K. Ch. Bergmann

K. Ch. Bergmann
Charité Universitätsmedizin Berlin | Charité · Department of Dermatology, Venerology and Allergology

MD, Prof. Dr. med

About

516
Publications
78,118
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
8,148
Citations
Additional affiliations
June 2005 - October 2015
Charité Research Organisation GmbH
Position
  • Senior Researcher

Publications

Publications (516)
Article
Full-text available
Antti Lauerma 76 | Susanne Lau 77 | Daniel Laune 78 | Michael Levin 79 | Desiree E Larenas-Linnemann 80 | Karin C Lodrup Carlsen 81,191 | Carlo Lombardi 82 | Olga M Lourenço 83 | Bassam Mahboub 84 | Hans-Jørgen Malling 85 | Patrick Manning 86 | Gailen D Marshall 87 | Erik Melén 88,188 | Eli O Meltzer 89 | Neven Miculinic 90 | Branislava Milenkovic...
Article
Background: Different treatments exist for allergic rhinitis (AR), including pharmacotherapy and allergen immunotherapy (AIT), but they have not been compared using direct patient data (i.e., "real-world data"). Objective: To compare AR pharmacological treatments on (i) daily symptoms, (ii) frequency of use in co-medication, (iii) visual analogu...
Article
Hintergrund: Vorratsmilben finden sich häufig in unserem täglichen Umfeld. Dennoch wird die Vorratsmilbenallergie oft in der allergologischen Diagnostik vernachlässigt und mögliche therapiebedürftige Allergien somit übersehen. Methodik: Die Handlungsempfehlungen wurden auf Grundlage einer Literaturanalyse im Zeitraum März 2021 bis August 2021 in Pu...
Article
Full-text available
The apple fruit (Malus domestica L. Borkh) is one of the most popular fruits worldwide. Beyond their beneficial properties, apples contain proteins that trigger allergic reactions in susceptible consumers. Mal d1 to d4 are allergens present in a variety of different isoforms in apples. In this study, we used proteomics to quantify all four Mal d pr...
Article
Background: Co-medication is common among patients with allergic rhinitis (AR), but its dimension and patterns are unknown. This is particularly relevant since AR is understood differently across European countries, as reflected by rhinitis-related search patterns in Google Trends. This study aims to assess AR co-medication and its regional patter...
Article
Full-text available
Background: Evidence regarding the effectiveness of allergen immunotherapy (AIT) on allergic rhinitis has been provided mostly by randomised controlled trials, with little data from real-life studies. Objective: To compare the reported control of allergic rhinitis symptoms in three groups of users of the MASK-air® app: those receiving sublingual...
Article
Full-text available
Purpose The long-term effects of targeted micronutrition with the holoBLG lozenge in house dust mite (HDM) allergic rhinoconjunctivitis (ARC) patients were evaluated at a follow-up visit in an allergen exposure chamber (AEC). Methods Patients who were supplemented for 3‑months with the holoBLG lozenge in a previous study with two controlled HDM-AE...
Article
Background Validated combined symptom-medication scores (CSMSs) are needed to investigate the effects of allergic rhinitis treatments. This study aimed to use real-life data from the MASK-air® app to generate and validate hypothesis- and data-driven CSMSs. Methods We used MASK-air® data to assess the concurrent validity, test-retest reliability an...
Article
In Deutschland leidet fast jeder siebte Erwachsene an medizinisch diagnostizierter allergischer Rhinitis, die häufig durch eine Reaktion auf Pollen verursacht wird. Wie in anderen europäischen Ländern gibt es auch in Deutschland ein nationales Pollenmessnetz (Stiftung Deutscher Polleninformationsdienst (PID)), das die Pollen- und Pilzsporenkonzentr...
Article
Full-text available
Airborne grass (Poaceae) pollen measurements are used in public warning systems to inform people about the risk of allergic symptoms. However, there is no consensus about which exact thresholds of pollen concentrations provoke the allergic symptoms. The aim of this study was to review the relevant scientific information on the relationship between...
