Julius WelzelUniversitätsklinikum Schleswig - Holstein | UKSH · Klinik für Neurologie (Kiel)
Julius Welzel
Master of Science
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36
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89
Citations
Citations since 2017
Introduction
Additional affiliations
October 2016 - May 2017
Publications
Publications (36)
INTRODUCTION It is well-known that, in Parkinson's disease (PD), executive function (EF) and motor deficits lead to reduced walking performance. As previous studies investigated mainly patients during the compensated phases of the disease, the aim of this study was to investigate the above associations in acutely hospitalized patients with PD. METH...
Introduction
Links between cognition and walking performance in patients with Parkinson’s disease (PD), which both decline with disease progression, are well known. There is lack of knowledge regarding the predictive value of cognition for changes in walking performance after individualized therapy. The aim of this study is to identify relevant pre...
Background:
Orthostatic hypotension (OH) in Parkinson's disease (PD) is frequent and associated with impairments in quality of life and reduced activities of daily living. Abdominal binders (AB) and compression stockings (CS) have been shown to be effective non-pharmacological treatment options.
Objective:
Here, we investigate the effect of AB v...
BACKGROUND
Individuals with heart failure (HF) frequently experience limitations in mobility, but specific aspects of these limitations are not well understood. This study investigated the association of HF severity, based on the New York Heart Association (NYHA) classes, with digital mobility outcomes (DMOs) and handgrip strength in older inpatien...
Abstract: Gait and balance dysfunctions are common in neurological disorders and have a negative
effect on quality of life. Regularly quantifying these mobility limitations can be used to measure
disease progression and the effect of treatment. This information can be used to provide a more
individualized treatment. Inertial measurement units (IMUs...
https://www.mdsabstracts.org/abstract/clinical-and-device-based-predictors-of-improvement-in-motor-experiences-of-daily-living-after-a-short-term-multidisciplinary-inpatient-treatment-a-cohort-study/
Objective: To determine predictors of improvement in motor experiences of daily living (m-EDL) after a multidisciplinary inpatient ‘PD multimodal com...
Essential tremor (ET) is a progressive movement disorder whose pathophysiology is not fully understood. Current evidence supports the view that the cerebellum is critically involved in the genesis of the tremor in ET. However, it is still unknown whether cerebellar dysfunction affects not only the control of current movements but also the predictio...
Essential Tremor (ET) is a progressive movement disorder whose pathophysiology is not fully understood. Current evidence supports the view that the cerebellum is critically involved in the genesis of the tremor in ET. However, it is still unknown whether cerebellar dysfunction, in addition to control of current movements, also affects prediction of...
Background:
Mobility deficits are highly prevalent among geriatric patients and have serious impact on quality of life, hospitalizations, and mortality. This study aims to capture predictors of mobility deficits in hospitalized geriatric patients using the International Classification of Functioning, Disability and Health (ICF) model as a framewor...
Introduction: It is well-known that, in Parkinson's disease (PD), executive function (EF) and motor deficits lead to reduced walking performance. As previous studies investigated mainly patients during the compensated phases of the disease, the aim of this study was to investigate the above associations in acutely hospitalized patients with PD.
Me...
Background:Fear of falling (FOF) negatively affects health-related quality of life and is common in neurogeriatric patients, however, related parameters are not well understood. This study investigated the relationship between FOF, physical performance (as assessed with the Short Physical Performance Battery and its subscores) and other aspects of...
Introduction: Essential tremor (ET) amplitude is modulated by visual feedback during target-driven movements: In a grip force task, tremor amplitude increases during large-scale visual feedback compared to low-scale visual feedback. It has not been examined whether visual feedback exclusively modulates action tremor severity or if an increase of ot...
Introduction: Evidence has accumulated to support the theory that the cerebellum is crucially involved in the primary pathophysiology of Essential Tremor (ET). The cerebellum is critical for integration of sensorimotor information to create an internal model of movement using prediction errors. Neurological disorders causing cerebellar injury, such...
Evaluating gait is part of every neurological movement disorder assessment. Generally, the physician assesses the patient based on their experience, but nowadays inertial measurement units (IMUs) are also often integrated in the assessment. Instrumented gait analysis has a longstanding tradition and temporal parameters are used to compare patient g...
Motor imagery (MI) in combination with neurofeedback (NF) is a promising supplement to facilitate the acquisition of motor abilities and the recovery of impaired motor abilities following brain injuries. However, the ability to control MI NF is subject to a wide range of inter-individual variability. A substantial number of users experience difficu...
Static balance is a commonly used health measure in clinical practice. Usually, static balance parameters are assessed via force plates or, more recently, with inertial measurement units (IMUs). Multiple parameters have been developed over the years to compare patient groups and understand changes over time. However, the day-to-day variability of t...
