Jyotsna S. Jagai

Jyotsna S. Jagai
University of Illinois at Chicago | UIC · Division of Environmental and Occupational Health Sciences

M.S., MPH, PhD

About

100
Publications
7,486
Reads
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1,294
Citations
Introduction
My work focuses primarily on health impacts of water quality and environmental stressors of water quality including climate change and land use patterns. I am also interested in the development of comprehensive indicators to characterize the cumulative environmental impact on human health. My methodological work includes time series analysis, meta-analysis methods, and development of environmental exposure measures.
Additional affiliations
August 2013 - present
University of Illinois at Chicago
Position
  • Research Assistant
September 2009 - July 2013
United States Environmental Protection Agency
Position
  • Health Scientist
May 2005 - August 2009
Tufts University
Position
  • PhD Student

Publications

Publications (100)
Article
Full-text available
Although studies have investigated cadmium and prostate cancer (PC) incidence and mortality, the role of cadmium in PC progression might be more clinically relevant. In this observational study, we assessed the association between air cadmium exposure and PC aggressiveness, with PC stage defined as metastatic or localized and Gleason grade defined...
Article
Full-text available
Environmental parameters, including built and sociodemographic environments, can impact diabetes control (DC). Epidemiological studies have associated specific environmental factors with DC; however, the impact of multidimensional environmental status has not been assessed. The environmental quality index (EQI), a comprehensive quantitative metric...
Article
Full-text available
Background Prostate cancer (PC) etiology is up to 57% heritable, with the remainder attributed to environmental exposures. There are limited studies regarding national level environmental exposures and PC aggressiveness, which was the focus of this study Methods SEER was queried to identify PC cases between 2010 and 2014. The environmental quality...
Article
Full-text available
Background Many studies neglect to account for variation in population served by community water systems (CWSs) when aggregating CWS-level contaminant concentrations to county level. Objective In an ecological epidemiologic analysis, we explored two methods—unweighted and weighted (proportion of CWS population served by county population)—to accou...
Article
Purpose To describe COVID-19 mortality in Chicago during the spring of 2020, and identify at the census-tract level neighborhood characteristics that were associated with higher COVID-19 mortality rates. Methods Using Poisson regression and regularized linear regression (elastic net), we evaluated the association between neighborhood characteristi...
Preprint
Full-text available
Background There is conflicting evidence of a relationship between cadmium exposure and prostate cancer (PC) mortality in the general population. Since most PCs are indolent and clinically inconsequential, low grade and low stage tumors may mask an association between cadmium exposure and PC mortality. Methods We collected patient data from the 201...
Article
Gastrointestinal (GI) illnesses are associated with various environmental factors, such as water quality, stormwater runoff, agricultural runoff, sewer overflows, and wastewater treatment plant effluents. However, rather than assessing an individual factor alone, two indices incorporating a combination of ecological and environmental stressors were...
Article
Full-text available
Study aim: Caloric excess and physical inactivity fail to fully account for the rise of diabetes prevalence. Individual environmental pollutants can disrupt glucose homeostasis and promote metabolic dysfunction. However, the impact of cumulative exposures on diabetes risk is unknown. Methods: The Environmental Quality Index (EQI) a county-level...
Article
Objectives To estimate county-level adult life expectancy for Whites, Black/African Americans (Black), American Indian/Alaska Native (AIAN) and Asian/Pacific Islander (Asian) populations and assess the difference across racial groups in the relationship among life expectancy, rurality and specific race proportion. Methods We used individual-level...
Article
Full-text available
Background The United States (U.S.) suffers from high infant mortality (IM) rates and there are significant racial/ethnic differences in these rates. Prior studies on the environment and infant mortality are generally limited to singular exposures. We utilize the Environmental Quality Index (EQI), a measure of cumulative environmental exposure (acr...
Article
Full-text available
Physical inactivity is a primary contributor to the obesity epidemic, but may be promoted or hindered by environmental factors. To examine how cumulative environmental quality may modify the inactivity-obesity relationship, we conducted a cross-sectional study by linking county-level Behavioral Risk Factor Surveillance System data with the Environm...
Data
