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Publications (16)
Purpose
The lamina cribrosa (LC) is a layer of fenestrated connective tissue tethered to the posterior sclera across the scleral canal in the optic nerve head (ONH). It is located at the interface of intracranial and intraocular compartments and is exposed to intraocular pressure (IOP) anteriorly and intracranial pressure (ICP) or Cerebrospinal flu...
The peripapillary retinal pigment epithelium-basement membrane (ppRPE/BM) layer angle was recently proposed as a potential index for estimating intracranial pressure noninvasively. However, the ppRPE/BM layer angle, measured from the optical coherence tomography (OCT) scans, varied across the radial directions of the optic disc. This made the ppRPE...
Purpose
Orbital veins such as the retinal veins and episcleral veins drain into the cavernous sinus, an intracranial venous structure. We studied the effects of acute intracranial pressure (ICP) elevation on episcleral venous pressure, intraocular pressure and retinal vein diameter in an established non-survival pig model.
Methods
In six adult fem...
Purpose: To develop and test an innovative semi-automatic method for quantifying the three-dimensional morphology of the peripapillary retinal pigment epithelium-basement membrane (ppRPE/BM) layer, with application to lumbar puncture (LP) patients. Methods: Nineteen patients undergoing LP were recruited. The optic nerve head images of both eyes wer...
Current knowledge of traumatic ocular injury is still limited as most studies have focused on the ocular injuries that happened at the anterior part of the eye, whereas the damage to the optic nerve known as traumatic optic neuropathy (TON) is poorly understood. The goal of this study is to understand the mechanism of the TON following the primary...
Purpose
To characterize the relative contributions of intraocular pressure (IOP) and intracranial pressure (ICP) on lamina cribrosa (LC) behavior, specifically LC depth (LCD) and LC peak strain.
Methods
An axially symmetric finite element model of the posterior eye was constructed with an elongated optic nerve and retro-orbital subarachnoid space...
Table 1: ICP and IOP measured by Berdahl et al. Table 2: pressure datasets from Ren's publication. Figure 1: secondary analysis using measured ICP and IOP from experiment by Berdahl et al. Figure 2: secondary analysis using measured ICP and IOP from experiment by Ren et al.
With the increasing application of improvised explosive devices, the ratio of traumatic ocular injury significantly increased in the past decades, which has become the fourth most happened injury to military deployment. The ocular injury treatment is costly and has been less effective, which influences the military service and life experience of th...
Stent implantation is widely used to treat blocked lumen. Stents were meshed structure made of polymers and metal alloys, including stainless steel, cobalt chrome and nitinol [1]. Clinical studies had demonstrated that stents helped to scaffold the diseased lesion up to one year when tissue adapted to the stented environment [2]. However, the perma...
Introduction:
The long-held belief that a ureteral re-implant tunnel should be five times the diameter of the ureter, as proposed by Paquin in 1959, ignores the effect of the orifice on the occurrence of reflux. In 1969, Lyon proposed that the shape of the ureteral orifice (UO) is more important than the intravesical tunnel. However, both theories...
Stent implantation is widely used to treat blocked lumen. Stents were meshed structure made of polymers and metal alloys, including stainless steel, cobalt chrome and nitinol [1]. Clinical studies had demonstrated that stents helped to scaffold the diseased lesion up to one year when tissue adapted to the stented environment [2]. However, the perma...
Vesicoureteral reflux (VUR) is the backward flow of urine from the bladder into the kidneys. There are many reasons for this reflux. In 1959, Paquin recommended a tunnel length 5 times the diameter of the ureter to prevent VUR based on anatomical comparisons of postmortem specimens of patients with and without VUR [1]. This has become the standard...
Biomechanics of optic nerve head (ONH) has attracted increasing attention in recent years due to its association with ganglion cell damage and tissue remodeling resulted vision impairments [1, 2]. The ONH is exposed to both intraocular pressure (IOP) and intracranial pressure (ICP), separated by the lamina cribrosa (LC) which is regarded as the pri...
In this work, the biomechanical responses of the optic nerve head (ONH) to acute elevations in intracranial pressure (ICP) were systematically investigated through numerical modeling. An orthogonal experimental design was developed to quantify the significance levels of ten input factors that govern the anatomy and material properties of the ONH mo...
Glaucoma is an eye disease related with vision field loss. Although previous study has investigated the influence of intraocular pressure (IOP) on the glaucoma damage to the lamina cribrosa (LC), the intracranial pressure’s (ICP) effect on the LC has never been elucidated. The goal of this work is to determine the effect of ICP on the LC.
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