Jun Liao

Jun Liao
University of Texas at Arlington | UTA · Department of Bioengineering

Ph.D.

About

154
Publications
25,317
Reads
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3,482
Citations
Citations since 2016
54 Research Items
2185 Citations
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
Additional affiliations
January 2017 - present
University of Texas at Arlington
Position
  • Professor
August 2013 - December 2016
Mississippi State University
Position
  • Professor
January 2007 - July 2013
Mississippi State University
Position
  • Professor

Publications

Publications (154)
Article
Mitral valve (MV) tissue engineering is still in its early stage, and one major challenge in MV tissue engineering is to identify appropriate scaffold materials. With the potential of acellular MV scaffolds being demonstrated recently, it is important to have a full understanding of the biomechanics of the native MV components and their acellular s...
Article
Full-text available
Cardiac extracellular matrices (ECM) play crucial functional roles in cardiac biomechanics. Previous studies have mainly focused on collagen, the major structural ECM in heart wall. The role of elastin in cardiac mechanics, however, is poorly understood. In this study, we investigated the spatial distribution and microstructural morphologies of car...
Article
Full-text available
Cardiac extracellular matrices (ECM) play crucial functional roles in cardiac biomechanics. Previous studies have mainly focused on collagen, the major structural ECM in heart wall. The role of elastin in cardiac mechanics, however, is poorly understood. In this study, we investigated the spatial distribution and microstructural morphologies of car...
Article
Bioadhesives are intended to facilitate the fast and efficient reconnection of tissues to restore their functionality after surgery or injury. The use of mussel-inspired hydrogel systems containing pendant catechol moieties is promising for tissue attachment under wet conditions. However, the adhesion strength is not yet ideal. One way to overcome...
Article
After myocardial infarction (MI), the infarcted tissue undergoes dynamic and time-dependent changes. Previous knowledge on MI biomechanical alterations has been obtained by studying the explanted scar tissues. In this study, we decellularized MI scar tissue and characterized the biomechanics of the obtained pure scar ECM. By thoroughly removing the...
Article
Biodegradable cardiac patch is desirable to possess mechanical properties mimicking native myocardium for heart infarction treatment. We fabricated a series of anisotropic and biodegradable polyurethane porous scaffolds via thermally induced phase separation (TIPS) and tailored their mechanical properties by using various polyurethanes with differe...
Article
Full-text available
Mussels are well-known for their extraordinary capacity to adhere onto different surfaces in various hydrophillic conditions. Their unique adhesion ability under water or in wet conditions has generated considerable interest towards developing mussel inspired polymeric systems that can mimic the chemical mechanisms used by mussels for their adhesiv...
Article
The number of people affected by heart disease such as coronary artery disease (CAD) and myocardial infarction (MI) increases at an alarming rate each year. Currently, the methods to treat these diseases are restricted to lifestyle change, pharmaceuticals, and eventually heart transplant if the condition is severe enough. While these treatment opti...
Preprint
Full-text available
Finite element (FE) models have been effectively utilized in studying biomechanical aspects of myocardial infarction (MI). Although the rat is a widely used animal model for MI, there is a lack of material parameters based on anisotropic constitutive models for rat myocardial infarcts in literature. This study aimed at employing inverse methods to...
Article
Full-text available
Heart valve (HV) diseases are among the leading causes of death and continue to threaten public health worldwide. The current clinical options for HV replacement include mechanical and biological prostheses. However, an ongoing problem with current HV prostheses is their failure to integrate with the host tissue and their inability grow and remodel...
Article
Full-text available
In automobile accidents, abdominal injuries are often life-threatening yet not apparent at the time of initial injury. The liver is the most commonly injured abdominal organ from this type of trauma. In contrast to current safety tests involving crash dummies, a more detailed, efficient approach to predict the risk of human injuries is computationa...
Article
Full-text available
The collective data associated with this article presents the biaxial mechanical behavior for six smaller, delimited regions of the mitral valve and tricuspid valve anterior leaflets. Each data set consists of five columns of data, specifically: (i) biaxial testing protocol ID, (ii) circumferential stretch, (iii) radial stretch, (iv) circumferentia...
