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January 2011 - December 2014
- Postdoctoral Research Assistant
Image scanning microscopy (ISM) coupled with pixel reassignment offers a resolution improvement of 1.41 over standard widefield imaging. By scanning point-wise across the specimen and capturing an image of the fluorescent signal generated at each scan position, additional information about specimen structure is recorded and the highest accessible s...
Humans can detect the E-vector of incident polarized light using a subtle, transient visual phenomenon known as Haidinger’s brush. The effect is a result of the human macula having the properties of a radial analyser with peak absorption at 460 nm. A number of mechanisms, each capable of generating radial diattenuation, have been proposed: (1) obli...
Environmental scanning electron microscopy (ESEM) (1) is an imaging technique which allows hydrated, insulating samples to be imaged under an electron beam. The resolution afforded by this technique is higher than conventional optical microscopy but lower than conventional scanning electron microscopy (CSEM). The major advantage of the technique is...
We present a mini review of the microscopical techniques that may be used to investigate the process of myelination in the tissues of the mammalian central nervous system. The biological background to myelination, the process by which neuronal axons are electrically insulated to achieve higher conduction velocities is outlined, including an introdu...
The Environmental Scanning Electron Microscope (ESEM) differs from a conventional SEM in that a differential pumping system maintains a pressure of gas (typically H2O) in thespecimen chamber whilst the gun remains at high vacuum. Ionizing collisions between electrons and these gas molecules create positive ions which drift down onto the sample neut...
Historically, electron microscopy of dynamic biological processes has been impossible to achieve in real time because conventional electron microscopy requires specimen fixation, dehydration and metallic coating. The advent of the environmental scanning electron microscope removes these restrictions, allowing fully hydrated samples to be imaged in...