Julius Oben

Julius Oben
University of Yaounde I | UY1 ·  Department of Biochemistry

PhD

About

127
Publications
44,287
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2,857
Citations
Citations since 2017
30 Research Items
1149 Citations
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
Additional affiliations
August 2004 - March 2005
University of Yaounde I
Position
  • Head of Department
January 1993 - October 2018
University of Yaounde I
Position
  • Head of Department

Publications

Publications (127)
Preprint
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Background Many interventions in Cameroon focus on addressing severe wasting rather than targeting moderate wasting, although the latter is more prevalent. The objective of the study was to evaluate a program designed to treat moderate wasting using a food voucher program (FVP) tested in the Far North, examining the factors associated with dietary...
Preprint
Background Research on moderate acute malnutrition (MAM) is limited, despite its high prevalence. This study examined the impact of bi-weekly locally available foods provided via a Food Voucher Program (FVP) on nutritional recovery (mid-upper arm circumference (MUAC) ≥ 125 mm) from MAM (defined as MUAC between 115 and 124 mm) and identify the facto...
Article
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Aims: Hypertension (HTN) is one of the major public health problems in the world, especially in developing countries. The objective of this study was to evaluate its prevalence and its association with anthropometric indices among students of the University of Maroua. Study Design: A cross-sectional, analytical, and descriptive study was designed....
Article
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Objectives The beneficial role of spices on health has long been proven. In Cameroon, spices are mostly been consumed as a mixture added in meal preparations not for their health benefits but for their capacity to enhance the taste or the flavour of the meals. Therefore, associating the health advantages with the culinary properties will make it po...
Article
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Background and Objective: Diabetes mellitus and its oxidative complications are progressing around the world and plant-based products appear to be promising alternative treatments. The present study aimed to evaluate the antioxidant potential of the leaves of Glyphaea brevis (Tiliaceae) in an experimental model of diabetic rats. Materials and Metho...
Article
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Objective To determine antioxidant potentials of Allium sativum and Persea americana seeds extracts and three formulation-based extracts in vitro, and to evaluate the effects of the best formulation on oxidative stress and dyslipidemia on rats fed with high fat and high sucrose diet (HFHSD). Methods Aqueous extracts of Allium sativum, Persia. amer...
Article
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To gain further understanding of the interlinkages between poor water access, household food insecurity, and undernutrition among children, this study used a cross-sectional design with 474 female caretakers of children suffering from moderate acute malnutrition (MAM) to explore the relationship between limited access to water and diarrheal disease...
Article
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Prolonged hyperglycemia enhances oxidative stress. Bioactive compounds extracted possess antioxidant, anti-free radical potentials or the ability to reduce blood sugar levels. The objective of this study was to evaluate the antioxidant properties of extracts of stem bark of Coula edulis Baill., their abilities to trap free radicals and glucose, as...
Article
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Background: The negative effects of alcohol abuse are well documented. However, definitions of moderate alcohol consumption are still controversial, differ in many parts of the world, and are rarely including African countries. Objective: This study aimed to assess the effects of moderate consumption of beer as defined in many studies (less than 30...
Article
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Metabolic syndrome (MetS ) is a multi-faceted condition involving dyslipidemia, hyperglycemia, and overweight. The present work investigates the effect of mucilage of Calophyllum inophyllum nuts on body weight, plasma glucose, and plasma lipids in an animal model. Firstly, male Wistar rats were fed a high-fat/high sucrose (HFS) diet made of standar...
Article
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Several micronutrients are essential for adequate growth of children. However, little information is available on multiple micronutrient status of preschool children in Cameroon. The present study was designed to evaluate the relationship between multiple micronutrient levels and nutritional status among preschool school children. This was a cross-...
Article
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Background: Malnutrition due to poor feeding habits, is still a serious public health issue in Cameroon. The objective of this study was to assess the dietary patterns and nutritional status of women of childbearing age in various geographical settings in Cameroon so as to propose intervention strategies. Methods: In a cross sectional study conduct...
Article
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Atherosclerosis is the leading cause of the cardiovascular disease (CVD). This study aimed to evaluate the effect of the aqueous extract of Detarium microcarpum on metabolic disorders in rats fed with an atherogenic diet. The extract at two doses (200 mg/kg and 400 mg/kg) was co-administered in rats with an atherogenic diet. After 28 days, rats wer...
