Jyotsana Dwivedi

• PhD. PGDIPR
• Professor (Associate) at PSIT-Pranveer Singh Institute of Technology (Pharmacy)

A high-performance thin-layer chromatography (HPTLC) method for the simultaneous quantitative determination of ursolic acid and β-sitosterol in the methanolic fraction of Paederia foetida L. leaves was developed for the first time. For achieving good separation, a mobile phase of toluene‒ethyl acetate‒formic acid (8:2:0.1, v/v) was used. The densit...

Bauhinia purpurea L., Bauhinia variegata L., and Bauhinia acuminata L., commonly known as Kanchanar and mountain ebony belongs to family Caesalpiniaceae. The current study was carried out to provide comparative macro-microscopy, physicochemical parameters and HPTLC analysis of three different Bauhinia species. TS of leaf show different outline, var...

Withania somnifera Dunal (Solanaceae), populaly known as Ashwagandha or Indian ginseng has been used in the traditional systems of medicine since several thousand years. CSIR-India has developed several chemotypes of this plant (NMITLI-101, NMITLI-118, NMITLI-128). The one currently being explored is NMITLI118R which is characterized by high root y...

Background When managing diabetes, polypharmacy the use of several drugs simul-taneously to obtain the best possible glucose control is typical. Drug-drug interactions (DDIs), which can result in side effects and reduced treatment efficacy, have increased. Objective This study evaluated the data mining approach of polypharmacy-based drug-drug in-t...

The therapeutic efficacy of various phytoconstituents is improved by the use of phytosome, innovative drug delivery methods based on phytochemicals, by enhancing their absorption, bioavailability, and therapeutic availability. This exceedingly complex type of herbal formulation contains the active phytoconstituent of the herbal extract and is joine...

The project aims to develop a sensitive, cost-effective, rapid and novel analytical method for the determination of centchroman and lomefloxacin so that in the future it could be used for estimating the drug from different formulations. To develop combination therapy for dysfunctional uterine bleeding (DUB), we selected centchroman, which is a sele...

Herbal medications provide universal benefits such as effectiveness, safety, cost, and acceptance. With increased interest in plant extract research, there is also increased concern about the activity of bioactive lumberjack climber plants indigenous to Sri Lanka and Indian submontane forests. It was recently determined that plants containing kotal...

Background Combination therapy with polyphenol-rich natural spices has gained acceptance as a proactive approach for modulating human health owing to the COVID-19 pandemic. However, bioavailability is a significant hurdle in determining the actual potential of any herbal drug. Aim & Objective To improve the absorption of herbal drugs and to enhanc...

Background: Aegle marmelos, an Indian plant, has been extensively utilized by the people of the Indian subcontinent over about 5000 years. The leaves, bark, roots, and fruits, including seeds, are widely used to cure a variety of diseases in the Indian traditional system of medicine, Ayurveda, along with numerous folk medicines. By revealing the ex...

In India, Ichnocarpous frutescens Linn R. Br. (I. frutescens) is a woody climbing shrub belonging to the Apocynaceae family. Tribes traditionally use it as a substitute for Indian Sarsaparilla (Hemidesmus indicus) to treat conditions such as delirium, convulsions, atrophy, diarrhea, measles, splenomegaly, tuberculosis, tumours, and diabetes. It has...

The discovery of novel counteractive pharmaceuticals, which have recently generated much interest, has played a significant role in the development of drugs derived from herbal medicines or botanical sources. Paederia foetida (P. foetida) is one such example of a role in both traditional and traditional medicine. Owing to its popularity in folk med...

Gene therapy has traditionally been used to treat individuals with late-stage cancers or congenital abnormalities. Numerous prospects for therapeutic genetic modifications have emerged with the discovery that gene therapy applications are far more extensive, particularly in skin and exterior wounds. Cutaneous wound healing is a complex, multistep p...

Phytosterols are bioactive substances found naturally in the cell membranes of plants and have an arrangement of molecules similar to that of fat, which is produced by mammalian cells. They are widely distributed as dietary sources of lipids in plants, such as nuts, seeds, olive oil, and legumes. This review provides a summary of the efficacy of BS...

Phytosterols are bioactive substances that are found spontaneously in the cell membranes of plants and have an atomic composition similar to cholesterol produced by vertebrate cells. They are widely distributed in dietary lipids from plants such as nuts, seeds, and beans with olive oil. β-sitosterol has a variation of pharmacological belongings, wi...

The devastating outcomes of the Coronavirus disease 2019 (COVID-19) outbreak have traumatized the world, as they are highly infectious and mainly attack the respiratory tract. Although pregnant women are not at a higher risk of infection, it may result in more severe consequences than in the general population. Treatment of pregnant women with COVI...

Background The "diabetic lung" has been identified as a possible target organ in diabetes, with abnormalities in ventilation control, bronchomotor tone, lung volume, pulmonary diffusing capacity, and neuroadrenergic bronchial innervation. Objective This review summarizes studies related to diabetic pneumopathy, pathophysiology and a number of pulm...

Nowadays, numerous diseases are benefitted from phytosomal therapy. However, poor selectivity and bioavailability may be limiting factors of their therapeutic applicability. The distribution of hydrophobic phytochemicals has been proposed as a potential use for nanovesicles. Phytosomes are more stable, according to a recent assessment of the litera...