Article
The heart epicardial layer, with elastin as the dominant component, has not been well investigated, specifically on how it contributes to ventricular biomechanics. In this study, we revealed and quantitatively assessed the overall status of prestraining and residual stresses exerted by the epicardial layer on the heart left ventricle (LV). During p...
Article
Full-text available
Abstract Decellularized porcine myocardium has shown many benefits as a cell delivery scaffold for cardiac therapy. However, using full thickness decellularized myocardium as cardiac patch may lead to poor viability and inhomogeneous distribution of delivered cells, due to perfusion limitations. In this study, we explored the feasibility of decellu...
Article
Full-text available
Nanoparticles (NPs) can be used to locally deliver anti-restenosis drugs when they are infused directly to the injured arteries after intervention procedures such as angioplasty. However, the efficacy of transferring NPs via infusion to the arterial wall is limited, at least partially, due to poor NP retention on the inner artery wall. To improve N...
Article
The facilitation of proper blood flow through the heart depends on proper function of heart valve components, and alterations to any component can lead to heart disease or failure. Comprehension of these valvular diseases is reliant on thorough characterization of healthy heart valve structures for use in computational models. Previously, computati...
Article
Explosions pose serious threats to US soldiers and civilians, often resulting in disability and death. Due to its direct contact with the ground, the lower extremity is commonly injured, and the blast loading often results in traumatic amputations and soft tissue rupture. The exact overpressure signatures that induce these primary blast injuries ar...
Article
Full-text available
A small percentage of babies born to Zika virus (ZIKV)-infected mothers manifest severe defects at birth, including microcephaly. Among those who appeared healthy at birth, there are increasing reports of postnatal growth or developmental defects. However, the impact of congenital ZIKV infection in postnatal development is poorly understood. Here,...
Article
Full-text available
The neonate transitions from placenta-derived oxygen, to supply from the pulmonary system, moments after birth. This requires a series of structural developments to divert more blood through the right heart and onto the lungs, with the tissue quickly remodelling to the changing ventricular workload. In some cases, however, the heart structure does...
Article
In this study, the damage evolution of liver tissue was quantified at the microstructural level under tensile, compression, and shear loading conditions using an interrupted mechanical testing method. To capture the internal microstructural changes in response to global deformation, the tissue samples were loaded to different strain levels and chem...
Chapter
With the growing prevalence of heart valve diseases, it is important to better understand the biomechanical behavior of normal and pathological heart valve tissues. Recent studies showed that heart valve leaflets exhibited a unique functionally elastic behavior, in which valvular tissues exhibited minimal hysteretic and creep behaviors under biaxia...
Chapter
Annually, over 50,000 deaths are attributed to heart valve disease (HVD) in the United States. The most common treatment for HVD, such as stenosis and regurgitation, is total valve replacement using mechanical and bioprosthetic heart valves, which often results in subsequent surgery to replace failed implants. For the pediatric population especiall...
Book
This book covers the latest research development in heart valve biomechanics and bioengineering, with an emphasis on novel experimentation, computational simulation, and applications in heart valve bioengineering. The most current research accomplishments are covered in detail, including novel concepts in valvular viscoelasticity, fibril/molecular...
Article
Popular bioadhesives, such as fibrin, cyanoacrylate, and albumin–glutaraldehyde based materials, have been applied for clinical applications in wound healing, drug delivery, and bone and soft tissue engineering; however, their performances are limited by weak adhesion strength and rapid degradation. In this study a mussel-inspired, nanocomposite-ba...
Article
OBJECTIVE To compare biomechanical and histologic features of heart valves and echocardiographic findings between Quarter Horses with and without heritable equine regional dermal asthenia (HERDA). DESIGN Prospective case-control study. ANIMALS 41 Quarter Horses. PROCEDURES Ultimate tensile strength (UTS) of aortic and mitral valve leaflets was asse...
Chapter
Volumetric muscle loss (VML) not only causes impaired function or a nonfunctional limb, but may also lead to limb amputation. Current treatments of VML are not able to address the functional deficiency of the damaged muscles due to a lack of effective regeneration. Tissue engineering and regenerative approaches, such as stem cell therapy and the us...
Article
Prevacularization strategy has been implemented in tissue engineering to generate microvasculature networks within a scaffold prior to implantation. Prevascularizing scaffold will shorten the time of functional vascular perfusion with host upon implantation. In this study, we explored key variables affecting the interaction between decellularized p...
