Junior Matangila

Junior Matangila
University of Kinshasa | UNIKIN · Tropical medicine

MD, MSc, PhD

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41
Publications
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557
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Publications

Publications (41)
Article
Full-text available
This study explored the experiences of healthcare providers (HCPs) and frontline workers who were involved in an Ebola vaccine trial in the Democratic Republic of the Congo. The researchers interviewed a total of 99 participants (HCPs and frontline workers) living and working in the Boende health district during the period of the study, from Februa...
Article
Full-text available
These authors contributed equally to this work. Abstract: This study aimed to evaluate scientific evidence of the benefit of the use of insecticide-treated nets (ITNs) and Intermittent preventive treatment (IPT) on the birth weight of newborns and the hemoglobin level of the mother when used to prevent malaria during pregnancy. This cross-sectional...
Preprint
BACKGROUND Iris scanning, as a means of human biometric recognition, has been increasingly deployed over the last decade and continues to improve and expand. To better understand the acceptability of this technology, we report the long-term experiences of healthcare provider (HCP) and frontline worker participants with iris scanning as an identific...
Article
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In this paper, we discuss challenges associated with implementing a policy for Ancillary Care (AC) for related and unrelated (serious) adverse events during an Ebola vaccine trial conducted in a remote area of the Democratic Republic of the Congo. Conducting clinical trials in resourceconstrained settings can raise context-related challenges that h...
Article
Full-text available
Introduction A serosurvey among health care providers (HCPs) and frontliners of an area previously affected by Ebola virus disease (EVD) in the Democratic Republic of the Congo (DRC) was conducted to assess the seroreactivity to Ebola virus antigens. Methods Serum samples were collected in a cohort of HCPs and frontliners (n = 698) participants in...
Article
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Background In response to recent Ebola epidemics, vaccine development against the Zaire ebolavirus (EBOV) has been fast-tracked in the past decade. Healthcare providers and frontliners working in Ebola endemic areas are at high risk of contracting and spreading the virus. Methods This study assessed the safety and immunogenicity of the 2-dose hete...
Preprint
Full-text available
Introduction A serosurvey among health care providers (HCPs) and frontliners of an area previously affected by Ebola virus disease (EVD) in the Democratic Republic of the Congo (DRC) was conducted to assess the seroreactivity to Ebola virus antigens. Methods Serum samples were collected in a cohort of HCPs and frontliners (n=698) participants in t...
Article
Full-text available
Since the largest Ebola outbreak in West Africa (2013–2016) highlighted the potential threat of the Ebola virus to the world, several vaccines have been under development by different pharmaceutical companies. To obtain vaccine licensure, vaccine trials assessing the safety, immunogenicity and efficacy of new vaccines among different populations (e...
Article
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Routine assessment of the efficacy of artemisinin-based combination therapies (ACTs) is critical for the early detection of antimalarial resistance. We evaluated the efficacy of ACTs recommended for treatment of uncomplicated malaria in five sites in Democratic Republic of the Congo (DRC): artemether-lumefantrine (AL), artesunate-amodiaquine (ASAQ)...
Article
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Introduction This article describes the protocol of an Ebola vaccine clinical trial which investigates the safety and immunogenicity of a two-dose prophylactic Ebola vaccine regimen comprised of two Ebola vaccines (Ad26.ZEBOV and MVA-BN-Filo) administered 56 days apart, followed by a booster vaccination with Ad26.ZEBOV offered at either 1 year or 2...
Article
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Implementing an Ebola vaccine trial in a remote area in the Democratic Republic of the Congo (DRC), and being confronted with a dysfunctional health care system and acute unmet health needs of participants, ethical considerations were made regarding the ancillary care obligations of the sponsor and researchers. Spurred by the occurrence of non-rela...
Preprint
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BACKGROUND As part of an Ebola outbreak preparedness initiative, a partnership between the University of Antwerp and the University of Kinshasa, through an Innovative Medicines Initiative-European Union (project ‘EBOVAC 3’), implemented a clinical trial on an Ebola vaccine regimen to be administered to health care provider participants (HCP-P) in T...
Article
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Background A partnership between the University of Antwerp and the University of Kinshasa implemented the EBOVAC3 clinical trial with an Ebola vaccine regimen administered to health care provider participants in Tshuapa Province, Democratic Republic of the Congo. This randomized controlled trial was part of an Ebola outbreak preparedness initiative...
Article
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Objectives To describe the clinical characteristics of patients infected with SARS-CoV-2 at Clinique Ngaliema, a public hospital, in Kinshasa, in the Democratic Republic of Congo (DRC). Methods This retrospective study analyzed medical records including socio-demographics, past medical history, clinical manifestation, comorbidities, laboratory dat...
Article
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Background The burden of malaria infection in sub-Saharan Africa among school-aged children aged 5–15 years is underappreciated and represents an important source of human-to-mosquito transmission of Plasmodium falciparum. Additional interventions are needed to control and eliminate malaria. We aimed to assess whether preventive treatment of malari...
Preprint
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Background The World Health Organization (WHO) End Tuberculosis Strategy calls for a 90% reduction in tuberculosis (TB) deaths and an 80% reduction in the incidence rate between 2015 and 2035. The 2018 WHO guidelines recognize the need for high-burden countries to implement outreach and treatment for the most vulnerable patients with latent TB infe...
Article
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Background Considerable upscaling of malaria control efforts have taken place over the last 15 years in the Democratic Republic of Congo, the country with the second highest malaria case load after Nigeria. Malaria control interventions have been strengthened in line with the Millenium Development Goals. We analysed the effects of these interventio...
