Julio Seijas

• Ph. D. Full Profesor
• Professor (Full) at University of Santiago de Compostela

A simple and efficient method was developed to prepare the novel fluorescent tetra‐substituted thiophene derivatives. This method involves using the Gewald's conditions, followed by the Vilsmeier–Haack–Arnold (VHA) formylation. By judiciously controlling the use of the VHA reagent, we have selectively introduced a formyl group into position 5 of th...

A convenient and effective synthesis of imidazo[1,2-a]pyrimidine derivatives has been developed under microwave irradiations using Al2O3 as a catalyst in solvent-free conditions. The functionalized imidazo[1,2-a]pyrimidine derivatives are useful in biochemistry and medical science. In our investigation, the antimicrobial activity of the synthesized...

The effect of doping the bisphenol A diglycidyl ether (DGEBA)/m-xylylenediamine (mXDA) system with gold nanoparticles (AuNP) has been studied with differential scanning calorimetry (DSC), thermogravimetric analysis, dynamic mechanical analysis (DMA), and dielectric analysis (DEA). The evolved heat (ΔHt), the glass transition temperature (Tg), and t...

Cholic acid is a trihydroxy bile acid with a nice peculiarity: the average distance between the oxygen atoms (O7 and O12) of the hydroxy groups located at C7 and C12 carbon atoms is 4.5 Å, a value which perfectly matches with the O/O tetrahedral edge distance in Ih ice. In the solid phase, they are involved in the formation of hydrogen bonds with o...

Polycyclic aromatic hydrocarbons are versatile building blocks for conjugated materials and can be applied in molecular electronics. Pyrenes are known as the best organic chromophores, and pyrene itself is known as an electron donor. Likewise, quinones are promising electrode materials for lithium-ion batteries. The calculations were performed for...

A new and suitable multicomponent one-pot reaction was developed for the synthesis of 2-amino-3-cyanopyridine derivatives. Background: This synthesis was demonstrated by the efficient and easy access to a variety of substituted 2-aminopyridines using enaminones as key precursors under solvent-free conditions. Methods: A range of spectroscopic techn...

The yellow-legged Asian hornet (Vespa velutina Lepeletier 1836 (Hymenoptera: Vespidae)) is naturally distributed in China, Southeast Asia, and India; however, recently it has been detected outside of its native area, confirmed as being established in South Korea, Europe, and Japan. Health risks and deaths caused by the invasive Vespa velutina sting...

The yellow-legged Asian hornet (Vespa velutina Lepeletier 1836 (Hymenoptera: Vespidae)) is naturally distributed in China, Southeast Asia and India; however it has since detected outside of its native area, confirmed as being established in South Korea, Europe and Japan. Health risks and deaths caused by the invasive Vespa velutina stings have beco...

Several computational studies have been published to predict the behaviour of naphthalenediimides (NDI) in the transport of electrons in batteries, as well as their physical properties. This communication compares NDI with their analogues resulting from replacing the nitrogen atom by phosphorus, sulphur, or selenium. The calculations were performed...

The yellow-legged Asian hornet (AH) (Vespa velutina Lepeletier 1836 (Hymenoptera: Vespidae)) is naturally distributed in China, Southeast Asia, and India; however, it has been detected outside of its native area, confirmed as being established in South Korea, Europe, and Japan. Health risks and deaths caused by AH stings have become a public health...

In a previous paper some of us presented the structure and some properties of a new family of ionic liquids, ILs, with a common cation, 1-butyl-3-methyl imidazolium (the popular [C4C1Im]⁺ or [BMIM]⁺) and a variety of anions based in thiocyanate (SCN)⁻: one reference sample and ten with anionic metal complexes of different valences: AlIII, MnII, FeI...

Lipophilicity of 15 derivatives of sodium cholate, defined by the octan-1-ol/water partition coefficient (log P), has been theoretically determined by the Virtual log P method. These derivatives bear highly hydrophobic or highly hydrophilic substituents at the C3 position of the steroid nucleus, being linked to it through an amide bond. The differe...

In this chapter we will present the basic concepts related to the physicochemical properties of the so-called surface active compounds or surfactants. In aqueous solution they significantly reduce the surface tension of water and above a given concentration they self-aggregate to form aggregates normally named as micelles, and the concentration at...

In this chapter we will present the basic concepts related to the physicochemical properties of the so‐called surface active compounds or surfactants. In aqueous solution they significantly reduce the surface tension of water and above a given concentration they self‐aggregate to form aggregates normally named as micelles, and the concentration at...

The specific synthesis of N-alkylated pyridone has attracted considerable attention due to the presence of these units in a wide range of components, both in natural products and in many active pharmaceuticals. Generally, the synthesis of N-alkyl-2-pyridones is feasible by the alkylation of 2-pyridones. In this case, selectively witching the reacti...

