Jung Y. Huang

Chiao Tung University · www.jyhuang.idv.tw

In the present paper, we demonstrate a technique that can simultaneously localize single epidermal growth factor receptors (EGFRs) in live cells and record their spectra as well. This technique possesses the advantages of both single-molecule sensitivity and parallel detection. By exploiting the environment-induced spectral changes of fluorescently...

Epidermal growth factor receptor (EGFR/ErbB1) is a transmembrane protein that can drive cell growth and survival via the ligand-induced dimerization of receptors. Because dimerization is a common mechanism for signal transduction, it is important to improve our understanding of how the dimerization process and membrane structure regulate signal tra...

We developed an energetic model by integrating the generalized Langevin equation with the Cahn-Hilliard equation to simulate the diffusive behaviors of receptor proteins in the plasma membrane of a living cell. Simulation results are presented to elaborate the confinement effects from actin corrals and protein-induced lipid domains. Single-molecule...

Two quantum control spectroscopic techniques were applied to study InAs quantum dot (QD) devices, which contain different strain-reducing layers. By adaptively control light matter interaction, a delayed resonant response from the InAs QDs was found to be encoded into the optimal phase profile of ultrafast optical pulse used. We verified the delaye...

Human adenylate kinase isoenzyme 1 (AK1) is the key enzyme in maintaining the cellular energy homeostasis. The catalysis-associated conformational changes of AK1 involve large-amplitude rearrangements. To decipher the conformational dynamics of AK1 at the single-molecule level, we tagged AK1 with two identical fluorophores, one near the substrate-b...

Hyperspectral imaging (HSI) can provide valuable information about the spatial distribution of ingredients in an object, therefore the technique has been widely adopted in numerous applications, ranging from remote sensing and land planning, food quality control, to biomedical applications. However, HSI instruments are expensive, which has limited...

Cell-penetrating peptides (CPPs) can translocate across cell membranes, and thus have great potential for the cellular delivery of macromolecular cargoes. However, the mechanism of this cellular uptake process is not yet fully understood. In this study, a time-lapse single-particle light-sheet microscopy technique was implemented to obtain a parall...

Background: The first step in many cellular signaling processes occurs at various types of receptors in the plasma membrane. Membrane cholesterol can alter these signaling pathways of living cells. However, the process in which the interaction of activated receptors is modulated by cholesterol remains unclear. Methods: In this study, we measured...

Ligand-induced receptor dimerization plays a crucial role in the signaling process of living cells. In this study, we developed a theoretical model and performed single-molecule tracking to explore the correlated diffusion processes of liganded epidermal growth factor receptors prior to dimer formation. We disclosed that both an attractive potentia...

The invention discloses a method for fabricating power-generating module with solar cell. The method includes the steps of providing a flexible substrate; forming a solar cell unit on the flexible substrate by using a high density plasma at a temperature lower than about 150° C.; and forming a circuit unit on the flexible substrate; wherein the sol...

A sandwiched light-trapping electrode structure, which consists of a capping aluminum-doped ZnO (AZO) layer, dispersed plasmonic Au-nanoparticles (Au-NPs), and a micro-structured transparent conductive substrate, is employed to stabilize and boost the conversion-efficiency of hydrogenated amorphous silicon (a-Si:H) solar cells. The conformal AZO ul...

For the first time, a sequentially processed 3D hybrid chip is demonstrated by stacking low-temperature (LT) Ferroelectric-like (FE-like) metal-oxide nonvolatile memory (NVM) and CMOS. The high-mobility (333 and 113 cm2/V-s) and low-subthreshold swing (97 and 112 mV/decade) N/P-type thin film transistors (TFTs) construct stacked inverters showing s...

We formalize a theory to help explore the effect of conformational fluctuation on the energy landscape evolution of single-molecule protein. Using this formalization, we investigate the photon emission from single photoactivated fluorescent protein. A bimodal regulation on the energy landscape evolution was discovered, and its origin was attributed...

We investigate the performance of amorphous Si (a-Si) solar cells fabricated with Inductively Coupled Plasma (ICP) deposition technique. The ICP system produces a-Si films with low defect density (3×1015cm−3), resulting in a conversion efficiency of 9.6%. Deep level transient spectroscopy (DLTS) reveals that hole carriers trapped at defects near th...

The growing body of data shows protein motion plays an important role in the catalytic processes of enzymes. Human adenylate kinase 1 (AK1) is the key enzyme in maintaining the cellular energy homeostasis. The conformational change of AK1 involves large-amplitude rearrangements of the enzyme's lid domain. Observing a single molecule can remove the...

