate (FeSO4) as a pulpotomy medicament in decayed primary molars.
Healthy subjects between 4 and 9 years with at least 2 primary molars needing pulpotomy consented to receive either NaOCl or FeSO4 and restoration with IRM base/stainless...
The purpose of this retrospective study was to evaluate the radiographic findings with formocresol and ferric sulfate pulpotomies in relation to early tooth loss.
Vital pulpotomies with either ferric sulfate or formocresol, performed by faculty members between 1992 and 2002 at The University of Iowa, were evaluated retrospectively. Radiographic cri...
The purpose of this retrospective study was to compare the effects of oral administration of a combination of chloral hydrate (CH) 25 mg/kg, hydroxyzine (H) 1 mg/kg, and meperidine (M) 1 mg/kg to midazolam 0.65 mg/kg using 50% nitrous oxide (N2O) on behavioral and physiological parameters of young children sedated for dental procedures. Factors ass...
Candidiasis is a significant cause of morbidity and mortality in immunosuppressed individuals. Currently, there are limited treatment options for this opportunistic infection and there have been many reports in the literature of increased resistance to treatment. There is evidence to suggest that phenotypic switching of Candida albicans may play a...
The purpose of this retrospective study was to examine different dosages of midazolam used alone or in combination with different dosages of meperidine for managing difficult young pediatric dental patients.
Patient records and sedation logs of 120 moderately to severely apprehensive/ uncooperative subjects, ages 24-48 mos, sedated in private pract...
Candida samples were taken over a period of 2 years from 54 human immunodeficiency virus (HIV)-positive asymptomatic subjects to
evaluate changes in yeast carriage, intensity of carriage, and genotype over time. Overall, we found that HIV-positive patients
with CD4+-cell counts of between 200 and 400/μl had significantly more yeast colonization tha...
The effects of cathelicidins against oral bacteria and clinically important oral yeasts are not known. We tested the susceptibilities
of Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum,Porphyromonas gingivalis, Streptococcus sanguis, Candida krusei, Candida tropicalis and Candida albicans to the following cathelicidins: FALL39, SMAP29...
Strains of Candida albicans obtained from human immunodeficiency virus (HIV)-positive individuals prior to their first episode of oral thrush were already in a high-frequency mode of switching and were far more resistant to a number of antifungal drugs than commensal isolates from healthy individuals. Switching in these isolates also had profound e...
Using a strategy to clone large genomic sequences containing repetitive elements from the infectious yeast Candida dubliniensis, the three unrelated sequences Cd1, Cd24, and Cd25, with respective molecular sizes of 15,500, 10,000, and 16,000 bp, were cloned and analyzed for their efficacy as DNA fingerprinting probes. Each generated a complex South...
Candida colonization of the oral cavity increases in the elderly. A major predisposing condition is denture use, which also increases in the elderly. To test whether the increase in colonization is age-related in a fashion independent of denture use, we analyzed the frequency (incidence) of carriage, the intensity of carriage, the multiplicity of s...
While the age of the host has been suggested as a determining factor in yeast carriage, no studies in which the genetic relatedness of isolates has been assessed in combination with the frequency and intensity of carriage as a function of host age have been performed in a single geographical locale and over a short time window. Therefore, by using...
To compare and contrast antibacterial activities of a baking soda-containing dentifrice, Arm and Hammer Dental Care (AHDC) with two fluoride dentifrices without baking soda (Crest and Colgate).
A biphasic approach was taken, utilizing newly-developed laboratory model systems to: (1) assess the activity of brief exposure to dentifrices on single and...
Candida albicans and related species switch frequently and reversibly between a number of general phenotypes usually discriminated by colony morphology and in some cases by cellular morphology. Switching has been demonstrated to affect a number of physiologic and architectural characteristics of single cells including most of the putative virulence...
Cells of the laboratory strain 3153A of Candida albicans can be stimulated to undergo high-frequency phenotypic switching by a low dose of UV. We have compared the adhesive properties of cells exhibiting the basic original smooth (o-smooth) phenotype and three switch phenotypes (star, irregular wrinkle, and revertant smooth) to buccal epithelium an...
Candida colonization oftheoral cavity increases intheelderly. A majorpredisposing condition isdenture use,whichalso increases intheelderly. Totest whether the increase incolonization isage-related inafashion indepen- dentofdenture use, weanalyzed thefrequency (incidence) ofcarriage, theintensity ofcarriage, themultiplicity of species, andthegenetic...
Purpose: Phenotypic switching is a reversible and heritable characteristic that provides C. albicans with the capacity to rapidly adapt to changes in its environment. The purpose of this study was to assess the ability of different switch phenotypes of a single strain of Candida albicans to colonize the oral mucosa of immunosuppressed Balb/c mice....
