Julio Sotelo

Julio Sotelo
Universidad de Valparaíso (Chile) | CINV · School of Biomedical Engineering

PhD
Associate Professor, School of Biomedical Engineering, Universidad de Valparaíso, Valparaíso, Chile.

About

112
Publications
14,421
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524
Citations
Introduction
My main research areas are biomedical imaging processing, finite elements, blood flow quantification, and cardiovascular magnetic resonance. I have been developed several numerical methods to extract quantitative information from 4D flow MRI data in a three-dimensional domain, focused principally in facilitating the use of these methods to clinicians. Github: https://github.com/JulioSoteloParraguez
Additional affiliations
April 2020 - May 2020
Universidad de Valparaíso (Chile)
Position
  • Professor (Associate)
Description
  • e-mail: julio.sotelo@uv.cl
July 2016 - March 2020
Pontificia Universidad Católica de Chile
Position
  • PostDoc Position
Description
  • e-mail: jasotelo@uc.cl
October 2013 - March 2014
King's College London
Position
  • Research Assistant
Description
  • “Experimental, imaging, and computational validation of thoracic aorta hemodynamics”, Collaboration between KCL and Pontificia Universidad Católica de Chile.
Education
March 2021 - December 2022
Universidad del Desarrollo
Field of study
  • Data Science, Machine Learning, Network Science, Cloud Computing
March 2012 - March 2016
Pontificia Universidad Católica de Chile
Field of study
  • Electrical Engineering, Structural and Geotechnical Engineering
March 2012 - March 2014
Pontificia Universidad Católica de Chile
Field of study
  • Electrical Engineering, Structural and Geotechnical Engineering

