Jurriaan Huskens

Jurriaan Huskens
University of Twente | UT ·  Institute for Nanotechnology (MESA+)

PhD, BA

About

575
Publications
53,105
Reads
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17,258
Citations
Citations since 2016
190 Research Items
7477 Citations
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201620172018201920202021202202004006008001,0001,200
201620172018201920202021202202004006008001,0001,200
201620172018201920202021202202004006008001,0001,200
Introduction
Jurriaan Huskens (1968) currently is Full Professor “Molecular Nanofabrication” at the University of Twente. Present research interests: supramolecular chemistry at interfaces, multivalency, nanofabrication, and solar fuels. He is a recipient of the Unilever Research Award 1990, of a Marie Curie fellowship (1997), of the Gold Medal 2007 of the Royal Netherlands Chemical Society, and of a “Vernieuwingsimpuls Vici” grant (2008). He is (co)author of about 230 research papers and three patents.
Additional affiliations
May 1998 - present
University of Twente
Position
  • (acad): Universiteit Twente
March 1997 - April 1998
Max Planck Institute for Coal Research
Position
  • (PD): Max-Planck Institute fuer Kohlenforschung
January 1995 - January 1997
University of Texas at Dallas
Position
  • (PD): University of Texas at Dallas
Education
September 2001 - August 2004
Saxion University of Applied Sciences
Field of study
  • Orchestral conducting
September 1990 - June 1994
Eindhoven University of Technology
Field of study
  • Chemical Engineering
September 1990 - November 1994
Delft University of Technology
Field of study
  • coordination chemistry & homogeneous catalysis

Publications

Publications (575)
Article
Two tripodal amides obtained from nitrilotriacetic acid with n-butyl and n-octyl alkyl chains (HBNTA(LI) and HONTA(LII), respectively) were studied for the extraction of Th(IV) ions from nitric acid medium. The effect of the diluent medium, i.e., n-dodecane alone and a mixture of n-dodecane and 1-decanol, onto aggregate formation were investigated...
Article
Full-text available
A comprehensive kinetic model describes the dehydration of xylose starting from the boronate diester-protected xylose (PBA2X). The model incorporates (de)esterification of PBA2X, partitioning, and xylose dehydration, and aims to evaluate the effects of the solvent system on these steps. The model explores the effect of the water contents in monopha...
Article
Complexation of Np⁴⁺ and NpO2²⁺ ions was studied in a room temperature ionic liquid (C8mim.NTf2) using two multiple diglycolamide (DGA) ligands with three and four DGA arms tethered to the nitrogen atoms of the aza-9-crown-3 and -12-crown-4 scaffolds termed as LI and LII, respectively. The studies include solvent extraction, UV-visible spectrophoto...
Article
The diglycolamide 2,2’-oxybis(N,N-di-n-decylpropanamide) (mTDDGA) is being studied as an extractant for actinides and lanthanides in the European Grouped Actinide Extraction (EURO-GANEX) process. The aim is the development of a more simplified process using a single extractant instead of a mixture of extractants used in the current EURO-GANEX proce...
Article
The preselection of hypermethylated DNA (hmDNA) from liquid biopsy samples is key to enable early‐stage cancer diagnostics. Due to limited selectivity of the existing preselection approaches, however, wide integration in the clinic is currently prohibited. Here, it is argued that an affinity method on a surface, such as used in affinity chromatogra...
Article
Full-text available
Plutonium-specific supported liquid membranes were developed and reported for the first time. The studies included in this paper are on the supported liquid membrane transport behavior of Pu(IV), Am(III) and U(VI) investigated using two tripodal amides viz. N,N,N,’N,’N,”N”-hexa-n-octylnitrilotriacetamide (HONTA) and N,N,N,’N,’N,”N”-hexa-n-dodecylni...
Article
Full-text available
Using the biomarker hypermethylated DNA (hmDNA) for cancer detection requires a pretreatment to isolate or concentrate hmDNA from nonmethylated DNA. Affinity chromatography using a methyl binding domain-2 (MBD2) protein can be used, but the relatively low enrichment selectivity of MBD2 limits its clinical applicability. Here, we developed a superse...
