Ka Hou Chu

Ka Hou Chu
The Chinese University of Hong Kong | CUHK · School of Life Sciences

AB, University of California at Berkeley, PhD, MIT/WHOI Joint Program
Visiting Professor, Education University of Hong Kong; Visiting Scholar, Hong Kong University of Science and Technology

About

596
Publications
82,242
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8,586
Citations
Additional affiliations
January 1979 - April 1979
Harvard University
Position
  • Professor
September 1977 - December 1983
Woods Hole Oceanographic Institution
Position
  • PhD Student

Publications

Publications (596)
Article
Full-text available
The Thoracotremata is a large and successful group of “true” crabs (Decapoda, Brachyura, Eubrachyura) with a great diversity of lifestyles and well-known intertidal representatives. The group represents the largest brachyuran radiation into terrestrial and semi-terrestrial environments and comprises multiple lineages of obligate symbiotic species....
Article
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Cryptic biological invasions are largely unrecognised, leading to an underestimation of the number of invading taxa and their potential impacts. The Chinese mitten crab, Eriocheir sinensis, is a highly invasive species with serious economic and ecological impacts in Europe. Recently, mitochondrial DNA (mtDNA) of the Japanese mitten crab, E. japonic...
Article
Background: Clinical management of shrimp allergy is hampered by the lack of accurate tests. Molecular diagnosis has been shown to more accurately reflect clinical reactivity but the full spectrum of shrimp allergens and their clinical relevance are yet to be established. We therefore sought to comprehend the allergen repertoire of shrimp, investi...
Article
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The Hong Kong oyster Magallana hongkongensis, previously known as Crassostrea hongkongensis, is a true oyster species native to the estuarine-coast of the Pearl River Delta in southern China. The species—with scientific, ecological, cultural, and nutritional importance—has been farmed for hundreds of years. However, there is only limited informatio...
Article
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The spiny lobster Panulirus argus is an ecologically relevant species in shallow water coral reefs and the target of the most lucrative fishery in the greater Caribbean region. This study reports, for the first time, the nervous system transcriptome of the Caribbean spiny lobster Panulirus argus assembled from short Illumina 150 bp PE raw reads. A...
Article
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Due to the lack of visible barriers to gene flow, it was a long-standing assumption that marine coastal species are widely distributed, until molecular studies revealed geographically structured intraspecific genetic differentiation in many taxa. Historical events of sea level changes during glacial periods are known to have triggered sequential di...
Article
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Gut microbiota have long attracted the interest of scientists due to their profound impact on the well-being of animals. A non-random pattern of microbial assembly that results in a parallelism between host phylogeny and microbial similarity is described as phylosymbiosis. Phylosymbiosis has been consistently observed in different clades of animal...
Article
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Cadmium (Cd) is a common pollutant in the aquatic environment, which puts the health and safety of aquatic organisms and humans at risk. In the present study, the freshwater crab Sinopotamon henanense was exposed to Cd (0, 50, 100, and 500 μg·L⁻¹) for 14 d (0–14th d), followed by 21 d (14–35th d) of depuration. The changes in Cd bioaccumulation, mi...
Article
One of the most notable evolutionary innovations of marine invertebrates is the snapping claw of alpheid shrimps (Alpheidae), capable of generating a powerful water jet and a shock wave, used for defense, aggression, excavation, and communication. Evolutionary analysis of this character complex requires the study of a suite of complementary traits...
Article
Understanding population connectivity is crucial for effective conservation management. Schemes for speculating potential connectivity patterns over large to medium geographic scales using riverscape and life history features have been developed, but whether they are still applicable over fine scales has rarely been examined. Caridina shrimps (Fami...
Article
Since their discovery, the systematic placement of two shrimp taxa, Amphionides and Procarididae, has been controversial. Both exhibit primitive features yet also possessing caridean traits. Amphionides was initially classified as a monotypic genus in the order Amphionidacea, while Procarididae was the only family in the superfamily Procaridoidea....
Article
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Background The complex life cycle of the coconut crab, Birgus latro , begins when an obligate terrestrial adult female visits the intertidal to hatch zoea larvae into the surf. After drifting for several weeks in the ocean, the post-larval glaucothoes settle in the shallow subtidal zone, undergo metamorphosis, and the early juveniles then subsequen...
Article
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The infraorder Brachyura (true or short-tailed crabs) represents a successful group of marine invertebrates yet with limited genomic resources. Here we report a chromosome-anchored reference genome and transcriptomes of the Chinese mitten crab Eriocheir sinensis, a catadromous crab and invasive species with wide environmental tolerance, strong osmo...
Article
