Julius Lukeš Jr.Thomayerova nemocnice | FTNsP · Department of Ophthalmology
Julius Lukeš Jr.
M.D. Ph.D.
About
8
Publications
321
Reads
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15
Citations
Citations since 2017
Introduction
Additional affiliations
October 2020 - April 2021
CLIP: Childhood Leukaemia Investigation Prague
Position
- PostDoc Position
Description
- Impact of genetic aberrations on the metabolic setup of leukemic cells during the formation of acute lymphoblastic leukemia and its relapse
February 2017 - October 2020
CLIP: Childhood Leukaemia Investigation Prague
Position
- PhD Student
Description
- Identification and characterization of genetic aberrations in childhood acute leukemias
Education
February 2017 - October 2020
January 2017 - October 2020
October 2009 - June 2016
Publications
Publications (8)
You can read our work here: https://rdcu.be/b17FF
Clonal proliferation of megakaryoblasts, called transient abnormal myelopoiesis (TAM), is a rare disease of newborns triggered by trisomy 21 (constitutional or somatic) together with acquired mutations of GATA1 resulting in the exclusive production of its short variant - GATA1s. No other TAM drivers have been described so far. We have diagnosed a u...
Transient myeloproliferative disorder (TMD) is a hematopoietic disease, characterized by a clonal proliferation of immature megakaryoblasts in the neonatal period occurring in approximately 10% of newborns with Down syndrome (DS). Rarely, TMD occurs in non-DS newborns but then it is associated with somatic trisomy 21 (tri21). Tri21 together with in...
Fusion genes resulting from chromosomal rearrangements represent a hallmark of childhood acute lymphoblastic leukemia (ALL). Unlike more common fusion genes generated via simple reciprocal chromosomal translocations, formation of the ETV6‐ABL1 fusion gene requires 3 DNA breaks and usually results from an interchromosomal insertion. We report a chil...