For the first time, we report a novel self-powered TFT panel (30×40cm2) by integration of sputtering/non-toxic Se vapor selenization copper-indium-gallium-selenide (CIGS) solar cell (conversion efficiency of 8%) and high electron-mobility (172 cm2/V-s) micro-crystalline (μc)-Si TFTs.

A liquid crystal polymer (LCP) self-assembled on a photoirradiated substrate can modify the viscoelastic response of liquid crystal medium on the substrate. Sum-frequency vibrational spectroscopy shows that the phenyl groups of LCP are oriented epitaxially with layer thickness and an in-plane alignment order much higher than that at the photoirradi...

We study the frequency-dependent nonlinear optical properties of the orthorhombic (wurtzite) ternary nitride tetrahedral semiconductors, i.e. ZnGeN2 and the related ternary nitrides based on the Linear Augmented Slater-Type Orbitals (LASTO) method.

We investigate the performance of a single-junction amorphous Si (a-Si) solar cell fabricated with inductively coupled plasma (ICP) deposition technique. The high-density plasma resulting from high dissociation capacity of ICP enables good-quality hydrogenated Si films to be synthesized at low temperatures. High-density ICP also promotes the diffus...

Recent molecular dynamics simulations and experimental observations have revealed that the native-state dynamics of a single-molecule protein can be distinguished with slow hopping among energy basins, mainly caused by backbone motions; and side-chain related fast processes within the individual basins. We successfully formalize the dynamic evoluti...

Highly stable high-density plasma-fabricated amorphous Si solar cells (7-9%) exhibit ultra-low photo-induced degradation in conversion-efficiency by 5.7%. This photovoltaic device with low-defect absorption layer is also a near-omni-directional solar-electricity generator.

The non-closely packed (surface-coverage of 55-65%) sub-micron silica sphere (400 nm) light-trapping monolayer was introduced to boost photocurrent (efficiency) of thin film amorphous solar cells by 15% (6.9%). The enhancement is nearly omni-directional.

For the first time, we report a low temperature silicon thin film deposition technology using high density plasma for high performance and low cost solar cells with embedded transistor modules. For process temperature at 140°C, energy conversion efficiency of 9.6% and electron mobility of 1.1 cm²/V-s have been achieved. Device performanc...

In this chapter, we reviewed our recent advances on the ordered structure and dynamic responses of ferroelectric liquid crystal to an external deterministic force and stochastic thermal excitation. We studied how the ordered structure and dynamic responses were tailored by doping the FLC with ZnO nanoparticles. Combined capacitance-voltage measurem...

This work first theoretically optimize the amorphous (a-Si:H) and the microcrystalline (μc-Si:H) devices characteristics, and then perform studies for micromorph tandem solar cells. The studies calculated by AMPS-1D show that the TCO work function has obvious influence on the open-circuit voltage. Moreover, the power conversion efficiency of an a-S...

Intra- and inter-particle coupling effects are important but have not been properly taken into account in modeling the optical response of an array of nano-objects. In this paper, we present a method to analyze the impact of electric quadrupolar coupling on the optical response of a layer of silver nanorods fabricated with oblique-angle deposition...

Record fabrication temperature, 100°C, of a single junction amorphous Si solar cell was demonstrated by a high-density plasma method. Present solar cell revealed conversion efficiency of 7.4% at 200°C (4.1% at 135°C).

Systematic studies based on first-principles calculations of second-order optical susceptibilities as well as the dielectric function of CsGeX3 (X = Cl, Br, and I; CGX) are presented. The relationship between structural properties and optoelectronic responses are examined. The structural factors delta alpha, and dGe, dX are proposed to describe the...

We show an artificially engineered electret with Si nanocrystals embedded in mesoporous silica for nonvolatile memory. We attribute the polarization to from polar layers lying at the interfaces between one-side bonded Si nanocrystals and mesoporous silica matrix. Under external field, the Si nanocrystals could be displaced in the porechannels causi...

Ordinary and extraordinary refractive indices of an ɛ - Ga Se crystal at terahertz (THz) frequencies are experimentally determined in this study. Fitting experimental data by THz time-domain spectroscopy (THz-TDS) and a Fourier transform infrared spectrometer (FTIR), we proposed revised complex dielectric functions and Sellmeier equations of GaSe f...

The nonlinear optical (NLO) property of hydrated rubidium germanium chloride (HRGC), RbGeCl3\cdotx(H2O), is identified. Infrared absorption data support structural evidence that HRGC contain co-ordinated water molecules with strong hydrogen bond. The infrared spectrum indicated HRGC is transparent in most of the infrared region with only little inf...

The optoelectronic response of a material governs its suitability for a wide range of applications, from photon detection to photovoltaic conversion. To conquer the material limitations and achieve improved optoelectronic responses, nanotechnology has been employed to arrange subunits with specific size-dependent quantum mechanical properties in a...

