Junna Oba

Junna Oba
Keio University · Department of Extended Intelligence for Medicine

MD, PhD

About

47
Publications
4,977
Reads
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1,704
Citations
Citations since 2017
22 Research Items
1549 Citations
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Introduction
Junna Oba currently works at the Department of Extended Intelligence for Medicine at Keio University School of Medicine. She trained as a dermatologist, and obtained a PhD in melanoma research. She worked at the University of Texas MD Anderson Cancer Center from 2013 to 2019, and was hugely involved in NIH-funded Uveal Melanoma TCGA project as well as Melanoma MoonShot Program. With her clinical, laboratory, multi-omics and big data experience, she currently works as a full-time researcher.
Additional affiliations
October 2019 - July 2020
Keio University
Position
  • Lecturer
May 2013 - September 2019
University of Texas MD Anderson Cancer Center
Position
  • Researcher

Publications

Publications (47)
Article
Full-text available
Melanoma cells display distinct intrinsic phenotypic states. Here, we seek to characterize the molecular regulation of these states using multi-omic analyses of whole exome, transcriptome, microRNA, long non-coding RNA and DNA methylation data together with reverse-phase protein array data on a panel of 68 highly annotated early passage melanoma ce...
Article
Full-text available
From the beginning of the COVID-19 pandemic, the demand for diagnostic and screening tests has exceeded supply. Although the proportion of vaccinated people has increased in wealthier countries, breakthrough infections have occurred amid the emergence of new variants. Pooled-sample COVID-19 testing using saliva has been proposed as an efficient, in...
Preprint
Full-text available
From the beginning of the COVID-19 pandemic, the demand for diagnostic and screening tests has exceeded supply. Although the proportion of vaccinated people has increased in wealthier countries, breakthrough infections have occurred amid the emergence of new variants. Pooled-sample COVID-19 testing using saliva has been proposed as an efficient, in...
Article
Full-text available
The dynamic evolution of chromatin state patterns during metastasis, their relationship with bona fide genetic drivers, and their therapeutic vulnerabilities are not completely understood. Combinatorial chromatin state profiling of 46 melanoma samples reveals an association of NRAS mutants with bivalent histone H3 lysine 27 trimethylation (H3K27me3...
Article
Melanoma represents the deadliest skin cancer. Recent therapeutic developments, including targeted and immune therapies have revolutionized clinical management and improved patient outcome. This progress was achieved by rigorous molecular and functional studies followed by robust clinical trials. The identification of key genomic alterations and ge...
Article
Full-text available
Assessing Erb-b2 receptor tyrosine kinase 2 ( ERBB2 ) amplification status in breast and gastric cancer is necessary for deciding the best therapeutic strategy. Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) are currently used for assessing protein levels and gene copy number (CN), respectively. The use of next-generation...
Article
Full-text available
The year 2020 will be remembered for the coronavirus disease 2019 (COVID-19) pandemic, which continues to affect the whole world. Early and accurate identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is fundamental to combat the disease. Among the current diagnostic tests, real-time reverse transcriptase–polymerase chain...
Article
Full-text available
Innate inflammatory features have been found in melanoma tumors from patients at all stages, and molecular analysis has identified definitive inflammatory proteins expressed by tumors cells in patients who presents the worst prognosis. We have previously observed weakened outcomes in patients with constitutive expression of inducible nitric oxide s...
Article
Purpose: Metastatic uveal melanoma (UM) has a very poor prognosis and no effective therapy. Despite remarkable advances in treatment of cutaneous melanoma, UM remains recalcitrant to chemotherapy, small-molecule kinase inhibitors, and immune-based therapy. Experimental Design: We assessed two sets of oxidative phosphorylation (OxPhos) genes within...
Article
The purpose of this study was to determine the role of BAP1 levels in cutaneous melanoma (CM). BAP1 is a tumor suppressor in which loss of heterozygosity (LOH) from mutation and copy number alteration is well described in germline and somatic cancers. Although BAP1 genomic alterations in CM are extremely rare (2% of 665 samples from 5 datasets), ma...
Article
Full-text available
Introduction Most metastatic prostate cancers acquire the capacity for androgen‐independent growth and become resistant to androgen deprivation therapy. A patient‐focused treatment strategy is needed for aggressive castration‐resistant prostate cancer. Case presentation We report the case of a 62‐year‐old man who presented with prostatic adenocarc...
Article
Full-text available