Article
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Background: COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite the World Health Organization’s publication of different measures to curb the spread of COVID-19, new cases are reported daily. These protective control measures put in place assumed that transmission of COVID-19 was mediated essentially through...
Article
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This work was aimed at evaluating the effects of C. anomala and C. arabica on Methotrexate (MTX) induced metabolic disorders. For this, the aqueous extract (AE) of C. anomala and C. arabica were prepared and their polyphenols, flavonoids and alkaloids contents determined as well as their antiradical and total antioxidant capacity. An animal experim...
Article
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Citrus sinensis, Persea americana and Allium sativum are good sources of large number of various bioactive substances including antioxidants. Antioxidants play an essential role in the prevention and treatment of type 2 diabetes and other metabolic diseases. This study was conducted to evaluate and compare the anti- lipid peroxidation, anti-hemolyt...
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Background Despite malaria, malnutrition and anaemia being major public-health challenges in Cameroon, very little has been reported on the interaction between these interconnected health determinants. This study therefore sought to investigate the relationship between malaria, anaemia, nutritional and socio-economic status amongst under—ten childr...
Article
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Sickle cell anaemia (SCA) is a genetic pathology which forms haemoglobin S (Hb S). Hb S under hypoxia condition polymerizes, leading to the free radicals production and the destruction of red blood cells' (RBCs) membrane. Considering the insufficiency and some adverse effects of existing treatments, the use of medicinal plant extracts as alternativ...
Article
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Citrus sinensis has intensively been used for its nutritional and therapeutic values, usually attributed to their antioxidant properties. Several studies have earlier focused on its fruits, seeds, oils, juice and flowers. This study focuses on leaves and aimed at determining radical scavenging capacity (RSC), antiradical power(ARP), total polypheno...
Article
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The present investigation aimed to study the effect of two culinary treatments (boiling and roasting) on the antidiabetic potential of Abelmoschus esculentus fruits and seeds in type 2 diabetic rats. Crude fiber, total phenolic content, and in vitro free radical scavenging capacity of the various culinary forms of the fruits and seeds were assessed...
Article
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The present study aimed at evaluating the effects of domestic culinary treatment on phytochemical contents (phenolic content and dietary fiber), and the antidiabetic potential of Vernonia amygdalina in type 2 diabetic rats. The culinary forms implied boiling leaves of V. amygdalina directly and eliminating the leaves’ bitterness before boiling. Sev...
Article
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Background: Previous work had shown the ability of an aqueous leaf and stem extract of Cissus quandrangularis (300 mg of CQR, CQR-300) to improve components of metabolic syndrome (MS) in overweight individuals. Objective: This small pilot study aimed to confirm the efficacy of CQR-300 in reducing the percentage body fat measured using two differ...
Article
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Objective To determine the prevalence of Hepatitis B Virus (HBV) infection in pregnant women and identify markers associated with vertical transmission of HBV. Methods Prospective and cross-sectional study over 10 months on 298 pregnant women attending antenatal clinics in the Cité Verte and Efoulan District hospitals in Cameroon. A dry tube blood...
Article
La generation des radicaux libres resultant de l’oxydation des lipides est l’un des problemes associes a la perte des aliments et des maladies notamment celles liees au surpoids et a l’obesite. Les especes oxygenees reactives telles que le radical hydroxyle et les hydroperoxydes sont generalement produites par des processus metaboliques normaux ou...
Article
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Background: Oxidation of macromolecules by free radicals leads to cellular oxidative damage implicated in several chronic human diseases. Natural antioxidants have become the target of a great number of research studies. Objective: This study was aimed at assessing in vitro inhibiting effects of Irvingia wombolu peel extracts on lipid peroxidation...
Article
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Background Quail eggs as a food item have recently been introduced into the diet of some Cameroonians. These eggs are being sold in local markets, but with many unfounded health claims. One claim is that quail eggs can reduce blood glucose levels in diabetics. It was therefore necessary to evaluate the effect of consuming quail eggs on blood glucos...