Diabetes is a chronic metabolic condition that is becoming more common and is characterised by sustained hyperglycaemia and long-term health effects. Diabetes-related wounds often heal slowly and are more susceptible to infection because of hyperglycaemia in the wound beds. The diabetic lesion becomes harder to heal after planktonic bacterial cells...

Background One of the most popular beekeeping products is propolis. The word "propolis," which alludes to a beehive, has Greek sources and implies "defense for the community." Propolis is a resinous material that honey worker bees (Apis mellifera L.) and other bee species make for a variety of uses. Since 300 BC, propolis has been used as a traditi...

Phytosomes stand sophisticated herbal preparations that contain the phytoactive ingredients found in extracted from herbs and have the ability towards change the cell membrane's hydrophilic to lipophilic state. They may be produced as pills, creams, gels, suspensions, and other medicinal forms. Many illnesses now have a fantastic treatment alternat...

Background The loss of dopamine neurons in the substantia nigra, as well as other mostly catecholaminergic neurons, causes many of the motor symptoms that define Parkinson's disease. Parkinson's disease is commonly thought of as a movement disorder, the significant prevalence of psychiatric complications such as cognitive impairment, and psychosis...

Mushrooms are an important aspect of the human diet, and their popularity has increased over the years. Pleurotus ostreatus (P. ostreatus) are the most commonly consumed mushrooms by the rural dwellers in South Western Nigeria, perhaps, based on their nutritive value and health-enhancing benefits. Pleurotus is a genus of about 40 mushroom species p...

Background COVID-19 may have an impact on diabetes pathogenesis. For people with COVID-19 infection as well as for healthy individuals, blood glucose control is essential. Nowadays, innovations like telemedicine are helpful in treating diabetic patients. Objectives We examined the data on the link between diabetes and COVID-19, the pathogenesis of...

Yerba Santa (Eriodictyon crassifolium) is a shrub which have large and wooly leaves. It has an attractive cluster of flowers. Native Americans use leaves of this plant to make tea or syrups. It is found in Southern California up to 4000 feet. It is also known as Felt leaved yerba santa which is a dicot angiosperm belonging to the family Boraginacea...

Broussonetia papyrifera also known as paper mulberry is native to Asia including China, Japan, India, and Burma belonging to the family Moraceae. It grows up to a height of 20 m and a diameter of 70 cm in sub-tropical regions at an elevation of 1600 m. The plant is dioecious, and leaves are papery which vary in shape and are alternate, acuminate, d...

Background In the present study, an HPTLC (high-performance thin-layer chromatography) method was developed for the quantitative determination and validation of the curcumin in the methanolic fraction of Curcuma longa L . For achieving good separation of curcumin, the mobile phase of chloroform:methanol (97:3) was used. The densitometric analysis o...

Diabetes mellitus had emerged as a metabolic menace which leads to the development of dyslipidemia, myocardial infarction, coronary artery diseases, obesity and hypertension. These are critical hallmarks for severe metabolic disorders owing to lack of proper balance between the energy intake and energy consumed. Previously, various potent biomarker...

A high-performance thin-layer chromatography (HPTLC) method has been developed for the quantitative determination and validation of plumbagin in the methanolic fraction of Plumbago zeylanica. For achieving good separation, the mobile phase of toluene‒ethyl acetate (9:2, V/V) for plumbagin was used. Densitometric determination of plumbagin was carri...

A simple, rapid, sensitive and reproducible method was developed for the simultaneous quantification of four bioactive compounds, quercetin, gallic acid, eugenol and β-sitosterol, by high-performance thin-layer chromatography (HPTLC) in Psidium guajava L. HPTLC was performed on silica gel 60 F254 by using toluene‒ethyl acetate‒formic acid (7:3:1, V...

A high-performance thin-layer chromatography method for the simultaneous quantitative determination of salicylic acid, kaempferol, gallic acid, and protocatechuic acid in hydro-alcoholic fractions of Cinnamomum verum J. Presl bark was developed for the first time in this species. For achieving good separation, a mobile phase of toluene‒ethyl acetat...

A high-performance thin-layer chromatography method for the simultaneous quantitative determination and validation of scopoletin and gallic acid in the methanolic fraction of Jatropha glandulifera L. was developed for the first time. For achieving good separation, the mobile phase of toluene‒ethyl acetate‒glacial acetic acid (7.5:2.5:0.1, V/V) was...

Background: Hypertensive disorders of pregnancy are important complications of pregnancy and are associated with high maternal and perinatal mortality and morbidity. Early diagnosis may improve maternal and perinatal outcome by ensuring appropriate management. Aim: Our aim is to assess the serum beta-human chorionic gonadotropin (hCG) and serum...

A high-performance thin-layer chromatography (HPTLC) method for the simultaneous quantitative determination and validation of ursolic acid, β-sitosterol, lupeol, and quercetin in the methanolic fraction of Ichnocarpus frutescens L. was developed for the first time. For achieving good separation, a mobile phase of toluene. ethyl acetate.formic acid...

Oxalis corniculata is an important medicinal plant, but chromatographic analysis for the simultaneous quantification of different phenolic compounds has not been performed till date in this plant species. A high-performance thin-layer chromatography (HPTLC) method for the simultaneous quantitative determination of caffeic acid, vanillic acid, and s...