Julieta Moreno

National Autonomous University of Mexico | UNAM · School of Higher Studies (F.E.S.) Iztacala

Background: Single suture craniosynostosis is the premature fusion of one or more cranial sutures. It may lead to structural and functional brain abnormalities. The prevalence of this condition has not been fully described in Mexico. Objective: To know the number of cases of the different types of single suture craniosynotosis at “La Raza” General...

Craniosynostosis is the premature closure of one or more cranial sutures that results in an abnormal skull shape. This condition has been associated with cognitive problems of different levels of severity in all developmental stages in a substantial percentage of children. However, the study of behavioral problems related to this condition has been...

INTRODUCTION: Craniosynostosis is the simple early closure of one or more cranial sutures that causes abnormal growth of the skull and that can lead to abnormal growth of the brain. The treatment of craniosynostosis is surgical and eliminates growth restriction caused by the fused suture. Neurodevelopmental assessments in these patients have genera...

Introduction: Single suture craniosynostosis is the premature closure of one or more cranial sutures. It leads to abnormal skull growth and in some cases to structural and/or functional brain abnormalities. If these anomalies cause a psychomotor development lag and/or cognitive impairment is a controversial topic. This study aims to review the main...

Rationale & Objective Peritoneal dialysis (PD) solutions provide both clearance of uremic toxins and sodium and water. An intraperitoneal (IP) solution of icodextrin and glucose designed without the requirement for uremic toxin clearance could provide substantially greater sodium and water removal than PD solutions. Study Design We examined varyin...

Background Torsemide is proposed to have clinically important pharmacokinetic and pharmacodynamic advantages over furosemide. However, clinical outcomes did not differ in the Torsemide Comparison with Furosemide for Management of Heart Failure (TRANSFORM-HF) randomized trial. Methods We conducted a multicenter mechanistic substudy of patients with...

Aims Loop diuretics may exacerbate cardiorenal syndrome (CRS) in heart failure (HF). Direct sodium removal (DSR) using the peritoneal membrane, in conjunction with complete diuretic withdrawal, may improve CRS and diuretic resistance. Methods and results Patients with HF requiring high‐dose loop diuretics were enrolled in two prospective, single‐a...

Objective Assess the Health-Related Quality of Life in children and adolescents with non-syndromic craniosynostosis and compare it with participants without craniosynostosis. Design Non-experimental, cross-sectional design. Setting The assessment was done remotely and the instrument was sent via chat or email. Patients/ Participants Participants...

Background: The effects of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on regional tubular sodium handling is poorly understood in humans but may be important for the cardio-renal benefits. Methods: The study utilized a previously reported randomized, placebo-controlled crossover study of empagliflozin 10 mg daily in patients with diabete...

Background and objectives: Approaches to distinguish pathologic cardiorenal dysfunction in heart failure (HF) from functional/hemodynamically mediated changes in serum creatinine are needed. We investigated urine galectin-3 as a candidate biomarker of renal fibrosis and prognostic indicator of cardiorenal dysfunction phenotypes. Design, setting,...

Aims: Previous studies have suggested venous congestion as a stronger mediator of negative cardio-renal interactions than low cardiac output, with neither factor having a dominant role. While the influence of these parameters on glomerular filtration have been described, the impact on diuretic responsiveness is unclear. The goal of this analysis w...

Introduction: The use of teleneuropsychology (TeleNP) increased as a result of the COVID-19 pandemic; however, there have been no studies of the benefits and difficulties with this modality in middle-income countries. This study aimed to assess the current use of TeleNP in Mexico. Method: Mexican neuropsychologists were invited to participate in...

Background: Following treatment for acute decompensated heart failure, in-hospital observation on oral diuretics (OOD) is recommended, assuming it provides actionable information on discharge diuretic dosing and thus reduces readmissions. Methods: In the Mechanisms of Diuretic Resistance (MDR) cohort, we analyzed in-hospital measures of diuretic...

This study aimed to determine the cognitive profile of preschool children undergoing surgery to correct non-syndromic craniosynostosis, compare them with typically developing children, and analyze possible cognitive deficits in the most prevalent subtypes: sagittal and unicoronal. Thirty-one children aged 3 years to 5 years and 11 months with non-s...

Background: Improvement in renal function (IRF) in acute decompensated heart failure is associated with adverse outcomes. The mechanisms driving this paradox remain undefined. Methods: Using the ROSE-AHF study (Renal Optimization Strategies Evaluation-Acute Heart Failure), 277 patients were grouped according to renal function, with IRF defined b...

Background: Congestion is central to the pathophysiology of heart failure (HF); thus, tracking congestion is crucial for the management of patients with HF. In this study we aimed to compare changes in inferior vena cava diameter (IVCD) with venous pressure following manipulation of volume status during ultrafiltration in patients with cardiac dys...

Objective The objective of this study is to propose a TeleNP model for remote assessment and offer practical recommendations for clinical practice with patients in Mexico and Latin America, based on a systematic literature review and clinical experience. Method A systematic review of studies from 2011 to 2021 in English and Spanish used TeleNP, te...

Williams Syndrome (WS) is a neurodevelopmental disorder with a distinctive physical, cognitive, and behavioral profile caused by a microdeletion in the q11.23 region of chromosome 7. The neuropsychological profile of WS is characterized by intellectual disability, hypersociability, and deficits, especially in attention and visuospatial skills. Our...

Background Animal models implicate FGF-23 (fibroblast growth factor-23) as a direct contributor to adverse cardiorenal interactions such as sodium avidity, diuretic resistance, and neurohormonal activation, but this has not been conclusively demonstrated in humans. Therefore, we aimed to evaluate whether FGF-23 is associated with parameters of card...

Aims In healthy volunteers, the kidney deploys compensatory post-diuretic sodium reabsorption (CPDSR) following loop diuretic-induced natriuresis, minimizing sodium excretion and producing a neutral sodium balance. CPDSR is extrapolated to non-euvolemic populations as a diuretic resistance mechanism; however, its importance in acute decompensated h...

Congestion is the primary pathophysiologic lesion in most heart failure (HF) hospitalizations. Renal congestion increases renal tubular pressure, reducing glomerular filtration rate (GFR) and diuresis. Because each nephron is a fluid filled column, renal negative pressure therapy (rNPT) applied to the urinary collecting system should reduce tubular...

Background Craniosynostosis is defined as a premature fusion of one or more cranial sutures. Several studies have revealed cognitive deficits in some children who had undergone surgery to treat craniosynostosis. However, no general distinction has been drawn in the cognitive abilities between the various types of craniosynostosis. The purpose of th...

Introducción: la craneosinostosis simple es la fusión prematura de una o varias suturas craneales. Esta patología puede provocar diversas alteraciones funcionales y estructurales cerebrales. En México no se ha caracterizado de forma específica la prevalencia de esta condición. Objetivo: conocer el número de casos atendidos con craneosinostosis simp...