Article
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Background The objective of this study is to evaluate the effect of protein-rich mucuna product (PRMP) on lipid parameters of hyperlipidemic rats. Methods Hyperlipidemia was induced in male rats for 3 weeks through high-fat diet. After induction, 30 hyperlipidemic rats were divided into five groups of six rats: control group (CG) received casein an...
Article
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Background: Cameroon, as many Sub-Saharan African countries, is undergoing epidemiological transition. Parents as well as well their children are getting overweight and obese, mainly in large cities. Aims: This was a pilot study to identify the relationship between parents, environment and children body size in urban Cameroon. Study Design: This wa...
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Please cite this article as: Fuh NK et al., Estimates of malnutrition in children 6-59monhts of age based on the WHO standard reveal higher prevalence compared to the NCHS reference in a cross-sectional sample of children from North Cameroon. ABSTRACT The assessment of nutritional status based on the 2006 WHO (World Health Organisation) Standards v...
Article
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Production of free radicals is a normal metabolic process which if uncontrolled can result in metabolic disturbances such as hyperglycaemia and insulin resistance. The management of metabolic syndrome as well as type II diabetes, therefore should take into account the existence of these conditions: free radical production, hyperglycemia and insulin...
Article
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The aim of this study was to evaluate the protective effects of hydroethanolic extracts of S. scabrum and C. verticillata against cyclophosphamide induced toxicity. In this light, female albino wistar rats were treated by intraperitoneal administration of 100 mg/kg BW of cyclophosphamide or distilled water every other day for 7 days associated with...
Article
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Background: The metabolic syndrome is a common metabolic disorder associated to the increasing prevalence of overweight and obesity. Aims: To assess the prevalence of metabolic abnormalities and metabolic syndrome (MetS) among 16-21 years Cameroonian adolescents and analyzed the influence of age, gender and weight status. Study Design: This was a c...
Patent
Methods of improving a variety of health related factors including, but not limited to weight, cholesterol levels, triglyceride levels and HDL levels, is provided. In one embodiment, a method of reducing body weight in a mammal is provided; the method comprises administering a composition containing an effective amount of Dichrostachys glomerata, t...
Article
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Aims: Metabolic complications related to antiretroviral therapy are rarely investigated among HIV-infected patients in Cameroon. The study reports the prevalence of metabolic syndrome and its individual components among HIV-infected Cameroonians. Materials and Methods: We conducted a prospective, cross-sectional study of the prevalence of metabolic...
Article
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Background: Increased visceral fat, dyslipidemia and increased markers of inflammation and coagulation are cardiovascular risk factors commonly encountered in obese people with metabolic syndrome. Previous studies have shown that ground Dichrostachys glomerata (DG), a spice used in Western Cameroon, can have beneficial effects on inflammation and v...
Article
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The inhibitory effects of Statroltea, a potential functional food beverage produced from the leaves of Stathmostelma sp., on pancre-atic lipase activity were investigated using the pH-Stat technique. Results showed that Statroltea exerted a competitive inhibition on porcine pancreatic lipase activity in a dose dependant manner. A half enzyme activi...
Article
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Obesity is a complicated multifaceted problem generally accompanied by disturbances in carbohydrate and fat metabolism, insulin resistance as well as an increase in oxidative stress. The bark of Hypodaphnis zenkeri (HZ) and dry fruits of Xylopia aethiopica (XA) commonly used as spices in Cameroonian cuisine also have applications in traditional med...
Article
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Background: Anemia is a condition that has multiple origins. One such origin is the destruction of red blood cells' (RBCs) membrane induced by free radicals. Treatment of anemia could therefore be enhanced by the use of free radicals' scavengers potentially found in some medicinal plants. In this study, the protective effect of Harungana madagasca...
Patent
Full-text available
Methods of improving a variety of health related factors including, but not limited to weight, cholesterol levels, triglyceride levels and HDL levels, is provided. In one embodiment, a method of reducing body weight in a mammal is provided; the method comprises administering a composition containing an effective amount of Xylopia aethiopica, to the...
Patent
The present invention relates generally to methods and related compositions using flavonoids and/or indanes extracted from the stems and leaves of C. quadrangularis to reduce weight and inhibit lipase, α-amylase and α-glucosidase activity in mammals. By example and not by way of limitation, embodiments of the present disclosure, a composition and r...