A fully silicon-based metal-oxide-semiconductor field-effect transistor is demonstrated for the detection of near-infrared light. Si nanocrystals (nc-Si) are synthesized in the nanopore channels of mesoporous silica (MS) inserted between two oxide layers to form a complete gate structure of polycrystalline Si/SiO2/nc-Si-in-MS/SiO2 with a polycrysta...

The capacitance–voltage (C–V) characteristics of surface-stabilized ferroelectric liquid crystal (SSFLC) cells doped with zinc oxide nanocrystals (nc-ZnO) have been studied and fitted to the Preisach model to reveal the behaviours of dipolar species. To explain the experimental results, we propose a physical picture depicting an interaction of nc-Z...

Fully Si-based MOSFET photodetector was demonstrated at optical telecommunication wavelengths by using a gate dielectric stack comprising of a Si quantum dots film. Illumination at wavelengths λ=1.55μm, photoresponse as high as 2.0A/W was measured.

Optical sum-frequency generation and ferroelectric-like switching in Si-O polar structures comprised of Si nanocrystals (nc-Si) in mesoporous silica was reported and attributed to polar layers lying at the interfaces between one-side bonded nc-Si and host.

We develop an inverse-problem mathematical approach to retrieve liquid crystal (LC) director profiles from optical transmittance curves. We propose a new regularization matrix based on a priori knowledge of LC, which allows us to successfully retrieve the LC director profiles even with noise-contaminating optical transmittance data spanning only a...

The electric-field-induced modulation of surface stabilized ferroelectric liquid crystal (SSFLC) films was in-vestigated with a phase sensitive Raman imaging. We found the technique not only effectively suppresses the nonresonant background of a Raman spectrum, but also yields an insight into the modulated amplitudes and phases of Raman peaks. By u...

We propose and experimentally demonstrate the generation of single-cycle terahertz radiation with two-stage optical rectification in GaSe crystals. By adjusting the time delay between the pump pulses employed to excite the two stages, the terahertz radiation from the second GaSe crystal can constructively superpose with the terahertz field injected...

We present the results of the ab initio calculated electronic properties, first and second harmonic generation for the AII BIV N2 (AII=Be, Mg; BIV =C, Si, Ge) compounds with chalcopyrite structure performed using the Linear Augmented Slater-Type Orbitals (LASTO) method. The second-order optical susceptibilities as functions of frequency for AII BIV...

Doping liquid crystal (LC) with nanomaterials has been shown to yield some degrees of freedom for tailoring LC properties. This approach can be employed to produce new LC materials with high application potentials by blending instead of synthesizing new mesogenic molecules. In this paper, we show that doping ferroelectric liquid crystal (FLC) with...

The symmetry of the twin boundaries of ZnO epitaxial film was detected with reflective second harmonic generation (RSHG). The twin boundaries exhibit mirror symmetry with a polar configuration across the boundary plane and yield a nonvanishing polar contribution to RSHG. The nonvanishing second-order susceptibility supports the notion that the meas...

Ab initio electronic structure calculations based on Linear Augmented Slater-Type Orbitals (LASTO) were carried out to analyze the optical responses, including the linear and second-order optical susceptibilities as functions of frequency for CsGeCl3 and CsGeBr3. In the mean while, the related properties of CsGel3 were also examined in this researc...

In this paper, single-grain-boundary (GB)-position-induced electrical characteristic variations in 300 nm surrounding-gate (i.e., gate-all-around (GAA)) polysilicon thin film transistors (TFTs) are numerically investigated. For a 2T1C active-matrix circuit, a three-dimensional device–circuit coupled mixed-mode simulation shows that the switching sp...

This study involves the collective electron transport behavior of sequestered Au nanoparticles in a nanostructured polystyrene-block-poly(4-vinylpyridine). The monolayer thin films (ca. 30 nm) consisting of Au nanoparticles self-assembled in the 30-nm spherical poly (4-vinylpyridine) domains of an polystyrene-block-poly (4-vinylpyridine) diblock co...

We report on the high average power third harmonic generation (THG) of a mode-locked picosecond laser in a CsB3O5 (CBO) crystal. The picosecond laser beam at 1064 nm is produced by a home-made 30 W master oscillator power-amplifier (MOPA) Nd:YVO4 laser system. The maximum THG output at 355 nm is up to 5.4 W. We also investigate the phase matching a...

The structures of the Zn–O bonding in ZnO (0002) thin films prepared by metal organic chemical vapor deposition have been studied by reflective second harmonic generation (RSHG). The polar Zn–O bond on the top layer is not canceled out and presents 3 mm symmetrical structures on the well-grown ZnO (0002) surface. The average polar strength of the Z...