Article
Biomarker measurements are essential for the early diagnosis of complex diseases. However, many current biomarker assays lack sensitivity and multiplexing capacity, work in a narrow detection range and importantly lack real time quality control opportunities, which hampers clinical translation. In this paper, we demonstrate a toolbox to kinetically...
Article
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The production of a new class of microfluidic devices built from thermoplastic materials has recently aroused interest in a high‐volume and cost‐effective fabrication of sensing devices. During device formation, the bonding of two slides, one containing the microchannels and another used as a non‐modified capping layer, is generally performed at hi...
Article
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The modification of surfaces with multiple ligands allows the formation of platforms for the study of multivalency in diverse processes. Herein we use this approach for the implementation of a photosensitizer (PS)‐nanocarrier system that binds efficiently to siglec‐10, a member of the CD33 family of siglecs (sialic acid (SA)‐binding immunoglobulin‐...
Article
The modification of surfaces with multiple ligands allows the formation of platforms for the study of multivalency in diverse processes. Herein we use this approach for the implementation of a photosensitizer (PS)‐nanocarrier system that binds efficiently to siglec‐10, a member of the CD33 family of siglecs (sialic acid (SA)‐binding immunoglobulin‐...
Article
Full-text available
Liquid–liquid extraction and liquid membrane transport behavior of tetravalent actinide ions viz. Th(IV), Np(IV), and Pu(IV) were investigated for the first time using a diglycolamide (DGA) based dendrimer with a tris(2-aminoethyl)amine (TREN) scaffold as the organic extractant. The generation of 1 dendrimer with six DGA pendent moieties (termed as...
Article
Appropriately functionalized dendrimers are exotic ligands and are expected to give rise to better extraction/transport results than the corresponding monofunctional ones. Diglycolamide- (DGA) based dendrimers and their transport studies are rarely reported. Transport of Am(III) and Eu(III) was studied across a PTFE- (polytetrafluoroethylene) based...
Article
Full-text available
It is a major outstanding goal in nanotechnology to precisely position functional nanoparticles, such as quantum dots, inside a three-dimensional (3D) nanostructure in order to realize innovative functions. Once the 3D positioning is performed, the challenge arises how to nondestructively verify where the nanoparticles reside in the 3D nanostructur...
Data
Supporting Info Publication Date: February 21, 2022 Targeted Positioning of Quantum Dots Inside 3D Silicon Photonic Crystals Revealed by Synchrotron X-ray Fluorescence Tomography
Article
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Natural supramolecular filaments have the ability to crosslink with each other and to interface with the cellular membrane via biomolecular non-covalent interactions. This behavior allows them to form complex networks within as well as outside the cell, i.e., the cytoskeleton and the extracellular matrix, respectively. The potential of artificial s...
Article
Full-text available
Affinity sensing of nucleic acids is among the most investigated areas in biosensing due to the growing importance of DNA diagnostics in healthcare research and clinical applications. Here, we report a simple electrochemical DNA detection layer, based on poly-l-lysine (PLL), in combination with gold nanoparticles (AuNPs) as a signal amplifier. The...
Article
Two diglycolamide (DGA) derivatives having n-butyl (nBuDGA) and s-butyl (sBuDGA) groups have been used for the extraction of Am3+ and Eu3+ to study the role of alkyl chain branching on...
Article
Liquid-liquid extraction of several actinide and lanthanide ions, viz., U(VI), Pu(IV), Am(III) and Eu(III) was investigated from nitric acid feed solutions employing N,N,N’,N’,N”,N”-hexa-n-octyl nitrilotripropamide (HONTP) in 90% n-dodecane + 10%...
Article
Dendrimers are exotic multi-functional ligands and are expected to give rise to better extraction/transport results as compared to the mono-functional ligands. Diglycolamide (DGA) based dendrimers are scarcely reported and literature on their transport studies are very limited. Transport of Am(III) and Eu(III) across a PTFE (polytetrafluoroethylene...
