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Publications (12)
Fluid energy mill (FEM) was utilized to simultaneously realize several functions, namely: size reduction of coarse micron-sized pre-coated particles into smaller (ca. 1–10 μm) particles, as well as de-agglomeration and coating of nanoparticles onto the ground particles, all within the FEM chamber. Three types of coating nanoparticles – silica, alum...
In this paper, a three-dimensional model taking into account the contact deformation and surface area coverage (SAC) of nanoadditives is proposed to predict the force required to separate two contacting particles (the pull-off force) under consolidation stress up to 10 KPa, for cornstarch, a Geldart group C powder, sparsely and densely dry-coated w...
Fluidized beds are widely used for particle coating and granulation in the pharmaceutical and chemical industries because of their excellent mixing properties, high heat and mass transfer rates, and ease of scale-up. However, a conventional fluidized bed cannot be used for handling fine cohesive particles (less than 40 μm) due to their poor fluidiz...
The difficulty of coating cohesive Geldart group C powders in a conventional fluidized bed is attributed to strong inter-particle force between fine particles leading to poor fluidization behavior. Dry coating approach involving deposition of nanosize particles on the surface of group C powders is considered to reduce the interparticle force and im...
While it is well known that flow aids such as fumed silica can be added to improve flowability and fluidizability of cohesive powders, the improvements observed depend on how well the flow aids are blended together with the cohesive powders. In this work, dry particle coating is used to deposit a very small amount of nano-sized particles (as low as...
Supercritical processes for drug delivery system design have attracted considerable attention recently. This present work investigates the application of a supercritical antisolvent coating process for controlled drug release design. Hydrocortisone as the host drug particles and poly(lactide-co-glycolide) (PLGA) as the polymer carrier were selected...
Macroporous monoliths consisting of silica nanoparticles embedded in poly(methyl methacrylate) (PMMA) were synthesized in supercritical CO 2 . Well‐dispersed silica particles, pretreated with functional 3‐(trimethoxysilyl)propyl methacrylate (MPS), were to form colloidal PMMA nanocomposites followed by a sol‐gel transition forming interconnected st...
Several dry processing techniques are used to coat cohesive cornstarch powder with different size silica particles. For nanosized silica guest particles, FESEM images show that both the magnetic assisted impaction coater (MAIC) and the hybridizer (HB) produce particles that are significantly more uniformly coated than using either a V-shape blender...
Fine Dechlorane (DCR) particles with an average size of 12 μm were successfully encapsulated with poly(methyl methacrylate) (PMMA) and poly(1-vinyl-2-pyrrolidone) (PVP) polymers via in situ dispersion polymerization in supercritical carbon dioxide (scCO2). Adjusting the process parameters can control the coating thickness, surface morphology, and d...
The suppression of bonding of micron-sized host particles due to the application of heat at temperatures below their melting point (deactivated sintering) when coated with submicron guest particles is theoretically predicted and confirmed by experiments. It was possible to preserve individual particles of polymethylmethacrylate (PMMA) at 150°C, abo...
Film coating of fine particles (5-20 microns) by polymers has a wide range of industrial applications, yet few techniques are commercially available that are environmentally friendly. In this study, four different techniques are considered with an ultimate goal of developing a reliable technique that is scaleable and is also environmentally friendl...
The mixing of two different species of nano-particles using an environmentally benign technique called rapid expansion of high-pressure suspensions (REHPS) has been studied experimentally. Comparative experiments were also performed by mixing the nano-particles in an organic solvent under ultrasonic agitation and in a dry mechanical mixing process...