Article
In this study a woodpecker's hyoid apparatus was characterized to determine its impact mitigation mechanism using finite element (FE) analysis. The woodpecker's hyoid apparatus, comprising bone and muscle, has a unique geometry compared to those of other birds. The hyoid starts at the beak tip, surrounds the woodpecker's skull, and ends at the uppe...
Article
Full-text available
Target drug deliveries using nanotechnology are a novel consideration in the treatment of cancer. We present herein an in vitro mouse model for the preliminary investigation of the efficacy of an iron oxide nanoparticle complex conjugated to vascular endothelial growth factor (VEGF) antibody and ligand cluster of differentiation 80 (CD80) for the p...
Article
Full-text available
There is a significant clinical need for new approaches to treatment of mitral valve disease. The aim of this study was to develop a tissue engineered mitral valve scaffold possessing appropriate composition and structure to ensure ideal characteristics of mitral valves, such as large orifice, rapid opening and closure, maintenance of mitral annulu...
Article
Full-text available
Myocardial infarction was experimentally induced in rat hearts and harvested immediately, 7, 14 and 28 days after the infarction induction. Anterior wall infarct samples underwent biaxial tensile and uniaxial compressive testing. Orientation of collagen fibres was analysed following mechanical testing. In this article, we present the tensile and co...
Article
Understanding the passive mechanical properties of infarcted tissue at different healing stages is essential to explore the emerging biomaterial injection-based therapy for myocardial infarction (MI). Although rats have been widely used as animal models in such investigations, the data in literature that quantify the passive mechanical properties o...
Poster
Poster presentation at the 2016 Summer Biomechanics, Bioengineering, and Biotransport Conference in National Harbor, MD. P. Berthelson, G. Liao, J. Liao, L. Williams, H. Rhee, X. Deng, R. Prabhu, ”A Study on the Mechanical Response of the Human Head during Single-Collision Car Crashes using Finite Element Analysis,” in Summer Biomechanics, Bioengin...
Article
The current study presents a nanoscale in silico investigation of strain rate dependency of membrane (phospholipid bilayer) failure when placed under strip biaxial tension with two planar areas. The nanoscale simulations were conducted in the context of a multiscale modelling framework in which the macroscale damage (pore volume fraction) progressi...
Chapter
Pelvic organ prolapse (POP) is characterized by the failure of vaginal wall support and protrusion of the pelvic organs through the vaginal orifice. The exact etiology of POP remains elusive to date, and one of the primary hurdles is the limited availability of animal models, which provide a means to better understand the weakening of supportive ti...
Article
We investigated the effectiveness of integrating tissue engineered cartilage derived from human bone marrow derived stem cells (HBMSCs) to healthy as well as osteoarthritic cartilage mimics using hydroxyapatite (HA) nanoparticles immersed within a hydrogel substrate. Healthy and diseased engineered cartilage from human chondrocytes (cultured in aga...
Data
Raw experimental data for shear strength for healthy cartilage constructs with HBMSCs in PEGDA with and without HA. (XLSX)
Data
Raw experimental Data for q(Rt-PCR) for HBMSCs derived engineered cartilage integrated to HC-secreted cartilage. (XLSX)
Data
Raw experimental Data for q(Rt-PCR) for HBMSCs derived engineered cartilage integrated to HCOA-secreted cartilage. (XLSX)
Data
Raw experimental data for cell viability of healthy and osteoarthritic chondrocytes cultured in Agar gels over 28 days. (XLSX)
Data
Raw experimental data for shear strength for osteoarthritis cartilage constructs with HBMSCs in PEGDA with and without HA. (XLSX)
Data
Additional details on EDS spectra and map analyses for Calcium and Phosphorous elements within the transition zone between engineered cartilage and engineered bone matrix. (DOCX)
Article
Myocardial infarction (MI) causes massive heart muscle death and remains a leading cause of death in the world. Cardiac tissue engineering aims to replace the infarcted tissues with functional engineered heart muscles or revitalize the infarcted heart by delivering cells, bioactive factors, and/or biomaterials. One major challenge of cardiac tissue...