Publications

Publications (112)
Preprint
Background After successful repair for coarctation of the aorta (CoA) abnormal blood flow patterns can be present, which may have a negative impact on left ventricular (LV) performance. The aim of this study is to investigate the relationship between aortic haemodynamics assessed by four-dimensional flow (4D flow) cardiac magnetic resonance imaging...
Article
Full-text available
Background and Purpose: Prognostic models based on cardiovascular hemodynamic parameters may bring new information for an early assessment of bicuspid aortic valve (BAV) patients, playing a key role in reducing the long-term risk of cardiovascular events. This work quantifies several three-dimensional hemodynamics parameters in different BAV patien...
Article
Full-text available
Three-dimensional (3D) engineered cardiovascular tissues have shown great promise to replace damaged structures. Specifically, tissue engineering vascular grafts (TEVG) have the potential to replace biological and synthetic grafts. We aimed to design an in-vitro patient-specific patch based on a hybrid 3D print combined with vascular smooth muscle...
Article
Full-text available
4D Flow Magnetic Resonance Imaging (MRI) is the state‐of‐the‐art technique to comprehensively measure the complex spatio‐temporal and multidirectional patterns of blood flow. However, it is subject to artifacts such as noise and aliasing, which due to the 3D and dynamic structure is difficult to detect in clinical practice. In this work, a new math...
Article
Full-text available
The hemodynamic parameters from 4D flow datasets have shown promising diagnostic value in different cardiovascular pathologies. However, the behavior of these parameters can be affected when the 4D flow data are corrupted by respiratory motion. The purpose of this work was to perform a quantitative comparison between hemodynamic parameters computed f...
Article
Full-text available
Ventricular-vascular interaction is central in the adaptation to cardiovascular disease. However, cardiomyopathy patients are predominantly monitored using cardiac biomarkers. The aim of this study is therefore to explore aortic function in dilated cardiomyopathy (DCM). Fourteen idiopathic DCM patients and 16 controls underwent cardiac magnetic res...
Article
Full-text available
Background: Chronic type B aortic dissection (TBAD) is associated with poor long-term outcome, and accurate risk stratification tools remain lacking. Pressurization of the false lumen (FL) has been recognized as central in promoting aortic growth. Several surrogate imaging-based metrics have been proposed to assess FL hemodynamics; however, their...
Article
Full-text available
Recent advances in medical imaging have confirmed the presence of altered hemodynamics in bicuspid aortic valve (BAV) patients. Therefore, there is a need for new hemodynamic biomarkers to refine disease monitoring and improve patient risk stratification. This research aims to analyze and extract multiple correlation patterns of hemodynamic paramet...
Article
Full-text available
In this paper, we applied a method for quantifying several left intraventricular hemodynamic parameters from 4D Flow data and its application in a proof-of-concept study in dilated cardiomyopathy (DCM) patients. In total, 12 healthy volunteers and 13 DCM patients under treatment underwent short-axis cine b-SSFP and 4D Flow MRI. Following 3D segment...
Article
Pulse Wave Velocity (PWV) corresponds to the velocity at which pressure waves, generated by the systolic contraction in the heart, propagate along the arterial tree. Due to the complex interplay between blood flow and the artery wall, PWV is related to inherent mechanical properties and arterial morphology. PWV has been widely accepted as a biomark...
Article
Purpose Three-dimensional (3D) quantification of circulation using a Finite Elements methodology. Methods We validate our 3D method using an in-silico arch model, for different mesh resolutions, image resolution and noise levels, and we compared this with a currently used 2D method. Finally, we evaluated the application of our methodology in 4D Fl...
Article
Full-text available
While the clinical gold standard for pressure difference measurements is invasive catheterization, 4D Flow MRI is a promising tool for enabling a non-invasive quantification, by linking highly spatially resolved velocity measurements with pressure differences via the incompressible Navier–Stokes equations. In this work we provide a validation and c...
Article
Full-text available
We addressed comprehensively the performance of Shortest-Path HARP Refinement (SP-HR), SinMod, and DENSEanalysis using 2D slices of synthetic CSPAMM and DENSE images with realistic contrasts obtained from 3D phantoms. The three motion estimation techniques were interrogated under ideal and no-ideal conditions (with MR induced artifacts, noise, and...
Conference Paper
Full-text available
Synopsis The clinical signi cance and economic burden of bicuspid aortic valve (BAV) disease justify the need for improved clinical guidelines and more robust therapeutic modalities. Recent advances in medical imaging have demonstrated the existence of altered hemodynamics in these patients. To identify hemodynamic biomarkers for BAV patients, we p...
Article
Aims In this study, we will describe a comprehensive haemodynamic analysis and its relationship to the dilation of the aorta in transposition of the great artery (TGA) patients post-arterial switch operation (ASO) and controls using 4D-flow magnetic resonance imaging (MRI) data. Methods and results Using 4D-flow MRI data of 14 TGA young patients...
Article
Full-text available
We proposed a novel method called HARP-I, which enhances the estimation of motion from tagged Magnetic Resonance Imaging (MRI). The harmonic phase of the images is unwrapped and treated as noisy measurements of reference coordinates on a deformed domain, obtaining motion with high accuracy using Radial Basis Functions interpolations. Results were c...
Preprint
Full-text available