![Maximum plantar force [times BW] mean ± Standard deviation (error bars)...](publication/350503682/figure/fig1/AS:1007288710090752@1617167751319/Maximum-plantar-force-times-BW-meanStandard-deviation-error-bars-at-different_Q320.jpg)
![Maximum plantar force [times BW] mean ± standard deviations (error...](publication/350503682/figure/fig2/AS:1007288710086656@1617167751388/Maximum-plantar-force-times-BW-meanstandard-deviations-error-bars-varies-with_Q320.jpg)
![Average contact times [ms] ± SD (error bars) at different speeds and...](publication/350503682/figure/fig3/AS:1007288710086657@1617167751484/Average-contact-times-msSD-error-bars-at-different-speeds-and-AlterGR-assisted_Q320.jpg)
![Average contact times [ms] mean ± SD (error bars) vary with gradient...](publication/350503682/figure/fig4/AS:1007288710090755@1617167751589/Average-contact-times-ms-meanSD-error-bars-vary-with-gradient-for-speeds-12_Q320.jpg)
Background
Anti-gravity treadmills are used to decrease musculoskeletal loading during treadmill running often in return to play rehabilitation programs. The effect different gradients (uphill/downhill running) have on kinetics and spatiotemporal parameters when using an AlterG® treadmill is unclear with previous research focused on level running o...
Current research on Parkinson’s disease (PD) is increasingly concerned with the identification of objective and specific markers to make reliable statements about the effect of therapy and disease progression. Parameters from inertial measurement units (IMUs) are objective and accurate, and thus an interesting option to be included in the regular a...
Background
Identification of individual gait events is essential for clinical gait analysis, because it can be used for diagnostic purposes or tracking disease progression in neurological diseases such as Parkinson’s disease. Previous research has shown that gait events can be detected from a shank-mounted inertial measurement unit (IMU), however d...
Motor imagery (MI) practice in combination with neurofeedback (NF) is a promising supplement to facilitate the acquisition of motor abilities and the recovery of impaired motor abilities following brain injuries. However, the ability to control MI NF is subject to a wide range of inter-individual variability. A substantial number of users experienc...
Neurological pathologies can alter the swinging movement of the arms during walking. The quantification of arm swings has therefore a high clinical relevance. This study developed and validated a wearable sensor-based arm swing algorithm for healthy adults and patients with Parkinson's disease (PwP). Arm swings of 15 healthy adults and 13 PwP were...
Background: Identication of individual gait events is essential for clinical gait analysis, because it can be
used for diagnostic purposes or tracking disease progression in neurological diseases such as Parkinson's
disease. Previous research has shown that gait events can be detected from a shank-mounted inertial
measurement unit (IMU), however de...
Background: Identification of individual gait events is essential for clinical gait analysis, because it can be used for diagnostic purposes or tracking disease progression in neurological diseases such as Parkinson's disease. Previous research has shown that gait events can be detected from a shank-mounted inertial measurement unit (IMU), however...
Background
Anti-gravity treadmills are used to decrease musculoskeletal loading during treadmill running often in return to play rehabilitation programs. The effect different gradients (uphill/downhill running) have on kinetics and spatiotemporal parameters when using an AlterG® treadmill is unclear with previous research focused on level running o...
Background:
Motor and cognitive deficits and consequently mobility problems are common in geriatric patients. The currently available methods for diagnosis and for the evaluation of treatment in this vulnerable cohort are limited. The aims of the ComOn (COgnitive and Motor interactions in the Older populatioN) study are (i) to define quantitative...
For motor imagery (MI) to be effective, an internal representation of the to-be-imagined movement may be required. A representation can be achieved through prior motor execution (ME), but the neural correlates of MI that are primed by ME practice are currently unknown. In this study, young healthy adults performed MI practice of a unimanual visuo-m...
Brain computer interfaces (BCIs) controlled by motor imagery can compensate for lost motor abilities. Motor imagery can also facilitate the recovery of impaired motor function when used in rehabilitative BCIs or neurofeedback. The event-related desynchronization is a neural correlate of motor imagery used in numerous EEG studies to control rehabili...
EEG-based motor imagery (MI) brain-computer interface (BCI) can potentially be used to help the recovery of motor function following a stroke [1]. By imagining a previously learned movement, improvements of neurophysiological motor pattern were shown in many occasions [2]. In a new paradigm, the usually simple movement of MI research was replaced b...
Projects
Projects (3)
The ComOn study (Cognitive and Motor Interactions in the Older Population) is a multicenter study with cooperation partners from Germany, Italy, Portugal, Austria and Brazil. ComOn investigates the relationships between cognitive functioning and mobility in elderly patients. There are 1000 geriatric patients measured both in-patient and in the home. Data collection is performed using sensor-based motion analysis, neuropsychological testing, imaging and clinical investigations. The goals of the ComOn study are to determine meaningful sensor-based parameters for the evaluation of gait, balance, and executive dysfunction. In addition, the study serves to evaluate treatment concepts in the (acute) clinical setting. The study also highlights everyday activity and the quality of specific everyday movements (such as getting up, walking, turning around, sitting, lying down).
Studying motor imagery by means of EEG and using EEG for imagery-based neurofeedback.
Mobile Brain/Body Imaging (MoBI) is a recently developed a method that allows for simultaneous recording of brain and body dynamics of humans actively behaving in and interacting with their environment. A mobile imaging approach is needed to study cognitive processes that are inherently based on the use of human physical structure to obtain behavioral goals.
The Berlin Mobile Brain/Body Imaging Lab investigates the brain dynamics underlying and interacting with cognitive and behavioral dynamics in a range of research projects. Here we investigate the brain dynamics in humans actively exploring space (BMBF and DFG projects), the neural dynamics of physical interaction with dynamic objects in 3D space and the impact of architectural space on human perception and emotion.