Article
Full-text available
Zusammenfassung Äpfel besitzen mehrere Allergene, die beim Essen innerhalb von 5–10 min zu Symptomen im Mundbereich führen – und deshalb von Apfelallergikern nicht gegessen werden können. In Deutschland haben rund 7,5 Mio. Menschen spezifische Antikörper gegen das Hauptallergen (Mal d 1) in Äpfeln entwickelt und sind damit sensibilisiert. Mindesten...
Article
Full-text available
Allergic rhinoconjunctivitis (hay fever) is the most common chronic disease in all industrialized nations. Therapy consists essentially in the use of anti-allergic and anti-inflammatory drugs, which mostly show a good and quick effect. With allergen-specific immunotherapy, there is also a causal possibility of tolerance induction. There is currentl...
Article
Allergo Journal 2021;30(6):45-8In der Online-Version dieses Artikels hat der Autor Daniel Wildner, Techniker Krankenkasse, Hamburg, Deutschland, gefehlt. Dies wurde nun korrigiert.
Article
Background Allergic diseases pose a health problem worldwide. Pollen are widespread aeroallergens which can cause symptoms like shortness of breath, cough, itchy eyes or rhinitis. Apart from preventive measures and pharmacological treatment, also non-pharmacological interventions have been suggested to reduce symptoms. The objective of this work wa...
Article
Full-text available
Pollen threshold values used in public warning systems are intended to inform people of the risk of developing allergy symptoms. However, there is no consensus about which pollen concentrations provoke allergy symptoms. The aim of this systematic review was the evaluation of studies investigating the relationship between pollen concentrations (alde...
Article
More than 150 million people in Europe suffer from allergic diseases. Allergic respiratory diseases in the form of allergic rhinoconjunctivitis represent the most common allergic disease, with allergenic pollen representing the main elicitor. Although allergenic pollen is known and recognized as a health problem related to outdoor air, it is not co...
Article
Full-text available
Climate change impacts on the structure and function of ecosystems will worsen public health issues like allergic diseases. Birch trees (Betula spp.) are important sources of aeroallergens in Central and Northern Europe. Birches are vulnerable to climate change as these trees are sensitive to increased temperatures and summer droughts. This study a...
Article
Full-text available
Purpose of Review Atopy is defined as the genetic predisposition to react with type I allergic diseases such as food-, skin-, and respiratory allergies. Distinct molecular mechanisms have been described, including the known Th2 driven immune response. IL-17A (IL-17) is mainly produced by Th17 cells and belongs to the IL-17 family of cytokines, IL-1...
Article
Full-text available
Background Since the outbreak of the coronavirus pandemic, the population in Germany has been asked to wear face masks in public areas. The masks are accepted by the public. People with a pollen allergy have an interest in knowing whether masks can also provide protection against pollen and thus prevent symptoms even without medication. Method In...
Article
Full-text available
Background The vaccines against the coronavirus disease 2019 (COVID-19) approved in the European Union represent a decisive step in the fight against the pandemic. The application of these available vaccines to patients with pre-existing immunological conditions leads to a multitude of questions regarding efficacy, side effects and the necessary pa...
Article
Full-text available
Allergen immunotherapy (AIT), the gradually increasing repeated administration of high doses of allergens to allergic patients, offers the potential for immune tolerance against reactions to the natural exposures to specific allergens. AIT may lead to the long-lasting remission of allergic symptoms and is the only disease-modifying intervention in...
Article
Ziel: Evaluierung einer Lutschtablette zur Mikronährstoff-Supplementierung basierend auf dem Bauernhof-Effekt, bei Patienten mit Hausstaubmilben(HDM)- assoziierter allergischer Rhinokonjunktivitis (ARC) in einer standardisierten Allergen-Expositionskammer (AEC). Methoden: Vor (V1) und nach (V3) täglicher Supplementierung mit holo-BLG (BLG, β-Lactog...
