Julio Levano Garcia

Julio Levano Garcia
Quimtia | QUIMTIA

Ph.D
Vaccine Development Research

About

15
Publications
10,456
Reads
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200
Citations
Introduction
I am interested in projects aimed on parasite, bacterial and viral vaccine development, cell line development, study new targets for drugs or vaccine to human and animals. However, interested on gene editing, protein engineering and bioprocess scaling.
Additional affiliations
July 2018 - December 2019
Universidad Privada del Norte (Perú)
Position
  • Lecturer
April 2018 - present
Universidad Privada del Norte
Position
  • Laboratory Coordinator
July 2017 - August 2017
National University of San Marcos
Position
  • Consultant
Description
  • Malaria research .
Education
March 2003 - February 2008
University of São Paulo
Field of study
  • Biochemistry
July 2000 - February 2003
University of São Paulo
Field of study
  • Biochemistry
July 1992 - June 1997

Publications

Publications (15)
Article
Full-text available
Worldwide, poultry infections by Salmonella are the cause of significant economic losses, not only due to reduced production (due to fowl typhoid disease), but also considering the efforts and control measures that must be constantly applied, especially due to zoonotic serovars. Poultry is a common reservoir of Salmonella and its transmission into...
Article
Full-text available
Inositol 1,4,5 trisphosphate (IP3) signaling plays a crucial role in a wide range of eukaryotic processes. In Plasmodium falciparum, IP3 elicits Ca²⁺ release from intracellular Ca²⁺ stores, even though no IP3 receptor homolog has been identified to date. The human host hormone melatonin plays a key role in entraining the P. falciparum life cycle in...
Article
Full-text available
The malaria parasite Plasmodium falciparum is exposed, during its development, to major changes of ionic composition in its surrounding medium. We demonstrate that the P. falciparum serpentine-like receptor PfSR25 is a monovalent cation sensor capable of modulating Ca2+ signaling in the parasites. Changing from high (140 mM) to low (5.4 mM) KCl con...
Article
Full-text available
Schistosomiasis is a debilitating disease caused by flatworm parasites of the Schistosoma genus and remains a high public health impact disease around the world, although effective treatment with Praziquantel (PZQ) has been available since the 1970s. Control of this disease would be greatly improved by the development of a vaccine, which could be c...
Article
Full-text available
We previously reported that melatonin modulates the Plasmodium falciparum erythrocytic cycle by increasing schizont stage population as well as diminishing ring stage population. In addition, the importance of calcium and cAMP in melatonin signaling pathway in P. falciparum was also demonstrated. Nevertheless, the molecular effectors of the indolea...
Article
Full-text available
Unlabelled: Plasmodium falciparum, the most important etiological agent of human malaria, is endowed with a highly complex cell cycle that is essential for its successful replication within the host. A number of evidence suggest that changes in parasite Ca(2+) levels occur during the intracellular cycle of the parasites and play a role in modulati...
Thesis
Full-text available
ATPDases or ATP-diphosphohydrolases are enzymes that cleave ATP and ADP to AMP and Pi and are involved in inhibition of platelet aggregation. In the parasite Schistosoma mansoni our group had identified and cloned the ATPDase1 gene and localized the protein on the tegument surface. Recently, we cloned the ATPDase2 gene using S. mansoni EST databank...
Article
Full-text available
Schistosoma mansoni is a major causative agent of schistosomiasis, which constitutes a severe health problem in developing countries. We have previously described the SmATPDase1 gene, encoding a protein from the external surface of the parasites. In this work, we describe the cloning and characterization of SmATPDase2, a novel CD39-like ATP diphosp...
Article
Full-text available
A novel mapping method based on touchdown PCR was developed for identifying a transposon insertion site in genomic DNA using a hybrid consensus-degenerate primer in combination with a specific primer that anneals to the transposon. The method was tested using Xanthomonas citri transposon mutants. PCR products contained adjacent DNA regions that bel...
Thesis
Full-text available
Xanthomonas axonopodis pv citri (Xac), a gram-negative bacteria, is the causer of the Citrus Canker disease that produce enormous losses to the Brazilian citrus sector. Many coding sequences with unknown functions were found in the genome sequences of this pathogen. Therefore, with the goal of functional studies of Xac´s genome, random mutants usin...

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