Article
This comparative study reports the nutritional and toxicological characteristics of Mucuna pruriens flour and a protein-rich product developed from it. The protein-rich mucuna product (PRMP) was obtained by the 3 steps procedure: protein solubilisation, heat-coagulation and sieving. Three weeks rats (n=6 per group) were fed for 28 days on standard...
Article
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This work evaluated the effect of Dichrostachys glomerata on the improvement of antioxidant biomarkers in obesity and type 2 diabetes participants, in an eight-week randomized, double-blind, placebo-controlled design study. The active (400 mg) or placebo formulation were administered twice daily throughout the study period to two normoglycemic and...
Patent
Full-text available
Methods of improving a variety of health related factors including, but not limited to weight, cholesterol levels, triglyceride levels and HDL levels, is provided. In one embodiment, a method of reducing body weight in an overweight subject is provided; the method comprises administering a composition containing an effective amount of Hypodaphnis z...
Article
Full-text available
Objective . This study examined the prevalence of thinness, overweight, and obesity in Cameroon children ranging from 8 to 15 years old using several published references as evaluation tools. Methods . A stratified sample was used with eleven schools randomly selected, and data from 2689 children (52.2% girls) ranging from 8 to 15 years were analyz...
Article
Hydroethanolic extracts of leaves of Solanum scabrum and seeds of Cola verticillata were analysed for anticancer properties. A MTT assay was done to evaluate their antiproliferative properties after 24 and 48 h treatment with varying concentrations. qRT-PCR was used to evaluate the modulation of seven genes involved in apoptosis and angiogenesis af...
Article
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Two different mucilages were extracted from dika nut (Irvingia gabonensis) kernels and nkui (Trimphetta cordifolia) stem barks and the hypolipidemic and antioxidant effects were studied on Triton WR-1339 induced hyperlipidemic rats. The GC analysis revealed that, dika nut mucilage is an arabinogalactan type while nkui is a rhamnogalacturonane type....
Article
Full-text available
The present study aimed at evaluating the in vitro antioxidant and in vivo anti-hyperglycemic potential of pulp extracts of Irvingia wombolu fruits on streptozotocin -induced diabetic rats. After phytochemical screening, aqueous and hydroethanolic extracts of I. wombolu were analysed for polyphenol content. Antioxidant activity was assessed using t...
Article
The present study evaluated the effect of aqueous and hydroethanolic extracts of Guibourtia tessmannii on blood lipids and oxidative stress markers in both triton (WR-1339) and high fat diet induced hyperlipidemic rat models. Results revealed that treatment of tritonized hyperlipidemic rats with G. tessmannii extracts at dose of 200 mg/kg BW result...
Article
This chapter profiles the potential usage of the seed extracts of the West African bush mango (. Irvingia gabonensis [IG]). Different parts of the IG plant have been used in the treatment of many ailments. Both animal and human studies have shown the ability of tree bark extracts to treat myringitis and to act as an antidiarrheal, anti-ulcer agent,...
Article
Cordia platythyrsa Baker is known for its medicinal value. This paper deals with a phytochemical investigation of this species, from which cordioxime (1), a new dioxime γ-lactam has been isolated. Its structure was determined by comprehensive analyses of its 1 H and 13 C NMR, COSY, HMQC, and HMBC spectroscopic, and HREIMS data. The remaining two kn...
Article
Previous in vivo and in vitro experimental studies have shown Dichrostachys glomerata (DG), a spice used in western Cameroon, to have potential antioxidant and hypoglycemic properties. The purpose of the present study was to evaluate the effects of orally administered DG on various cardiovascular disease risk factors in obese normoglycemic and obes...
Article
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Summary: Amphimas pterocaroides, Harungana madagascariensis, Myrianthus arboreus and Cussonia barteri which are medicinal plants commonly used in Cameroon for the management or reversal of anaemia, were screened for their scavenging radical kinetic and the antianaemic properties. The scavenging radical kinetic was defined as the inhibition rate of...
Article
Full-text available
Several studies indicate that obesity is closely related to insulin resistance (IR). However, this relationship has not been adequately explored among Africans. This study aims to evaluate the prevalence of insulin resistance among obese Cameroonian women using some indirect methods for assessment of insulin resistance. We also analysed the correla...