Purpose: Metastatic uveal melanoma (UM) has a very poor prognosis and no effective therapy. Despite remarkable advances in treatment of cutaneous melanoma, UM remains recalcitrant to chemotherapy, small-molecule kinase inhibitors, and immune-based therapy. Methods: We assessed two sets of oxidative phosphorylation (OxPhos) genes within 9858 tumo...
Preprint
Full-text available
Chromatin deregulation is an emerging hallmark of cancer. However, the extent of epigenetic aberrations during tumorigenesis and their relationship with genetic aberrations are poorly understood. Using ChIP-sequencing for enhancers (H3K27ac and H3K4me1), promoters (H3K4me3), active transcription (H3K79me2) and polycomb (H3K27me3) or heterochromatin...
Article
Full-text available
Although treatment with immune checkpoint inhibitors provides promising benefit for patients with cancer, optimal use is encumbered by high resistance rates and requires a thorough understanding of resistance mechanisms. We observed that tumors treated with PD-1/PD-L1 blocking antibodies develop resistance through the upregulation of CD38, which is...
Article
Full-text available
199 Background: KIT-mutated MM is a rare melanoma entity. Response rates of KIT-mutated MM to anti CTLA-4 and anti PD-1 have not previously been reported. Methods: A single-institution retrospective review identified patients (pts) with KIT-mutated MM treated with at least two doses of anti CTLA-4 or anti PD-1 between 2008-2017 with response determ...
Article
Full-text available
Main Text: (Cancer Cell 32, 204–220; August 14, 2017) During the course of revising the manuscript, the authors inadvertently did not include the reference to a paper by Royer-Bertrand et al. in the reference list as well as the corresponding citation in the discussion of copy number variants in uveal melanoma and their consistency in high-risk pri...
Article
Topical corticosteroid phobia is an important problem in the treatment of atopic dermatitis as it can affect the ability to control disease severity and itch by reducing treatment adherence. Topical corticosteroid phobia often ends up even non-corticosteroid adherence. As such, non-corticosteroid adherence, disease severity and itch are likely to b...
Article
Full-text available
Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis monosomy 3 (M3) and two with better-prognosis disomy 3 (D3). We show that BAP1 loss follows M3 occurrence and correlates with a global DNA methylation state that is distinct from D3-U...
Article
Background: Major advances have been made in the treatment of metastatic melanoma through the use of molecularly targeted therapy and immunotherapy, and trials incorporating these agents are now being extended to patients with earlier-stage disease. The current standard of care (SOC) therapy for high-risk resectable melanoma (stage IIIB/IIIC) is up...
Article
Full-text available
This exploratory study was carried out to determine the expression levels of hepatocyte growth factor (HGF), insulin-like growth factor 1, thyroid-stimulating hormone (TSH), and leptin in serum and tumor samples from patients with uveal melanoma and to investigate the potential association of these expression levels with disease progression and pat...
Article
Full-text available
Background While clinical outcomes following immunotherapy have shown an association with tumor mutation load using whole exome sequencing (WES), its clinical applicability is currently limited by cost and bioinformatics requirements. Methods We developed a method to accurately derive the predicted total mutation load (PTML) within individual tumor...
Article
Full-text available
The metabolic hormone leptin has been implicated in the pathogenesis of various malignancies and may contribute to the high rate of cancer in obese individuals. We reported that leptin and its receptor are expressed by melanoma tumors and cell lines, and that leptin stimulates proliferation of cultured melanoma cells. Here, we tested the hypothesis...
Article
Melanomas of the choroid, ciliary body, and iris of the eye are collectively known as uveal melanomas. These cancers represent 5% of all melanoma diagnoses in the United States, and their age-adjusted risk is 5 per 1 million population. These less frequent melanomas are dissimilar to their more common cutaneous melanoma relative, with differing ris...
Article
Full-text available
CD10 has been widely used in cancer diagnosis. We previously demonstrated that its expression in melanoma increased with tumor progression and predicted poor patient survival. However, the mechanism by which CD10 promotes melanoma progression remains unclear. In order to elucidate the role of CD10 in melanoma, we established CD10-overexpressing A37...
Article
Full-text available
Dendritic cells (DCs) have a critical effect on the outcome of adaptive immune responses against growing tumors. Tumor-infiltrating dendritic cells (TIDCs) play diverse roles in the regulation of tumor regression or growth, but the characteristics that distinguish those effects are obscure. In this study, we investigated the frequency, phenotype an...
Article