Article
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Background: Worldwide, the highest malaria mortality is due to Plasmodium falciparum infection. However, other species of Plasmodium (Plasmodium vivax, Plasmodium ovale, Plasmodium malariae, and Plasmodium knowlesi) can also cause malaria. Therefore, accurate identification of malaria species is crucial for patient management and epidemiological s...
Article
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Background Malaria and schistosomiasis remain life-threatening public health problems in sub-Saharan Africa. The infection pattern related to age indicates that preschool and school-age children are at the highest risk of malaria and schistosomiasis. Both parasitic infections, separately or combined, may have negative impacts on the haemoglobin con...
Article
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Background: In 2012, the World Health Organization recommended blocking the transmission of Plasmodium falciparum with single low-dose primaquine (SLDPQ, target dose 0.25 mg base/kg body weight), without testing for glucose-6-phosphate dehydrogenase deficiency (G6PDd), when treating patients with uncomplicated falciparum malaria. We sought to deve...
Article
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In endemic areas, malaria and its adverse effects in schoolchildren may be prevented by intermittent preventive treatment (IPTsc). However, the most appropriate drug regimen for IPTsc remains to be identified. A randomised controlled trial was conducted in Kinshasa, DRC. Enrolled schoolchildren were assigned to a passive control arm (n = 212), sulf...
Article
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Background Intermittent preventive treatment (IPT) is likely to be the most promising therapeutic strategy to prevent malaria and its related adverse outcomes in schoolchildren. However, its successful implementation will depend on acceptability to key stakeholders such as parents and teachers. Methods A qualitative research was conducted, followi...
Article
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Background: Intermittent preventive treatment (IPT) is a proven malaria control strategy in infants and pregnancy. School-aged children represent 26 % of the African population, and an increasing percentage of them are scholarized. Malaria is causing 50 % of deaths in this age group and malaria control efforts may shift the malaria burden to older...
Conference Paper
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Background Anaemia reduces cognitive potential in school children, retards their growth and predisposes them to other diseases. As there is a paucity of data on the current burden of P. falciparum, S. mansoni and soil transmitted helminths (STH) infections and their correlation with schoolchildren’s anemia in the Democratic Republic of Congo (DRC),...
Conference Paper
Full-text available
Background In malaria endemic areas, asymptomatic malaria infection causes anemia, malnutrition and reduces cognitive abilities in schoolchildren. Intermittent preventive treatment (IPT) may be a suitable strategy to prevent malaria and its adverse effects in this specific group. The most appropriate drug regimen for IPT needs to be identified. Metho...
Article
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Introduction : Malaria is responsible for significant morbidity in tropical areas mostly in young children. The IPT given to infants under the expanded program of immunization reduced the incidence of malaria disease and infant mortality rates. However, the success of intermittent preventive treatment in infants (IPT) with sulfadoxine-pyrimethamine...
Article
Full-text available
Background: Anaemia reduces cognitive potential in school children, retards their growth and predisposes them to other diseases. As there is a paucity of data on the current burden of P. falciparum, S. mansoni and soil transmitted helminths (STH) infections and their correlation with schoolchildren's anemia in the Democratic Republic of Congo (DRC...
Article
Full-text available
Background Neurological disorders of infectious origin are common in rural sub-Saharan Africa and usually have serious consequences. Unfortunately, these syndromes are often poorly documented for lack of diagnostic tools. Clinical management of these diseases is a major challenge in under-equipped rural health centers and hospitals. We documented h...
Article
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In areas of high malaria transmission, Plasmodium falciparum infection during pregnancy is characterized by malaria-related anaemia, placental malaria and does not always result in clinical symptoms. This situation is associated with poor pregnancy outcomes. The aim of this study was to determine the extent of asymptomatic P. falciparum infection,...
Conference Paper
Full-text available
Background: In areas of high malaria transmission, P. falciparum infection does not usually result in clinical symptoms. Malaria infection during pregnancy is characterized by malaria related anemia and placental malaria. This situation has been associated with poor pregnancy outcomes across many populations. The aim of this study was to determine...
Article
Full-text available
In malaria endemic areas, schoolchildren usually have asymptomatic malaria infections and consequently remain untreated. Therefore, intermittent preventive treatment with sulfadoxine-pyrimethamine in schoolchildren would be a plausible strategy in malaria stable transmission areas to prevent anaemia and malnutrition. However, in contrast to infancy...
Conference Paper
Introduction The aim of this study was to determine the extent of asymptomatic P. falciparum infection and its related anemia in healthy pregnant women living in Kinshasa, Democratic Republic of the Congo, an endemic area for malaria transmission. Material and Methods A cross-sectional study was conducted in pregnant women attending prenatal care c...
Conference Paper
Introduction Several rapid tests are marketed for malaria diagnosis. The detection of low parasitemia is one of criteria for a good rapid test, although in high transmission areas people may carry parasites at a certain level without being ill. This study aims to determine the discrimination level of parasite density between symptomatic and non sym...
Conference Paper
Full-text available
Introduction The diagnosis of malaria is a significant challenge in resource-limited nations. The current standard method for determining whether a patient has malaria is to carry out a peripheral blood examination using a Giemsa-stained thick and thin blood film smears. This test requires a laboratory setting with a trained microscopist for accura...

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