Associations between LTPIA and obesity for each domain-specific EQI tertile, for the overall population, males, and females. (DOCX)
Data
Associations between LTPIA and obesity for each EQI tertile, for the overall population, males, and females. (DOCX)
Article
As of 2014, approximately 7.4% of U.S. adults had current asthma. The etiology of asthma is complex, involving genetics, behavior, and environmental factors. To explore the association between cumulative environmental quality and asthma prevalence in U.S. adults, we linked the U.S. Environmental Protection Agency's Environmental Quality Index (EQI)...
Article
Full-text available
Purpose of review: Diabetes is a burgeoning threat to public health in the USA. Importantly, the burden of diabetes is not equally borne across society with marked disparities based on geography, race/ethnicity, and income. The etiology of global and population-specific diabetes risk remains incompletely understood; however, evidence linking envir...
Article
Full-text available
Background: Sanitary sewer overflows (SSOs) occur when untreated sewage is discharged into water sources before reaching the treatment facility, potentially contaminating the water source with gastrointestinal pathogens. Objectives: The objective of this paper is to assess associations between SSO events and rates of gastrointestinal (GI) illnes...
Article
Full-text available
Burgeoning epidemiological, animal, and cellular data link environmental endocrine-disrupting chemicals (EDCs) to metabolic dysfunction. Disproportionate exposure to diabetes-associated EDCs may be an underappreciated contributor to disparities in metabolic disease risk. The burden of diabetes is not uniformly borne by American society; rather, thi...
Article
Background: Methicillin-resistant Staphylococcus aureus (MRSA), a bacterial pathogen, is a predominant cause of skin and soft tissue infections (SSTI) in the United States. Swine-production facilities have been recognized as potential environmental reservoirs of MRSA. To better understand how swine production may contribute to MRSA infection, we e...
Article
Background: Individual environmental exposures are associated with cancer development; however, environmental exposures occur simultaneously. The Environmental Quality Index (EQI) is a county-level measure of cumulative environmental exposures that occur in 5 domains. Methods: The EQI was linked to county-level annual age-adjusted cancer inciden...
Article
Full-text available
Background The disease burden due to heat-stress illness (HSI), which can result in significant morbidity and mortality, is expected to increase as the climate continues to warm. In the United States (U.S.) much of what is known about HSI epidemiology is from analyses of urban heat waves. There is limited research addressing whether HSI hospitaliza...
Article
Full-text available
The Flint Water Crisis—due to changes of water source and treatment procedures—has revealed many unsolved social, environmental, and public health problems for US drinking water, including opportunistic premise plumbing pathogens (OPPP). The true health impact of OPPP, especially in vulnerable populations such as the elderly, is largely unknown. We...
Article
Full-text available
Background Environmental exposures often occur in tandem; however, epidemiological research often focuses on singular exposures. Statistical interactions among broad, well-characterized environmental domains have not yet been evaluated in association with health. We address this gap by conducting a county-level cross-sectional analysis of interacti...
Article
Full-text available
Background: Assessing cumulative effects of the multiple environmental factors influencing mortality remains a challenging task. Objectives: This study aimed to examine the associations between cumulative environmental quality and all-cause and leading cause-specific (heart disease, cancer, and stroke) mortality rates. Methods: We used the ove...
Conference Paper
Background/Question/Methods Many environmental factors influence human mortality simultaneously. However, assessing their cumulative effects remains a challenging task. In this study we used the Environmental Quality Index (EQI), developed by the U.S. EPA, as a measure of overall environmental exposure for 2000-2005. We investigated the relative co...
Article
Full-text available
Many environmental factors have been independently associated with preterm birth (PTB). However, exposure is not isolated to a single environmental factor, but rather to many positive and negative factors that co-occur. The environmental quality index (EQI), a measure of cumulative environmental exposure across all US counties from 2000-2005, was u...
Article
Full-text available
Combined sewer overflows (CSOs) occur in combined sewer systems when sewage and stormwater runoff are released into water bodies potentially contaminating water sources. CSOs are often caused by heavy precipitation and are expected to increase with increasing extreme precipitation associated with climate change. To assess whether the association be...
Article
Full-text available