Article
Hintergrund: Zur vorbeugenden Behandlung von COVID-19 (Coronaviruserkrankung 2019) wurden in einer beispiellosen weltweiten Forschungsanstrengung Sicherheit und Wirksamkeit neuer Impfstoffplattformen studiert, die noch nie zuvor am Menschen eingesetzt wurden. Weniger als ein Jahr nach der Entdeckung der SARS-CoV-2-Virussequenz (SARS-CoV-2, "severe...
Article
Full-text available
Background For the preventive treatment of the 2019 coronavirus disease (COVID-19) an unprecedented global research effort studied the safety and efficacy of new vaccine platforms that have not been previously used in humans. Less than one year after the discovery of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral sequence, t...
Article
Full-text available
Pollen exposure weakens the immunity against certain seasonal respiratory viruses by diminishing the antiviral interferon response. Here we investigate whether the same applies to the pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is sensitive to antiviral interferons, if infection waves coincide with high airborne pol...
Article
Background Although there are many asymptomatic patients, one of the problems of COVID‐19 is early recognition of the disease. COVID‐19 symptoms are polymorphic and may include upper respiratory symptoms. However, COVID‐19 symptoms may be mistaken withthe common cold or allergic rhinitis. An ARIA‐EAACI study group attempted to differentiate upper r...
Article
Full-text available
Climate change affects the reproductive life cycles of plants, including pollen production, which has consequences for allergic respiratory diseases. We examined climatic trends at eight locations in Bavaria, Southern Germany, with pollen time series of at least 10 years (up to 30 years in Munich). Climate change in Bavaria was characterized by a r...
Article
Allergische Atemwegserkrankungen werden von zahlreichen Faktoren ausgelöst und beeinflusst. Die Reduzierung des Rauchens ist die einfachste und eine der konkretesten Möglichkeiten der praktischen Prävention von Atemwegsinflammationen. Die WHO geht davon aus, dass 44% aller Asthmaerkrankungen umweltbedingt sind und durch geeignete Präventionsmaßnahm...
Article
Full-text available
Evaluation of a lozenge for targeted micronu-trition (holo-BLG), a new invention based on the farm effect, in house dust mite (HDM) allergic rhinocon-junctivitis (ARC) patients in a standardized allergen exposure chamber (AEC). Eligible HDM allergic patients were exposed to HDM raw material in an AEC for 120 min before (V1) and after (V3) 3 months...
Article
With the advent of biologicals, more and more therapeutics are available that specifically address specific switch points in the pathomechanism of immunologically dominated diseases. Thus, the focus of diagnostics and therapy (precision medicine) is more on the individual disease characteristics of the individual patient. Regarding the different ph...
Article
Full-text available
Background Allergic rhinitis/rhinoconjunctivitis is the most common immune disease worldwide, but still largely underestimated, underdiagnosed, and undertreated. Dysbiosis and reduced microbial diversity is linked to the development of allergies, and the immunomodulatory effects of pro- and prebiotics might be used to counteract microbiome dysbiosi...
Article
Full-text available
With the advent of biologicals, more and more therapeutics are available that specifically address specific switch points in the pathomechanism of immunologically dominated diseases. Thus, the focus of diagnostics and therapy (precision medicine) is more on the individual disease characteristics of the individual patient. Regarding the different ph...
Article
Full-text available
Background: Anti-IL-5 antibodies represent an established therapy for severe eosinophilic asthma (SEA), but some patients show inadequate response. The objective of this study was to assess the effects of a switch to anti-IL-5Rα therapy in patients with inadequate response to anti-IL-5 therapy. Methods: In this retrospective multi-centre, real-life...
Article
Background Pollen exposure has both acute and chronic detrimental effects on allergic asthma, but little is known about its wider effects on respiratory health. This is increasingly important knowledge as ambient pollen levels are changing with the changing global climate. Objective To assess associations of pollen exposure with lung function and...
Article
Full-text available
An amendment to this paper has been published and can be accessed via the original article.
Article
Full-text available
Large differences in COVID‐19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbag...
