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Citations since 2016
1 Research Item
The metastable and stable equilibria during the precipitation of calcium phosphates in three biomimetic systems, namely SBFc-CaCl2–K2HPO4–H2O, SBFc-CaCl2–MgCl2–K2HPO4–H2O and SBFc-CaCl2–ZnCl2–K2HPO4–H2O, where SBFc denotes a conventional simulated body fluid, were modeled by a thermodynamic approach (ion-association model, computer program PHREEQCI...
Biomimetic approach and subsequent high-temperature treatment were used to synthesize ion modified calcium phosphate -fine powders. Thus, using Simulated Body Fluid (SBF) as an ion modifier, a bi-phase mixture of ion modified beta-tricalcium phosphate and hydroxyapatite (beta-TCP + HA) was prepared. The use of SBF electrolyte solution enriched with...
The effect of biomimetic synthesis method, reaction medium and further precursor treatments on the chemical and phase composition, crystal size and morphology of calcium phosphates was examined. Nanosized calcium phosphate precursors were biomimetically precipitated by the method of continuous precipitation in three types of reaction media at pH 8:...
Two types of calcium phosphate materials prospective as bone implants were prepared in the shape of granules and their biochemical behavior was tested by in vivo studies: (i) composite materials consisting of gelatin and bi-phase ion modified calcium phosphate Mg,Zn-(HA + β-TCP); and (ii) ceramics of ion modified calcium phosphate Mg,Zn-(HA + β-TCP...
Biochemical blood indices (Ca, P, total and bone alkaline phosphatase and osteocalcin) in rats with implanted in tibia hydroxyapatite-gelatine-xanthan gum composite materials were studied. Two types of composites with high temperature treated ceramic powder and additionally high energy treated ceramic powder were applied. The result showed reductio...
Powders of magnesium-modified as well as zinc-modified calcium phosphates (Me-β-TCP and HA) with a (Ca(2+)+Mg(2+)+Zn(2+)+Na(+)+K(+))/P ratio of 1.3-1.4 and various Me(2+)/(Me(2+)+Ca(2+)) ratios (from 0.005 to 0.16) were prepared in biomimetic electrolyte systems at pH 8, mother liquid maturation and further syntering at 600-1000°C. Some differences...
Aim of the project The main goal of the project is to obtain fundamental scientific data and to find out some regularities of the relationship between composition – structure – interface transitions – mechanical properties – biological properties and to use them as a scientific basis for the design of a large group of functional composite organic and composite polymer-reinforced calcium phosphate pastes (cements and injection suspensions) with taylored properties for their use in medicine (bone surgery and rehabilitation) and dental medicine. In the project offers an innovative approach in order to enhance the inter-penetrating ability between implant and bone/dentin through the introduction of polymer nanogels in the composition of the developed composite calcium phosphate cements