2-aminopyridines scaffolds are an important class of nitrogen heterocyclic compounds with a wide range of biological activities. Multicomponent reactions (MCRs) are useful methods for the construction of nitrogen heterocyclic compounds. In this context, syntheses of 2-aminopyridines derivatives via MCRs have attracted considerable attention in rece...

Metabolism is one of the prime reasons where most of drugs fail to accomplish their clinical trials. The enzyme CYP3A4, which belongs to the superfamily of cytochrome P450 enzymes (CYP), helps in the metabolism of a large number of drugs in the body. The enzyme CYP3A4 catalyzes oxidative chemical processes and shows a very broad range of ligand spe...

Fifteen years ago, at least one multimated female yellow-legged Asian hornet (Vespa velutina Lepeletier 1836) arrived in France, which gave rise to a pan-European invasion. In this study, the isolation and characterization of chitin (CHI) that was obtained from Vespa velutina (CHIVV) is described. In addition, an easy procedure is carried out to ca...

The isolation and characterization of chitin (CHI) obtained from Vespa velutina (CHIVV) is described. Moreover, a trapping procedure is presented to selectively catch the invasive species. The chitin contents of dry Vespa velutina was observed to be 11.7 %. The physicochemical properties of CHIVV was characterized by Fourier transform infrared spec...

A complete characterization of the aggregation process of the sodium salts of chenodeoxycholic (NaCDC) and obeticholic (NaObC) acids has been carried out by using different experimental techniques. Since it is well known that the presence of hydrophobic groups strongly reduce the critical aggregation concentrations and modifies the type of aggregat...

The crystal structure of the iodide salt of a quaternary ammonium derivative of cholic acid having a naphthalene group attached to the 3rd position of the steroid nucleus through an amide bond ([3,5,7,12]-3-(2-naphthyloylamino)-7,12-dihydroxycholan-24-triethylammonium iodide) has been resolved. The compound crystallizes in the P212121 orthorhombic...

We present a new family of ionic liquids (ILs) with a common cation, 1-butyl-3-methyl imidazolium, the popular [BMIM] ⁺ (also written C 4 C 1 Im ⁺ ) and a variety of anionic complexes (also called adducts) based in thiocyanate (SCN) ⁻ : one blank compound, BMIM(SCN), and ten doped with metals having different oxidation states: Al ⁺³ , Mn ⁺² , Fe ⁺³...

This work reports synthesis of ten novel derivatives of 5-(1-(substituted phenyl)-4,5-diphenyl-1H-imidazol-2-yl)-4-methylthiazole 5(a–o). The reaction of benzil, primary aryl amines, 4-methylthiazole-5-carbaldehyde and ammonium acetate was carried out in one pot in the presence of eco-friendly catalyst Ceric ammonium nitrate in solvent ethanol to g...

This work reports ultrasound assisted synthesis diethyl (2-(1-(morpholinomethyl)-2-oxoindolin-3-ylidene)hydrazinyl) (substituted phenyl/heteryl) methylphosphonate 9(a–j) derivatives. The derivatives are synthesized using a green protocol. In the first step, 3-hydrazonoindolin-2-one is synthesized using ultrasound. In the second step, diethyl (subst...

The ester 3-(octanoyloxy) -4-nitrobenzoic acid is a standard for the assay of the activity of phospholipase enzymes (the main toxins involved in tissue-damaging after snake bites). Because of its amphiphilic nature, it probably behaves as a surfactant but the instability of the ester bond prevents its characterization. Its eter analogous, 3 (octylo...

Two ether and one ester derivatives of the 4-nitro-3-hydroxybenzoic acid were synthesized and characterized. The in vitro antimicrobial and cytotoxic activities of the three novel compounds were also evaluated. The aromatic derivatives showed antibacterial activity against one of the four microorganisms tested and two compounds (C8 and NOBA) had a...

We report a spectroscopic, structural, optical and magnetical characterization of tetra(1-butyl-3-methylimidazolium) hexaisothiocyanatonickelate. This paramagnetic ionic liquid exhibits reversible and continuous thermochromism from 298 K up to 400 K and it is solar responsive resisting numerous heating-cooling cycles. Its appearance changes from pa...

The work reports the facile synthesis of novel α-aminophosphonate derivatives coupled with indole-2,3-dione moieties, namely the diethyl(substituted phenyl/heteroaryl)(2-(2-oxoindolin-3-ylidene)hydrazinyl)methylphosphonates derivatives 4(a–n). One-pot three component Kabachnik-Fields reactions were used to synthesize these derivatives. The reaction...