The authors report a two-terminal metal-oxide-semiconductor photodetector for which light is absorbed in a capping layer of silicon nanocrystals embedded in a mesoporous silica matrix on p -type silicon substrates. Operated at reverse bias, enhanced photoresponse from 300 to 700 nm was observed. The highest optoelectronic conversion efficiency is a...

In this paper, we have demonstrated, for the first time, a new and simple technique for generation ultrabroadband white light OPA. Over 300 nm bandwidth OPA output was generated.

We report a study of the effect of optical absorption on generation of coherent infrared radiation from mid-IR to THz region from GaSe crystal. The infrared-active modes of ε-GaSe crystal at 236 cm⁻¹ and 214 cm⁻¹ were found to be responsible for the observed optical dispersion and infrared absorption edge. Based upon phase matching characteristics...

The population-split genetic algorithm (PSGA) was successfully applied to retrieve femtosecond optical fields from interferometric autocorrelation traces. PSGA strikes a balance between diversity and the size of population in the genetic algorithm. As a result, PSGA is less likely prematurely converging to sub-optimal solutions. Theoretical and exp...

A systematic first-principles calculation of the linear and second-order optical susceptibilities as functions of frequency for CsGeBr3 is presented. Specifically, we study the relation between the structural properties and the optical responses. Three structural deformation factors, Deltaalpha, dGe, dX are used to express the degree of distortion...

Time-resolved two-dimensional infrared (2D IR) spectroscopy has been applied to analyse an electro-optic switching ferroelectric liquid crystal (FLC) mixture. The 2D IR correlation technique clearly shows that the Goldstone mode in the SmC* phase is suppressed by an applied electric field. The field-induced reorientation process initiates from intr...

We reported a type-I difference-frequency generator (DFG), based on erbium doped GaSe (Er:GaSe) crystals as a coherent infrared source tunable from 2.4 µm to 28 µm. The two mixing beams used for the DFG are a tunable near infrared output (1.1–1.8 µm) from an optical parametric amplifier (OPA) and the fundamental beam of a picosecond Nd:YAG laser at...

We demonstrated that in a nanocrystalline TiO2/poly(2-methoxy-5-(2′-ethylhexyloxy)-1,4-phenylene vinylene) (MEH-PPV) composite, electroluminescence of this composite is enhanced via addition of TiO2 nanoneedles. The TiO2 nanoneedles enhance the partial crystallization of MEH-PPV around TiO2, which in turn causes a decrease in the hole barrier heigh...

Ultraviolet light was detected by MOS devices with silicon nanocrystals-embedded mesoporous silica sensing layers. The detector reveals high photoresponse of 2.0 (0.3) A/W at wavelength 370 (275) nm, and is blind to green light.

Highly luminescent dendron-substituted copolyfluorenes that incorporate surface-modified cadmium sulfide nanoparticles have been prepared. A small percentage of these nanoparticles can be incorporated into the dendritic structures upon tailoring the interfaces between the ligands on the nanoparticles and the dendritic structures in the copolyfluore...

The application of an electric field to induce the orientation of CdSE nanorods that were self assembled in the poly(4-vinylpyridine) (P4VP) nanodomains of a diblock copolymer thin film was discussed. The number of CdSe nanorods incorporated in the P4VP nanodomains varied by controlling the strength of the polar interactions and the loading concent...

2Department of Electro-Optical Engineering, National Chiao Tung University, 1001 Ta Hsueh Road, Hsinch 30050 (Taiwan ROC)

An innovative infrared nonlinear optical crystal CsGeBr 3 was synthesized. Ab initio calculations on CsGeBr 3 were also carried out in order to analyse the second-order nonlinear susceptibilities. From its powder x-ray diffraction pattern, this crystal was characterized as a rhombohedral structure with an (R3m, No 160) space group symmetry. The ref...

We report on the development of a freezing phase scheme for complete-field characterization and adaptive coherent control with a femtosecond pulse shaper. The operational principle is based on a concept that the highest peak intensity will correspond to a frozen phase state of all spectral components involved in a coherent optical pulse. Our experi...

A freezing phase concept has been proposed for adaptive coherent control with a femtosecond pulse shaper. We applied the scheme to investigate multiphoton processes in InAs quantum dot saturable Bragg reflector (SBR). The optical transition of InAs quantum dots can be revealed in the spectral phase sensitivity plot of second harmonic signal. We als...

Tunable femtosecond laser pulses from 380nm to 460nm, attributed to a cascaded SFG process, can be directly generated from a 405nm-pumped type-I BBO NOPA. The optical conversion efficiency is more than 5%.

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We report an intense picosecond infrared light source on microjoule energy level, widely tunable in the 2.4 - 38 μ m with pulse durations ∼5ps by DFG in GaSe. The maximum photon conversion efficiency is greater than 43%.