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Publications
Publications (14)
Cryo-electron tomography maps often exhibit considerable noise and anisotropic resolution, due to the low-dose requirements and the missing wedge in Fourier space. These spurious features are visually unappealing and, more importantly, prevent an automated segmentation of geometric shapes, requiring a subjective and labor-intensive manual tracing....
Electron cryo-tomography allows for high-resolution imaging of stereocilia in their native state. Because their actin filaments have a higher degree of order, we imaged stereocilia from mice lacking the actin crosslinker plastin 1 (PLS1). We found that while stereocilia actin filaments run 13nm apart in parallel for long distances, there were gaps...
The original version of this chapter contained an error in the fourth author’s name. The spelling of Julio Kovacs’s name was incorrect in the header of the paper. The author name was corrected.
Cryo-electron tomography maps often exhibit considerable noise and anisotropic resolution, due to the low-dose requirements and the missing wedge in Fourier space. These spurious features are visually unappealing and, more importantly, prevent an automated segmentation of geometric shapes, requiring a highly subjective, labor-intensive manual traci...
Electron cryo-tomography allows for high-resolution imaging of stereocilia in their native state. Because their actin filaments have a higher degree of order, we imaged stereocilia from mice lacking the actin crosslinker plastin 1 (PLS1). We found that while stereocilia actin filaments run in parallel for long distances, 13 nm apart, there were gap...
Flexible Fitting and Refinement of Atomic Structures Using the Coarse-Grained DDFF Force Field Tailored to 5-10A Resolution Cryo-TEM Maps - Volume 23 Issue S1 - Julio Kovacs, Vitold E. Galkin, Willy Wriggers
An Information Theoretic Approach for Creating 3D Spatial Images from 4D Time Series Data - Volume 23 Issue S1 - Willy Wriggers, Julio Kovacs, Federica Castellani, P. Thomas Vernier, Dean J. Krusienski
Three-dimensional density maps of biological specimens from cryo-electron microscopy (cryo-EM) can be interpreted in the form of atomic models that are modeled into the density, or they can be compared to known atomic structures. When the central axis of a helix is detectable in a cryo-EM density map, it is possible to quantify the agreement betwee...
Cryo-electron microscopy (cryo-EM) is an important biophysical technique that produces three-dimensional (3D) density maps at different resolutions. Because more and more models are being produced from cryo-EM density maps, validation of the models is becoming important. We propose a method for measuring local agreement between a model and the dens...
A navigation system for an autonomous mobile robot is described, which is basically probabilistic. The sensing of the environment is made through a rangefinder, each measurement updating an occupancy grid, which is the internal representation of the robot's environment. The vehicle uses only local information for path planning and obstacle avoidanc...
In this work we prove a global uniqueness theorem about Schwarzschild space-time. It uses the notions of static-completeness and of compatible family of local isometries, which are defined in this work. The theorem says that a static complete, simply connected space-time, which is compatibly locally isometric to Schwarzschild space-time, is (global...
The diffusion model presented is able to describe the parabolic and cubic behavior of the pretransition oxidation kinetics of polycrystalline zirconium in dry oxygen during isothermal oxidation treatments at 573 and 623 K. The model considers that the dynamic process of crystallization and recrystallization during oxidation modifies the oxygen diff...
The codes that simulate materials interactions in nuclear core degradation or core meltdown generally use the kinetic rate constants obtained from isothermal diffusion experiments. They calculate the interphase boundaries (IB) movements during temperature transients as a succession of isothermal steps at different temperatures. An alternative proce...