Article
Full-text available
Background Allergic rhinitis (AR) continues to increase in incidence and is the most common allergic disease. If abstention of the allergen triggering substances is not possible, allergen-specific immunotherapy (AIT) as causal treatment or a drug therapy with mast cell stabilizers, antihistamines (AHs), glucocorticoids (GCs), leukotriene (LT) recep...
Article
"An die Herausgeber Vor Kurzem (am 25. Juli 2019) hat die Europäische Union den Götterbaum (Ailanthus altissima [Mill.] Swingle, engl. Tree of Heaven) aus der Familie der Bittereschengewächse (Simaroubaceae) auf die „Liste invasiver gebietsfremder Arten von EU-weiter Bedeutung“ gesetzt. Damit steht dieser Baum unter Beobachtung und die Einfuhr, der...
Article
Full-text available
Zusammenfassung Das pollenassoziierte Orale Allergie-Syndrom (OAS) ist eine Sonderform der IgE-vermittelten Nahrungsmittelallergien. Besonders bei Birkenpollenallergikern kommt es aufgrund der Ähnlichkeit der Epitope des Apfelallergens Mal d 1 und dem Birkenpollenallergen Bet v 1 häufig zu einer sog. Kreuzreaktion beim Essen handelsüblicher Superma...
Article
Full-text available
Allergic rhinitis affects the quality of life of millions of people worldwide. Air pollution not only causes morbidity, but nearly 3 million people per year die from unhealthy indoor air exposure. Furthermore, allergic rhinitis and air pollution interact. This report summarizes the discussion of an International Expert Consensus on the management o...
Article
Full-text available
Background: Pollen allergies affect a significant proportion of the population globally. At present, Web-based tools such as pollen diaries and mobile apps allow for easy and fast documentation of allergic symptoms via the internet. Objective: This study aimed to characterize the users of the Patient's Hayfever Diary (PHD), a Web-based platform...
Article
Full-text available
Letter to the editor - Open Access - https://link.springer.com/article/10.1007/s40629-020-00122-w
Article
Allergen immunotherapy (AIT) is a proven therapeutic option for the treatment of allergic rhinitis and/or asthma. Many guidelines or national practice guidelines have been produced but the evidence-based method varies, many are complex and none propose care pathways. This paper reviews care pathways for AIT using strict criteria and provides simple...
Article
Full-text available
Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body: As an example...
Article
Full-text available
Allergene Pollen sind natürliche, biologische luftgetragene Partikel und der Hauptauslöser allergischer Atemwegserkrankungen. Die Messung allergener Pollen ist Voraussetzung für die gesundheitliche Vorsorge und zeigt Veränderungen im Pollenspektrum an, wie sie zum Beispiel im Rahmen des Klimawandels zu erwarten sind. Das in Deutschland einzige bund...
Preprint
Full-text available
BACKGROUND Pollen allergies concern a significant proportion of the population globally. Today, online tools such as pollen diaries and mobile applications allow an easy and fast documentation of allergic symptoms via the internet. OBJECTIVE This study aimed to characterize the users of the Patient´s Hayfever Diary, to apply different symptom scor...
Article
The selection of pharmacotherapy for patients with allergic rhinitis aims to control the disease and depends on many factors. Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines have considerably improved the treatment of allergic rhinitis. However, there is an increasing trend toward use of real-world evidence to i...
Article
Airborne pollen is a recognized biological indicator and its monitoring has multiple uses such as providing a tool for allergy diagnosis and prevention. There is a knowledge gap related to the distribution of pollen traps needed to achieve representative biomonitoring in a region. The aim of this manuscript is to suggest a method for setting up a p...
Article
Background House dust mite (HDM) allergens are responsible for the most prevalent persistent respiratory allergies. Clinical trials in this field often use a four‐component nasal symptom score (T4NSS) as a measure of efficacy. Methods The present observational, prospective, multinational, multicentre study determined the minimal important differen...
Article
The effect of height on pollen concentration is not well documented and little is known about the near-ground vertical profile of airborne pollen. This is important as most measuring stations are on roofs, but patient exposure is at ground level. Our study used a big data approach to estimate the near-ground vertical profile of pollen concentration...