Article
Extraction of Am³⁺ and Eu³⁺ was carried out into a room temperature ionic liquid, C8mim⋅Tf2N, using two multiple-diglycolamide extractants with three or four diglycolamide arms tethered to either a triaza- or tetraazamacrocyclic ligand termed as TAM-3-DGA and TAM-4-DGA, respectively. The metal ion extraction was highly efficient as only 5 × 10⁻⁴ M...
Article
Full-text available
Biosensors and other biological platform technologies require the functionalization of their surface with receptors to enhance affinity and selectivity. Control over the functionalization density is required to tune the platform’s properties. Streptavidin (SAv) monolayers are widely used to immobilize biotinylated proteins, receptors, and DNA. The...
Article
Liquid-liquid extraction of the actinide ions UO2²⁺, Pu⁴⁺, Am³⁺ was carried out from nitric acid feed solutions using two tripodal amide extractants, viz., N,N,N’,N’,N”,N”-hexa-n-octylnitrilotriacetamide (HONTA) and N,N,N’,N’,N”,N”-hexa-n-dodecylnitrilotriacetamide (HDDNTA) in 10% isodecanol + 90% n-dodecane diluent. The metal ion extraction trend...
Preprint
It is a major outstanding goal in nanotechnology to precisely position functional nanoparticles, such as quantum dots, inside a three-dimensional (3D) nanostructure in order to realize novel functions. Once the 3D positioning is performed, the challenge arises how to non-destructively verify where the nanoparticles reside in the 3D nanostructure. H...
Preprint
Full-text available
It is a major outstanding goal in nanotechnology to precisely position functional nanoparticles, such as quantum dots, inside a three-dimensional (3D) nanostructure in order to realize novel functions. Once the 3D positioning is performed, the challenge arises how to non-destructively verify where the nanoparticles reside in the 3D nanostructure. H...
Article
Solutions of two nitrilotriacetamide (NTA) ligands, viz., N,N,N’,N’,N”,N”-hexa-n-butylnitrilotriacetamide (HBNTA) and N,N,N’,N’,N”,N”-hexa-n-hexylnitrilotriacetamide (HHNTA) in 20% isodecanol–80% n-dodecane were employed for the extraction of U(VI), Np(IV), Pu(IV), and Am(III) from nitric acid feed solutions. Limitations of ligand solubility and th...
Article
Two novel extraction chromatography resins (ECRs) containing two diglycolamide (DGA) -functionalized calix[4]arenes with n-propyl and isopentyl substituents at the amide nitrogen atom, termed as ECR-1 and ECR-2, respectively, were evaluated for the uptake of Th(IV) from nitric acid feed solutions. While both the resins were having a quite high Th(I...
Article
An efficient extraction chromatography resin, containing tetraaza-12-crown-4 functionalized with four diglycolamide moieties, was evaluated for the separation of plutonium. This chromatography resin yielded very large distribution coefficients for Pu⁴⁺ (>10⁵) in 0.5 – 6 M HNO3 feed solution. Various physicochemical properties such as sorption kinet...
Article
Full-text available
Standard protocols for the analysis of circulating tumor DNA (ctDNA) include the isolation of DNA from the patient’s plasma and its amplification and analysis in buffered solutions. The application of such protocols is hampered by several factors, including the complexity and time-constrained preanalytical procedures, risks for sample contamination...
Article
Full-text available
The influenza A virus (IAV) interacts with the glycocalyx of host cells through its surface proteins hemagglutinin (HA) and neuraminidase (NA). Quantitative biophysical measurements of these interactions may help to understand these interactions at the molecular level with the long-term aim to predict influenza infectivity and answer other biologic...
Article
Full-text available
Xylose is a promising feedstock for the fuel and chemical industry. We propose here an integrated process to recover and purify xylose from an acidic hydrolysate stream, e.g., coming from pretreated lignocellulose. This process consists of selectively extracting the xylose as the diboronate ester and back-extracting it into a clean aqueous solution...