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Osmoregulation and osmoconformation are two mechanisms through which aquatic animals adapt to salinity fluctuations. The euryhaline crab Scylla paramamosain, being both an osmoconformer and osmoregulator, is an excellent model organism to investigate salinity adaptation mechanisms in brachyurans. In the present study, we used transcriptomic and pro...
Chapter
Food allergy has been rising in prevalence over the last two decades, affecting more than 10% of the world population. Current management of IgE-mediated food allergy relies on avoidance and rescue medications; research into treatments that are safer and providing guaranteed and durable curative effects is, therefore, essential. T-cell epitope-base...
Article
Background: The diagnosis of shellfish allergy currently relies on patient history, skin prick test (SPT) and serum specific IgE (sIgE) quantification. These methods lack sufficient diagnostic accuracy, while the gold standard of oral food challenges are risky and burdensome. Markers of reactivity and severity of allergic reactions to shellfish wi...
Article
We present a full description and analysis of the complete mitochondrial genome of a Pacific Ocean specimen of the coconut crab Birgus latro (Linnaeus, 1767), the largest extant terrestrial arthropod in the world. Our de novo-assembled mitogenome has a massive 16,161 times organelle read coverage, a length of 16,411 bp, contains 22 tDNAs (20 unique...
Article
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The phylum Cnidaria represents a close outgroup to Bilateria and includes familiar animals including sea anemones, corals, hydroids, and jellyfish. Here we report genome sequencing and assembly for true jellyfish Sanderia malayensis and Rhopilema esculentum. The homeobox gene clusters are characterised by interdigitation of Hox, NK, and Hox-like ge...
Article
A striking feature of micro-RNAs is that they are often clustered in the genomes of animals. The functional and evolutionary consequences of this clustering remain obscure. Here, we investigated a micro-RNA cluster miR-6/5/4/286/3/309 that is conserved across drosophilid lineages. Small RNA sequencing revealed expression of this micro-RNA cluster i...
Article
This study investigates the properties of Scy p 9 in mud crab (Scylla paramamosain). The gene sequence of filamin C obtain from crabs, which is termed Scy p 9 contains a 2544-bp open reading frame and encodes 848 amino acid residues. Recombinant Scy p 9 (rScy p 9) is expressed in Escherichia coli, it exhibited tertiary structure changes, and the Ig...
Article
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Shellfish allergy caused by undesirable immunological responses upon ingestion of crustaceans and mollusks is a common cause of food allergy, especially in the Asia-Pacific region. While the prevalence of shellfish allergy is increasing, the mainstay of clinical diagnosis for these patients includes extract-based skin prick test and specific IgE me...
Article
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Background: Decapods are an order of crustaceans which includes shrimps, crabs, lobsters and crayfish. They occur worldwide and are of great scientific interest as well as being of ecological and economic importance in fisheries and aquaculture. However, our knowledge of their biology mainly comes from the group which is most closely related to cr...
Article
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Shellfish allergy is one of the most common food allergies, with tropomyosin as the major cross-reactive allergen. However, no allergen-specific immunotherapy is clinically available. Recently, we designed two shrimp hypoallergens MEM49 and MED171. This study aimed to examine and compare the efficacy of the MEM49- and MED171-based DNA vaccines (pME...
Article
Freshwater fauna is highly threatened owing to various human disturbances and a lack of natural connectivity among populations. Immediate conservation actions are vital to save freshwater wildlife from population decline and extinction. Given the paucity of resources, conservation prioritization is essential to guide resource allocation for effecti...
Article
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Food allergy imposes a severe global health burden, and thus, there is a dire need for safe and effective treatments. Allergen-specific immunotherapy (AIT) is currently the only approach to restore immune tolerance through administrating increasing doses of allergen extracts. Unfortunately, the development of AIT for food allergies has been impeded...
Article
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Emerging evidence suggests that the increasing prevalence of food allergies is associated with compositional and functional changes in our gut microbiota. Microbiota-host interactions play a key role in regulating the immune system. Development of a healthy gut microbiota and immune system occurs early in life and is largely shaped by exposure to m...
Preprint
Full-text available
A striking feature of microRNAs is that they are often clustered in the genomes of animals. The functional and evolutionary consequences of this clustering remain obscure. Here, we investigated a microRNA cluster miR-6/5/4/286/3/309 that arose and conserved in the drosophilid lineages. Small RNA sequencing revealed expression of this microRNA clust...
Article
The clam Coelomactra antiquata (Spengler, 1802) is one of the most economically important marine bivalves in China. Previous genetic analysis shows that C. antiquata possibly consists of two cryptic species, a northern and a southern lineage. Some differences between the two lineages are observed in their morphology and fitness in aquaculture. Howe...
Article