A series of ten novel derivatives of 4-(benzyloxy)-N-(3-chloro-2-(substituted phenyl)-4-oxoazetidin-1-yl) benzamide 6a–j were synthesized in good yield from the key compound 4-(benzyloxy)-N′-(substituted benzylidene) benzo hydrazide, called Schiff ’s bases 5a–j, by Staudinger reaction ([2 + 2] ketene-imine cycloaddition reaction) with chloro acetyl...

In this work we introduce the zinc 5,10,15,20-tetra(4-pyridyl)-21H,23H-porphine (ZnTPyP) macrocycle as a crosslinking agent of the epoxy resin BADGE n = 0. NMR, TEM and FTIR confirm that both homopolymerization and heteropolymerization (resulting in the formation of a pyridone) are taken place. DSC evidences two exothermic signals at 170 and 290°C,...

Cancer is a group of diseases involving abnormal cell growth with the potential to spread to other parts of the body, is one of the most formidable afflictions in the world. However, 100% effective cancer treatment is not available. The design of cancer chemotherapy has become increasingly difficult. Currently, cancer therapy interfering with a sin...

The actual significance of the so-called compensation temperature Tcfor micellization of surfactants is reviewed. It is demonstrated that it is possible to obtain as many Tcvalues as the number of temperature intervals in which the dependencies of enthalpy and entropy changes with temperature are analyzed. The value of each Tcwill be the central va...

Herein, we report an environmentally friendly, rapid, and convenient ionic liquid ([Et3NH][HSO4])-promoted facile synthesis of ethyl 4-(6-substituted-4-oxo-4H-chromen-3-yl)-6-methyl-2-thioxo/oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives 4(a–f) and 4-(6-substituted-4-oxo-4H-chromen-3-yl)-6-methyl-2-thioxo/oxo-1,2,3,4-tetrahydropyrimidin...

The crystal structures of two ester compounds (a monomer in its methyl ester form, with an amino isophthalic group, and a dimer in which the two steroid units are linked by a urea bridge recrystallized from ethyl acetate/methanol) derived from cholic acid are described. Average bond lengths and bond angles from the crystal structures of 26 monomers...

A series of 6-amino-4-substituted-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles 5a–j were synthesized via one-pot, four-component condensation reactions of aryl aldehydes 1a–j, propanedinitrile (2), hydrazine hydrate (3) and ethyl acetoacetate (4) under solvent-free conditions. We report herein the use of the Brønsted acid ionic liquid...

The work reports the synthesis under solvent-free condition using the ionic liquid [Et3NH][HSO4] as a catalyst of fifteen novel 3-((dicyclohexylamino)(substituted phenyl/heteryl)-methyl)-4-hydroxy-2H-chromen-2-onederivatives 4a–o as potential antimicrobial agents. The structures of the synthesized compounds were confirmed by IR, ¹H-NMR, ¹³C-NMR, ma...

In the present work, 12 novel Schiff’s bases containing a thiadiazole scaffold and benzamide groups coupled through appropriate pharmacophore were synthesized. These moieties are associated with important biological properties. A facile, solvent-free synthesis of a series of novel 7(a–l) N-((5-(substituted methylene amino)-1,3,4-thiadiazol-2-yl)met...

A series of 6-amino-4-substituted-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles 5(a-j) as a potent anticancer agent were synthesized via one-pot, four-component condensation reaction of aryl aldehydes, ethyl acetoacetate, malononitrile, and hydrazine hydrate in solvent-free conditions using ionic liquid [Et3NH][HSO4] as an efficient, ec...

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Microwave induced synthesis has various advantages over conventional synthesis, such as highly accelerated reaction rate , reasonable better yields, simple open systems, no solvent or very less amount of solvents required, eco friendly method, clean heating system and control on reaction parameters .In the present work novel Schiff’s bases containi...

The work reports synthesis of 15 novel 3-((dicyclohexylamino)(substituted phenyl/heteryl)methyl)-4-hydroxy-2H-chromen-2-one derivatives 4 (a-o) as potential antimicrobial agents in solvent-free condition using Triethyl ammonium sulphate [Et3NH][HSO4] as an efficient, eco-friendly and reusable catalyst. Compared to other methods, this new method con...

The main objective of this work is the synthesis of epoxy nanocomposites with gold nanoparticles. The curing process was optimized by microwave taking into account variables such as time and temperature.

Herein, we report an environmentally friendly, rapid, and convenient one-pot ultrasound-promoted synthesis of 5-amino-2-(4-chlorophenyl)-7-substituted phenyl-8,8a-dihydro-7H-(1,3,4)thiadiazolo(3,2-α)pyrimidine-6-carbonitrile derivatives. The in-vitro anticancer activities of these compounds were evaluated against four human tumor cell lines. Among...