Background Trends in gastroenteritis-associated mortality are changing over time with development of antibiotic resistant strains of certain pathogens, improved diagnostic methods, and changing healthcare. In 1999, ICD-10 coding was introduced for mortality records which can also affect trends. We assess trends in gastroenteritis-associated mortali...
Conference Paper
The relationship between environmental conditions and human health varies by urbanicity. To estimate ambient environmental conditions, an Environmental Quality Index (EQI) for 2000-2005 was constructed by the Environmental Protection Agency using county-level data representing five environmental domains (air, water, land, built and sociodemographic...
Conference Paper
Physical inactivity has been associated with numerous adverse health outcomes including obesity, heart disease, and depression, and is considered a major contributor to all-cause mortality worldwide. Many studies have shown associations between specific environmental features (lack of sidewalks, safe surroundings, clean air) and physical inactivity...
Conference Paper
Combined sewer systems collect rainwater runoff, sewage, and industrial wastewater for transit to treatment facilities. With heavy precipitation, volumes can exceed capacity of treatment facilities, and wastewater discharges directly to receiving waters. These combined sewer overflows (CSOs) are a source of episodic pollution for downstream water u...
Article
Full-text available
Introduction Floods and other severe weather events are anticipated to increase as a result of global climate change. Floods can lead to outbreaks of gastroenteritis and other infectious diseases due to disruption of sewage and water infrastructure and impacts on sanitation and hygiene. Floods have also been indirectly associated with outbreaks thr...
Article
Full-text available
Background A more comprehensive estimate of environmental quality would improve our understanding of the relationship between environmental conditions and human health. An environmental quality index (EQI) for all counties in the U.S. was developed. Methods The EQI was developed in four parts: domain identification; data source acquisition; variab...
Article
Full-text available
Under the Clean Water Act, the US Environmental Protection Agency (EPA) collects information from states on intended use and impairment of each water body. We explore the feasibility of using these data, collected for regulatory purposes, for public health analyses. Combining EPA impairment data and stream hydrology information we estimated the per...
Chapter
This chapter identifies the role environmental tracking plays in identifying public health water hazard and water quality issues. It outlines public health issues to be examined and provides an integrated overview of water and diseases by combining knowledge of the hydrologic cycle, which describes how water serves as a significant component of exp...
Conference Paper
The relationship between environmental conditions and human health varies by environmental media. In order to account for multiple ambient environmental conditions, we constructed an Environmental Quality Index (EQI) for health research. We used county-level data for the United States representing five environmental domains (air, water, land, built...
Article
Full-text available
Rotavirus infection causes a significant proportion of diarrhea in infants and young children worldwide leading to dehydration, hospitalization, and in some cases death. Rotavirus infection represents a significant burden of disease in developing countries, such as those in South Asia. We conducted a meta-analysis to examine how patterns of rotavir...
Article
Full-text available
Waterborne gastrointestinal (GI) illnesses demonstrate seasonal increases associated with water quality and meteorological characteristics. However, few studies have been conducted on the association of hydrological parameters, such as streamflow, and seasonality of GI illnesses. Streamflow is correlated with biological contamination and can be use...
Chapter
This chapter identifies the role environmental tracking plays in identifying public health water hazard and water quality issues. It outlines public health issues to be examined and provides an integrated overview of water and diseases by combining knowledge of the hydrologic cycle, which describes how water serves as a significant component of exp...
Conference Paper
The Clean Water Act was established to restore and maintain the chemical, physical, and biological integrity of the Nation's waters. Under this act, the U.S. Environmental Protection Agency (EPA) collects information from states on intended use and impairment of each stream. We hypothesized that counties with waters impaired for drinking and recrea...
Conference Paper
Environmental exposures range across multiple domains to affect human health. In an effort to learn how environmental factors combine to contribute to health outcomes we constructed a multiple environmental domain index (MEDI) for use in health research. We used principal components analysis to construct the MEDI with county-level data representing...