Background: With the growing epidemic of obesity in developed nations, considerable interest has been generated in the metabolic hormone leptin. Upon caloric intake, leptin is secreted by adipocytes and detected as a satiety signal in the hypothalamus. Obese individuals tend to have higher levels, likely due to hormone resistance. Less well-known i...
Article
Background: Uveal melanoma arises from melanocytes in the uveal tract of the eye and is biologically different from cutaneous melanoma due to different genetic alterations and a propensity to metastasize to the liver. We hypothesize that growth factors synthesized in liver can play a significant role in this preferential homing of uveal melanoma me...
Article
c-Jun N-terminal kinase (JNK) known as the stress activated protein kinase, is a key mediator of a variety of stress stimuli, including proinflammatory cytokines, reactive oxygen species, and ultraviolet radiation (Bogoyevitch et al., 2010). By phosphorylating crucial molecules such as c-Jun, p53, and Bcl-2, active JNK regulates cell growth, differ...
Article
It is important to recognize pruritic occasions/conditions and how their treatment is effective in soothing pruritus in patients with atopic dermatitis (AD) to facilitate patient communication and improve patient instructions in a typical clinical setting. For this purpose, we conducted a web-based questionnaire survey.This article is protected by...
Article
Full-text available
CD10 has been widely used in cancer diagnosis. We previously demonstrated that its expression in melanoma increased with tumor progression and predicted poor patient survival. However, the mechanism by which CD10 promotes melanoma progression remains unclear. In order to elucidate the role of CD10 in melanoma, we established CD10-overexpressing A37...
Article
Sentinel lymph node biopsy (SLNB) is the standard of care for staging melanoma. However, limited research has been carried out on the prognostic value of SLNB in patients with primary cutaneous melanoma in Asian countries. The objective is to evaluate the efficacy of SLNB in Japanese patients with primary cutaneous melanoma and to elucidate whether...
Article
Special AT-rich sequence-binding protein-1 (SATB1), a new type of gene regulator, has been reported to be expressed in several human cancers and may have malignant potential. However, no data on SATB1 expression and its relationship to tumor progression in cutaneous malignant melanoma (CMM) has yet been reported. We examined the immunohistochemical...
Article
Full-text available
CD10 expression in malignant melanoma (MM) has been reported to increase according to tumor progression and metastasis; however, its association with patient outcome has not been clarified. We examined the immunohistochemical expression of CD10 in MM to determine whether or not it could serve as a marker for tumor progression and prognosis. A total...
Article
Endothelin-1 (ET-1) is a potent multifunctional peptide linked to wound healing, pigmentation, carcinogenesis, and fibrosclerotic processes in the skin. Whereas ET-1 was thought to be digested by receptor-mediated endocytosis, it is also reported to be biochemically degraded by the neutral endopeptidase CD10 using kidney homogenates. Although kerat...
Article
Full-text available
Milk fat globule epidermal growth factor-VIII (MFG-E8) is a secreted protein that binds phosphatidylserine and promotes apoptotic cell ingestion by phagocytes, mediating the immune tolerance and maintenance of homeostasis. A recent study has shown that MFG-E8 expression in human melanoma is increased with tumour progression; however, the effect of...
Article
Full-text available
The mitogen-activated protein kinase (MAPK) signaling pathway is one of the major cascades that are crucial for the initiation and progression of melanoma; however, the influence of these signaling molecules on patient survival has not been clarified. The purpose of this study was to analyze the protein expression of MAPK signaling molecules in mel...
Article
Substance P (SP) is a multipotent neuropeptide that affects the proliferation, activation and motility of keratinocytes and fibroblasts (Fbs). SP in pulmonary and synovial cells is degraded by CD10, a 90- to 110-kDa cell surface zinc-dependent metalloprotease. However, the expression and function of CD10 in human dermal Fbs have not yet been invest...
Article
Itching is a mandatory symptom of atopic dermatitis (AD), and consequent scratching behavior contributes to the formation, maintenance and exacerbation of the skin manifestation, It is therefore reasonable for clinicians to know when patients with AD feel itching and how they manage it in daily life for better communication with patients and for mo...
Article
Phototherapy has become a widely used treatment for a variety of skin diseases. In particular, 311-nm narrowband ultraviolet B (nb-UVB) is commonly used and quite effective in the treatment of psoriasis, atopic dermatitis, prurigo. mycosis fungoides and many other dermatoses. However, the use of this modality is limited because it irradiates uninvo...

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