Article
Osteochondral xenografts are potentially inexpensive, widely available alternatives to fresh allografts. However, antigen removal from xenogenic cartilage may damage the extracellular matrix and reduce compressive stiffness. Non-crosslinked xenogenic cartilage may also undergo rapid enzymatic degradation in vivo. We hypothesized that natural crossl...
Article
Fundamental to developing a deeper understanding of pathophysiological remodeling in mitral valve (MV) disease is the development of an accurate tissue-level constitutive model. In the present work, we developed a novel meso-scale (i.e. at the level of the fiber, 10-100 μm in length scale) structural constitutive model (MSSCM) for MV leaflet tissue...
Article
Full-text available
There is a great need for living valve replacements for patients of all ages. Such constructs could be built by tissue engineering, with perspective of the unique structure and biology of the aortic root. The aortic valve root is composed of several different tissues and careful structural and functional consideration has to be given to each segmen...
Article
High strain rate compression of soft tissues has recently gained attention due to its application in computational simulation of traumatic injuries. To understand high rate tissue behavior, a comparative study is needed to examine the biomechanical responses of multiple soft tissues. We hypothesized that the underlying mechanisms of soft tissue hig...
Article
Introduction: Biodegradable cardiac patches need to be mechanically matching with native heart muscle, in order to provide appropriate mechanical support to rapidly restore heart functions and promote tissue remodeling for myocardial infarction (MI) management. Here, we utilized chemical molecular design to develop biodegradable elastomers with low...
Article
Introduction: Myocardial infarction (MI) affects more than 8 million Americans, causing massive heart cell death and heart function decrease. To better understand the scar biomechanics, we characterized the mechanical properties of pure scar ECM, obtained by decellularizing the MI tissues. Materials and Methods: Infarcted rat hearts were generated...
Article
Guided bone regeneration is a new concept of large bone defect therapy, which employs a barrier membrane to afford a protected room for osteogenesis and prevent the invasion of fibroblasts. In this study, we developed a novel barrier membrane made from lyophilized multilayered acellular human amnion membranes (AHAM). After decellularization, the AHA...
Presentation
Podium presentation at the 2015 Summer Biomechanics, Bioengineering, and Biotransport Conference in Snowbird, UT. M. A. Murphy, S. Mun, M. F. Horstemeyer, S. R. Gwaltney, T. W. Stone, M. C. LaPlaca, et al., ”Constructing Rudimentary Limit Curves For Neuronal Phospholipid Bilayer Failure and Theoretical Calcium Penetration,” in Summer Biomechanics,...
Poster
Poster presentation at the 2015 Summer Biomechanics, Bioengineering, and Biotransport Conference in Snowbird, UT. M. A. Murphy, M. F. Horstemeyer, S. R. Gwaltney, T. W. Stone, M. C. LaPlaca, J. Liao, et al., ”Validation of High Rate Strip Biaxial Tension Deformations of the Neuronal Phospholipid Bilayer Using Empirical Data,” in Summer Biomechanics...
Poster
Poster presentation at the 2015 Summer Biomechanics, Bioengineering, and Biotransport Conference in Snowbird, UT. M. A. Murphy, M. F. Horstemeyer, S. R. Gwaltney, T. W. Stone, M. C. LaPlaca, J. Liao, et al., ”The Effects of Stress State on the Mechanical Response and Failure of the Neuronal Phospholipid Bilayer: a Molecular Dynamics Study,” in Summ...
Article
The atrioventricular valve leaflets (mitral and tricuspid) are different from the semilunar valve leaflets (aortic and pulmonary) in layered structure, ultrastructural constitution and organization, and leaflet thickness. These differences warrant a comparative look at the bending properties of the four types of leaflets. We found that the moment–c...
Article
Pulmonary injuries are a major source of morbidity and mortality associated with trauma. Trauma includes injuries associated with accidents and falls as well as blast injuries caused by explosives. The prevalence and mortality of these injuries has made research of pulmonary injury a major priority. Lungs have a complex structure, with multiple typ...
Article
Polypropylene mesh has been shown to shrink up to 50%; however, little is known about other changes that may occur while it is implanted. It is unclear whether such changes have clinical impact; nonetheless, knowledge of such can ultimately affect the technique of implantation and may affect outcomes. The objective of this study was to evaluate sur...