A novel series of 5-(4-(benzyloxy)substituted phenyl)-3-((phenyl amino)methyl)-1,3,4-oxadiazole-2(3H)-thione Mannich bases 6a–o were synthesized in good yield from the key compound 5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazole-2(3H)-thione by aminomethylation with paraformaldehyde and substituted amines using molecular sieves and sonication as green che...

Nonlinear absorption has been investigated by open aperture Z-scan in ionic liquids obtained by combination of 1-butyl-3-methyl-imidazolium cations with anions containing a transition metal (Co, Zn, Cu or Ni) and thiocyanate groups. The laser source was a Ti:Sapphire oscillator (80-fs pulses, λ = 810 nm, repetition rate of 80.75 MHz). All liquids p...

In the category of microorganism, fungi are considered as the special class of microbes responsible for opportunistic pathogenic infections in humans species. Due to the side effects of commercially available antifungal drugs and the emergence of new drug resistant fungal species in the past few years has forced the researchers to search for novel...

The curing reaction of a system consisting of a diglycidyl ether of bisphenol-A (n= 0) and ZnTPyP (Zinc 5,10,15,20-tetra(4-pyridyl)-21H,23H-porphyrin) was studied by Fourier Transform infrared spectroscopy (FTIR). A semi-empirical quantum chemistry program (MOPAC) was used to corroborate the experimental data. The tertiary amine ZnTPyP not only ini...

Here is the report of an environment friendly, rapid, and convenient one-pot ultrasound-promoted synthesis of 5-amino-2-(4-chlorophenyl)-7- substituted phenyl-8,8a-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidine-6-carbonitrile derivatives. Multi-component reactions are useful for the creation of chemical libraries of drug-like compounds with levels...

Nonlinear absorption has been investigated by open aperture z-scan in ionic liquids obtained by combination of 1-butyl-3-methyl-imidazolium cations with anions containing a transition metal (Zn) and thiocyanate groups. The laser source was a Ti: Sapphire oscillator (80-fs pulses, λ= 810 nm, repetition rate of 80.75 MHz). This ionic liquid presents...

A highly sensitive, accurate and robust LC-MS/MS method was developed and validated for determination of nimorazole (NMZ) in rat plasma using metronidazole (MNZ) as internal standard (IS). The analyte and IS were extracted from plasma by precipitating protein with acetonitrile and were chromatographed using an Agilent Poroshell 120, EC-C18 column....

Litsea polyantha Juss. (Lauraceae) also known as Litsea monopetala Roxb. is a small to medium sized evergreen tree distributed chiefly in tropical and subtropical Asia, Australia and the Pacific Islands. The bark of Litsea polyantha Juss. has a long history of medicinal use among the traditional healers of Oraon and Munda community of Jharkhand (In...

Flavonoids and phenolic compounds from plants have been reported to have multiple biological effects. In the present communication, bioactive compounds from Litsea polyantha Juss. bark were studied. The total phenolic content was determined by using the Folin-Ciocalteu reagent and aluminum chloride colorimetric method was used for determination of...

A novel, fast and efficient method for the synthesis of (3E)-3-(1-aminoethylidene)-6-methyl-3,4-dihydro2H- pyran-2,4-dione, a natural antiproliferative and cytotoxic product isolated from Fusarium incarnatum (HKI0504), was developed from dehydroacetic acid and urea under solvent-free microwave irradiation. The analysis of the co-crystal structure r...

Ammonium trichloro[1,2-ethanediolato-O,O′]-tellurate (AS101) is the most important synthetic Te compound from the standpoint of its biological activity. It is a potent immunomodulator with a variety of potential therapeutic applications and antitumoral action in several preclinical and clinical studies. An experimental design has been used to devel...

The ionic liquid 1-allyl-3-methylimidazolium chloride was prepared in a fast and efficient way by solventless microwave irradiation of allyl chloride and N-methylimidazole in a sealed vessel.

Plant oils are important supplies in world markets due to their widespread use in many branches of industry, cosmetics and nutrition. Control of their composition is a subject of major interest. In particular argan oil (from the kernels of Argania spinosa L.) has been claimed to have beneficial properties from therapeutical and cosmetic fields. Up...

Administration of hormonal compounds as growth promoters in livestock farming was banned by Council Directive 96/22/EC. However, this kind of substances is sometimes reported within the framework of European monitoring residue plans. Various analytical methods have been previously developed to screen for their misuse, and they are now especially ef...

Virgin oils obtained from seeds of Camellia oleifera (CO), Camellia reticulata (CR) and Camellia sasanqua (CS) were studied for their triacylglyceride composition, antioxidant and antimicrobial activities. Levels of fatty acids determined by ¹H-nuclear magnetic resonance analysis were similar to those reported for olive oils (82.30%–84.47%; 5.69%–7...