K. Navaneetha

Nalla Narasimha Reddy educational society's group of institutions · School of Pharmacy

Tablet Coating is a process by which an essentially dry, outer layer of coating material is applied to the surface of a dosage form in order to confer specific benefits over uncoated variety. The advantages of tablet coating are taste masking, odor masking, physical and chemical protection, protection of the drug from the gastric environment etc. T...

Elvitegravir is an antiretroviral drug which belongs to BCS class-II of Biopharmaceutics classification. In the present work an attempt has been made to prepare solid dispersion of elvitegravir by using polyethylene glycol (PEG) and then compressing it along with suitable excipients to develop fast disintegrating tablets. Preparation of solid dispe...

The aim of the present work is to prepare and evaluate the sustained release nanoparticles of Linagliptin an anti diabetic in order to improve its therapeutic effect and reducing dosing frequency and its dose related side effects. Linagliptin containing Polycaprolactone and Polyvinyl Alcohol (PVA) nanoparticles were prepared by solvent evaporation...

Cyclobenzaprine Hydrochloride is a centrally acting muscle relaxant which is mostly available in the form of tablets and capsules. The present aim of the study was to develop a sustained release formulation of cyclobenzaprine Hydrochloride pellets using powder layering technique. Nine different formulations of pellets were prepared by using differe...

The purpose of the present investigation is to formulate and evaluate Lercanidipine pulsatile drug delivery system by press coating method. The inner core tablets were prepared by using direct compression method by using cross-carmellose sodium (Ac-Di-Sol), sodium starch glycolate, crospovidone as super disintegrants. The drug polymer interaction w...

The present work is aimed to develop a sustain release microspheres for sitagliptin, a antihyperglycemic drug by employing polymers such as albumin and chitosan. These polymers have been taken in various proportions and the effect of these polymers on the drug release pattern is studied. Total of nine formulations have been developed and were evalu...

In the present work, bioadhesive microspheres of Methylprednisolone were formulated using Sodium alginate along with Methocel, Carbopol 971, and pectin as copolymers. Methylprednisolone is a synthetic glucocorticoid or corticosteroid drug. The results of this investigation indicate that ionic cross linking technique Ionotropic gelation method can b...

In the present research work, topical gel composed of solid lipid nanoparticles of monobenzone was prepared to produce sustain release of monobenzone to produce whitening effect. Initially solid lipid nanoparticles were prepared by double emulsification solvent evaporation method by using lecithin. PVA and PEG-600 are used as emulsifiers. The prepa...

A. Abstract: Ziprasidone Hydrochloride (HCl) is an antipsychotic drug which is mostly available in the form of tablets and capsules.

Cefuroxime is a broad spectrum cephalosporin antibiotic mainly absorbed from the gastrointestinal tract and has the bioavailability of the drug is 30% to 40% when taken on fasting and 50 to 60 % when taken with food. Thus to enhance the bioavailability and to obtain control release of cefuroxime axetil, osmotic tablets were prepared. These formulat...

The present study was aimed to develop a formulation which provides dual therapy for the treatment of peptic ulcer. Dual therapy goal was attained by preparing a bilayer tablet containing antimicrobial agent amoxicillin and anti-gastric acid secretory agent famotidine for the effective treatment of H. pylori associated gastric/duodenal ulcer, in an...

Candesartan cilexetil is prodrug of candesartan. It is a non-peptide angiotensin П type-І (ATІ) receptor antagonist which is used in the treatment of hypertension and congestive heart failure. It was formulated as an orodispersible tablet as there is a need to develop a formulation for this drug which overcomes problem such as difficulty in swallow...

In the present work, an attempt has been made to develop mouth dissolving tablets of Mosapride citrate by using new generation super disintegrants beta cyclo dextrin and Eudragit E100. Mosapride is an antiulcer and antisecretory drug, which accelerates gastric emptying, and is used for the treatment of acid reflux, functional dyspepsia. Total of 10...

Venlafaxine is an antidepressant which belongs to the class of Serotonin-nor epinephrine reuptake inhibitor (SNRI). In the present study hydrophilic bioadhesive buccal tablets of venlafaxine were formulated by using different polymers like Carbopol 934 and carbopol 940 and found that these can be successfully employed as a bioadhesive controlled re...

The present research work was carried out with the aim to prepare and evaluate sustain release pellets of Ambroxol HCl, a drug which is used as mucolytic agent. The basic goal is to sustain the drug release upto 24hours. Pellets have been prepared by Wurster process employing different viscosity grades of ethyl cellulose as polymer for sustain drug...

The present research work is aimed to design oral twice a daily sustained release matrix tablets of Mebeverine hydrochloride 135mg, used for treating or preventing spasmodic conditions of the lower gastrointestinal tract which can release the drug for 10 to 12 hours. The tablets were prepared by the Wet granulation method using varying concentratio...