We proposed a novel method called HARP-I, which enhances the estimation of motion from tagged Magnetic Resonance Imaging (MRI). The harmonic phase of the images is unwrapped and treated as noisy measurements of reference coordinates on a deformed domain, obtaining motion with high accuracy using Radial Basis Functions interpolations. Results were c...
Conference Paper
Full-text available
An important number of patients with dilated cardiomyopathy have improved their left ventricular function with an optimal treatment. However, it is not well understood whether remodeling represents a recovery in left ventricular (LV) hemodynamics. In this abstract, we discuss the capacity of the ejection fraction to represent disease remission, by...
Conference Paper
Full-text available
In this work, we introduce the Phase Complementary Spatial Modulation of Magnetization (PCSPAMM) acquisition sequence, designed to measure the tissue motion simultaneously with the flow velocity. With a pair of complementary acquisitions, PCSPAMM allows the estimation of a CSPAMMand a Phase-Contrast (PC) MR image, leading to improved tagging contra...
Conference Paper
Full-text available
The circulation is normally analyzed in a 2D cross-section of the aorta, manually placed. To avoid this problem, evaluate and validate a new methodology based on Finite Elements (FE) to calculate the circulation in three-dimensions, in in-silico models, and in the ascending aorta of a group of volunteers and patients. In in-silico experiment, we ob...
Preprint
Purpose: While the clinical gold standard for pressure difference measurements is invasive catheterization, 4D Flow is a promising tool for enabling a non-invasive quantification, by linking highly spatially resolved velocity measurements with pressure differences via the incompressible Navier–Stokes equations. In this work we provide a validation...
Chapter
Full-text available
Valve-related heart disease affects 27 million patients worldwide and is associated with inflammation, fibrosis and calcification which progressively lead to organ structure change. Aortic stenosis is the most common valve pathology with controversies regarding its optimal management, such as the timing of valve replacement. Therefore, there is eme...
Article
Full-text available
Objectives: Current risk assessment strategies in type B aortic dissection are focused on anatomic parameters, although haemodynamic abnormalities that result in false lumen (FL) pressurization are thought to play a significant role in aortic growth. The objective of this study was to evaluate blood flow of the FL using 4D flow magnetic resonance...
Article
Full-text available
Objective: To assess the relationship between regional wall shear stress (WSS) and oscillatory shear index (OSI) and aortic dilation in patients with bicuspid aortic valve (BAV). Approach and Results: Forty-six consecutive patients with BAV (63% with right-left-coronary-cusp fusion, aortic diameter ≤ 45 mm and no severe valvular disease) and 44 he...
Preprint
Full-text available
Valve-related heart disease affects 27 million patients worldwide and is associated with inflammation, fibrosis and calcification which progressively lead to organ structure change. Aortic stenosis is the most common valve pathology with controversies regarding its optimal management, such as the timing of valve replacement. Therefore, there is eme...
Article
Full-text available
Introduction In cardiovascular obstructions, as Coarctation of the Aorta (CoA), guidelines recommend treatment based on a relevant pressure drop (ΔP). Diagnostic ΔP is estimated by simplified Bernoulli (SB) and is measured as peak-to-peak (PtP) ΔP via catheterization. The divergences amid methods are understood, but it is common practice to widely...
Conference Paper
Full-text available
Tagging MR is still considered the gold standard for motion quantification in the heart walls. Although there are several methods for postprocessing this kind of images, harmonic phase methods such as HARP and SinMod has been widely used because of its simplicity and reliable results. In this work, we present a novel Harmonic Phase Interpolation (H...
Conference Paper
Full-text available
The generation of synthetic MR images allows the testing of several for postprocessing methodologies under controlled conditions. In this work, we developed an open source Python/C++ library for the generation of synthetic SPAMM, C-SPAMM and DENSE images, based on known magnetization expressions and using finite element geometries. Introduction Tag...
Article
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Purpose: To decompose the 3D wall shear stress (WSS) vector field into its axial (WSSA ) and circumferential (WSSC ) components using a Laplacian finite element approach. Methods: We validated our method with in silico experiments involving different geometries and a modified Poiseuille flow. We computed 3D maps of the WSS, WSSA , and WSSC using...
Article
Purpose: To decompose the 3D wall shear stress (WSS) vector field into its axial (WSSA) and circumferential (WSSC) components using a Laplacian finite element approach. Methods: We validated our method with in silico experiments involving different geometries and a modified Poiseuille flow. We computed 3D maps of the WSS, WSSA, and WSSC using 4D f...
Article
Full-text available
Objectives To compare the values of pulmonary regurgitation in patients with repaired Tetralogy of Fallot quantified from two-dimensional phase-contrast data, by using a new pixel-wise analysis and the standard velocity-averaging method. Design Quantitative in silico and in vivo analysis. Setting Hospital Sótero del Río. The magnetic resonance im...
Article
Purpose: To assess the variability of peak flow, mean velocity, stroke volume, and wall shear stress measurements derived from 3D cine phase contrast (4D flow) sequences under different conditions of spatial and temporal resolutions. Methods: We performed controlled experiments using a thoracic aortic phantom. The phantom was connected to a pulsati...