Acorn barnacles are important model species in researches on intertidal ecology, larval development and biofouling. At present, with the development of mitochondrial genomics, it is helpful to understand the phylogenetic relationship from the mitogenomic level. The complete mitochondrial genome of Chthamalus challengeri was presented. The genome is...
Article
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Recent fossil calibrated molecular phylogenies have revealed that the Brachyura underwent rapid radiation during the Cretaceous and Early Tertiary, resulting in many early diverging lineages separated by short internodes that remain difficult to resolve. Here we present the first phylogenomic analyses of Brachyura using transcriptome data from 30 b...
Article
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Crustacea, the subphylum of Arthropoda which dominates the aquatic environment, is of major importance in ecology and fisheries. Here we report the genome sequence of the Pacific white shrimp Litopenaeus vannamei, covering ~1.66 Gb (scaffold N50 605.56 Kb) with 25,596 protein-coding genes and a high proportion of simple sequence repeats (>23.93%)....
Article
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Macrobrachium rosenbergii de Man, 1879 (Caridea: Palaemonidae), commonly referred to as giant freshwater prawn, is commercially important worldwide, and a primary inland cultured species. The first complete mitochondrial genome of M. rosenbergii from China (CN) was sequenced and compared with that in Indonesia (ID) in this study. The results show t...
Article
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Fine-scale genetic studies are essential for understanding population connectivity and formulating appropriate conservation measures for freshwater inhabitants. Despite their significance, such studies remain relatively limited in South China and Asia in general. We examined the genetic structure of the predaceous chub Parazacco spilurus in Hong Ko...
Article
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Background Understanding the factors shaping population genetic structure is important for evolutionary considerations as well as for management and conservation. While studies have revealed the importance of palaeogeographic changes in shaping phylogeographic patterns in multiple marine fauna, the role of reproductive behaviour is rarely considere...
Article
Unlike most of the freshwater gastropod families, the family Ampullariidae includes members that exhibit both underwater and aerial oviposition, making it an ideal model for understanding mechanisms underlying the evolutionary transition from water to land. We applied SDS-PAGE and LC-MS/MS to analyse the proteome of the egg perivitelline fluid (PVF...
Article
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Eukaryotic nucleic acid binding protein database (ENPD, http://qinlab.sls.cuhk.edu.hk/ENPD/) is a library of nucleic acid binding proteins (NBPs) and their functional information. NBPs such as DNA binding proteins (DBPs), RNA binding proteins (RBPs), and DNA and RNA binding proteins (DRBPs) are involved in every stage of gene regulation through the...
Article
Aim The high species richness of the Indo‐Australian Archipelago (IAA) marine biodiversity hotspot has been attributed to three competing hypotheses: Centre of Origin/Centre of Overlap/Centre of Accumulation. While most phylogeographic studies testing these hypotheses have focused on marine fishes, we provide a new perspective on this evolutionary...
Article
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Seafood allergy is a hypersensitive disorder with increasing prevalence worldwide. Effective and accurate diagnostic workup for seafood allergy is essential for clinicians and patients. Parvalbumin and tropomyosin are the most common fish and shellfish allergens, respectively. The diagnosis of seafood allergies is complicated by cross-reactivity am...
Article
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Bacteria, archaea and fungi play crucial roles in wetland biogeochemical processes. However, little is known about their community structure, dynamics and interactions in subtropical coastal wetlands. Here, we examined communities of the three kingdoms in mangrove and mudflat sediments of a subtropical coastal wetland using Ion Torrent amplicon seq...
Article
Citation: Chow LH, Ma KY, Hui JHL, Chu KH. 2018. Isolation and characterization of polymorphic microsatellite loci for Caridina cantonensis and transferability across eight confamilial species (Atyidae, Decapoda). Zool Stud 57:19. (2018) Caridina cantonensis is a common freshwater shrimp found in Guangdong Province, China. The species is landlocked...
Article
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The complete mitochondrial genome of Tesseropora rosea (Tetraclitidae) was presented. The genome is a circular molecule of 15,330 bp, which encodes 13 PCGs, two rRNA genes, and 22 tRNA genes. The length of all non-coding regions is 768 bp, with the longest one speculated as the control region (255 bp), which is located between 12S rRNA and trnK. Ph...
Article
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The complete mitochondrial genome of the intertidal barnacle Tetraclita rufotincta Pilsbry, 1916 (Crustacea: Maxillopoda: Sessilia) is presented. The genome is a circular molecule of 15,236 bp, which encodes a set of 37 typical metazoan mitochondrial genes. All non-coding regions are 438 bp in length, with the longest one speculated as the control...
Article
Arthropods comprise the majority of all described animal species, and understanding their evolution is a central question in biology. Their developmental processes are under the precise control of distinct hormonal regulators, including the sesquiterpenoids juvenile hormone (JH) and methyl farnesoate. The control of the synthesis and mode of action...