Article
Full-text available
Understanding how influenza viruses traverse the mucus and recognize host cells is critical for evaluating their zoonotic potential, and for prevention and treatment of the disease. The surface of the influenza A virus is covered with the receptor‐binding protein hemagglutinin and the receptor‐cleaving enzyme neuraminidase, which jointly control th...
Article
Two solid phase extraction resins (SPER) were prepared by impregnating solutions of two diglycolamide-functionalized calix[4]arenes in 10% isodecanol in n-dodecane into Chromosorb W, as the stationary phase. While SPER-I contained n-propyl functionalized calix[4]arene, SPER-II contained the calix[4]arene with isopentyl groups at the carboxamide nit...
Article
An extraction chromatographic resin was prepared by impregnating Chromosorb-W with a unique ligand consisting of four diglycolamide moieties functionalized to a tetraaza-12-crown-4 scaffold. This resin was evaluated for the uptake of Eu³⁺, as a representative of trivalent lanthanides and actinides, from moderate acid solutions. The distribution coe...
Article
Solutions of N,N,N’,N’,N”,N”-hexa-n-hexylnitrilotriacetamide (HHNTA) in 20% isodecanol-80% n-dodecane (v/v) were employed for the supported liquid membrane (SLM) transport of U(VI), Np(IV), and Pu(IV) from nitric acid feed solutions using PTFE (polytetrafluoroethylene) flat sheet membranes. Preliminary transport studies revealed poor transport U(VI...
Article
Neptunium is one of the most important minor actinide elements with some of its isotopes having very long half-lives, therefore necessitating its separation from acidic radioactive wastes. Solvent extraction of Np ⁴⁺ and NpO 2 ²⁺ was studied using three multiple diglycolamide (DGA) extractants with n -propyl, n -octyl and 3-pentyl substituents term...
Article
Two diglycolamide (DGA) functionalized poly(propylene imine) diaminobutane dendrimers, first generation (Gen I) and second generation (Gen II), termed as LI and LII, were used for the extraction of the tetravalent...
Article
Two benzene-centered tripodal diglycolamide ligands (LI and LII) were used for the extraction of Am3+ and Eu3+ from nitric acid solutions into a diluent medium of n-dodecane modified with varying...
Article
Quantitative extraction of Np(IV) was achieved using a room temperature ionic liquid containing submillimolar concentrations of two poly(propyleneimine) based dendrimer ligands with four (LI) and eight diglycolamide (DGA) moieties (LII)...
Article
Full-text available
We show the effective conversion of xylose into furfural, with selectivities >90 mol%, in an aqueous-organic three-solvent system, composed of an apolar aromatic solvent, a polar organic solvent and acidic...
Article
A dendrimer of tris(2-aminoethyl)amine (TREN), containing six diglycolamide (DGA) pendent arms (TREN-G1-DGA) was evaluated for the extraction of different actinides and Eu3+ in a methylimidazolium-based room temperature ionic liquid (RTIL;...
Article
Full-text available
Furfural and hydroxymethylfurfural are promising platform molecules for manufacturing chemicals and fuel components. These furanic compounds are the product of the acid-catalyzed dehydration of sugars (e.g., xylose and glucose), components obtained from lignocellulosic biomass. Manufacturing furans employs the use of mineral acid catalysts (e.g., H...
Article
Full-text available
Understanding how emerging influenza viruses recognize host cells is critical in evaluating their zoonotic potential, pathogenicity, and transmissibility between humans. The surface of the influenza virus is covered with hemagglutinin (HA) proteins that can form multiple interactions with sialic acid-terminated glycans on the host cell surface. Thi...
Article
Full-text available
In this paper, we obtain maps of the spatial tunnel barrier variations in self-assembled monolayers of organosulfurs on Au(111). Maps down to the sub-nanometer scale are obtained by combining topographic scanning tunneling microscopy images with dI/dz spectroscopy. The square root of the tunnel barrier height is directly proportional to the local w...