The purpose of this research work was to develop and evaluate dispersible tablets of Olmesartan medoxomil employing different ratios of hydrophilic polymers by direct compression method. The main objective is to avoid first pass effect and to improve bioavailability of Olmesartan medoxomil which is used in the treatment of hypertension. The physico...

Objective: Sustained release tablets of ramipril were prepared in order to increase the half life (3 hours) of the drug and to reduce the adverse events associated with ramipril, a drug used in treatment of hypertension. Methods: The tablets were prepared by direct compression method and evaluated for various parameters. HPMC K15, HPMC E15 and HPMC...

The present investigation of work is to prepare floating tablets of Ciprofloxacin Hcl which is an acidic drug and is primarily absorbed in stomach. The bioavailability of Ciprofloxacin is 69% and its half life is 4 hours. Thus formulating it into floating tablets can enhance the bioavailability. Ciprofloxacin floating tablets were prepared by using...

Dasatinib is a selective Tyrosine Kinase Inhibitor (TKI) used in treatment of chronic myeloid leukemia (CML) and acute myeloid leukemia (AML). Dasatinib have become first line drug in the pharmacotherapy of patients with CML. This is because the drug possesses tolerability and safety advantages over the other Tyrosine Kinase Inhibitors. Tablets of...

The present study was aimed to formulate and evaluate fast dissolving oral films of Zolmitriptan using sodium alginate, xanthan gum and sodium starch glycolate, guar gum. The suitable plasticizer and its concentration were selected on the basis of flexibility, tensile strength and stickiness of the film. The films are prepared by solvent casting me...

The aim of this study is to develop a novel liquid-solid technique to enhance the dissolution rate of poorly water soluble drug of candesartan, which is a BCS class II drug. The technique is based upon the admixture of drug loaded solutions (or) liquid drug with appropriate carrier and coating materials to convert into acceptably flowing and compre...

Pulsatile drug delivery systems are developed to deliver drug according to circadian behavior of diseases. This means that these systems will deliver drug at time when disease display it"s most morbid and mortal state within a circadian cycle (24 hrs). The product follow a sigmoidal drug release profile characterized by a time period of no release...

Indian pharma industry has been making tremendous progress not only in creation of excellent infrastructure but also attending to the global needs of the supply of APIs as well as quality medicines in addition to entering into growing fields of contract research and manufacturing and clinical trials. Like most chemical industries,the Pharma industr...

In the present work, fast dissolving tablets of Losartan Potassium were prepared by mass extrusion method. As precision of dosing and patient's compliance become important prerequisites for a long-term treatment, there is a need to develop a formulation for Losartan Potassium which overcomes the problems such as difficulty in swallowing, inconvenie...

A new series of benzotriazole aldehyde and ketone derivatives were prepared starting from ortho-phenyl di amine (OPDA) in five steps which includes dehydration, cyclization,acetylation, reaction with hydrazine hydrate and finally reacting with aromatic aldehydes oraromatic ketones groups. All these synthesized compounds were evaluated for anti-conv...

The purpose of this study is to formulate a controlled release matrix tablet of simvastatin a drug which is used in the treatment of dyslipidemia. Simvastatin has a short biological half life of 3 hours which necessitates multiple daily dosing hence a controlled release formulation of simvastatin is developed. Controlled release tablets of simvasta...

The present work aims to develop a bilayer dosage form containing one immediate release drug amlodipine besylate and another extended release drug metoprolol succinate. The immediate release layer was prepared by using micro crystalline cellulose, sodium starch glycolate, crosspovidone and dicalcium phosphate. The sustain release layer was prepared...

The objective of the current investigation is to reduce dosing frequency and improve patient compliance by designing and systematically evaluating mucoadhesive microspheres of valsartan. Frequent administration and variable low bioavailability (20-25%) after oral administration are problems of conventional dosage forms of valsartan. This can be att...

The objective of the present study is to develop a sustained release matrix tablets of Losartan potassium, an anti hypertensive drug. The sustained release tablets were prepared by wet granulation and formulated using different drug and polymer ratios, formulations such as F1 to F9. Natural polymers like Xanthan Gum (XG), Guar gum, Cellulose were u...

Bilayered Tablets are used to produce repeat action or prolonged action by separating physically or chemically incompatible ingredients. The present study was carried out to exploit the feasibility of using controlled delivery bilayered tablets of labetalol as an alternative carrier for targeting adrenergic receptors.This tablet contains two layers...

Gastroretentive floating tablets of atorvastatin calcium were formulated by using synthetic and natural polymers like HPMC and guar gum, Xanthan gum, karaya gum, aleovera powder respectively in order to enhance the bioavailability (14%) of atorvastatin calcium a drug used in the treatment of dyslipidemia and for the prevention of cardiovascular dis...

Gastroretentive floating drug delivery systems (GFDDS) of atenolol, an antihypertensive drug, with an oral bioavailability of only 50% (because of its poor absorption from lower gastrointestinal tract). Hydroxypropyl methyl cellulose of different viscosity grades (K4M and K100M) were used as the polymers and sodium bicarbonate as gas generating age...