Article
Full-text available
Surface-based biosensing devices benefit from a dedicated design of the probe layer present at the transducing interface. The layer architecture, its physicochemical properties, and the embedding of the receptor sites affect the probability of binding the analyte. Here, the enhancement of the probe density at the sensing interface by tuning the exp...
Article
Full-text available
Microfluidic devices are widely used for the sensing of small quantities of analytes. In these applications, the measurement can be easily perturbed by loss of analyte due to binding of the analyte outside the sensing area. We studied the binding of small molecules and nanoparticles up to 400 nm in a state‐of‐the‐art sensing platform – receptor gra...
Article
Full-text available
Thrombocytopenia is a common complication of influenza virus infection, and its severity predicts the clinical outcome of critically ill patients. The underlying cause(s) remain incompletely understood. In this study, in patients with an influenza A/H1N1 virus infection, viral load and platelet count correlated inversely during the acute infection...
Article
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The Cover Feature shows the local microwave heating of the reagent xylose in the water phase and the transfer of the product furfural into the cool organic phase. More information can be found in the Communication by L. Ricciardi et al. on page 3589 in Issue 14, 2020 (DOI: 10.1002/cssc.202000966).
Article
Full-text available
The sensitivity and performance of an asymmetric Mach-Zehnder interferometer (aMZI) were compared to quartz crys-tal microbalance with dissipation (QCM-D). The binding of streptavidin to sensor chips coated with poly-L-lysine (PLL), modified with biotin and oligoethyleneglycol (OEG) (PLL-biotin), was used to compare the binding signals obtained fro...
Article
Full-text available
Reactive extraction is an emerging operation in the industry, particularly in biorefining. We show here reactive extraction enhanced by microwave irradiation to selectively heat the reactive phase (for efficient reaction) without unduly heating the extractive phase (for efficient extraction). These conditions aim at maximizing the asymmetries in di...
Article
Two tripodal diglycolamide (DGA) ligands with a central N atom, dissolved in a mixture of 5% isodecanol and 95% n-dodecane, were evaluated for the liquid-liquid extraction and the pertraction across a flat sheet PTFE membrane of tetravalent Np(IV) and Pu(IV) from dilute nitric acid medium. The ligand with an isopropyl group substituted at the inner...
Article
Full-text available
The available active surface area and the density of probes immobilized on this surface are responsible for achieving high specificity and sensitivity in electrochemical biosensors that detect biologically relevant molecules, including DNA. Here, we report the design of gold-coated, silicon micropillar-structured electrodes functionalized with modi...
Article
Full-text available
The possibility of tuning the chemical moieties and their density plays a fundamental role in targeting surface-confined molecular structures and their functionalities at macro and nanoscale levels. Such interfacial control is crucial for engineered coating formation and biorecognition purposes, where the type and density of ligands/receptors at th...
Article
Liquid-liquid extraction and subsequent supported liquid membrane (SLM) transport studies involving Am³⁺ ion were carried out from nitric acid feed solutions using three N-pivot tripodal diglycolamide (DGA) ligands with varying substituent at the inner carboxamide N atom and spacer length. The ligand with an isopropyl substituent and with C2 spacer...
Article
N,N,N′,N′,N“,N”‐hexaalkylnitrilotriacetoamide (HRNTA) derivatives were found to be promising for the separation of trivalent actinides from lanthanides, which is a burning topic in the back end of the nuclear fuel cycle. In the present work, separation of Am3+ from Eu3+ was studied using the N,N,N’,N’,N’’,N’’‐hexa‐2‐ethylhexylnitrilotriacetamide (H...
Article
Two potentiometric sensors were developed containing tailor made multiple diglycolamide-containing ionophores based on the planar benzene scaffold, viz. LI and LII, embedded in a polyvinyl chloride (PVC) membrane. The membrane composition was optimized for best analytical performance for the detection of Eu(III) in acidic solutions. In order to imp...
Article
Full-text available
Correction for ‘Influenza as a molecular walker’ by P. H. (Erik) Hamming et al. , Chem. Sci. , 2020, 11 , 27–36.